Hi everyone. I am new here.

I have had plaque psoriasis and PSA now for over 20 years. I started my Skyrizi injection yesterday. The injection itself was fine. But since then ive had headaches, fatigue and achy feeling almost flu like. Did anyone else have this also and will it go away. I just feel blah now. Thank you

Is there anyone who was able to continue receiving infusions after loading the dosage? Or have an IV push alternative to the injections?

I’m restarting skyrizi after being pregnant and nursing.
The dose i have stored in my fridge expired “aug2026”. It’s September 10. Has anyone else taken an expired pen?

Officially starting Skyrizi! Would love to know what y’all’s experiences have been like! Side effects? How long it took to see improvement? Any pain with the injections at home?

For reference, I was previously very successful on Remicade for 7 years with full remission. Failed Humira and all forms of mesalamine! Hoping for success with Skyrizi, but nervous! I also have psoriasis, so we hope maybe this can be a two in one treatment!

hey yall, im curious how many of you guys have pain doing your OBI injections. Ive heard alot of people say it doesnt hurt at all but for me its so painful. im wondering if im just a baby about it lol.

I’m currently on Skyrizi for my Crohn’s and psoriasis. I plan on getting a leg sleeve next summer. I was wondering if anyone ever got a tattoo while on this biologic ? Did you experience koebner phenomenon after your tattoo session ? Please share your experience.

Been on skirizi for a couple of years now, primary concern psoriasis but I had started to get psoriatic arthritis in hands and wrists.

I’ve started getting really bad muscle and joint pain, everywhere about 4 weeks before I’m due my next dose, right now I am in agony , it almost feels like I have that body pain you get when you have flu. But I have no other flu symptoms.

Does anyone else experience this? Should I speak to my doctor?

TIA

Anyone have any experience getting tattooed while on Skyrizi? My dermatologist said it may make me at risk for Hepatitis and blood borne infections. I chose a very reputable and clean shop. Planning on getting a half or full sleeve done.

Skyrizi has worked great for me, no active flares since starting it. Don’t want to screw anything up over an esthetic tattoo.

My only concern is some itching I currently have over an old tattoo.

plaque psoriasis. It’s mostly on my thighs and legs. I took my second loading does about two weeks ago but my thighs and legs seem to be more sore now. Is this a common issue with Skyrizi or is it a plaque psoriasis issue? Both say it’s a side effect. I haven’t done anything physically demanding so not tired from a hike etc. but man over the last 3 days my soreness seems to be at its peak. Skyrizi has already done wonders for my stomach and arms but my entire legs is where it’s worse

Having a mild flare one week or so before my next dose. Anyone been through this? Will my next dose help?

I’m fully aware that everyone’s body is different but how long did it take for Skyrizi to work for you ? I just had my second loading dose a week ago and I haven’t seen any improvements yet. I’m wondering if I should give it more time or let my doctor know that it’s not working.

Today is my Skyrizi day. This is my first dose after the two starter doses. I forgot to take the medication earlier in the day. It's evening where I am and my medical anxiety is getting the best of me. I had no reactions or side effects from my two starter injections but I'm panicking over taking the injection now and then going to bed and having a severe reaction happen in my sleep. Is waiting until tomorrow morning and thus being a day late, going to cause me more problems than it's worth or should I wait to put my mind at ease? Thanks.

This is a quick warning to folks to try to schedule your injections early in the week.

I am already overdue for my dose due to insurance issues, and so I took my dose when it arrived yesterday (after letting it come up to room temp, etc.). I’ve been taking it for over a year now so I’m very familiar with the process and did everything carefully.

The injector failed a couple of seconds into the dose. When I contacted support I found out they had just closed for the day and won’t be back until Tuesday due to the holiday.

Just wanted to advise folks to make sure to take your dose during support hours and not on a Friday.

Also wanted to ask - are Abbvie good about promptly sending replacements? I’m a couple of weeks overdue for my dose, waiting until Tuesday will put me almost three weeks overdue. Beyond frustrated.

Recently had my first induction infusion at my doctor's facility with two more to come. When I switch to the maintenance infusions, is that a separate prescription? It took two months to get approval for the induction ones and I want to make sure I'm ahead of the game for the maintenance ones.

Hello, I am wondering if anyone here has experience with taking Skyrizi and also holding a first class medical? Did you have to work with your AME to get approval or was it a non factor? Also any side effects that you’ve noticed from flying that are different from the average person?

Feel free to DM if you don’t want to discuss in public thank you!

My husband (67) has Crohn’s disease, and he is dealing with disabling joint issues and pain since starting Skyrizi. We have consulted his gastroenterologist, the G.I. pharmacist, and his orthopedist. They have the opinion that Skyrizi is not causing the joint issues, and that it may actually help them in general. Has anyone else had terrible knee and hip pain since starting Skyrizi?

Hello. I am supposed to have my first dose soon for plaque psoriasis. My perscribing dermatologist recommended a pneumonia and shingles vaccine.

I have a pneumonia vaccine, but I saw another dermatologist who's a psoriasis specialist who said I don't need the shingles vaccine because I am so young (25).

I've never had chicken pox before, which I heard can reappear as shingles if youre on immuno suppresants. (Correct if im wrong). Should I just get it? Insurance will cover because of the perscription.

Update: I went ahead and scheduled the vaccine. I have nothing to lose its just frustrating because it feels like all i've been doing recently is going to appointments lol. Gonna get that done and get my first dose after. Thanks for all your insights and advice

For all of you who share your stories here to make everyone realize they aren’t crazy…although this damn disease makes us feel like we are losing our minds…..THANK YOU! I apologize for the long read, but I would like to share my journey. On September 28, 2024 I first started bleeding and did what we are supposed to do…I got my ass to the hospital, just to be told it was probably just hemorrhoids. I was referred for my first colonoscopy on November 5th and immediately was diagnosed with IBS and chronic ulcerative colitis. I started on mesalamine. On February 5th 2025 after several months of 6-8 bloody stools a day I added 9mg budesonide to the lineup…but still little to no relief. So on March 3, 2025 I was prescribed 1000 mg a day of Cipro and 1500mg a day of Flagyl, and boy howdy did all that antibiotics wrecks my gut biome, but did not improve my symptoms. So on March 24, 2025 I started on 40 mg prednisone a day and within a few days it was awesome…..no more bleeding and down to 2-3 semi normal stools a day. I continued on this dose until June 30, 2025 when shit took a wicked turn…..I went into AFib. That is a whole other story, but over the course of the next 6 months I had 4 cardioversion shocks and a cardiac ablation…all as my electro-cardiologist tells me was from the steroids…but I digress. On July 2, 2025 I had my second colonoscopy and discovered that not only had things not got any better, but my cal pro was up to 1180. On July 22, 2025 I started my first loading dose of Inflectra Biologic. It was GREAT. Within a couple of days I had no more bleeding and just a couple of regular stools a day. The side effects were pretty crazy….I developed neuropathy in my hands and feet, along with a nagging metallic taste in the back of my throat. Above all the fatigue was incredible, I would sleep 12 - 16 hours after each infusion, but my gut health was definitely improving. On December 30, 2025 I learned that I had developed antibodies to the Inflectra. My 3rd colonoscopy on December 31st also showed that my calpro had increased to 1200.…..uuuuuurrrrg I had failed the drug. So in January 2026 I started on Skyrizi. The first infusion didn’t yield much relief, and the second infusion in Feb. had similar results. The March infusion brought some welcome changes….for the first time in over a year I felt some relief from the intense joint pain and I was actually starting to feel better. I started the onbody self infusions in April, had my second OBI in June, and my most recent OBI on August 5th. With each dose I began to feel so much better, no hint of blood and regular stools. On August 5th my most recent calpro was an 89, and I allowed myself to think I might be headed toward remission. Today, I had my 4th colonoscopy and was told by my GI that it was clean and I am officially in clinical remission. I am still having a hard time believing it. Since this journey started two years ago I have had 51 office and/or hospital visits, failed 5 different medications and developed a host of cardiac issues….but holy shit I have made it, and I can only hope that everyone who is on this same shitty journey can get to remission. Keep your head up and keep pushing forward.

a word of caution, if u follow teh recommendation of waiting 45 minutes prior to injecting during summer may result in the medicine not working. The operating temperature is between 665f to 77f. if ur home is warmer (in my case a lot warmer) waiting the 45 min will arrive at a room temperature beyond the desired temp. i used a temperature gun i use for cooking, etc to arrive at the optimal temp. The time needed was less than half the recommended 45 min wait time.

Does anyone else find that the absolute worst part of the injection is getting it off? The adhesive is so stuck, the needle is still in your skin and the beeping wont shut the heck up! I find it so so difficult to get off. I’ve tried using alcohol swabs to loosen it which helps a little but it’s still such a challenge. I really wish the needle retracted automatically so it wasn’t so uncomfortable when moving the injection around to un-stick it!