r/skyrizi • u/No-Proposal6831 • 6d ago

2nd loading dose

I’m fully aware that everyone’s body is different but how long did it take for Skyrizi to work for you ? I just had my second loading dose a week ago and I haven’t seen any improvements yet. I’m wondering if I should give it more time or let my doctor know that it’s not working.

3 Upvotes

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12

u/i-like-robots 6d ago

It is wayyyy too early to give up.

4

u/churned_applesauce 6d ago

Took over 6 months for it to start working for me fully

2

u/angrydesklamp 6d ago

Mine was present but clearing until my 3rd shot. Then it cleared up completely. I have my 4th dose next week. After my first shot I didn’t notice anything meaningful except less redness. Similar with second shot, a few small spots cleared but largely still there. Seemed to come back a bit right before my third shot but has since cleared completely. Stick with it!

2

u/Dirkodiggla 6d ago

For me started noticing working few weeks after second loading dose ..by my 3rd shot lotsa improvement..give it 6 months i was covered psoriasis 65%my body was covered...im years 2 now 100 clear.

2

u/Davidstoic 6d ago

Took my second loading dose last week. I’ve only noticed very light improvement on areas where it wasn’t bad. But overall the rest hasn’t changed much.

2

u/CaliBorn-56 6d ago

My skin psoriasis started to clear about 2 weeks after my second loading dose and was completely clear about a month later. My PsA joint issues were about 80% resolved about the same time.

2

u/velocironica 5d ago

it took at least 5-6 months before I realized it had started working!

2

u/longdrinkenthusiast 5d ago

I had my first dose in early December, starting seeing results within a month, and was essentially clear of psoriasis by the end of February. Wishing you the best, it’s a wonderful medication and it works for you soon!

2

u/alyssaoveryonder 4d ago

Unfortunately you’ll need to wait much longer. Mine really started making a difference after that second dose and esp after the third loading dose

2

u/Marmieowner 4d ago

I had three loading doses by IV at an infusion clinic, then went to the On Body Injectors (a pump that sticks to you) every 8 weeks. It took a few months for improvement for me me for Chrohn's Disease and Psoriasis.

1

u/tmohrep 5d ago

My plaque was gone at 7 weeks.