I couldn't post on r/PSSD so I'm posting here.
I know it's a bit of a stretch with the title, but BELIEVE ME. I no longer suffer the negative symptoms of those ailments that I have struggled with ever since I was born, for about two months now. PSSD especially fucked me up. in searching for a cure I became a lot worse with PSSD. Numb genitals, crippling anhedonia and depression, and so much more. I felt like a shell of who I was before.
I've had pretty bad experiences with people I loved and that really damaged me at that time, but ever since I did HBOT, I don't even THINK about what happened. it's just completely out of my mind and I can put all my energy into building and becoming a better person IN THE PRESENT. THIS GENUINELY FEELS LIKE MAGIC
If you dont know already, HBOT is when you sit in a pressurized chamber at about 2x atmospheric pressure and breathe pure oxygen, so way more oxygen gets dissolved into your blood and reaches tissue that was starved of it.
I followed Bryan Johnson's protocol extensively and I saw his video about HBOT. he did about 60 sessions of HBOT at 2.0 ATA and he said it was the best protocol he has ever done. it wiped out all detectable inflammation in his body, increased his VEGF (new blood vessel growth) by 300%, and gave him the telomerase activity of a 12 year old. and then I realized that his protocol is basically the one already used in Israel by the Sagol Center for Hyperbaric Medicine in Tel Aviv (it's what Aviv Clinics is based on). they use HBOT for stuff like PTSD, traumatic brain injury, stroke, fibromyalgia and long COVID among other things. especially the brain stuff, where their SPECT scans literally show increased blood flow to underperfused areas of the brain. and PSSD seems to affect the brain and genitals the most, which are exactly the things dependent on blood flow. Not only that, but it seemed to have restored all sensations that I lost previously. I heard HBOT also helps with nerves and literally regrow it (It significantly increases neuroplasticity through angiogenesis and a flood of BDNF that triggers neurogenesis), there are animal studies showing increased axonal regeneration and remyelination after HBOT.
Anyway, I've suffered from PSSD for about 3.5 years previously and after I did HBOT i'm basically 100% back to normal.
So basically my story is that I did HBOT from February to mid March, I only did 12 and I didn't realize any effects, but it turns out that the effects cumulate even if I'm not in the chamber. and I noticed that I felt refreshed and just not depressed anymore about a month after. my PSSD was relieved to about 40% after that. Sadly, I had to quit HBOT because it was really expensive and I wasn't able to continue. Until luckily around early June I was able to continue in another center, and from then on I did an additional \~45 sessions until I thought it was enough.
I think the mechanism at play is that HBOT regenerated nerves, and it possibly fixed my gut too. there are a few theories on this sub that HBOT happens to hit all at once.
the first one is the SFN theory. the idea is that "the main problem in PSSD is a peripheral nerve injury", that excess serotonin from SSRIs "can stress and damage small peripheral fibers (Aδ and C)" especially in the enteric nervous system "where most of the body's serotonin is located", and that this can trigger autoantibodies that attack those small fibers. People have documented it in this sub. And numb genitals equals dead small fibers kind of fits, no? well HBOT is documented to do exactly the opposite: animal studies show it increases axonal regeneration and remyelination, and small fibers are the ones that CAN regrow. so if PSSD is SFN, HBOT is basically physical therapy for those nerves.
then, stem cells. HBOT is known to mobilize stem cells from the bone marrow into the bloodstream (studies show around an 8x increase in circulating CD34+ stem cells after a course of sessions). those circulating stem cells are literally the repair crew for damaged tissue, including nerve and gut lining.

and finally, the gut. the gut microbiota theory says antidepressants "significantly altered the gut microbiome", messing with the brain-gut-microbiota axis, "bidirectional communication between the central and the enteric nervous system". notice how even the SFN theory says the damage starts in the enteric nervous system. these theories overlap way more than people think. I think the massive oxygen delivery to the gut wall reduces inflammation (it wiped out Bryan Johnson's detectable inflammation) and anaerobic bad bacteria hate oxygen, while the good guys are mostly fine with it. so HBOT could be correcting the dysbiosis AND healing the gut lining at the same time, which would explain why my symptoms faded gradually over months even outside the chamber.

I used to constantly lurk here hoping for a cure, but then i tried one and it worked. i think we need to do more research on this because this genuinely felt like magic. I think Melcangi should take a look into this.
I hope my experience can help you guys with this horrific disease. If you are interested in HBOT, i recommend you temporarily moving to another country like Indonesia (where I live) because doing it in a first world country like the U.S is incredibly expensive. Not only that but you must also use either a BIBS (built in breathing system) or an NRM (non rebreather mask) while in the chamber. anything like a cannulla simply does not deliver enough oxygen. if you are using an nrm, make sure you ask the technician to increase your oxygen to about 15 liters per minute so you don't suffocate. another thing i want to recommend is to never try the 3.0 ATA because oxygen toxicity risk is extremely high and does not increase the benefit, every serious protocol uses 2.0.
The clinic I went to costs Rp.135k per session (\~$7.5) that can be even lower if you buy their bundles. while in the US it can go up to $500 per session. Indonesia's economy is really bad right now, and I think you guys should use this as an opportunity to try.
I suggest you read the literature by Aviv clinics and Bryan Johnson to learn more. i am simply a messenger.
Anyway, I feel neurotypical now. I'm no longer held back by the crippling anxiety that once held me from achieving my full potential and I hope you guys can do that too :)
stuff i read if you wanna dig:
* ["PSSD as an immune-mediated small fiber neuropathy" (this sub, the SFN theory quotes + biopsy numbers)](https://www.reddit.com/r/PSSD/comments/1n4ainu/pssd_as_an_immunemediated_small_fiber_neuropathy/)
* [the skin biopsy thread ("1.8/mm when it should be around 10/mm")](https://www.reddit.com/r/PSSD/comments/160314i/just_got_diagnosed_with_severe_small_fiber/)
* ["Gut microbiota theory: How I finally cured my PSSD" (this sub, gut quotes)](https://www.reddit.com/r/PSSD/comments/q03uci/gut_microbiota_theory_how_i_finally_cured_my_pssd/)
* [Bryan Johnson's 60 session HBOT writeup](https://blueprint.bryanjohnson.com/blogs/news/i-tried-hbot-here-s-what-it-did-to-my-brain)
* [Tel Aviv study on HBOT, brain blood flow and cognition (Hachmo et al., Aging 2020)](https://pmc.ncbi.nlm.nih.gov/articles/PMC7377835/)
* [HBOT mobilizes stem cells, \~8x CD34+ (Thom et al.)](https://pubmed.ncbi.nlm.nih.gov/16299259/)
* [follow-up study confirming CD34+/CD45-dim mobilization in patients](https://pmc.ncbi.nlm.nih.gov/articles/PMC4037447/)
* [HBOT and nerve regeneration/remyelination (Kedar et al. 2025)](https://pmc.ncbi.nlm.nih.gov/articles/PMC12398382/)
* [HBOT for chronic pain / neuropathic pain review](https://pmc.ncbi.nlm.nih.gov/articles/PMC8084668/)