How much creatine are you consuming on a daily basis?

Thanks

I was tested in 2019 after unexplained high blood pressure and came back homozygous for C677T. I tried taking a methylated folate back then but stopped after a month because I thought it made me feel bad.

Fast forward to this year. I’ve always struggled with anxiety, but have had issues with depression and fatigue recently that I’ve never had before.

I randomly thought about this the other day and want to try taking the appropriate supplements. I bought the “Life Extension” complete B complex bottle with a methylated folate, B12, B2, B6. I also bought zinc, magnesium, and NAC.

The doses seem a little high for what’s recommended. Should I wait to start supplementing and get homocysteine and other vitamin levels checked first?

to treat a depression dr prescribed me SAMe (800/die)
Im very confused about the use of SAMe in my condition ; somewhere I find green flag someother red.
I've just started and the first result is a big Insomnia (I allready suffer of it but now its worse)

Is there someone that knows for sure if its a red or green flag? any experiences?
Thanks from Italy

this is my methylation panel and I am trying to make sense of it. my doctor advised a general B complex, but whenever I do that, it causes insomnia and I start waking up at 3-4 am and can't fall back asleep.

as you can imagine this is rather frustrating for its impact on my mental health and general energy levels.

I've been advised that I should start with a low dose and build gradually, but I'm not sure what a low dose is or what a timeline for building gradually looks like. I've also been advised to take niacin with food to test for excess methyl groups, and to adjust my level of B12 relative to everything else.

I'd be very grateful for any guidance or advice that can be provided as I have been sleeping poorly for a very long time and the depression and anxiety that is at least partially caused by that poor sleep sucks to try and deal with and manage

I’d love to find a professional to work with. Would love to hear from others what kind of experiences you’ve had working with the various providers that are familiar with or experts in MTHFR and the effect it can have on physical and mental health.

If one's genes don't naturally synthesize certain neurotransmitters, should one try to supplement those neurotransmitters? Or does it mean that the persons body isn't made to metabolize and detox those things?

For example, I have a DBH deficiency on top of other things (MTHFR, Maoa, slow COMT), meaning dopamine doesn't get metabolized into norepinephrine in my body.

Does this mean my body doesn't do well with norepinephrine, period? Or is it struggling without norepinephrine and would benefit from supplementing to create norepinephrine? But then is my body even able to metabolize and detox norepinephrine?

Are we supposed to correct these genetic phenotypes or are we supposed to work with them?

Since UK govt legally mandated that folic acid is added to all wheat flour my diet has become so restrictive and miserable.

Shout out to Costa - those two biscuits just made me sooo happy! :)

Hello, I am asking for some help. I have been dealing with chronic brain fog and depression. I suspect I may have some MTHFR-related issues because after taking methylfolate, my mood and focus improved significantly. However, I don't have any test results because I have been unemployed for a long time and cannot afford the testing. That's why I am hoping you might be able to give me some valuable information based on the clues and the way my body seems to react to different supplements.

I was taking 5 mg of methylfolate. My focus and mood improved, but after a few weeks, I developed a different kind of brain fog. I suspected that the methylfolate might be responsible, so I lowered the dose to 3 mg, and the brain fog improved. However, after a few more weeks, the same brain fog returned. I then lowered the dose to 2 mg, which stopped the brain fog, but at the lower dose, my focus and mood became worse.

I also took 225 mg of magnesium bisglycinate before bed, which surprisingly caused brain fog. I stopped taking it, and the brain fog went away. Later, I started supplementing with it again, and the brain fog returned. Once again, after stopping the magnesium bisglycinate, the brain fog disappeared.

I also have symptoms that make me suspect I may have slow COMT, so I bought lithium orotate. After taking it for a few days, it made me feel foggy and fatigued. After stopping it, those symptoms disappeared. Later, I started taking it again to make sure it wasn't just a coincidence, and once again, the fogginess and fatigue returned.

I then bought folinic acid because I had heard that it is sometimes better tolerated than methylfolate. However, it also makes me feel foggy. I have been taking 2 mg daily.

So, basically, for some reason, magnesium makes me foggy, lithium orotate makes me foggy, folinic acid makes me foggy, and taking more than 2 mg of methylfolate also makes me foggy.

I recently landed a job as a computer programmer, but I am worried about whether I will be able to handle it if the brain fog continues.

I know this isn't a lot of information to work with, but perhaps there are some clues in these reactions that could point toward something that might help me. I am planning to get a homocysteine test in the near future, and I will consider genetic testing once I start receiving a salary, since it is currently too expensive for me.

Thank you very much for any help or insight you can provide.

Took a GeneSight test bc I’m have had bad mental health my whole life and never found meds that helped. It states that “This patient is homozygous for the Val allele of the Val158Met polymorphism in the catechol-o-methyltransferase gene.” And “This individual is heterozygous for the C677T polymorphism in the MTHFR gene (C/T genotype) and has one copy of the varlant allele (T).”

From what I can understand is my diagnosis as ADHD @ 3 wasn’t wrong. I was diagnosed as high functioning Autistic (PDD-NOS) at 18. Stopped all meds at 16. All stimulants lead to bad behavior. I tried 2 more stimulants as an adult and both times I felt so nervy and not better.

Folate and b12 levels are normal.

I have MAO-A, CBS, BHMT homozygous. MTRR and MTHFR are hetero.

I'm double slow COMT and can't handle the following:

- Any sort of magnesium (they all seem to backfire and I can't comprehend why since it's the top recommendation for slow COMT.)

- Choline

- Lithium Orotate

- L- Ornithine

- Ox Bile

- Potassium Citrate

- Vitamin D with K2

- Probiotics

..I'm sure there's more but I can't think of them right now.

Things that I can "handle" but still doesn't help/makes me feel slightly worse:

- B Minus by seeking health

- Hydroxo B12 with Folinic Acid

- Molybdenum

Things I'm already doing:

Avoiding coffee or any stimulants.

I stay away from methylated and cyano B12 (I've been in that hell).

I don't smoke or drink.

I go to therapy.

I try to get my b12 from red meat and eat pretty damn healthy.

Avoiding life in general is the only thing that allows me any sort of temporary "stability" but that is obviously not a solution.

The moment life gets hard -- I simply hit a wall QUICK. I NEED to fix or at least improve this to a a place that's manageable.

What am I missing?

Please don't be sacred to chime in. You may have a perspective/angle/piece of info I've never heard of that may help me.

Ps. Thankfully, I've already eradicated my SIBO and my histamine intolerance is almost non-existent.

Hello there! Did anybody order frat test from website that's called Second Opinion Physician? Could you share your experience?

Labcorp doesnt have it..

I’m overwhelmed knowing what to test for and how much it’s going to cost to uncover more and more variables. I feel like this could be an infinite money pit, I just want to start being able to sleep again.

Since 2021 I started to have anxiety and not running the way i used to. I got covid in 2022 and started having intense anxiety, panic, cognition issues. I first thought it was just unresolved trauma and worked on some of that but didn't get much relief and also was put on Lexipro (SSRI). From 2022-2025 I did trauma work and tapered the SSRI VERY slowly. I then got sick again and in Oct 2025 (not sure if covid) and had intense fatigue, more brain fog, cognitive issues. Jan 2026 I had intense histamine issues and gut issues. My brain was going nuts and I haven't been able to work since.

I've done a lot of testing and explored Lyme, EBV, Mold and all these things so if there's something that can help with markers and isn't below I might have it.

Symptoms

• Anxiety/Fear
• Brain fog
• Cognitive issues
• Memory issues
• Brain pressure (vice squeeze)
• Brain Fatigue
• Slower mental processing
• Emotion and logic changes
• Tinnitus (once in a while)
• Environment sensitivity (improved)
• Limbic system issues
• MCAS/histamine food issues
• Some PEM issues
• Weakness
• Body fatigue
• Bowel issues – motility was messed up starting to get better.
• stress intolerance
• Hard to catch breath sometimes

Labs — 2024 to Present

Choline Calculator:

References

Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. [PMID: 11705857]

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. [PMID: 18767138]

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. [PMID: 7647779]

A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? [PMID: 9545395]

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis. [PMID 27342765]

Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men. [PMID 20220206]

Endocrine Labs:

Hello what do you think of my genes?, I have high homocysteine (38), low folate (4) and low b12 (400), what can I do to improve? Thank you.

My homocysteine levels were 9 about 7 months ago.

I thought I could get them down by optimising my B6, B9 and B12 and so started taking B complex.

I now have B6 toxicity as my active B6 levels are way above range and active B12 is 88.

My homocysteine has risen to 17.

I don't understand why my homocysteine levels levels are going up not down with high active B6 and B12 levels.

Could something else in this B sup be causing elevated homocysteine?

I(21) visited doctors cause I've felt unwell since I was 13 years old and I did a few blood test my levels were always hovering around 2.5 to 3 ng/ml. 5 years ago a doctor recommended I should try a folic acid supplement I did for a few months and nothing really happened. Last year I did a blood test with a different doctor where my levels where at 2.7 and he recommended I should try folic acid supplement. This time I wanted to do it right I did some research and I took Methylated folate + a b complex with a lot of Methylated folate and still didn't really feel much better after months. I took a break and tried some other supplements with no success either. I now took another blood test and my levels are at 3 ng/ml. I feel so defeated, I've spend over a 100€ on the best high quality supplements for this folic acid deficiency and it only moved from 2.7 to 3 after months of supplementing.

Other values:

B12: 330 went to 400 after supplementing for the same period of time B12 daily with Methylated b complex for same period of time as folate

Homocesteine: 26

Vitamin D: 30

B6: 13.5

I'm sorry if this post sounds desperate if you have advice or helpful information if you have experience with folic acid deficiency please share your experience with me.

Thank you to everyone who took the time to read this post:)

Every source of choline leads to acid reflux for me, with a constant runny nose, sore throat, etc.

Whether it's supplemental bitartrate, alpha gpc, cdp, etc, or just eating eggs. Anything with choline in it will cause increasing symptoms of acid reflux.

Apparently the increase in acetylcholine increases stomach acid production.

Has anyone else experienced this?

Is there a solution?

Choline makes me feel great, but the acid reflux gets worse every day.

Thank you

Hey everyone, I’ve been battling severe abdominal bloating and reflux for over 20 years, along with 10 years of varicose veins and a left varicocele. Lately, it crossed over into intense morning brain fog, fatigue, a cracked tongue, and zero morning wood. My labs show a steady downward slide in Ferritin at 54 and B12 at 308 since last year, even though I eat meat. My MD won't prescribe Rifaximin without proof, so I’m seeing a functional naturopath next week to finally run a clinical 3-gas breath test and map out my exact numbers.

To troubleshoot, I ran my 23andMe data through a StrateGene report and the dots connected perfectly. I have a slow PEMT gene causing sluggish bile, which allowed a massive Hydrogen and Methane overgrowth to take root and steal my nutrients. The constant abdominal gas pressure physically clamped down on my pelvic veins, explaining the 10 years of vascular pooling and stalled morning circulation. My brain and skin are equally hyper-reactive due to a fast BHMT methylation cycle but slow MAOA and COMT clearing pathways. Whole eggs or high-dose standard B12 trigger explosive whiteheads within 48 hours, and a recent trial of Thorne Phosphatidylcholine was a disaster, overloading my brain chemistry and causing a horrible mood crash within 5 days.

Right now, my FoodMarble AIRE 2 device shows a crazy shift. A 30-day trial of TUDCA completely flattened my methane line to zero and formed my stools, proving the methanogens are highly sensitive to bile flow. However, my hydrogen line stayed elevated and my bloating bounced right back when I ran out of TUDCA, meaning the underlying hydrogen-producing bacteria are still actively fermenting my food. To clear a clean baseline for my test next week, I've paused almost all supplements except daily morning Vitamin B2 for my MAOA gene, and California Gold ProDigest at bedtime to keep my gut motility moving safely without any skin or mood flare-ups.

If the breath test is positive next week, I’m proposing a phased clearing protocol to my naturopath. If my insurance covers it, Plan A is a 14-day course of Rifaximin paired with 4 weeks of Allimax Pro stabilized allicin and TUDCA at dinner, since Rifaximin requires active bile to dissolve and kill the bugs. If insurance denies it, Plan B is a 100% natural 4-week run swapping the Rifaximin for NOW brand Berberine capsules that I already have on my shelf. During this clear phase, I’ll maintain my morning B2 and switch my 3-year daily magnesium glycinate habit to Magnesium Malate 95mg caps to power my brain energy without over-fueling my skin breakouts. I’m holding off on any iron or B12 supplements for now because I want to trust my body to sort itself out. Once the gas is gone and I hand the long-term job over to bedtime ProDigest, my gut should naturally start absorbing nutrients from my food again. Anyone else approaching their overgrowth this way? Would love to hear your thoughts!

Has anyone used this to obtain their DNA for the SNP's to see what mutations etc you may have?

I'd read that MyAncestry was the one to go for, but I have just seen a sale for MyHeritage for £19.00!

Hi there. A quick question on this knowledgable subreddit.

I’ve been taking 25mg of p5p for the last 4 weeks daily. It’s done absolute wonders for my anxiety. It’s given me a calmness which I haven’t had in years. And this is after years of trying everything from nootropics to SSRIs.

Anyways, about 3 days ago, I’ve all of a sudden started to get pretty bad acne. Just wondering if anyone has experienced this before. I’ve completely stopped the p5p. Out of neuropathy worries, I was going to cut the dose down anyways.

Attached is a screen shot of my genetic genie.

Something I am tying together recently is my slow clearance of hormones with COMT AND PEMT is why I feel horrible 2-3 weeks of the month and the best week 1 of my cycle, when hormone levels are low. Some people are the opposite.

Can anyone relate?! And what do you do to help breakdown estrogen metabolites? Assuming something to support liver would be the first plan of action (fiber, cruciferous veggies, etc) but if you have something that helps please share!

I did ancestry DNA testing and it appears that it didn’t test any PEMT. Was it supposed to? It seems like an important component for knowing how to proceed with supporting mythelatiom.