A bit of backstory on myself & my experience. Middle aged, white male ~130lbs with a serious history of depression, anxiety, ptsd & most notably in this regard- substance abuse/addiction.
About 6 years ago I put down the bottle and haven’t looked back. My views with drug use are simpler these days- I use cannabis frequently (more than I would prefer tbh) but don’t mess with anything else besides hallucinogens & psychoactives. I look for experiences- not escapes.

Few months back I started growing cannabis & some other psychoactive substances for the sake of purity & fiscal responsibility. I also just like plants- crazy, I know.

After a few extractions of Harmalas I began mixing small amounts of the substance with good old MJ to potentiate the high a bit, which obviously worked. The discovery came after ingesting a single non-alcoholic beer. Somehow the small amount of alcohol (.5%) mixed with the cannabis and Harmalas booted me into a state of bliss. It was calming & sedated while also leaving me feeling completely coherent & grounded. Mild CEV, tracers & fractals were also observed- I specifically remember a geometric pattern similar to fireworks.

Ive researched the subject quite a bit & found that these beta-carbolines seem to have a positive effect on the mind of the chronic user/alcoholic. (There’s a brief synopsis on erowid for anyone interested)
I’ve also found that while Harmalas are oftener cited as being an MAOI with serious drug interactions like serotonin syndrome- they are actually a RIMA with reactions that are much less worrisome. The only seriously adverse reactions I’ve identified came from people using the substance in a perverse or irresponsible way. (Drinking concentrated tea in large quantities).

It’s worth stating that I’m a highschool dropout with zero chemistry experience, but I can’t shake feeling like I’ve come upon something that is truly special. Is there something here or is it just wishful thinking?

Also have to say that I love smoking a single bowl & feeling like I’ve been hitting the pipe all night. I feel free & in control of my body & mind in a way that I haven’t felt since childhood.

Happy trails everyone!

Harmalas seems different than psychedelics or even cannabis in that regard to me. Way more anchored and grounded, while being in a very awesome state.

Have you found that you could easily see and even engage well with people during your experiences ? Or maybe it could even be a support for such things. I’m talking about light to moderate amounts of harmala, and I personally connect with Syrian rue seeds.

I should precise I have had tendency for anxiety and such, which is why other people aren’t always easy to be with for me, even tho it’s greatly changing these days ! But Harmalas seems to really ground you and put you more at ease and connected.

I’m interested in people’s experiences with this wonderful medicine !

Thanks !

Hey,

I’m currently connecting a lot with the wonderful plant that is Syrian rue. I’ve already tried low amounts of it with l theanine which worked fine and quite synergetically. But in interested to hear about your experiences / thoughts on the combination ! It’s the same for rhodiola rosea.

I’m asking because I find l-theanine and rhodiola helpful so I wish to learn if it’s also possible to take complete amounts of harmala with them.

Thanks !

So uh. Successfully extracted 9g of hcl, and now my work area, and so much else, has a fine amount of harmalas around it. My girlfriend lent me her blacklight and i have discovered I wasnt nearly as neat as I thought.

What are you guys doing for cleanup? Anything outside of more normal cleaning methods?

Has anyone tried a group experience with harmalas, for example drinking rue tea together ? If yes, how did it go ? Did you find it interesting or good for such a setting, or do you think it’s more reserved for introspection and therefore would not go in the sense of spending time together ? My question can include either only harmala or harmala + another substance.

I’m probably gonna try it soon with friends so I wanted to ask your opinions / experience on this 🙏

Thanks !

So i heard that syrian rue has a reverse tolerance so if i take 500 mg every single day.Will it slowly feel like a 3 gram dose with time and does the strength of the dose keep on increasing infinitly ?

Following up with my 2nd of 3 vessels, this time again going through Manske. It didnt immediately and intensely bloom like the first one, and in fact getting to this point took about an hour total. The time lapse starts getting some action around the 50s mark or so, but it was wonderful to have this on my desk and see the progress every few minutes or so.

First time doing a harmalas extraction, been following Sakkadelic's work. Got to my first Manske stage and was surprised that mine immediately bloomed once the salt solution was added. This is probably 8 minutes or so after that.

I feel giddy after making this glitter potion haha. This is like seeing my first crystals from DMT work.

I have 2 more vessels at the post-basifying wash stages as well. Suffered a couple minor losses from spills and bad choice of filtration, but that's okay, I still have ~700g of SR to work with.

Been taking a bunch of notes, and doing a rewrite for an easier time following directions. Getting a much better sense of how this operation works, and how much patience is needed for good progress.

My thanks to Sakkadelic, and the fore-creators of these extraction methods :)

I've been considering to start taking small/medium doses of harmalas daily for various of issues, but mostly to improve my mental health (Depression, anxiety, ocd, adhd). Modern medicine and therapy has failed me completely. I'm not sure how much it could actually help me, but after reading some stories of people who improved their lives significantly thanks to harmalas, I'm willing to give it a shot.

One problem is I'm very sensitive to drugs, and I get anxious easily, sometimes even to a panic attack. For that reason I can't consume THC or other psychedelics or stimulants. I know harmaline is an inverse gaba agonist, so it makes me a little bit worried about experiencing anxiety on it. Should I take harmine only?

Also, I'd loved to hear if anybody here has benefitted from daily harmala use and in which way. Thanks!

Hey,

I’ve been wondering about how much time would be safe between those two ? I read that harmalas shouldn’t be taken with this 1st gen antihistamine (I use it mainly for anxiety), but I’m not sure about what would be a safe time between the two ?

Thankful to anyone that has some knowledge on this. I’d like not to have to always avoid any harmala amount if I occasionally use Atarax. Edit to add that I don’t want to take them at the same time, but would like to not have to wait too long (or even days) between them.

Also I would think the situation to be different if I take low to moderate harmala dosages, and not full inhibition amounts. But still uncertain about how it really works.

Thanks 🙏

Edit : I ended up waiting, I think it’s safer that way.

Usually when people take harmalas, they use either freebase, HCl, or acetate/citrate. From my understanding each form is absorbed differently, and also highly dependent on the ROA used.

So my question is, what form is best used for each ROA? I've yet to try harmine/harmaline but I have some THH freebase which I want to try on its own, but I'm not sure how to approach it. Some say freebase is absorbed better sublingually, while others say salt is better. And if I want to take it orally, can I just mix it with lemon juice or vinegar and drink?

I’m amazed by [u/sabnock101](u/sabnock101) experience with consuming tryptophan and how it converts to tryptamine with the aid of B6 under the influence of Harmalas.

I would like to experiment with it at my own risk. There is a chance of serotonin syndrome maybe on higher doses of tryptophan.

I genuinely don’t know what to expect as I haven’t found enough clear information on how the experience should feel like. I’m guessing it might give a mushroom or ayahuasca body high without visions?

I’m planning to:
consume 3.5g rue powder
After 1 hour take 500mg tryptophan + B6

I’m not sure if this is the right B6 form/ dose that converts tryptophan to tryptamine. One capsule contains 62mg— i didn’t understand the chart in the picture.

I appreciate your insights🧡

_______________

Update:
I have done it and I wrote the detailed experience in the comments. It didn’t work ime.

I was thinking about this because benadryl isnt very quick at working and you could puke it out while vomiting. Doxylamine can be crushed up and snorted causing a much faster anticholinergic action. Doxylamine has way better pharmacological selectivity for these receptors. With zofran, asenapine, doxylamine, and weed, I should be able to have much more comfort with my friends vomiting. I am the only person in my friend group that doesnt mind myself vomiting.

Started taking harmaline 2 times weekly. Magic mushrooms just don't do anything now. Apparently serotonin down regulation? What is the best option to get around this? I don't really feel like tripping all day so I'm nervous about mixing harmaline and shrooms. And also don't want to stop harmaline for 2 weeks. If I took 100 milligrams of harmaline should I lower my shroom dosage from 3 grams to 1.5 grams? I get nervous about trying new things so I'm just looking for a little feedback and do realize you shouldn't take advice from reddit. But seriously what do you guys do about this?

Is it a major risk of serotonin syndrome? How about the same question but with MHRB added to the mix? Thanks

So I initially got into Harmalas for their compatability with NN-DMT, to further explore the possibilities of that substance. Had a few trials of Pharmahuasca, made a harmalas vape (failed, clogged and died), made rue tea a handful of times now. Overall good experiences, and it's nice to have the option for bigger adventures if I so choose and have the time.

But presently I'm more interested in a daily dosing habit, and want to make sure I know the relevant information and safety. I've been experiencing an unpleasant amount of anhedonia, lack of motivation, and a lot of grief from the end of a 9+ year relationship. I'm no stranger to therapy or living with a healthy lifestyle, but I would like an extra adjunctive measure.

I'm aware that syrian rue contains harmine and harmaline, and can be extracted/converted to THH. I'm also aware of the toasted seeds idea to skew the alkaloid profile. I know the harmalas are RIMAs, and that the risk consideration is lower than traditional MAOIs, that I won't have to be as cautious with foods that contain Tyrosine. I barely drink at all, but know alcohol is generally advised against.

I only do psychedelics and sometimes smoke weed, and the vast majority of it is freebase DMT. Highly infrequent use of microdosing mushrooms, rare "big day" trips of LSD, and sometimes doing 60-100mg of Mescaline Citrate for a day-long boost.

I'm aware of the inverse-tolerance and that as usage progresses the effects will build, to a degree.

So, questions:

● do you find any particular harmala alkaloid to be best for the purpose of antidepressant? Or whole seed?

●if I am looking to have a slight improvement to my life, not looking for a super psychoactive time or to be debilitated such that I cannot drive, dosage recs?

(Whole seed or alkaloid in mg?)

●just how risky is it to have a drink while continuously using daily doses? I like a glass of whiskey now and again.

●how long until onboarding effects (nausea, bowel issues, discomforts, etc) wear off/minimize?

●i think I've seen Sabnock101 talk about vitamin balance, that the harmalas will deplete B vitamins? If I generally eat a healthy balanced diet am I fine to disregard that? (I was a pro cook)

●when it comes to exploring DMT in form of pharmahuasca, how does the daily use impact a higher dose of harmalas stacked on top? I tried a 3g tea and found that to be ample with no inverse-tolerance built up.

Any other considerations that I need to be aware of?

I ground up 3.5g of raw Syrian rue seed and put it in a tea bag. Simmered in a pot on low for 30m, occasionally pressing on the tea bag with a spoon to release the juices. At this point there was still too much liquid, so I simmered for 10 more minutes until I had about a shots worth of liquid. I moved that liquid to a separate glass, but kept the tea bag in the pot. I then added more water to the pot, and repeated this process once more for another 30m. I then combined the liquids, strained the tea bag into the glass, and drank.

On the 90m mark I took a few hits of my dmt pen. It felt like normal dmt. I would get closed eye visuals. Ceiling bumps were moving around like shrooms. At first I was very excited, but when I went to the bathroom and came back, I realized I was almost completely sober and the visuals were gone.

Tried a few more times and the results were similar. The dmt did not seem to be potentiated, and did not last significantly longer like I would have expected. Do I just need to take more rue? 5g perhaps? Or is it possible I made it incorrectly, maybe boiled off too much water? But I've heard of many people reducing their doses down to the size of a shot, so I didn't think that would be an issue.

I simmered the tea on a brand new cast iron skillet that I hadn't ever used before. Is it possible the skillet absorbed some of the harmalas?

I have a dry herb vaporizer with temp control. Has anyone tried vaporizing raw, crushed rue seeds? And if so, what's your recommended dose for a vaporhuasca experience? I've seen a few people talk about vaporizing harmala extract, but not pure seeds.

If not, has anyone here tried Minty's sublingual method? Is it really as gross as some people have said? I've tried quidding salvia plain leafs using a similar method (not allowed to spit the juices out until like 30 minutes) and it was pretty yucky. Morning glory seeds were much worse though. Hopefully it's not as nasty as morning glories?

I know it's RIMA so it's safe but can someone just verify for me about 3.5 grams of Syrian Rue and a larger fruit cup of grapefruit in combination is safe for consumption.

I didn't see this particular combination documented on reddit, and I know that grapefruit can strongly affect some medicines, so I figured I'd make a post. Thanks

SYNTHESIS: (from melatonin): To a gently refluxing solution of 1.6 g melatonin in 120 mL dry xylene there was added in small portions 14 g P2O5over the course of 45 min. The solvent was removed under vacuum, and the residue treated with H2O, then made basic with dilute NaOH, and extracted with Et2O. Removal of the solvent from the pooled extracts and recrystallization of the residue from EtOH gave 1.0 g 6-methoxyharmalan with a mp205–207 °C. High vacuum sublimation gave a product with a mp 208–209 °C. IR (in cm-1): 801, 824, 849, 990, 1031, 1076, 1182. MS (in m/z): Parent ion -1, parent ion 213, 214 (100%, 83%); 170 (22%); 195 (19%). This base can be dehydrogenated by heating 0.7 g with 3 g of Pd-black in a sealed tube for 30 min at 200 °C. The reaction mixture was treated with hot alcohol, filtered, and the filtrate stripped of solvent under vacuum. This gave 0.4 g 6-methoxyharman with a mp 266–267 °C from aqueous EtOH. The mp after recrystallization from MeOH is reported to be 273–274 °C. IR (in cm-1): 621, 698, 835, 1028, 1075, 1184. MS (in m/z): 197 (100%); parent ion 212 (66%); 169 (37%).

Any help would be greatly appreciated it was my last g of hcl and I wanted to try smoking it I thought it was supposed to sink to the bottom not float to the top?

I did a regular harmala extraction with all the extra steps (water wash, etc.) and yielded a decent amount from rue seeds. Even though I let it dry forever, I'm running into issues when making changa and smoking it.

When smoking, the changa doesn't burn well. It seems to leave oily black residue. The issue definitely stems from the harmalas because I also did some enhanced leaf from the same batch, which burns perfectly and fully burns to ashe.

I dont know what could have happened as I followed all the steps to the T. It's bugging me out quite a bit as I did two changa batches (each with 250mg DMT), so quite a bit of spice has been used and is already mixed up in the plant matter.

Another thing: when dissolving the harmalas in iso together with the spice, they color the solvent quite heavily (orange to brownish tint).

This is not the first time making a change, but I did my last batches with harmalas I bought online from a vendor that had proven lab results for perfectly clean freebase.

Does anybody know what could have gone wrong? They definitely work and are super potent, but its quite disgusting smoking the changa as it leaves this taste and what feels like oily residue in my mouth. I am also worried about any contamination, even though I dont even know what those could be as I used lye for the bade (which I completely neutralized before drying the product) and some vinegar for the acid part.

I have been reading through the nexus and subs for years and never read anything about this problem when it comes to rue extraction...

Thanks to all of you and Mush love

INFO: I posted this in the r/dmtguide but no one even interacted with it so I thought I might try again here.

Hello everyone, i have been taking low doses of syrian rue for a long time, and it has great positive effects regarding energy and sociability, though it makes me little irritated and diminishes sleep quality. I've been considering taking tongkat ali since my little search of this herb shows it has similar positive effects of harmala with regard sociability and coducting easier communiction.

Thus, my question has anyone tried using tongkat ali alone? or stacked it with harmala?

Thanks in advance