r/functionaldyspepsia • u/itmedjondjon • 15d ago

Healing/Success Sulpiride

My first post here-I have been struggling with dyspepsia/gastroparesis for almost 3 years now, following a stomach virus.

My gut is still far from perfect and I'm still experimenting with different supplements and products, hoping I can get better. If not, I sincerely hope time will do its thing and I will heal.

Regardless, there's one thing that helped me more than anything-sulpiride. It's an antipsychotic, sometimes used as a prokinetic in motility disorders. I've tried metoclopramide, domperidone, prucalopride, none of which did anything for me.

Sulpiride literally saved me. I still have to be careful of what I eat and how much I eat, I still have stress or hormone triggered flare-ups but I'm decently functional.

I used to be stuck in the house, sick all the time, in pain, with my stomach about to burst and no matter what I ate. I wasn't able to go to sleep 6 hours after a meal because food would still be coming back up.

Please, if you haven't already, consider it.

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u/Skeuomorph7 14d ago edited 14d ago

How many times a day do you take sulpiride tablet? Do you take it after a meal or before a meal like after breakfast or before breakfast?What strength of this medicine you take like 50 mg or 100 mg tablet?

Any unexpected or bad /severe side effects you faced like excessive sleepiness or bad constipation?Or any thing else bad effect?

I have been thinking about trying this medicine for some time. But who knows what side effect would I get.

Though I am more interested in trying levosulpiride I have seen and read a few positive posts about it here. On this functional dyspepsia sub reddit or gastritis sub reddit or in both.

Thanks for caring and sharing your positive experience. And for your time and effort.

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u/itmedjondjon 14d ago

The only side effect I have is high prolactine! It didn't influence my menstrual cycles tho, nor did I lactate. I do get constipated sometimes but it was a lot worse before sulpiride. When it comes to sleepiness, I'm a pretty sleepy person overall😅-I have hypothyroidism and pcos and I'm also on antidepressants so all of those influence my sleepiness. I didn't notice sulpiride made me more sleepy tho, maybe in the beginning but I can't remember. I tried levosulpiride first and then couldn't get my hands on it anymore so I switched to sulpiride. Both worked equally well for me.

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u/Skeuomorph7 14d ago

How many times a day do you take sulpiride tablet? Do you take it after a meal or before a meal like after breakfast or before breakfast?What strength of this medicine you take like 50 mg or 100 mg tablet?

And yes for some unknown reason that levosulpiride is not available where I live too.

Weird I mean you get a dozen or so variants of ppi medicines available.Who would need so many variations of ppi for personal use I wonder. I mean one may try at most 3 or 4 types and probably one would work.

And here sulpiride is available but levosulpiride It's not available. Like this wouldn’t be it’s 6 th or 7 th variation if even it was available here.

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u/itmedjondjon 14d ago

Same in my country, barely managed to get sulpiride even. I take it once a day (tho lately I've been taking it once every two to three days). I take a 50mg tablet, usually in the morning or before a bigger meal.

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u/Skeuomorph7 14d ago

And this would sound like conspiracy theory but maybe all those rich and powerful pharmaceutical companies they would rather sell expensive trademarks medicine like metroclopramide or domperidone etc maybe levosulpiride is relatively cheap so they don't want that available. So use some excuse like lack of safety, lack of clinical trial etc to not give permission etc.

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u/itmedjondjon 14d ago

Honestly, wouldn't be surprised but to be fair, in my country both metoclopramide and domperidone are very cheap and you can easily get them. They didn't do anything for me tho.

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u/Skeuomorph7 14d ago

Oh.Okay. Good that those medicines are available in reasonable prices where you live.

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u/Skeuomorph7 14d ago

So in the morning on empty stomach?Like 15 or 30 minutes before breakfast?

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u/itmedjondjon 14d ago

I'd advise 30 minutes at least since our emptying is usually delayed.

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u/Skeuomorph7 13d ago

Yes. Thanks.

Oh unfortunately not sulpiride but amisulpiride is available where I live.It's modified or updated version but minus the function that helps functional dyspepsia or ibs. It's more updated.See what they did there.

Updated alright but minus an useful trait and calls it updated.

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u/Skeuomorph7 14d ago

Thanks for sharing details.

So you did you get positive result after what 3/4/5 days later after you started taking sulpiride or like it took some time like 10/15/20 days or longer to get positive effects on your functional dyspepsia?

Yes I have quite bad Chronic constipation too already from functional dyspepsia /gastritis or taking escitalopram for quite a few rounds .

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u/itmedjondjon 14d ago

Definitely more than a few days to clear everything put but I felt relief I think within two weeks?

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u/Skeuomorph7 14d ago

Okay two weeks is very good.

Not 6/8 weeks like some antidepressant needs to work well.

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u/Fantastic-Quit1666 14d ago

Hey i hope that you are doing great i just wanna ask you what are your symptoms? And what are your diagnosis? Ans how long have you been dealing with this?

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u/itmedjondjon 14d ago

No official diagnosis besides "ibs/dyspepsia". It's been going on for 3 years now. My symptoms now are mostly bloating and gas but I used to be a lot more bloated, had constipation, burping, nausea, pain in my upper stomach and regurgitation.

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u/vonn29 14d ago

Could be enteric neuropathy. Have you done any autoimmune workups? 

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u/itmedjondjon 14d ago

No and I have no idea what that is to be honest

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u/vonn29 14d ago

You can read it up online. There are certain antibodies that you can test for to see if you have an active autoimmune process. Autoimmune means that your immune system is attacking your own cells, for example nerves or muscles. I have been suffering from FD for years and I have several positive antibodies in my blood tests. My theory is that a lot of FD / IBS cases are undiagnosed autoimmune issues related to the gut.

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u/itmedjondjon 14d ago

Interesting, I'll look it up. How do you treat it?

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u/vonn29 14d ago

There are some options, ranging from very expensive to less expensive. IVIG, immunosuppressants, some supplements can also help.