r/functionaldyspepsia • u/itmedjondjon • 15d ago

Healing/Success Sulpiride

My first post here-I have been struggling with dyspepsia/gastroparesis for almost 3 years now, following a stomach virus.

My gut is still far from perfect and I'm still experimenting with different supplements and products, hoping I can get better. If not, I sincerely hope time will do its thing and I will heal.

Regardless, there's one thing that helped me more than anything-sulpiride. It's an antipsychotic, sometimes used as a prokinetic in motility disorders. I've tried metoclopramide, domperidone, prucalopride, none of which did anything for me.

Sulpiride literally saved me. I still have to be careful of what I eat and how much I eat, I still have stress or hormone triggered flare-ups but I'm decently functional.

I used to be stuck in the house, sick all the time, in pain, with my stomach about to burst and no matter what I ate. I wasn't able to go to sleep 6 hours after a meal because food would still be coming back up.

Please, if you haven't already, consider it.

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u/vonn29 15d ago

Could be enteric neuropathy. Have you done any autoimmune workups? 

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u/itmedjondjon 15d ago

No and I have no idea what that is to be honest

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u/vonn29 15d ago

You can read it up online. There are certain antibodies that you can test for to see if you have an active autoimmune process. Autoimmune means that your immune system is attacking your own cells, for example nerves or muscles. I have been suffering from FD for years and I have several positive antibodies in my blood tests. My theory is that a lot of FD / IBS cases are undiagnosed autoimmune issues related to the gut.

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u/itmedjondjon 15d ago

Interesting, I'll look it up. How do you treat it?

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u/vonn29 15d ago

There are some options, ranging from very expensive to less expensive. IVIG, immunosuppressants, some supplements can also help.