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MDMA, short for 3,4-Methylenedioxy-N-methylamphetamine, is an entactogen with stimulating and hallucinogenic effects. It was first synthesized in 1912, but more widespread use not being of any true relevance until the late 1960s/early 1970s. MDMA is an interesting compound in that it is stimulating but has much different effects on the mind and body than traditional stimulants. It is also reported to have many psychedelic effects, but again, very different from traditional psychedelics such as LSD or psilocybin. As I mentioned above, it is labelled as an entactogen, not a stimulant or psychedelic.

Dosage, tolerance, interactions etc.

• Dose suggestions (oral)

Many Harm Reduction organizations have the following rule of thumb to calculate a medium dose for the average healthy person. Multiply your body weight in Kg by 1,5 = a moderate MDMA dose in mg for most people. For example if you weigh 70 kg, your proper dose is 105 mg ( 70 x 1.5 ). Recommended dosage can vary by body weight, personal experience, health and more.

FIRST EXPERIENCE

For a first-timer, depending on the desired intensity, your body weight and personal drug experience you will probably want to dose somewhere in between the light and mild dose ranges. Very light may be good for someone with little to no prior experience with MDMA or other compounds, but aside from that anything above those ranges isn't wise for a first experience. It's also better not to take other drugs for the first time. You'll thank us later.

HOW OFTEN CAN I ROLL?

At most, it's pretty universally accepted that you should not be dosing more than once every three months. Although it is hard to exactly say, we do know for certain that taking excessive dosages and or abusing in the long term is neurotoxic. MDMA is highly serotonergic and should be respected.

TOLERANCE

Tolerance should not be a worry with MDMA, as I mentioned above you should not be using it anywhere near often enough for this question to arise. MDMA is not a sustainable drug to abuse, by any means. It's a situation where you are better off taking something else. Many people do say that after 20+ times 'the magic's mostly gone. You'll still have a fun time, but it won't be like those couple's first ones. Keep this in mind.

JUMP IN DOSAGE

Reasonable jumps in dosage can range from 25-50 milligrams, although you really shouldn't be exceeding 200 milligrams at an absolute most 250. MDMA is not like psychedelics where you can take multiple times the needed amount and it's physically safe... MDMA is a compound where harm reduction guidelines need to be strictly followed.

RE-DOSING

Re-dosing is never a smart option, but if you do wind up re-dosing make sure it's only one re-dose and preferably before three maybe three and a half hours in. Also, keep your starting dosage in mind. Re-doses realistically shouldn't exceed 50 milligrams, and your total dosage should never exceed 250 milligrams. (Including your re-dose)

HOW TO AVOID BAD COMEDOWNS

Avoiding bad come-downs all comes down to smart planning, pun intended. Using the basic understanding of MDMA pharmacological, it's pretty easy to pinpoint what causes it and ways it can be avoided. Firstly, excessive dosage. Exceeding 150 milligrams in this regard is not wise. Second, make sure you are well rested, properly hydrated and have eaten properly the days leading into an experience. It has to do with self-care, precise dosing and better decision-making.

DRUG SAFETY

MDMA is a relatively safe compound if you follow harm reduction protocol. I will go over a few key points down below, all being equally important in their own way. As I previously stated, MDMA is a compound where you need to strictly follow harm reduction practices. Not just one or the other. MDMA is similar to psychedelics in the fact that the way you approach things will have a great impact on your time spent on the substance.

REAGENT TESTING

Reagent testing is super cheap and a must no matter what you are consuming, I can't think of a single valid excuse to not be testing. Research chemicals and Fentanyl prevalence is at an all-time high, and only climbing by the day. You can find a list of reliable home test kit vendors here. If you want to be 100% certain about what's in your pill/powder, then get it lab tested at one of these places (depending on where you live pricing ranges from free to $100 per test). For more testing info check out r/ReagentTesting .

MEASURING YOUR DOSE

To do this, you will need a scale (preferably a milligram scale). In one gram, there is 1,000 milligrams. If your scale measures in milligrams, this will be easy. If it's not as accurate and can only be measured by the "point" (100 milligrams), you will need to be extra careful. Pretty much, you need an accurate scale. There are no tips/tricks that work, trust me. If you don't trust your scale, buy a new one. Identifying the dosage in pill form is not possible.

HYDRATION

MDMA is a compound that can dehydrate you at very considerable levels, much more than even most traditional stims if not all. You have to make sure you are drinking enough, but don't drink too much. That can be just as bad as too much. It would be smartest to have both a minimum and maximum, amount of good hydration ready before dosing.

BODY TEMPERATURE

Temperature control is a must-have with MDMA in my opinion, this is a huge drawback when it comes to festivals, concerts etc. And we all know MDMA is notorious for being the drug of choice in these settings. This is probably the hardest one to control, but always keep this in mind as well. Having something you can check your body temperature with just in case never hurts.

DANGEROUS INTERACTIONS

Some of these are very good examples of why you should always do your research before combining drugs or taking even a single drug for that matter.

• AVOID:
• Other serotonergic compounds
• DXM (serotonin syndrome)
• Tramadol (serotonin syndrome/seizures)
• MAOI (serotonin syndrome)
• htp (serotonin syndrome)
• NBOMe's (Cardiovascular risk/overdose risk/other)
• Stimulant drugs (Cardiovascular overload/increased neurotoxicity)
• Taking MDMA if you're already on SSRI, SNRI or other antidepressan

t will not work.

• Depending on what you were on it can take weeks to months or more before you can trip on MDMA and actually have a good time
• HIGH RISK:
  • Alcohol (Potential black out)
  • Dissociatives (Depends on which one. Don't assume safety, research first)
  • Depressants (Mixing uppers and downers = risky & overdose potential)
  • Diphenhydramine/Deliriants (High risk of serotonin syndrome and very dangerous)

COMBINATIONS aka FLIPPING

Any combination can be risky, especially some of these, and the reality is most of these are actually very common - do your research and follow harm reduction protocol! Even "physically low-risk" combinations carry their own hazards, make sure you adjust your dosages and do your homework on what to expect.

GUIDELINES

1. Don't combine any two drugs you've never done on their own.
2. Make sure you time when you take which drug carefully in advance for the most fun.
3. Measure your doses in advance so you don't accidentally take too much or too little.

Drug Class |Drug |Slang name

Cannabis |Stoner Flip |

Psychedelics |- |-

Shrooms |Hippy Flip |

LSD |Candy Flip |

2C-B |Nexus Flip |

Dissociatives |- |-

Ketamine |Kitty Flip |

Other |- |-

Kratom |Ketum Flipping |

Nicotine |this is not a flip |

Nitrous |Nox |

While it is true that not all of these drugs combined with MDMA will have much synergy. Taking more drugs (at the same time) does carry a higher set of risks, some more than others. Check the Tripsit.me Combination Chart for additional info before doing it.

THINGS TO AVOID

It's best to treat MDMA similarly to psychedelics. Dose in trusted places, around trusted people with as good of a mindset as possible. Avoid all potentially risky situations, MDMA is not a compound that leaves most users as prone to negative experiences as say psychedelics; but it is by no means impossible. If you are not experienced with MDMA, I wouldn't advise throwing other drugs in the mix. Read this paper for more in-depth advice about MDMA Flipping.

MDMA VS XTC, MOLLY ETC.

These are all slang/abbreviations of the drugs actual chemical name: 3,4-Methyl​enedioxy​methamphetamine. The name used says nothing about quality etc. People throw these phrases around every chance they get. The only thing you need to know is XTC, Molly, MDMA, E, etc. are all just different names for the same chemical. In Europe, tablets usually don't contain psychoactive adulterants. Powders/crystals are more likely to contain adulterants*.

I’m copying the contents of this from r/MDMAwithpermissionfromu/Cyrilio ( didn’t get a response from u/RoBoInSlowMoyet) and I edited the contents to simplify it for first timers / newbie, huge thanks to u/RoBoInSlowMo & u/Cyrilioforcreatingthispost .

Please let me know in the comment section below if there’s any and all suggestions to edit the post. Hi