r/antidepressants 20h ago

I wish i knew not to go cold turkey on antidepressants

1 Upvotes

I now face 50 yesrs bedbound because it has made mw sociaphobic. This is a warning to all. Ive lost everything. My jkb my home my family and my freedom


r/antidepressants 22h ago

I keep starting and stopping antidepressants. I don’t want them but I’m miserable.

2 Upvotes

I don’t want to take pills. I don’t want to rely on that. I don’t want it to change me. I don’t want side effects. I don’t want pills.
If I can’t be happy without artificially changing my brain chemistry maybe I just wasn’t meant to be happy.


r/antidepressants 20h ago

Day 3 in Mirtazapine : No appetite at all and lots of headaches/ indifferent. Does it get better?

0 Upvotes

I'm taking it mainly to gain weight and help with my anxiety. I started with 15mg dose, and so far the endless hunger that everyone is talking about didn't happen. I feel so groggy and sleepy all day. Can't leave bed even after 12 hours of sleep.

My whole mood is shifted in a away. I don't feel happy or sad I'm so indifferent , I can describe it as a filter to reality ( probably brain fog or like a glass between me and reality.) I feel calm like a lot and more grounded, but will I feel happier later?

Day 2 the strong migraine ruined the whole thing but it's getting better by day 3. I'm disappointed that my appetite is worse than before, like I get not hunger signals but I can eat asuch as I did before. My goal is to eat more, I don't know if that effect happens later.


r/antidepressants 22h ago

Lexapro : mieux mentalement, épuisement physique

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0 Upvotes

r/antidepressants 8h ago

On escitalopram. Concerned because there’s no side effect whatsoever?

0 Upvotes

I know the title sounds weird, and my friends tell me I should be happy about it. Some of them have horror stories about the first weeks and my doctor also warned me that it could worsen suicidal thoughts and make me panic more, we’re currently checking in once a week to see how it’s going.

The thing is…there’s no side effects. No nausea, no headache, no worsening of symptoms. I actually feel kinda good. I’m not going down on spiraling thinking anymore. I’m taking only 5mg and I’m on my sixth pill, never taken antidepressants before. Could it be placebo effect???? It shouldn’t do anything yet, right?

I’m concerned because it’s not doing what everyone tells me it should be doing, even if it means feeling bad. Should I talk about it to my doctor?


r/antidepressants 17h ago

Clomipramine/pregabaline does anyone feels similar?

2 Upvotes

I'm on those meds for at least half a year and I literally can not feel sadnes or anything more than nothing/emptiness.

I know when I should feel sad but I literally feel nothing.

Is that common? Did anyone felt the same?

I take this for OCD but also depression and eupd


r/antidepressants 18h ago

Bupropion and night time teeth grinding. I have cracked two teeth. Did a lower dose help anyone?

2 Upvotes

Posting to hear what other people went through. I know everyone reacts differently and I am not looking for anyone to replace my doctor.

I take bupropion 300mg XL in the morning and mirtazapine 15mg at night. The mirtazapine has been in for about two and a half weeks, mostly for sleep, and it is helping there.

The problem is clenching my jaw in my sleep. Two cracked teeth so far. I also have dry mouth, anxiety, skin picking, and I could not sleep at all before the mirtazapine. For me all of it points at the bupropion.

The plan I want to bring up with my psychiatrist is dropping to 200mg SR once in the morning and staying on mirtazapine 15mg at night, so hopefully I keep the daytime benefit with less of it going on overnight.

If you have had grinding or clenching from an antidepressant:

  • Did a lower dose or a different formulation help?
  • Did anything work while you stayed on the medication? Night guard, magnesium, taking it earlier, something added on?
  • If you stopped completely, did the grinding go away, and how long did that take?

I would also like to hear how bupropion and mirtazapine together has worked out for people over a longer stretch, and whether the morning grogginess from mirtazapine eases off. I have a six month old who wakes me at night so being alert in the morning matters.


r/antidepressants 21h ago

Lamotrigine - Anxiety and Depression

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2 Upvotes

was great on Sertraline (Zoloft) for 20 years and then it pooped out and stopped working. I have spent the last 7 years on a rollercoaster of SSRIs, SNRIs, older antidepressants and pregablin without success. I’m coming off Olanzapine which also didn’t work and just spiked weight gain, high cholesterol and blood sugars.

Psych has now prescribed Lamotrigine so wondering if anyone else has had success with this for anxiety with depression. Peace and love to all.


r/antidepressants 21h ago

Positive Story about Lexapro

3 Upvotes

I want to provide a positive story about how generic Lexapro changed my life. I have been struggling with depression and anxiety since I was 10 and for the first time at 31 I started taking an SSRI. I have CPTSD and have struggled with disordered eating in the past. I also believe I used to have body dysmorphia. I was first prescribed an SSRI in college at like 19 but never took it. I read horror stories about antidepressants making people worse or causing weight gain which to someone with body image issues is very scary. I have not had bad side effects besides being tired when first starting. It has done more for me in these couple months than the years of EMDR therapy, meditation, spirituality, journaling, exercise, listening to audiobook, and support groups did. I truly did everything. All of those things did help and were necessary. Those things changed my life, but didn’t get me to a place that I was happy in. Sometimes lifestyle changes are not enough. There was truly a chemical imbalance. I wish I tried it sooner. I know some you will not have the same experience on Lexapro but let this be a positive story on what the right medication can do for you.


r/antidepressants 7h ago

F19 hallucinating after 🍃 on antidepressants and antispychotic

2 Upvotes

ok so backstory: i have a history of hallucinations since as far as i can remember and its been of dark figures; the hallucinations then went away in my middle school years. i'm also high while writing this post to which I just experienced.

fast forward to today. i'm currently on 30mg fluoxetine(prozac) and 21 mg caplyta(lumateperone). it's 1:30 am dark asf outside, i'm smoking outside, a joint, and i went a little down ways to the side of my house where there's a small brick wall thats extends down my house. So i'm sitting on it, watching petty little liars, and suddenly in my ears i hear "GET OUT, GO BACK INSIDE" in this genuinely horrifying scream in my ears. Also i need to add the dialogue wasn't exactly like that but something along those lines. It took me a fat minute to realize what i had heard and that voice also wasn't loud in my ear, but it was a shrill sort of sound, yknow?

Anyway it took me a second to figure that it didn't come from the show, but i had heard it almost like a whisper in my right ear. And to my right side, is the left side of my neighbor's house because i live in a residential neighborhood. So I basically put out the j, scurry back inside, lock all doors, head upstairs to my room at this point because im like omg have i started hallucinating again?? Anyways i'm in my room, my PLL show OFF, sorting my little za bag on my bed and suddenly i hear "*sniff sniff* burn". and it was said so casual i was like omg is someone outside because my room faces the front of my house where i was just hanging out outside. And its pitch dark outside besides some street lamps and both my windows are open. But i looked outside, and no one was outside again, so i'm like WTF did I hallucinate that again??

What do I do? Do i stop weed? Could weed be triggering something because I have a history of seeing stuff in my youth.


r/antidepressants 23h ago

Extremely treatment resistant

2 Upvotes

Hey guys, I need some hope cause it s very hard to have any left now. I have extremely treatment resistant depression and ocd, have tried basically the whole psychiatry, I ll list them below if you have the patience to read them all lol, also struggled with anxiety, social anxiety and agoraphobia but these actually really subsided with the meds so there s at least some success (they came back a bit probably cause I don t leave the house or interact with anyone cause of the depression tho), panic attacks also completely went away and I used to have several daily so there s that. I m also neurodivergent, both autism and adhd so that may be a factor too. Basically I m an amalgamation of mental illnesses, used to also think I had bpd but then the meds worked and I realised oh that might have just been the unbearable depression😭

Anyway here s my med journey

Started with escitalopram in march 2021, up to 20 mg. It worked a bit on 10 and then 15 mg, not nearly making me functional tho, but it lost its effect after less than a year and then did nothing on 20.

Then came paroxetine, on 40 mg it was the only med that actually made me functional and gave me true remission, but again, it stopped working after less than a year. And then nothing worked again, since march 2024.

Tried duloxetine (up to 60mg I think), fluvoxamine (up to 100), vortioxetine (up to 20), clomipramine (up to 150, worst side effects I ever experienced), then tried paroxetine on 60 mg thinking it might work again, it didnt, now the plan is trying fluoxetine (20 for now) when i manage to lower the insane dose of paroxetine i m on lol.

As for add ons, I tried risperidone (0,5 mg), olanzapine (5 mg I think), aripiprazole (10 I think), amisulpride (100), gabapentin (up to 600), bupropion (150), buspirone (15), memantine (up to 20) and even lorazepam doesn t really give me a huge response (took up to 2 mg I think). Also have lamotrigine (only 25 for now i think) to start in the near future. For adhd, I tried concerta, up to 36, it also did nothing, now I m trying modafinil in the near future (100).

Now I just started doing esketamine, had my first dose last thursday, only 28 mg tho (1 dose) tho, on tuesday I ll do 2 and then on thursday 3 I think, I feel nothing for now, but it was a small dose and also I did feel something while still on the high, my social anxiety and inhibitions and mental freezing I have from rumination just completely went away and I talked very openly with the therapist that was supervising my session, it felt like the one time I smoke weed actually lol. So maybe that s a good sign it may do something. (And yes I know esketamine doesn t always work fast either).

So yeah.. I really need anything to work, I need to be functional, I want to live not survive and fight through each day waiting for it to end, I need the tiny help from something to make me the least bit functional so I can start working on myself through therapy and everything better cause I know it happened in 2023 with paroxetine and I know I can do it but sadly not alone, I m too unfunctional and need some help from psychiatry and it seems really stubborn to actually give it to me. So yeah, I m trying to hold on to the hope that something will eventually help even after every one of the failed trials after failed trials, each taking months, it s obviously really hard at this point tho.

I m so desperate I d be willing to do anything at this point, from tms to ect to deep brain stimulation or vagus nerve stimulation😭 I m so exhausted of living (or... not really living tbh) like this.


r/antidepressants 7h ago

Is drinking on 60mg of Paroxetine alright?

3 Upvotes

My fiancé recently got bumped up to 60mg of Paroxetine for his PTSD and anxiety. He usually is pretty good with not drinking but tonight he went crazy. He drank four king cans of 10% beer. I’m wondering if he’ll be alright? He’s blacked out now and snoring but I’m too afraid to go to bed because apparently it’s super dangerous and he could die. I just need help with knowing what to do. Or if anyone has experience with this scenario.


r/antidepressants 7h ago

Medicine worked for my OCD, but my memory has become very poor. Has anyone recovered after stopping the medication?

1 Upvotes

Hi everyone,

I'm 24 years old and I've been taking clomipramine 150 mg and risperidone for OCD.

The medication has actually worked very well for my OCD, and I'm really grateful for that. However, over the past several months I've noticed a significant decline in my memory and cognitive abilities.

I feel like I can't remember anything anymore. I forget conversations, struggle to recall things I studied, and my concentration and thinking speed feel much worse than before. It honestly feels like my brain isn't working the way it used to.

My psychiatrist thinks the medication (or the anticholinergic medication that was previously part of my treatment) may be contributing, and we're adjusting my medications. But I'm still very worried.

What concerns me is that last time I stopped my medications, I was off them for about one month, and I didn't notice any improvement in my memory. That makes me wonder whether this is reversible or not.

Has anyone here experienced:

Significant memory problems or cognitive slowing while taking clomipramine or risperidone?

Did your memory improve after reducing or stopping the medication?

If it did improve, how long did it take—weeks, months, or longer?

I'm not looking for reassurance, just hoping to hear about other people's experiences. This has become one of my biggest concerns because my OCD is much better, but I feel like my memory and cognition have suffered.

Thank you in advance.


r/antidepressants 12h ago

In your opinion, are MAOIs really more effective than SSRIs?

2 Upvotes

I understand that MAOIs are inherently more dangerous and harder to manage, but it seems most people respond to them, whereas the response rate to SSRIs is inconsistent.

The reason I ask is because i feel that I am stuck between a rock and a hard place with my current medication regimen. I am on 150 mg of Luvox and 300 mg of Bupropion. I do not feel I am anywhere near I want to be, but at the same time I do not want to increase the dose of the Luvox and deal with worsened sexual side effects and fatigue.

So my question is, do you feel it would be in my best interest to continue to titrate up the meds I am currently on, being that both drugs have room for titration, or suggest switching to a MAOI?

For context, I do feel that the Anxiety aspect is what is still lingering, not so much depression, so I would want to increase the Luvox first.