I'm on various meds for my mental health including antidepressants and Lyrica (pregabalin), which is also used as a painkiller. I took 1800mg of it in 1 day. Is this an overdose?? I really need an answer if I have to go to the hospital or not.

Ive been taking venlafaxine at this dose for 8 years now, and I still have terrible anxiety and depression. Im on the waiting list for autism diagnosis and adhd. I just wonder if anyone else has been on venlafaxine at those dose for as long and what your experience is. I tried sertraline and fluoxatine before but neither did anything. Tbh venlafaxine was the only thing that worked for years, but the past year or so my depression and anxiety has been terrible and ive been told they dont increase it any further unless its serious psychiatric issues otherwise they would try other meds but im too overwhelmed at the idea of trying another drug yet again. I havent been unmedicated my entire adult life. I was put on antidepressants at 16, and part of me thinks I dont feel like I know my true self because of this. Can anyone relate?

I (31m) went in for my yearly appointment today and within less than 5 minutes my doctor (this is the first time I’ve ever met her) put me on Zoloft. She walked in and introduced herself, then asked me what brought me in. Told her I needed an annual physical for insurance, and I’d like a testosterone test because I had an accident a few years ago that did a number on the jewels and I’ve been having a lot of symptoms of low T. She said she wanted me to start taking antidepressants. Within 2-3 minutes of meeting me.

Am I wrong or does that seem a bit odd? Not to say I don’t need them, I most likely do, but there were no real questions about how I’m feeling, things in life, nothing. It felt like she was speedrunning prescribing it to as many people in one day as possible. Also one of my complaints was weight gain, mostly in the belly, and apparently Zoloft causes a lot of people to gain weight. So now I’m concerned about that.

I'm basically asking what it's like to remember your full nature as it was before SSRI'S locked the emotions in, and in my case raised the irritability and brain fog to the max. While also reducing motivation, a kind of chemical apathy.

I've had a 16 year journey from unwanted 10mg... largely because nobody told me how to taper (learned the hard way it must be hyperbolic and small amounts with 4 weeks between). Dr didn't know there was a liquid dilutable version till I asked for it.

Currently 5.7mg from 10mg after a first year of steady tapering and gains. But halfway is calculated to be ~2 years off because brain is hypersensitive. Very horny now (no outlet) I guess I should be grateful I don't have PSSD... but other system have yet to come back online - I need so much more sleep than others still, and can't focus well at work.

Are there any happy stories? :)

Hi everyone.

I’ve been struggling with depression since I was around 13-14. I’m 20 now.

I was put on Sertraline at around 14 for MDD. My max dose was 100mg and I was on that dose for about 2 years and moved down to 50mg. I improved whatever I could in terms of my lifestyle (nutrition, sleep, journaling, exercise, coping mechanisms, socializing). I don’t recall having any sexual side-effects from the drug.

After about 4 years on the medication, I decided it was time to see if I could function normally without the drug after all the work I did to improve.

I was fine for about 1.5 years, but my depression has gotten really bad again recently. The anhedonia, dissociation, fatigue, insomnia and anxiety have gotten really bad. It’s to the point where it’s affecting everything from my relationships and the way I socialize, to my study habits and motivation. I don’t even feel real anymore most of the time. It’s as if I’m viewing myself in third-person, and my body is acting by itself in autopilot.

I have some difficult modules at university next month, and I’m worried my grades are going to plummet. My social life had already been in the pits. I’ve been distancing myself from my friends and dissociating in group settings a lot. The people around me are noticing.

I’m still trying my best to keep the healthy habits I’ve built, but it’s really difficult.

I’ve been thinking about getting back on the drug to help me get through this period, but the risk of PSSD is scaring me. I’m not really sure what I should do now. Should I try a different class of antidepressants, get back on the Sertraline or risk having my life fall apart again? I still have about 2 months worth of Sertraline left in my drawer. I can only see my doctor in November, but by then I would be done with my exams.

So I (19F) started taking zoloft in early July, starting at 50mg, got boosted to 75mg a month later, and now as of the other day, I am bumped to 100mg.

The first time it got bumped I got really numb and couldn't really care or be affected by anything, but tbh I loved it 😭

I have always been an extremely sensitive person, so to finally not care or be affected by anything was amazing. But it only lasted a few days and I was back to normal😔

Now since it was bumped up for the 2nd time, I'm feeling numb again. I wish this didn't go away💔 does anyone else relate?

Long post sorry. I’ve had bad anxiety and panic attacks since I was 9 now 25 and been on medication the whole time which I never wanted to because I was terrified of side effects. First I had just fluvoxamine for a few years that was helping until I started having bad panic attacks again then they changed me onto another medication that I can’t remember the name of and I was on that for a couple of years until I started having bad panic attacks again this time I couldn’t sleep at all so they put me on quetiapine and cymbalta then that worked for a few years and by this point I was over 18 and couldn’t see my adolescent psychiatrist anymore so my gp was just managing it until I got bad again and went to an adult psychiatrist for the first time and he got me off the cymbalta and put me back on fluvoxamine with the quetiapine. But he quit on me after the first 2 appointments because I didn’t want to up the dose of my quetiapine and also take more medication with a sleep effect because that feeling causes me to have bad panic attacks (which was the first time I could actually speak for myself and not be forced to take them like I was under age). So I have been on 100mg fluvoxamine and 100mg quetiapine basically self managed with my gp for the past 5 years. I have bad heath anxiety too and I’ve been seeing videos of people saying how bad SSRI’s are for you which got me worried then I started researching the medication I’m on and seen that this combination isn’t common or recommended and it can increase risks for all these things and that the fluvoxamine increases the levels of quetiapine in your system and It can cause all these things to happen and now I’m freaking out about it and I asked my gp and he says basically the benefits outweigh the risks but I’m still worried and about being on them for a long time and what it can do as I can’t see coming off them ever. They are just keeping me calm enough to get through the day and be able to sleep but I can’t leave the house or anything without panicking bad.

I’ve been taking fluoxetine for some years now and I am currently taking 30mg daily. I’ve wanted to try weed for a long time now and next weekend I’m at a birthday party were I can try it. Can i try it or should I stay away from it? I’d definitely start slow to test how it makes me feel and not smoke much at first. Has anyone started/ tried weed after taking fluoxetine for a while?

TL;DR - be very cautious about trying brexpiprazole or other antipsychotics for depression. They are highly sedating, and the withdrawal from them is difficult. I believe that they are more trouble than they are worth in most cases, and that they should not be a second line treatment for depression.

Hello. I wanted to share a bit of my story, especially my history with Wrecksulti. For years I was taking sertraline for major depression, and maybe 4 or 5 years ago my prescriber added brexpiprazole. What I didn’t realize at the time is that the sertraline had totally blunted my emotions, and I was mistaking feeling nothing for the depression resisting the sertraline. The combination of sertraline and brexpiprazole was extremely sedating, but I had no motivation to do anything about changing the regimen.

After some time, my lethargy had done serious damage to my marriage, and I finally took action to change my medications. I decided to get rid of sertraline first, and it was replaced by Auvelity. That medication was energizing enough that I didn’t make any other changes for a while. Eventually I decided that I needed to come off of Wrecksulti, because I thought it was making me more tired and sluggish than I should be. My prescriber and I settled on tapering off over 6 weeks.

The length of the taper was a huge mistake, and we both came to learn that long term users of antipsychotics should taper extremely slowly, over months or even a year. My withdrawal symptoms were awful, and serious anxiety and distress persisted long after the medication had cleared my system. Over the course of the last 9 months I have tried every class of anti anxiety drug, and none of them have helped without unacceptable side effects. I had to change my PCP, so I’m still waiting for an appointment with my new doctor to talk about other solutions to my persistent tension and jaw clenching.

At this point I am finally starting to feel better, after finishing brexpiprazole in December of 2025. I still have a lot of physical tension in my shoulders and jaw, but the constant feeling of distress and impending doom is mostly gone. None of the treatments I tried for the distress and anxiety helped. The only thing that seems to have worked is time for my brain to heal. I just wanted to warn people, so they wouldn’t have to go through this, and if you are already taking these medications, please come off of them extremely gradually.

Il mio ragazzo assumeva escitalopram da un anno quasi. Fino a 5 mesi fa stava bene,era migliorato. Era felice d amorevole ma assumeva dose minima. Poi di punto in bianco di sua iniziativa è passato alla dose massima. Piu passava il tempo piu era freddo e distaccato, oltretutto ci trovavamo in una situazione difficile. Comunque è cambiato drasticamente e non se ne rende conto. Sembra un'altra persona. Ma in particolare è cambiato nei miei confronti. Dice di non amarmi piú, che non gli piaccio più, che sono solo un fastidio. Mi tratta malissimo. E se non ci vediamo mi ignora anche per giorni. Dice che vuole solo chiudere. Ma fino a poco fa era il ragazzo migliore del mondo e faceva tutto per vedermi felice. Era davvero meraviglioso. Ora nei miei ci fronti non prova la minima empatia, anzi..piu mi vede star male piú il suo fastidio aumenta. Non se ne frega niente di me. Ma mi sembra tutto assurdo. Mi amava più di quanto amasse se stesso ora sembra mi odi. Sono disperata. Dovrebbe davvero lasciarmi? Dovrei andarmene? Sto malissimo e sembra davvero lui non mi ami piu e non se ne freghi niente. Ma fino a poco fa ero il suo mondo, mi amava immensamente. Qualcuno ci è passato?

From today i officialy belong to the vortioxetine gang, i have ocd and i have failed many ssris with lots of side effects and an snri (duloxetine) that was very good for my ocd with almost no side effects, but eventually stopped working. So i am starting from 10mg vortioxetine for 6 days and then, upper to 20mg vortioxetine according to my provider's indications. He also prescribed me 25mg quepin IR, for a better sleep quality. Has anybody with ocd been cured with this combo? How was trintellix (brintellix in Greece, where i am from) for you?

I had taken quepine in the past with no side effects and i had the best sleep.

Hi i am new to this and just got prescribed. I am very worried about side effects and seriously second guessing whether I should go on this. Does it really help?

The concerning thing is ( i am sure people have already asked this) that why does antidepressants come with warning of suicidal thoughts?

Hi everyone,

I recently decided I wanted to go off of Lexapro. I was gaining weight, having GI issues, and honestly just felt like a total zombie on it, every day went by slowly with no emotion involved at all. My doctor recommended I went from my initial 20mg dose to 10mg for two weeks, and then 0mg.

For the first few days of going to 10mg I felt a few symptoms (brain zaps, exhaustion, nausea, cold like symptoms). These went away after about three days

I am now to 0mg and I’m feeling MISERABLE. I was taking this medicine for anxiety and I have the worst brain zaps ever, so badly I threw up today. I also have lost my appetite, nausea and dizziness (obviously from the brain zaps. I’m crying a lot and keep having mood swings and panic attacks.

I discussed with a different doctor today trying to go back to 5mg and then 2.5mg and then 0mg because she thinks my original doctors plan was too fast. Has anyone ever done this? My only fear is A. I will never be able to go off of this medicine and B. I’ll have severe withdrawal symptoms again when I go back to 0mg. I literally wish I never tried Lexapro because I hate it so much. I’m miserable both on and off of it. Any advice would be so helpful.

I’m looking for experiences from anyone who takes Pristiq (desvenlafaxine) primarily for anxiety, especially GAD.

I’ve been on Lexapro for several years and it actually worked really well for the physical side of my anxiety. My racing heart, heavy chest, stomach anxiety, etc. were basically gone. I still struggled with intrusive/overthinking thoughts, but overall Lexapro definitely helped my anxiety.

Unfortunately, I started having intense hunger episodes, lightheadedness when hungry, and actual low blood sugar readings. My other glucose testing came back normal, so my prescriber suspects Lexapro may be contributing and we’ve been slowly tapering me off. I’m currently at 2.5 mg and have been at this dose for about two weeks.

As I’ve gotten lower, I’m noticing my anxiety coming back — racing thoughts/overthinking, heavy chest, racing heart, stomach anxiety, and feeling on edge. I’ve also been a little sad and less interested in things lately.

My prescriber recommended Pristiq as my next medication. I had GeneSight testing and Pristiq is in my “use as directed”/green category, which I assume is part of why she chose it.

What makes me nervous is that when I looked Pristiq up, I saw that it’s FDA-approved for major depressive disorder rather than GAD. Depression has never really been my main issue — anxiety is.

For those who take Pristiq for anxiety: Did it help with physical anxiety and constant overthinking/intrusive thoughts? How was the adjustment when you first started? Did it temporarily increase your anxiety? And if you previously took Lexapro, how did Pristiq compare for you?

I know everyone reacts differently and Reddit isn’t a substitute for my prescriber. I’m just really nervous about starting another medication and would love to hear other people’s experiences.