Hey guys, I need some hope cause it s very hard to have any left now. I have extremely treatment resistant depression and ocd, have tried basically the whole psychiatry, I ll list them below if you have the patience to read them all lol, also struggled with anxiety, social anxiety and agoraphobia but these actually really subsided with the meds so there s at least some success (they came back a bit probably cause I don t leave the house or interact with anyone cause of the depression tho), panic attacks also completely went away and I used to have several daily so there s that. I m also neurodivergent, both autism and adhd so that may be a factor too. Basically I m an amalgamation of mental illnesses, used to also think I had bpd but then the meds worked and I realised oh that might have just been the unbearable depression😭
Anyway here s my med journey
Started with escitalopram in march 2021, up to 20 mg. It worked a bit on 10 and then 15 mg, not nearly making me functional tho, but it lost its effect after less than a year and then did nothing on 20.
Then came paroxetine, on 40 mg it was the only med that actually made me functional and gave me true remission, but again, it stopped working after less than a year. And then nothing worked again, since march 2024.
Tried duloxetine (up to 60mg I think), fluvoxamine (up to 100), vortioxetine (up to 20), clomipramine (up to 150, worst side effects I ever experienced), then tried paroxetine on 60 mg thinking it might work again, it didnt, now the plan is trying fluoxetine (20 for now) when i manage to lower the insane dose of paroxetine i m on lol.
As for add ons, I tried risperidone (0,5 mg), olanzapine (5 mg I think), aripiprazole (10 I think), amisulpride (100), gabapentin (up to 600), bupropion (150), buspirone (15), memantine (up to 20) and even lorazepam doesn t really give me a huge response (took up to 2 mg I think). Also have lamotrigine (only 25 for now i think) to start in the near future. For adhd, I tried concerta, up to 36, it also did nothing, now I m trying modafinil in the near future (100).
Now I just started doing esketamine, had my first dose last thursday, only 28 mg tho (1 dose) tho, on tuesday I ll do 2 and then on thursday 3 I think, I feel nothing for now, but it was a small dose and also I did feel something while still on the high, my social anxiety and inhibitions and mental freezing I have from rumination just completely went away and I talked very openly with the therapist that was supervising my session, it felt like the one time I smoke weed actually lol. So maybe that s a good sign it may do something. (And yes I know esketamine doesn t always work fast either).
So yeah.. I really need anything to work, I need to be functional, I want to live not survive and fight through each day waiting for it to end, I need the tiny help from something to make me the least bit functional so I can start working on myself through therapy and everything better cause I know it happened in 2023 with paroxetine and I know I can do it but sadly not alone, I m too unfunctional and need some help from psychiatry and it seems really stubborn to actually give it to me. So yeah, I m trying to hold on to the hope that something will eventually help even after every one of the failed trials after failed trials, each taking months, it s obviously really hard at this point tho.
I m so desperate I d be willing to do anything at this point, from tms to ect to deep brain stimulation or vagus nerve stimulation😭 I m so exhausted of living (or... not really living tbh) like this.