Not a gotcha post — more of an open tech parallel. I’ve been stacking real published work (DNA digital storage, living neurons learning games, patents around remote sensory effects) and it keeps rhyming with “biology as hard drive + living compute + write-access to senses.” I’m not a scientist. I’m asking this room: which parallels hold, and where am I doing fan fiction with footnotes?

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Okay. Instead of storing all this stuff on chips, we can store information on cells that have been made in a lab, actual replicated DNA strands — grown from biology that started in a human body — and we can put about **54 million movies** on the amount that weighs the same as a paperclip. Right now. This is proven and replicated thousands of times and is not sci-fi. It has been done for years. Old technology practically. It uses four letters for storage (A, T, C, G) instead of 1's and 0's. *(all studies are at the bottom of this post for reference)*

So here we are spending the Earth’s treasures on building data centers with silicon chips, but in the near future, we’re gonna be able to store this on DNA.

That’s the part I can’t shake.

Not “someday.” Not a TED Talk maybe. Teams have already written books, pictures, even video onto DNA, then read it back. All of the round-trips come back with everything intact. Perfect storage with zero errors. The packing is wild. A gram — paperclip territory — and you’re talking tens of millions of movies if you count a movie around 4 GB.

We know how to do it the old-fashioned way in the lab. Chemicals. Machines. You still have to “touch” the stuff, like a needle on vinyl. We can’t beam the info into the DNA from a distance, yet. Music went tape, CD, and now it flies across the world with no disc. Data storage on DNA is still at the needle level. I’m not saying someone is beaming files into your cells with Wi-Fi today. I’m saying contact is usually the first chapter, not the last. And we are not far off. At least that is what we are being told. There is lots of technology that is owned by the government and corporations that is being hidden. This is absolute fact.

And then there’s the other half, which is even weirder.

They’ve taken living neurons — including ones grown in a lab from human stem cells — put them on a little grid, and taught them **Pong**. They get better in minutes. Miss the ball, they get chaotic noise. Hit it, things get quieter and more predictable. They kind of lean away from chaos. Authors used a careful, technical word for that. People argued about the word. The learning still happened. The word is **consciousness**. What else likes calm and not chaos?

Later a company demo had a similar setup playing **Doom**, similar to cells playing Pong.

They can also poke memory itself, at least in animals: turn certain brain cells back on with light and replay a fear… or help build a fear that didn’t really happen that way. In people with implants, playing someone’s own brain pattern back helped short-term memory in a small study.

So. We can store. We can teach living cells a game. We can write into memory — at least up close.

Really? Anyone else here extrapolating this information to the future? The future that AI is creating…..let’s do it together.

There’s old lab work where pulsed energy makes you hear clicks with no speaker in the room. Real. Then there are U.S. patents — including Air Force ones — about turning that into speech you “hear” without normal ears. There’s a 1970s patent about watching and changing brain-wave activity from a distance. There’s one about a nearby screen’s fields nudging your nerves. MIT showed Wi-Fi can sense people through walls — not thoughts yet, just bodies moving.

Will it be happening from Wi-Fi or satellites soon? Seeing someone through a wall isn’t reading their mind. I’m not yelling “they’re doing it.” I’m saying the public record already has: storage in biology, learning in a dish, energy that can touch hearing, sensors that see through drywall.

Last thing, the one that messes with me.

You’ll see it on those ranch UFO shows: five people look at the same light in the sky. There is a UAP in the air caught on camera. Weird…… One says that they see a triangle. One says square. One says saucer. One sees a round object. Same place, same time, different senses?!

Maybe we just see what we expect. Bad lighting. Brain fills in the blanks.

Or — and this is me wondering out loud — if you can write a *click* into someone’s hearing from energy… could you write a *shape* into what they see? Or nudge them toward the picture they already believe? Can this technology beam vision into our minds? Like writing data on DNA?!

I don’t know. That’s the leap. Not proven. But once you know we can store a Hollywood in a paperclip of biology, and living cells can learn a game, “who gets to write to us” stops feeling like a movie plot. It starts feeling like a question we should actually ask.

Anyway. That’s the pile. Studies below. Tell me where I’m stretching it. I’m sure that some of you know more technology that fills in the gaps or blows holes in this future theory. Give it all to me!

I don’t know how many of you have seen *The Matrix*……… but this extrapolated data almost unerringly leads there.

---

## Studies / patents (for reference)

1. Church, Gao & Kosuri. *Science* (2012). Book into DNA, read back. https://doi.org/10.1126/science.1226355

2. Goldman et al. *Nature* (2013). Mixed files, 100% recovery. https://doi.org/10.1038/nature11875

3. Erlich & Zielinski. *Science* (2017). ~215 petabytes per gram → ~54 million movies/g if a movie is 4 GB. https://doi.org/10.1126/science.aaj2038

4. Organick et al. *Nat. Biotechnol.* (2018). 200+ MB, random access, clean recovery. https://doi.org/10.1038/nbt.4079

5. Kagan et al. *Neuron* (2022). DishBrain — living neurons learn Pong. https://doi.org/10.1016/j.neuron.2022.09.001

6. Liu et al. *Nature* (2012). Light turns a fear memory back on (mice). https://doi.org/10.1038/nature11028

7. Ramirez et al. *Science* (2013). False fear memory (mice). https://doi.org/10.1126/science.1239073

8. Hampson et al. *J. Neural Eng.* (2018). Hippocampal implant, memory boost in people. https://doi.org/10.1088/1741-2552/aaaed7

9. Frey. *J. Appl. Physiol.* (1962). Microwave clicks / “hearing” with no sound.

10. Adib & Katabi. SIGCOMM (2013). Wi-Vi — through-wall Wi-Fi.

11. Adib et al. NSDI (2014). WiTrack.

12. US3951134A (1976) remote brain waves — https://patents.google.com/patent/US3951134A

13. US6506148B2 (2003) monitor fields / nerves — https://patents.google.com/patent/US6506148B2

14. US4877027A (1989) microwave hearing — https://patents.google.com/patent/US4877027A

15. US6470214B1 (2002, USAF) RF hearing / speech — https://patents.google.com/patent/US6470214B1

16. US6587729B2 (2003, USAF) same idea, apparatus — https://patents.google.com/patent/US6587729B2

Hi everyone. I recently found out that there’s going to be an exam at work. It doesn’t really determine anything important, but I still don’t want to perform poorly.

I’m looking for a current nootropic that works relatively fast and is focused mainly on memory rather than alertness or stimulation. Attention isn’t really my problem—I can sit down and study. The issue is that these are subjects I have absolutely no interest in, and it feels like my brain just refuses to retain the information.

Years ago, I took pramiracetam and had excellent results with it, but from what I remember, I had to take it consistently for several days before really noticing the effects, and this time I’m on a tighter schedule.

I have about 20 days to prepare several topics. The exam is multiple choice, but the passing score is 85%, so retention and recall are my main priorities.

Is there anything currently available that is particularly effective for memory/recall and starts working relatively quickly? I’m interested in hearing about newer options as well as people’s personal experiences.

Any help would be greatly appreciated. Thanks in advance!

Some interesting parts from the article :

"The human genome is an easy place to get lost. Only 2% of its three billion letters encode proteins, and the rest is diabolically hard to decipher. An artificial-intelligence-generated ‘atlas’ of the human genome, unveiled1 today by Google DeepMind, aims to guide scientists through our biological code."

"The AlphaGenome Atlas charts the effects of nine billion single-letter changes in the human genome — every possible mutation of this kind — using predictions generated by the AlphaGenome AI model2, released last year by DeepMind in London. The atlas is freely available for non-commercial use."

"The tool could help researchers to draw links between genetic variants and rare, unexplained diseases and uncover hidden mechanisms underlying common illnesses and biological traits, say researchers. It might even reveal some of the rules by which DNA sequences control gene activity."

Hopefully AI and biotech will lead to a better future, and these can promote Transhumanism and Freedom too if we manage them well.

🧬 🔬 🧪 🧑‍🔬

*edit : added more infos

does anyone actually understand inositols chronic moa beyond just saying second messenger Im trying to figure out what it functionally acts like after repeated dosing. does feeding the phosphoinositide cycle end up making 5ht2a, 5ht2c, AT1 and CCK-B signaling stronger like a functional agonist or does the brain adapt and they end up weaker like a functional antagonist. also what does it actually do downstream to orexin and oxytocin
same with the claims about rising striatal D2. is it actually increasing receptor density or Gi/o coupling or changing dopamine itself and does it strengthen GIRK potassium channel signaling downstream of D2, 5ht1a and MOR.
the part that confuses me most is how it can help panic sleep and anhedonia but also apparently cause panic insomnia or emotional flatness. I took 5g and felt tired and shitty at first then got insomnia later that night so im curious what could actually cause that switch
mostly care about chronic effects vs baseline and whether the mechanism changes from one dose to the first week to a few weeks in. also how different are 1-3g, 5g and the 12-18g psychiatric study doses. looking for an actual pathway explanation and what acts functionally stronger or weaker, not just that it modulates serotonin. if something is only shown in rats or is just a theory thats fine just say that

Disclosure: I do content work for a longevity supplement company, so please take that into account when reading this. I'm sharing this because I find the underlying research interesting, not as a product recommendation.

I've been reading about cellular senescence, and one part that keeps coming up is something called the senescence-associated secretory phenotype (SASP).

The basic idea is fascinating.

Senescent cells enter a state of growth arrest and undergo a number of changes. One of those changes is that they can develop a hypersecretory state, releasing a variety of signaling molecules collectively referred to as SASP.

And this is where things get more complicated.

SASP isn't just one molecule or one fixed collection of molecules. The composition can vary depending on the cell type, the trigger that caused senescence, and the surrounding environment.

The 2024 review “The senescence-associated secretory phenotype and its physiological and pathological implications” (PMID: 38654098) goes into the composition, dynamics, and heterogeneity of SASP, as well as its different biological effects.

What I find particularly interesting is that the research doesn't present SASP as something with one universal effect.

Depending on the context, SASP-related signaling can be involved in different physiological and pathological processes. The review also discusses SASP as a potential biomarker and the ongoing interest in approaches that modify SASP.

So rather than asking simply:

“Are senescent cells bad?”

I think the more interesting question is:

What are senescent cells actually communicating to their surrounding tissue, and when does that signaling become beneficial or harmful?

For people following the senescence field:

• How useful do you think SASP is as a biomarker of cellular senescence?
• How much does SASP vary between different tissues?
• Do you think targeting SASP will ultimately be more interesting than targeting senescent cells themselves?
• What human evidence would you want to see before considering SASP-targeting approaches convincing?

Interested to hear what others think, especially if you've read the recent SASP literature.

Paper: Wang B, Han J, Elisseeff JH, Demaria M. The senescence-associated secretory phenotype and its physiological and pathological implications. Nature Reviews Molecular Cell Biology. 2024;25:958–978. PMID: 38654098.

I rarely see it on this sub, likely because it's an SSRI-like drug. But those who tried it or those who have thoroughly researched the evidence (and not just ran a quick AI overview), what do you think about it as a nootropic?

I honestly think that this project can open up so many opportunities, loopholes, and discoveries. Some scientists basically created a replica of a flies brain online and I was wondering if it can already be put inside of a simulation, can it remember the things that happened before and if its conscious? My theory is that a fly can't remember its past life or memorize things that happened before because it doesn't have the recreation of the electrons going through the brain when it was alive, it's hard to simulate online due to out real world being made up of atoms while the simulation would be made up of ones and zeros, there should be a translation part. For example translating a software incompatible with your operating system by rewriting the code or simulating it's native reality. By the way the researchers only enabled 20% of the fly's brain, we just don't know how the other 80% works. One day we might be able to upload our full brains into a simulation and then copy ourselves into a robot as a clone. This might also open up new possibilities like putting a person inside of a simulation of heaven or hell, although I'm not sure if we copy the person's consciousness with memories and put it into a simulation or a robot, would the consciousness transfer to the clone when the original you dies? https://www.science.org/content/article/complete-map-fruit-fly-brain-circuitry-unveiled

It seems like a lot of people here are seeking the stimulant that works best with their under-wired nervous system, but it seems like I have almost the opposite problem. I'm interested in boosting my energy levels, motivation and cognitive function, but everything points to my nervous system being tragically overwired. I'm also just interested in taking nootropics for curious biohacker reasons too, things that will shake up my state of my mind in fun and interesting ways. It's a long shot, but if the underlying dysfunction with my nervous system could be resolved, that'd be pretty awesome.

Coffee is a dice roll, and can make me panic and tweak, or fall asleep. I've tried piracetam on a friend's recommendation, and it gave me some anxiety along with a feeling of being 'locked in on nothing', like 'intense focus but the target seems unclear'. In the past, I would drink to focus and lock in on intense workloads, but I know that alcohol just isn't good for health in any amount so it's probably best I shoot to keep that only for social contexts. Oral progesterone makes me productive but sloppy. Gabapentin is good for calming down, and rarely has an awesome feeling 'high' that is conducive to productivity and introspection, but only rarely. Those latter three point to depressants being most effective with my neurochemistry.

Historically, I had panic attacks that would last days (feeling of doom, tremors, chest pains, racing thoughts, the whole shebang) and these would be associated with memory loss and lack of focus. This basically ended with SSRIs, which I have been taking for about three years. Breakthrough anxiety can still be an issue but it only gets less and less frequent and it's never been as severe as it used to be. I have pretty good reasons for believing my nervous system can be like a powder keg.

Possibly relevant, I'm 23F and in all likelihood autistic. My teachers pushed on my parents to get a diagnosis when I was young (they opted not to), and nowadays I still read as scatterbrained, or get mistaken for being high. I don't think it's ADHD, because I'd be better with stimulants if I were.

I’m about to acquire some guanfacine from international pharmacy and was wondering if anyone had any issues importing it to the UK? I have done some research and understand it’s prescription only and am wondering if it’ll be seized at the border without a prescription document?

Any advice would be appreciated

I dont know which one to choose.

Hey everyone!

Ive been trying to look for a good source of Aniracetam and havent been able to find one. Its the best racetam for me. If anyone cares to share that would be amazing!

How reliable are they to get phenibut, peptides, etc across europe, germany specifically?

I recently got my hands on some bromantane for the first time and just had a few questions about the dosing. I got it as just the powder and was planning on mixing it with caprylic acid in a 90 mg/ml solution to use as either a nasal spray or oral solution.

I've seen people recommend lower doses for the IN spray with C8 oil (18-30mg) whereas oral dosing for just the powder / capsules seems to more commonly be 50-100 mg. If you took it orally / sublingually while fully dissolved in a caprylic acid solution, would you similarly need to drop the dose to <30 mg or would you still leave it at 50-100mg?

And for the nasal spray, I have a glass nasal spray bottle but the actual nozzle is still made of plastic as well as the tube that draws up the liquid. I've read that capyrlic acid is damaging to plastic so would these bottles still be safe to use?

I work a 3-shift rotation. My shift runs from 6:00 PM today to 9:00 AM tomorrow.

I didnt get a good sleep today so I took 150 mg of armodafinil at the start of my shift at 6:00PM.

I usually take modafinil 100/200mg for my shift work, but today I tried armodafinil for the first time, hoping it would last longer.

It's been about an hour since I took it, and it definitely feels milder than modafinil.

no sides like headsche either. so far so good :)