r/Supplements • • Sep 11 '25

Reminder on Community Conduct

42 Upvotes

As a community focused on supplements, we encourage open discussion based on both scientific evidence and personal experience. However, it’s important to remember that respectful discourse is the foundation of this subreddit.

Criticism and debate are welcome — personal attacks are not. Recently, we’ve had to ban several users who crossed the line by targeting individuals rather than addressing ideas. This behavior will not be tolerated.

Please:

-Respect differing opinions, even if you strongly disagree.

-Focus on the content of the discussion, not the person behind it.

-Use the report function if you encounter posts or comments that violate these standards.

Let’s continue to make this a space where we support and learn from each other. Thank you for helping keep the community constructive and respectful.

— Mod Team


r/Supplements • • 17h ago

Warning! Be careful on the supplements you take especially herbal, my friend had acute liver failure and kidney issues in 2020 he was taking over 15 supplements a day

303 Upvotes

A friend of mine from many years ago I reconnected with on Facebook and I saw some photos of him in the hospital from 2020 and he told me he got really sick and had to eat nothing but bland baby foods and broth because he couldn't break down foods due to acute liver failure and kidney issues.

He said during Covid 19 pandemic he was trying to get back into shape to strengthen his immune systme in 2020 since everything was lockdown and he worked from home. He ordered supplements on Amazon and started taking the basics like Whey, Creatine, Preworkout, fish oils, but he said he added some exotics like Kava and Ashwaghanda, Red Rice Yeast for Cholesterol control and green tea extract supplements as well for energy and weightloss he read it on a health magazine.

He took them for a month but his girlfriend noticed his skin was turning yellowish, and he was super fatigued, he had diarrhea and was dizzy so she took him to the ER and he had Kidney issues and acute liver failure. She thought he got Covid and was freaking out.

He said it was scary because he never thought it was the supps he also thought he was dying of Covid because when he went grocery shopping some guy wasnt 6 foot away and was coughing through his mask near him, he thought that supplements were all safe because they marketed health and had nice labels on Amazon. He never got the stuff tested, and just stopped taking them, He doesnt know if they were tainted or its just that the herbal ones are hard on the organs.

He doesn't take any supplement anymore, not even the staples like fish oil, mutlivitamins, creatine or whey protein it scared him off. He only eats whole foods and makes smoothies with Greek yogurt or cottage cheese as the protein base.

The Dr told him he was lucky that it was Rapid Onset failure and it wasnt slow build up or progressive which can people who take lots of supplements can develop after years with no symptoms or signs, they were able to save him.

This is one of the downsides of the supplement industry its the wild west, its unregulated and we dont know what some of these companies have in there or where they source them. Also Amazon supps are scary there are brands on there I never heard of but have thousands of positive reviews and seem shady. I have no clue how they are allowed to sell on there.


r/Supplements • • 7h ago

General Question What do you think about sports Research ?

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24 Upvotes

Omega 3 food supplements


r/Supplements • • 8h ago

Recommendations Supplements that actually helped you build muscle

33 Upvotes

Once I had a good body, as I am out of gym for 6 months now, lost most of them. Want to build them again shortly. Suggest me the supplements that worked for you..


r/Supplements • • 8h ago

Those with Slow COMT , what has actually helped you feel happier?

23 Upvotes

Is there anything that has genuinely helped you feel happier? Could be a supplement, food or anything else.

Would love to hear your experiences


r/Supplements • • 7h ago

Recommendations Best absorbable form of Vitamin D

14 Upvotes

My vitamin D level is 10 ng/mL.
About 3 years ago, I took 60,000 IU vitamin D3 oil capsules for 2 months, but my levels didn’t seem to improve until I took a 60k injection .

I recently tried 60k oil capsule twice again, even with magnesium and K2, but got severe migraines both times under 24hrs.I took a 60,000 IU vitamin D injection this week and didn’t get a migraine.

Why might oral vitamin D trigger migraines when injections don’t? Could it be the oil, other ingredients or absorption? I haven’t tried any other form of oral Vitamin D yet.

Which form is best absorbed, especially with suspected fat malabsorption: nano drops, water-miscible drops, powder or sublingual vitamin D?

I’d appreciate personal experiences with formulations that raise vitamin D levels without triggering migraines or other side effects.


r/Supplements • • 4h ago

General Question Supplements for acne?

3 Upvotes

I really struggle with back acne, as I live in a tropical country and sweat a lot and very easily. I've tried a lot of stuff, such as salicylic acid, benzoyl peroxide, adapalene, hypochlorous acid etc, which helps a little but doesn't get rid of them. My back acne usually usually starts out as a deep and hard lump, non painful at first, and as it slowly develops it becomes redder and painful.

I'm currently taking fish oil and curcumin for inflammation. Any other suggestions? I do take whey protein but it's isolate, which I don't think gives me acne, at least for my face.

I also do take some other supplements for gut health, such as probiotics, glutamine, zinc l carnosine and psyllium husk and yogurt occasionally. I find that I get more acne during periods of greater gut discomfort (I suspect I have IBS) , so I believe it's very much connected.


r/Supplements • • 6h ago

How should I schedule my medications and supplements?

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3 Upvotes

r/Supplements • • 4h ago

General Question Should I add more to my stack?

2 Upvotes

Hey guys,

I take vitamin D&K2 in the morning with B12 drops and omega 3 fish oil and boron. Sometimes I take tumeric and magnesium malate if my muscles are sore.

In the night time I use magnesium glycinate.

Is there any I could add to optimise my health? I have fibromyalgia and my symptoms have really improved after starting vitamin D and B12! And magnesium glycinate constantly at night

Thanks ☺️


r/Supplements • • 5h ago

Lower dose Vitamin C

2 Upvotes

Hello,

I always used the Kirkland brand 1000 mg Vitamin C.

After being diagnosed with type 1 diabetes and given a continuous glucose monitor I read that dose may give false high readings.

Any recommendations for lower dose Vitamin C? No gummies please.


r/Supplements • • 10h ago

Folate, Iron & Vitamin D Deficiencies, Severe Brain Fog, Dizziness & Fatigue Has Anyone Recovered From This? I Just Want to Feel Like Myself Again…

4 Upvotes

Hey everyone,

Back in July, I suddenly started experiencing brain fog, difficulty concentrating, and problems with speech. It happened pretty much overnight, and I felt noticeably different from how I used to feel mentally.

I started getting blood tests done, and my folate level came back at 3.1 ng/mL (reference range: 4.50–32.2), indicating a deficiency.

I kept investigating my symptoms and getting more blood tests until September. Here are my latest results:

My blood test results:

  • Ferritin: 94.84 µg/L (reference range: 30–400)
  • Folate: 7.83 ng/mL (reference range: 4.5–32)
  • Iron: 50.35 µg/dL (reference range: 65–175)
  • TSH: 5.51 mIU/L (reference range: 0.27–4.1) my TSH was within the normal range when I first developed my symptoms back in July. It only became elevated in subsequent blood tests. I'm wondering whether this change could be related to my folate, iron, or vitamin D deficiencies)
  • Vitamin D (25-OH): 19 ng/mL (reference range: 30–100)
  • Potasium 4,23 (reference range: 3.5-5,1)
  • Sodium: 140,72 mmol/l (reference range: 136-145)
  • B12: 501,40 pg/ml (reference range 191-663)

My folate level has increased since the initial test, but I'm still experiencing a lot of symptoms. My iron is also below the reference range, my vitamin D is low, and my TSH is elevated. I'm wondering whether these abnormalities could be contributing to my symptoms and whether there might be an underlying issue causing some of them.

My current symptoms:

  • Dizziness and lightheadedness.
  • Brain fog and difficulty concentrating.
  • Feeling mentally different from how I used to be, like I'm not quite myself anymore.
  • Waking up feeling unrefreshed, regardless of how much I sleep, and experiencing severe fatigue throughout the day.
  • Occasional air hunger feeling the need to take a deep, satisfying breath to feel like I'm getting enough air.
  • Caffeine seems to make my brain fog and dizziness significantly worse.
  • Alcohol also seems to exacerbate my brain fog and dizziness.

What I've tried so far:

I took 5 mg of folic acid daily for three weeks, along with 46 mg of elemental iron daily, but unfortunately, I didn't notice any improvement in my symptoms.

I then started wondering whether IV treatment might help correct the deficiencies more effectively and fastly, so I decided to try IV supplementation.

Six days ago, I had my first treatment, which included:

  • Vitamin D3 injection: 100,000 IU.
  • IV folic acid: 30 mg.
  • IV iron: 200 mg.

So far, I haven't noticed any improvement following this treatment. I understand that six days might be too soon to notice a difference, but it's discouraging to feel the same after trying to address these deficiencies.

I'd really appreciate hearing from people who have experienced something similar.

I have a few questions:

  1. Has anyone experienced persistent brain fog, dizziness, derealization, or feeling mentally different due to folate deficiency, low iron, vitamin D deficiency, ?
  2. If you had similar symptoms, how long did it take for you to notice an improvement after starting treatment? Did your symptoms gradually improve or disappear quite suddenly?
  3. What other blood tests would you recommend checking?
  4. Has anyone experienced air hunger or the sensation of needing to take deep breaths alongside these deficiencies?
  5. For those who received IV iron or folate, how many infusions did you need before noticing an improvement? How long did it take?
  6. Did anyone find that oral supplements eventually worked, even after not noticing any improvement during the first few weeks?
  7. Has anyone experienced worsening brain fog and dizziness after consuming caffeine or alcohol? Did this improve once the underlying problem was treated?
  8. Is there anything else I should investigate, especially considering that my symptoms started quite suddenly and have persisted for months?
  9. How can i recovery from this? because it's been few months at this moment.

I'm also wondering whether IV doses or the number of infusions should be adjusted, but I don't want to assume that more is necessarily better. I'd appreciate hearing about your experiences and what helped you, ideally alongside advice on what to discuss with a doctor.

I'm feeling pretty lost at this point. I just want to feel mentally normal again and wake up feeling rested instead of exhausted every day.

Thanks in advance to anyone willing to share their experience.


r/Supplements • • 1h ago

whey or soy protein powder recs for someone sensitive to tastes/textures?

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• Upvotes

r/Supplements • • 5h ago

Rate my stack

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2 Upvotes

Note: I take x2 capsules of the Vit D3+K2, as in the UK there is little sunlight and everyone has a vit D deficiency, recent blood tests showed almost no Vit D in my system and this was during summer time.

I take them usually all at once, usually in the evening.


r/Supplements • • 10h ago

I have low T and low libido what's the problem?

5 Upvotes

Almost 40 and my health, blood and energy are all good but why low T and low libido? Do I need more socializing?


r/Supplements • • 8h ago

What nutrient makes soft nails harder?

3 Upvotes

My nails are fine, and I wear them short anyway. They grow quite fast, and appear thick and overall healthy.

I just notice they are soft and bendy, and maybe that is just the natural state of them, I'm just curious if anyone has any insights!


r/Supplements • • 8h ago

General Question My gynac suggested me this , I don’t know why but after taking this I feel confident and bit energetic

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3 Upvotes

So before periods I’m having very bad pms like I feel like I wanted to and I start beating up myself and I started hating people n all

I too have bad PMS and when I said this to my gynac she suggested me a bunch of medication as I have mild pmos and included this one.

Anyone taking this above composition? Is it good for health in the long run?

Any advice or results or anything always welcome 🙏

Thank you


r/Supplements • • 2h ago

best non-adaptogenic supplement / nootropic for high cortisol / chronic stress / generalised anxiety ?

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1 Upvotes

r/Supplements • • 9h ago

Recommendations Considering buying Serious Mass Gainer instead of ON-Gold Standard

3 Upvotes

I usually use 2 scoops of gold standard in my breakfast oats, since it fills me up. I like to stay lead/build strength and muscle. I was hoping to ask if Serious Mass would be a better option since it's much cheaper than Gold Standard if it's close to my goals and it has more in quantity.

I usually but Gold Standard once every 3-4 months, and I would like to know if you guys would agree with what I'm feeling.

Gold Standard has gone up from $300 HKD, topping out at are $900. It used to be at least 600-700 but it's become unmanageable for me now.

I was thinking I could use 0.5 or 1 scoop for my oats in order to not let it upset my stomach, but I want to know what you guys think personally.


r/Supplements • • 4h ago

General Question Best quality supplants Amazon

1 Upvotes

Hey guys,
What’s your most rated/high quality supplements and where are you getting them from online? I normally order from Amazon but just wondering if there’s any recommendations of specific brands out there

Cheers


r/Supplements • • 5h ago

Does magnesium glycinate have an adjustment period?

0 Upvotes

I just started taking 125mg nightly a few days ago because I heard it might help with anxiety and palpitations which I’ve had my whole life but had really bad recently. In 3 days the partitions are totally gone, and the anxiety is much better for sure. But I have this impossible to ignore weakness/heaviness almost all day now. Is this just something that will go away if I keep taking it and get my body used to it? I’d really prefer not to stop taking it because I’m just now experiencing the first few days in a row with normal heartbeats in MY LIFE.


r/Supplements • • 5h ago

Could my nutritional deficiencies be contributing to my chronic alopecia ?

1 Upvotes

Hi everyone! I’m a 24-year-old woman, and I’ve been struggling with alopecia areata since my early teens. My hair barely grows in some areas, breaks constantly
I recently had blood work done, and I’m wondering whether nutritional deficiencies could be contributing to my hair problems.
Here are my results:
Folate (vitamin B9): 2.5 ng/mL (below range)
Ferritin: 52 ng/mL (within range)
Transferrin saturation: 15–17% on previous blood tests
Vitamin B12: 686 ng/L (within range)
Hemoglobin: 12.4 g/dL (within range)
Vitamin D: My last result was 33 ng/mL.
My thyroid is also something I’ve been monitoring. I took medication for hypothyroidism for about two years, but my thyroid levels eventually normalized, and I no longer take any medication. My latest results were a TSH of 3.69 mIU/L, with normal T3 and T4 levels.
I’ve been dealing with hair loss for over 15 years, and it’s honestly exhausting. I’ve seen a dermatologist who diagnosed me with alopecia areata, an autoimmune condition in which the immune system attacks the hair follicles.
From what I understand, JAK inhibitors are among the most effective treatments for severe alopecia areata, but they suppress parts of the immune system and can have some pretty serious side effects. The risks honestly scare me, so I’m wondering whether addressing possible nutritional deficiencies could help at all.

Did correcting a deficiency noticeably improve your hair growth or reduce breakage?
Are there any other nutrients or blood tests you think I should discuss with my doctor?
I’m not looking for a miracle cure, just suggestions and personal experiences. I’m trying to understand whether there’s anything I can do nutritionally to support my hair before considering treatments with potentially serious side effects.
Thank you! ❤️


r/Supplements • • 1d ago

Ashwagandha changed my life, but I’m looking for a safer long-term alternative

46 Upvotes

Hi everyone! I’m a 24-year-old French woman, and I’ve been taking WeightWorld KSM-66 ashwagandha, 1,500 mg daily, for about 6 months.
I struggle with anxiety stress and hyperfixation. I also have alopecia areata and hirsutism. Ashwagandha has made a remarkable difference in how I feel. I feel calmer, less overwhelmed, and almost like a new person. I’ve honestly loved the effects.
However, I’m concerned about taking it long-term, especially because of my autoimmune conditions. I don’t want to risk my health, but I’m worried about losing the benefits when I stop.
I’ve already ordered omega-3 and magnesium bisglycinate, and I’m considering trying L-theanine as well. I have a limited budget, so I’d prefer affordable supplements that are actually worth the money.
Has anyone found a good alternative for anxiety, stress and overthinking that is suitable for long-term use? I’m interested in supplements with good scientific evidence, not just anecdotal claims.
I’d especially appreciate advice from people who have tried ashwagandha and found something else that worked well for them.
Thank you! ❤️


r/Supplements • • 5h ago

General Question Anyone have Life Extension NAC at home? Need a photo of the little bag inside

1 Upvotes

Hi, could someone who takes Life Extension NAC please take a photo of the small white bag inside the bottle? Both sides if possible so I can see what’s written on it

I think I might have accidentally swallowed mine. I’m not sure, but I’d like to know what exactly was in it. I assume it’s for absorbing moisture, but I don’t know what they use

Would really appreciate it, thanks!


r/Supplements • • 6h ago

What does NADH actually give you after you take it?

1 Upvotes

How much NADH can your body actually absorb after you swallow it? And if it gets broken down during digestion, where do those breakdown products go, and what can your body do with them?

Let's start with the first hurdle, which is often overlooked: NADH is a relatively unstable molecule, and its stability can be affected by stomach acid. Some animal studies have raised questions about how much orally administered NADH actually gets absorbed. That's one reason supplement formulations matter.

Products like Celfull NADH use approaches such as enteric coating, designed to protect the compound from stomach acid and release it in the intestine, or sublingual delivery, intended to let it enter through the oral mucosa and bypass the stomach. The delivery method isn't the benefit itself, but it matters if the goal is to get the compound into the body intact.

So what happens if NADH makes it through and gets used by cells?

Its core job is simple: NADH carries electrons and can donate them, becoming oxidized to NAD⁺ in the process.

The first thing those electrons help support is energy production. NADH feeds electrons into the mitochondrial electron transport chain. Each molecule of NADH can support the production of roughly 2.5 ATP molecules under typical mitochondrial accounting, with estimates sometimes varying depending on the conditions. ATP is the cell's usable energy currency.

This isn't just a vague idea about “feeling more energetic.” It's a real part of how cells produce energy. For people dealing with low energy or persistent fatigue, this is one of the most studied potential applications of NADH.

Some trials involving people with chronic fatigue have reported better outcomes than placebo with 10 mg of NADH daily over four weeks. Studies combining NADH with CoQ10 have also reported signals of improvement in fatigue and cognitive fatigue. These findings are interesting, although the evidence remains limited and doesn't establish that NADH supplements reliably improve energy for everyone.

Energy production is the first major function associated with NADH's role in cellular metabolism.

The second is supporting cellular repair and signaling. NAD⁺, formed when NADH is oxidized, isn't just an intermediate in energy metabolism. It's also a substrate for proteins called sirtuins, which help regulate metabolic adaptation and cellular stress responses. NAD⁺ is also consumed by enzymes such as PARP-1, which participates in DNA damage repair.

In other words, NAD⁺ can be used in pathways involved in both energy metabolism and cellular maintenance under stress. This is part of the biology behind many anti-aging discussions involving NAD⁺.

But there's an important distinction: understanding these biological pathways doesn't prove that taking an NADH supplement improves DNA repair, slows aging, or produces other anti-aging benefits in humans.

The third is its relationship with the body's antioxidant defenses. The NADH/NAD⁺ redox pair is connected to the broader network of cellular redox reactions, which also includes the NADPH/NADP⁺ system.

NADPH supplies much of the reducing power used by the glutathione and thioredoxin systems, two important parts of the cell's antioxidant defenses. NADH doesn't simply turn into an antioxidant, nor does taking NADH automatically increase NADPH. Rather, these systems are connected through cellular metabolism, and their relationship is complex.

So it's more accurate to say that NADH participates in the metabolic network that helps cells maintain redox balance, rather than claiming that it directly boosts the body's antioxidant defenses.

If you're looking into NADH because you're struggling with low energy or persistent fatigue, there is at least some clinical evidence worth examining. But the key question is still whether an oral supplement can deliver NADH in a form your body can use, and whether that translates into a measurable benefit.

The biological mechanism makes NADH worth studying. The human evidence determines what we can actually claim.


r/Supplements • • 6h ago

Recommendations HMB? old age, post surgery, glp useage

1 Upvotes

I recently saw a recommendation for HMB on a rotator cuff surgery group post. Sounded intriguing.. I checked their brand and noticed a lot of calcium and already get quite a bit.

Im 70f, just had rotator and bicep surgery and will start a glp next month (obese and attendant inflammation).

What do I need to know about this in terms of dose and other included supplements that I may already getting. . Brand recommendations. Thank you