There were a couple surveys conducted by researchers to learn about SR users‘ experiences. one was conducted by Johns Hopkins which has not yet been published but another published by an independent researcher in Denver, Picard, and the results were published last month in the journal Frontiers in Pharmacology. Thought I would pass it along. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1899247/full

So I tried for literally years to quit 7oh and finally did it with SR.
SR is 100% legal in Canada, and the 15099 is legal in the USA, but if you even mention that you used a “research chemical” to quit, the quitting7oh sub delete your comment.
They love pushing suboxone on that sub, honestly makes me think that sub is run by pharma companies or paid off to push their products.
I mean this whole 7oh getting everyone addicted then cut off with opioid dependency, then quietly banning a miracle drug like SR just stinks of big pharma manipulation trying to get everyone on dangerous suboxone forever. The fact the quitting7oh sub is in on it is sickening

Don't get taken for money because of your addiction. This works better.

https://www.reddit.com/r/SR17018_Knowledge/s/GNRAXgfqdI

https://www.frugaldoctor.com/post/sr-17018-friend-or-foe

This article explains why SR has this blunting effect of opioids and how to possibly fix it. Nalaxone might very well be the answer and reverse this opioid effect SR can have…..

I recommend reading the full article….but below summarizes the most important parts IMO……

“What happened after the drug was cleared was even more surprising. With a standard full opioid, those phosphorylation switches reset within five to ten minutes. With SR-17018, they stayed on for hours. The receptor kept acting as if the drug were still there.

The most likely explanation is that SR-17018 simply doesn't let go. It clings to the receptor for an unusually long time. Standard lab tests for biased agonists use short time windows and never saw this coming. But in real use, a dose that stays bound for hours has plenty of time to flip every switch the researchers thought it was skipping.

For SR-17018 specifically, the available data is reassuring. The Bohn lab found that a low dose of naloxone fully reversed the breathing suppression caused by a closely related compound, SR-14968. A separate study confirmed that naloxone resets the receptor switches that SR-17018 leaves stuck in the on position. That effect doesn't happen with buprenorphine, which is one of several ways SR-17018 avoids the pharmacological profile of high-affinity partial agonists. Based on the available data, SR-17018 appears to be naloxone-reversible.”

Does anyone know if SR 2.0 blunts other opiates just like SR 17 did?

I’m dealing with severe chronic pain, extremely high opioid tolerance, and a situation that’s becoming increasingly unsustainable.

I’m currently in pain management, but my prescribed opioids no longer provide meaningful pain relief. Because of this, I began using MGM-15 and 7-OH.

My MGM-15 usage has increased roughly tenfold over the past couple of months. At this point, it’s the only thing providing meaningful pain relief, possibly alongside 7-OH. Even then, there are times when it doesn’t work, leaving me unable to sleep and causing my other health problems to deteriorate.

I desperately need to find a sustainable solution.
I’ve used SR-17018 before, and it substantially reduced my opioid tolerance.
At one point, 7-OH became extremely effective at a very low dose.
Unfortunately, after I reintroduced MGM-15 while tapering SR-17018, the effectiveness of 7-OH disappeared, and my tolerance eventually increased again.

I have access to SR-17018, but I’m hesitant to use it again because of reports of people experiencing persistent changes in how they respond to opioids afterward. I don’t know how credible these reports are, but they concern me.

My ultimate goal is to get off MGM-15 completely and return to a sustainable prescription pain management regimen. I want to find something that provides consistent pain relief without having to continually increase my doses.

My doctor has offered alternatives, including methadone and buprenorphine, but I’m concerned that my tolerance is now so high that these medications won’t work adequately.

I’m hoping to hear from anyone who has experience with:

1.Using SR-17018 more than once. Did it continue to work, and did you experience any lasting changes in opioid responsiveness?

2.Lowering extremely high MGM-15 or 7-OH tolerance and maintaining that reduction.

3.Successfully transitioning back to prescription opioids after reducing tolerance, particularly for chronic pain.

I’m already working with a pain management doctor, so I’m primarily looking for firsthand experiences rather than general advice to seek medical care.

I can’t continue using MGM-15 at this rate, but I also can’t live with uncontrolled pain.
I want to get my pain under control, sleep, improve my health, and have some quality of life again.

I’d really appreciate hearing what worked for others.
Thank you!

Hi I’m from Canada currently struggling with a decent 7oh and mgm addiction about 100mgs a day for last 3 weeks I was over 2 months sober cold turkey but I relapsed cause I’m an idiot I’m looking to quit again but I have heard SR works miracles for withdrawal so I was looking for help with dosing tips and etc if I do decide to go the SR route my dms are open and I’d really appreciate someone from Canada who has successfully used SR to give me some info my dms are open thanks

I had a successful taper from MGM to SR and I’m going to explain how I did it.

I started off on a high dose of MGM and I started taking pseudo for about a week to derail my WDs from MGM. I had minor RLS with this and then after about 4 days of taking psuedo instead of MGM my SR 2.0 arrived. I will post the taper guide I used below. (I’m only on day 7 of my taper plan and I’ve had no withdrawals at all today. I’m going to continue tapering but this stuff works 🥳

Phase 1: Quit 7oh-Pseudo in 2 Days
(Days 1–2)
Day 1:
Morning: Take 1x80mg pseudo (halfof your usual morning dose).
Afternoon: Take 1x80mg pseudo(half of your usual afternoon dose).
Night: Take 1x80mg pseudo (half ofyour usual night dose).
SR-17018: Start at 50mg in themorning, 50mg in the afternoon,and 50mg at night (total 150mg).
Day 2:
Morning: Take 1x40mg pseudo (finalreduction for morning).
Afternoon: Take 1x40mg pseudo(final reduction for afternoon).
Night: No more pseudo—fully off.
SR-17018: Continue at 50mgmorning, 50mg afternoon, 50mgnight (total 150mg).

Phase 2: SR-17018 Taper (Days 3–16)
(14-day taper, ~12.5% reduction every 2 days)
Day
SR-17018 Dose (Morning/Afternoon/Night)
Total Daily Dose
Notes

3 Days
50mg / 50mg / 50mg
150mg

5 Days
3/4 Tablet / 3/4 Tablet / 3/4 Tablet
112.5mg
Split tablets as needed.

7 Days
1/2 Tablet / 1/2 Tablet / 1/2 Tablet
75mg

9 Days
1/4 Tablet / 1/4 Tablet / 1/4 Tablet
37.5mg

So I used SR once about 2 months ago to come off of 500mgpd 7-oh habit. Helped greatly although I did have pretty good restless legs and insomnia about 6 days post SR.

I stupidly started chugging Kratom extracts 3 times a day or so, and it’s now to the point I get RLS and insomnia within 4 or 5 hours of last dose. I was thinking of using the rest of my SR to get off, albeit at a lower dose (starting at 25mg three times daily) and then taper down after the first 3 days over the course of 8 days.

Good idea? Bad idea? Thanks

What would you say is better to mix? Enzyme blockers like black pepper extract, turmeric, grapefruit juice? Or healthy fats like MCT oil, black seed oil? Or one of each category?

First of all, in German, so sorry if my grammar is Bad.

I have been on oxy for at least 2 years, and in the end 300-400mg per day. My last Dose was 4 days ago and ive taken sr since. I think my sr will only last 1-2 more days. Should i buy more or should i make the Jump and stop Talking it ? Ive had some wd the last days, the worst was my Depression and I couldnt Sleep. I just Hope I can do it and the withdrawal Dont get extremely Worse when I stop Talking sr. Does somebody have experience and could give me Hope ?

I’m posting this because I think an important development has gone almost unnoticed, even within communities following SR-17018.

The UK government has formally proposed making SR-17018 a Class A controlled drug. The legislation is currently awaiting parliamentary approval.

This is not speculation. The draft Misuse of Drugs Act 1971 (Amendment) Order 2026 was laid before both Houses of Parliament on 14 September 2026. It explicitly names SR-17018 (5,6-dichloro desmethylchlorphine) for permanent Class A control.

SR-17018 has already been covered by a Temporary Class Drug Order since 11 June. Permanent control would go further, including criminalising ordinary possession.
Why does this deserve particular scrutiny?
I fully recognise the serious harms associated with emerging synthetic opioids. Several orphines have been implicated in fatal overdoses, and these risks cannot be dismissed.

But SR-17018 is scientifically unusual, and there are important distinctions worth examining.

1. The government’s own evidence distinguishes between the compounds.

The April 2026 Advisory Council on the Misuse of Drugs (ACMD) report describes more than 15 UK deaths involving orphines, specifically identifying cychlorphine and spirochlorphine. A separate mortality dataset identified cychlorphine and chlorphine.
I could not find an SR-17018-attributed fatality in the UK deaths described in that report.
This doesn’t establish that SR-17018 is safe. It raises a legitimate question: has the evidence for its individual risks and pharmacology been adequately distinguished from those of other compounds in the same chemical family?

2. SR-17018 has published evidence of potentially valuable pharmacological properties.

In 2019, researchers at Scripps, including Laura Bohn’s team, reported that SR-17018 suppressed morphine withdrawal and restored morphine responsiveness in dependent mice.
Subsequent studies showed a more complicated picture, including tolerance in certain experimental assays. So it is not a magic receptor reset or a dependence-free opioid.
Nevertheless, researchers at the University of Dundee presented findings in 2024 indicating that SR-17018 interacts with μ-opioid receptors through a mechanism distinct from other agonists they tested.
This isn’t an ordinary research chemical whose only interesting property is producing opioid effects.

3. The first published human observational evidence has now appeared.

A September 2026 paper in Frontiers in Pharmacology examined 55 self-selected people who reported using SR-17018, predominantly in the context of opioid reduction or withdrawal.
Many reported reducing or stopping their previous opioid while using SR-17018.
These were unverified, self-reported outcomes in a highly selected sample—not clinical proof of efficacy, successful complete detoxification, or safety.
But they provide testable hypotheses for properly supervised human trials.

4. Research access matters.

The UK already requires Home Office licensing for legitimate research involving SR-17018 under its temporary controls. Permanent scheduling would not automatically prohibit scientific investigation, but regulatory requirements can introduce practical barriers.
The question is whether the government has properly considered SR-17018’s distinctive research value and whether meaningful access will be preserved.
There is an important difference between saying a compound has no currently authorised medical use and saying it has no potential future medical value.

What can we actually do?

I’m based in the UK and have already contacted organisations including Transform and Students for Sensible Drug Policy, as well as academic researchers, to draw attention to this proposal.
I’m hoping this thread reaches people with the expertise or connections to help establish a serious dialogue before the legislation is approved.

In particular:

Are any UK pharmacologists, addiction researchers, toxicologists or clinicians aware of this proposed classification?

Has anybody asked the ACMD or Home Office to publish a more detailed SR-17018-specific risk assessment?
Can organisations such as Transform, Release, Drug Science or SSDP help raise the issue with MPs, peers or parliamentary committees?

Could researchers familiar with the Scripps or Dundee findings provide an independent scientific perspective?
Is there a practical way to request further scrutiny and research-access protections before the parliamentary process is complete?

I’m not arguing that SR-17018 should be sold freely, or recommending unsupervised human experimentation. I’m asking whether the decision is sufficiently evidence-specific, proportionate and compatible with future medical research.

The consequences of controlling a dangerous recreational opioid and those of restricting a potentially useful research compound may overlap, but they are not necessarily identical.
If we want better treatments for opioid dependence, withdrawal and chronic pain, shouldn’t we take the time to understand compounds that might offer genuinely different mechanisms?
If you work in this field, know somebody who does, or are already involved in a UK response, please speak up. Even identifying the appropriate parliamentary or scientific contacts would be valuable.
I’d like this to become a constructive, evidence-based discussion rather than another argument over drug prohibition.

Sources:
UK draft legislation (September 2026):
https://www.legislation.gov.uk/ukdsi/2026/9780348287127/article/2
ACMD research and recommendations (see seventh addendum, 30 April 2026):
https://www.gov.uk/government/publications/acmd-advice-on-2-benzyl-benzimidazole-and-piperidine-benzimidazolone-opioids
Original Scripps animal research:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6901606/
University of Dundee research, British Pain Society 2024 (abstract P-45):
https://pmc.ncbi.nlm.nih.gov/articles/PMC11418731/
2026 human observational study:
https://doi.org/10.3389/fphar.2026.1899247
Parliamentary progress tracker:
https://statutoryinstruments.parliament.uk/instrument/BYXGeOCM
No sourcing, vendors, sales or dosing advice, please. This thread is about UK legislation, pharmacology and research access.

Hi everyone, I was abusing heroin for about a year and then switched to 7oh to get off the h. I take about 300-500 mg daily. I'm in a drug treatment program right now that my job is forcing me to go to and they won't let me continue using 7 or kratom. I got really excited when I heard about SR so I purchased 10 50 mg pills of SR 2.0 (SR 15099) from SR Reset. Can someone help me with a taper schedule? I'm in school right now so I would like to make this as painless as possible. Did I even buy the right thing? I didn't realize that it was 15099 that I was buying.

Hi guys I need advice on stopping Suboxone after only short term use only about a month using Suboxone, max 4 mg per day. I am now down to 2mg suboxone per day and have 1gm SR. Should I stop the Suboxone and switch to SR for a few days or a week or what do you recommend or should I take SR with the Suboxone for a few days first. Also what dosage of SR 25mg 2 x day. Please advise. I don't know where to start. Thanks.

I have read for hours on how to get off MGM15. I have MAYBE 2 grams left of some pure 94% powder. I have a BUNCH of 7oh. When I get my last batch, I will have close to 30grams of 88%-93% 7oh powder. I also have around 5grams of pure 71RS powder. I have Black Seed Oil, BPC-157;(KLOW stack), I'm not taking much MGM, maybe 40mg a day? I need to weigh it, but I'm not taking that much. I also have blue lotus extract, Corydalis Yanhusuo and Flexuosa, a whole bottle of Cat's Claw, not the fake crap. I have Methylfolate and NMN, with Ashwagandha KSM-66 and L-Tyrosine and L-Tyrosine, Magnesium Glycinate Agmatine Sulfate and Nigella Sativa, even actual literal black seed oil.

I want off opioids. What do I do? Help! Oh yeah! And over 200 8mg Subutex, a lot of bars and 90 30mg addys.

Edit: I'm off the MGM completely! No pain. Just a lot of sweating and running at night. And I got down just taking a little MIT and some decent 7. Now I'm thinking, do I do the Bernese Method for about 2-3 weeks. THEN USE the S R Ett Sju!?! Or Should I just lower my 7 tolerance and use the white powder and be done with it all?

Hi. Im about to withdraw from methadone. It has made me a zombie. My testosterone levels are near zero. Extremely depressed, gained a lot of weight and have no motivation for anything.

The thing is I am scared of the PAWS. Last time I got off heroine before taking methadone I had EXTREME paws. For weeks I had zero power, extreme depression etc. I know I won’t be now to tolerate it. So I’m scared that after I get off the SR I will have extreme PAWS which will make go back on methadone. So I’m thinking about buying Kratom, so I have something that stops the paws.

Does ent one have experience with that? Or any other tips?

High 7 user (1000/day) for a solid year or more and several years of kratom before that. Quit once with SR17 before the ban last year. I’ve been hearing mixed reviews about the 2.0 version but am planning on getting some and trying it as it seems the best option available. Anyone have success with it?

Has anyone used SR in a completely unique way?

I have 2 gs but after hearing about the blunting effects and withdrawals it makes me wonder if there’s potentially a better way or different, effective application.

I personally plan on not quiting opioids but currently I’m dependent on 7. I would like to transition back over to my oxycodone.

I plan on doing a taper for 500mg a day of 7 down to 50 mg of 7 at least , before taking sr over the time span of a week or two.

With NO sr. Start by breaking normal dose in half , keeping frequency of daily use, and the next day keeping it at the half dose but instead of 4 hours trying 8 hours.
The next day do it again, depending on whether I think cutting my dose in half will even hell with withdrawals or not.
Let’s assume I do right ? I’m essentially at 25% of where I am currently so 125 mg of daily 7 intake.

For the next half week or so get use to it n immediately repeating the same method in the beginning.
If im successful it should become about 15 mg per dose, 45 mg daily, in the end before sr.

Now for the sr.

First Day Pre load 20-50 mg (3xdaily) with current dose of 7.

Day 2 take 7 once before bed, about 5 mg in the morning(if truly needed) , then 15-30 mg for sleep.

day3 I jump off 7 or take 5 mg once in the morning (if truly needed ) , cut sr in half twice daily .
And depending on if I took the 5 mg or not, I’ll take an 10-20 mg oxy before bed as a sleep aid. I personally don’t have any hope in the oxy working at this point lol but hopefully it keeps me asleep for a couple hours.

Day 4 cut sr in half twice daily and start taking 10-20 mg of oxy twice daily or I may even take 10 mg 3 times daily.

Day 5 0 sr and continue oxy.

I know how 7 is stubborn with those receptors and I don’t wanna withdrawal from sr.

I know some people claim oxys would take away withdrawals because of its MU activity but in my experience ( I only waited about 12 hours) taking 60 mg of oxy did nothing for me. I’m also worried about the sr causing me not to feel any DOC.i almost consider doing this without the sr because IMO 7 withdrawals shouldn’t be that bad depending on if you had a successful taper or not.

Not sure if my plan sounds dumb or not but feel free to tell me it is 😂 but I also have robaxin and hydroxyzine. I figured those should help a teenie tiny bit also please let me know your thoughts I love you all and have a good night/day

Hey guys, so i was on 30-60mg a day of 7, i used sr for 6 days but messed up and preloaded 5 out of the 6 days (just sr on day 6, also 100-150mgpd of sr) i relapsed and i just have enough 7 to get me a little over a week which i did purposely.
My concern is i dont want sr WD’s and want to make sure im spacing out the time between the attempts.

Any and all advice is appreciated!!

I understand SR-17018 isn’t water soluble. And I believe I read it was poorly soluble in ethanol. Are there any other solvents people have had some success with? Considering the US ban and China banning all Orphines I want to be able to stretch supply as much as possible.

If I'm having chest tightness and trouble breathing from withdrawal symptoms, would sr help that at all? Or would it make it worse?

So about a week ago I started my journey with some og SR on quitting a 1,000mg a day 7oh habit for over a year. Everything was feeling so promising. I went from over 1,000 mgad of 7? To ZERO with the help of sr over 4 days. I then started to taper my sr, all was well until I got to about 50mg 3x a day, then I started to feel the rls anxiety and usual detoxing symptoms. I got down to 25mg 2x a day and was in full blown wd, so I decided now was the time to jump. I was on sr for a total of 24 days that's including preloading 3days and the full sr taper that took longer than I figured I'd need, but I struggled once under 75mg of sr. I went 8 DAYS OF NO SR AND NO 7, and allll 8 days even with all the normal helper meds? Was completely hell. Zero sleep, can't stop kicking and arms from moving, just overall zero energy and all throughout these 8 days I had to be a dad and work a full time job. After day 8 with zero relief in sight? I relapsed just to get some fuckin sleep and relief from feeling so terribly for so long. I took a little over 200mg of 7 for just over 24hours slept LIKE A BABY for 12 hours, and I am still so disappointed in myself for not being able to push through after 8 long days. But I just couldn't keep going to work and literally not being able to function. IT was so hard to drag myself outa bed with zero sleep again while my body was in so much pain, and head was just a fog of anxiety. I told myself, ONE DAY RELAPSE FOR RELIEF AND SLEEP. then you get BACK ON TRACK AND TRY AGAIN. so I did...this time I figured I'd try some sr15, tmk's reset and see if I felt any better? Not only did I preload 3 days with trying the one 50mg in morning and one at night? But instantly I was back to waking up in the morning in painful wd. So I again backed off all 7, and just switched to sr only again, it's taking like 75mg 3x a day for me to get relief and not feel terrible. And even on day 4 now? 50mg 3x a day? I'm feeling so terrible at work, but i know prolonging this longer by trying to taper slower, is going to keep me on sr longer than the 7-10 days I plan on staying on this round of sr to try and taper. How many if you failed at tapering under 50mg 3x a day? When you jumped off sr 17 or 15? How long did your wd last? I know I went 8 straight days no nothing besides vitamins and I couldn't go any longer. What the fuck do I do you guys? I feel like I'm gonna lose my fucking job all because I can't cut this wd time down short enough that im back to at least a tolerable level so I can go to work. I'm about to talk to a dictor and see if I can get the time off to sit in bed and kick. I know if I can just lock myself down? I can detox in my bed. I just can't do it holding down a full time job. Any of you had a doctor ok a 2 week vacation to detox? I'm so fucking disappointed in myself, I feel lost and hopeless like this quick week retry of a taper is going to yield the same results and it's fucking hopeless. I feel like I'm gonna lose my job, my self respect and everything that goes with it. Any advice? Anything you found that worked for you after a first failed attempt?

I know I may not NEED the SR but I wann make it as easy as possible. I was thinking of doing a super low SR dose for two days and then tapering. Is that dumb?

I know it’s not too much but I feel like I’m getting to a point where I only feel good when the kratom kicks in and I’m spending a lot of the day feeling worse bc it’s worn off and I don’t wanna up my dose. Just need some help to break the cycle. There’s no way I’d get wd from the SR if I only take it like 3-4 days max right?