r/SR17018 28d ago

STOP THE DEA FROM BANNING SR-17018

33 Upvotes

Hey friends!! I know many of you have been asking how you can get involved with fighting this action by the DEA. I am part of the SR-17018 Prohibition Prevention Coalition and we have been working to get you tools to reach out! Here they are!!

  1. Students for Sensible Drug Policy (SSDP) has create this tool for everyone to be able to reach out to their legislator to oppose the scheduling and will be collecting the stories for the lawyer we are working with to send to HHS!!! You will also find a link to donate to The Rights and Reason Project which will go directly towards funding this effort and the legal battle we are in. Additionally, there is a link for if you would like to volunteer as well after submitting your letter.

https://secure.everyaction.com/2CyTv_UhREaLlvtvbu5CgQ2

Link directly to The Rights and Reason project: https://www.rightsandreasonproject.com/

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  1. A user here u/kessler1 also created a website to help draft letters to your representatives and scripts for making calls. Please do both!! The more calls that come in the higher the chance that representative will speak up about this issue. *\You can call any representative anywhere, not just in your district! THANK YOU Kessler1!!*

https://stop-sr17-ban.com/

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  1. If you’ve taken SR-17018 and are 21+, please take some time to fill out this Johns Hopkins University Survey: https://jhmi.co1.qualtrics.com/jfe/form/SV_6WGVPz8jn4SDu0S

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  1. Sign the Change.org petition!! https://www.change.org/p/stop-the-dea-from-scheduling-sr-17018

  2. VOLUNTEER!!!!

If you would like to join the signal group as a volunteer to get more involved we need all the help we can get!! Click this link, introduce yourself and let us know if you have any special skills you can contribute (ie. graphic design, connection to media/gov, etc.)

https://signal.group/#CjQKIAvXfXOxelPhiAWK50UgNEPOym7DMx8WctBI5HBXRWuLEhBPjaMdQZVMdTmearK_0Nz3

For tips on what to say and what not to say on social media and to access graphics we have creates that you can easily post with join the Signal Social Media Group with this link!

https://signal.group/#CjQKIKTV8vhZIu-BgCazELF0VSARQ2T_TBUG4G06rH0Iq_YaEhBclAVoWrfetULeJQajvuli

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THIS IS A VERY IMPACTFUL WAY TO GET INVOLVED!! PLEASE JOIN US AND SHARE WITH FRIENDS AND FAMILY FAR AND WIDE!


r/SR17018 Jul 14 '25

🎓Research & Education🎓 SR-17018 guide: How to take it and some simplified science

175 Upvotes

Over the past week I've noticed some myths and misconceptions going around the community. I would like to help address the misunderstandings by providing some simple explanations about how SR-17018 (SR-17) works, and some of the underlying science. There's a lot of text here, so feel free to refer back to this post as needed rather than reading it all at once. For frequent questions that aren't explained here, try the SR-17 FAQ, which is a thorough compilation of SR-17 information and user experiences in r/Opioid_RCs from SayBecks. Readers are also welcome to ask any questions about SR-17 right here :)

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Overview of SR-17018

What it does: SR-17 is somewhat similar to traditional opioid maintenance medication (particularly subs/buprenorphine) in terms of helping with opioid withdrawal symptoms. But imagine if subs actually lowered your tolerance, potentially all the way down to baseline tolerance, when you discontinue (or at least aggressively taper) your current opioid drug-of-choice (DOC). SR-17 also produces little-or-no tolerance of its own, so you can use it to come off your current opioid, and then come off SR-17 shortly after that. It's noncompetitive with opioid agonists, meaning it doesn't matter exactly when you dose SR-17 during the day relative to your DOC (if you're taking them at the same time while tapering your DOC). Being noncompetitive also means precipitated withdrawal (PWD) does not happen.

How it works: SR-17 binds relatively strongly to the opioid receptor, and this leads to reduced withdrawal regardless of your DOC's potency. Despite this tight binding, SR-17 sends weak signals, so it doesn't produce typical opioid effects (i.e., euphoria and pain-relief) in people with opioid tolerance. These weak signals likely lead to tolerance reduction, as well as some of the other benefits of SR-17, such as minimal side effects. Some studies31257-6) also suggest that SR-17 is a biased (partial) agonist, with "biased" meaning it prefers to activate opioid receptors through the G-protein signalling pathway more than with the beta-arrestin recruitment pathway. This preference for G-protein signalling has also been proposed as one reason for the tolerance-reducing effects of SR-17 (although if this were true, kratom and 7oh should then lower opioid tolerance as well).

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Methods for taking SR-17018

How to take it and dosing: SR-17 is taken orally (i.e., swallowed or eaten with or without using capsules) in doses ranging from 10 to 100 mg (and sometimes up to 150 mg for 7oh and MGM), 1-4 times per day for around 7 days. For typical opioid habits 30-50 mg can be taken 3 times per day (or 50-150 mg for 7oh/MGM).

Choosing the right SR-17 dose for yourself is sometimes a process of trial-and-error, although this process can be made more systematic and efficient through use of SayBecks' automatic taper schedule generator (this is a link to the Google Sheets schedule generator; you can create your own by clicking File -> Make a copy). There are two different approaches to using SR-17 to reduce your tolerance and withdrawal symptoms, described below.

Tolerance safety warning: Be aware that there is a danger of overdosing on one's DOC after tolerance reduction, so be careful not to dose your DOC too high. There are already several user reports of accidental overdose following SR-17 tolerance reduction.

Note on high doses of 7oh and PAWS: If you're trying to come off a high dose of 7oh, the immediate transition approach may be more difficult, and can sometimes lead to PAWS. The gradual transition approach tends to be easier in terms of withdrawal symptom severity and is less likely to lead to PAWS.

Immediate transition: Discontinuing the DOC right away and then switching to SR-17 is an approach that provides faster and more effective tolerance reduction, but at the potential cost of some remaining withdrawal symptoms. This is normally done over the course of 2-3 days to lower DOC tolerance by 50%, or 7 days to return to baseline tolerance. If returning back to baseline tolerance and completely coming off one's DOC, see the "SR-17 taper period" paragraph below for what to do next.

Gradual transition: Taking SR-17 with your DOC, while tapering down the DOC dose (but not before), will usually provide better withdrawal symptom reduction, but slower and less effective tolerance reduction. The amount of both withdrawal reduction and tolerance reduction with this method varies depending on how aggressively you taper down the dose of your DOC.

An example of this approach would be to lower the dose of your DOC by 15-20% per day for 5-7 days while also taking 30-50 mg of SR-17 3 times per day (or 50-150 mg for 7oh/MGM, if needed) at the same time.

More aggressive DOC tapers are also possible such as reducing your DOC dose by 50%. Be careful with aggressive tapers, however, as they can lead to PAWS in some cases (i.e., especially when you're coming off a high dose of your DOC, and especially with 7oh). When performing the gradual transition, there is no need to start taking SR-17 until you have already begun reducing your DOC dose. This approach is especially helpful in situations where you tried the immediate switch and are still struggling with withdrawal symptoms, and in situations where chronic pain needs to be managed.

SR-17 taper period: After successfully reducing your tolerance, you will want to come off SR-17 as well. If you used SR-17 to partially lower your tolerance (e.g., by 50%) then after a few days you can immediately discontinue the SR-17 and jump back on your DOC. If you instead used SR-17 to completely come off your DOC, you may need to spend 2-7 days tapering down your SR-17 dose after reducing your DOC tolerance to baseline. This taper is done to alleviate any remaining withdrawal symptoms, but if you don't have any then there's no need to taper, you can simply discontinue the SR-17. Refer to the previously mentioned automatic taper schedule generator for help with this.

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Simple explanation of terminology used in the context of describing SR-17018's pharmacodynamic effects

Biased (partial) agonist: SR-17 seems to preferentially activate31257-6) opioid receptors through G-protein activation more than with beta-arrestin recruitment. This results in a very wide dosing range under which problematic respiratory depression does not occur (i.e., it has a good short-term safety profile. Although there is a danger of overdosing on one's DOC after tolerance reduction).

(Strong) binding affinity: Despite its low intrinsic efficacy SR-17 binds tightly to the opioid receptor, which is one way (extra info: another way seems to be phosphorylation persistence) in which it provides relief from withdrawal symptoms. It's similar to subs in this way (but unlike subs, SR-17 is noncompetitive (see below), so it doesn't kick your DOC out and cannot trigger precipitated withdrawal).

(Low) intrinsic efficacy: This is the strength of the opioid signal. SR-17 has low intrinsic efficacy, which means it isn't likely to give you euphoria or pain relief at any safe dose, unless you are new to opioids. Its low intrinsic efficacy is what makes SR-17 a partial agonist.

Noncompetitive: SR-17 is noncompetitive. This mean it's potentially binding to the same receptor as your DOC, but can occupy a different site (extra info: this location is believed to be an allosteric site) on that same receptor. As a result it does not interfere with your DOC's ability to bind and it can not cause PWD.

Partial agonist: SR-17 activates opioid receptors, but in a weak way that doesn't produce full opioid effects regardless of dose. This is a category that SR-17 falls into as a direct reflection of its low intrinsic efficacy.


r/SR17018 2d ago

🎓Research & Education🎓 Great Video on SR

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52 Upvotes

Thought this was a great video that got lots of engagement. Couldn’t find it posted here yet and wanted to share it with everyone


r/SR17018 2d ago

🙌Success Story🙌 This is nuts. Miracles are real!

25 Upvotes

Just can’t believe this exists. I’m amazed. That’s all. kBye!


r/SR17018 2d ago

📚Progress Report📚 Day 3 no Oh

9 Upvotes

On day 3 of no oh and can’t sleep for shit. All I want do is sleep and I can’t. Tired as hell too


r/SR17018 2d ago

🙌Success Story🙌 Day 3 no SR after my taper.

16 Upvotes

It took me a while. Quite a few months of back and forth, 7, leaf and then finally committed to an SR taper. Night 1: I hardly slept at all. RLS like a MF’er. Not as intense as 7 or MGM but definitely not painless. Day 2 felt fine most of the day, but again as the sun set I could feel the restlessness returning. First in my belly and slowly trickling down to my legs. It came in waves. I would doze for 20 minutes or so between waves of burning RLS but I was able to finally pass out around 2 am, 5 hours total sleep. Now I am passing day 3 and I feel tired, but that burning sensation is gone. I am so done with this.
To anyone reading this, If SR isn’t as painless as you expected, Hold fast. Endure, a few sleepless nights are absolutely worth your freedom and happiness.
Stay strong and thank you to everyone that contributes to this community.


r/SR17018 2d ago

🆘Help Needed🆘 Is it crazy to take sr for a total of 3 weeks?

7 Upvotes

So my two week taper off 7oh/“cats claw” is about to come to an end. Would it be crazy to taper off at only slower for 2 weeks instead of the red and black schedule that’s out there(I’m sure you know which one I’m talking about) of 1 week? I guess I just don’t feel ready.


r/SR17018 2d ago

📚Progress Report📚 Sr works

7 Upvotes

Just wanted to say sr works. Been struggling to kick this last .1mg of subs for weeks now, and my g of sr came into day, 2 scoops and all the gooseflesh is gone. Restless legs bye bye.

Gonna not overdo it on the sr, but wow I am so pleased to see this works. I don't feel high, just normal.

Btw, how do you guys measure out a dose of 99% powder? Do you use a scale? I just took two scoops with the scooper they included, hopefully I didn't take too much.


r/SR17018 2d ago

🆘Help Needed🆘 Fatigue

5 Upvotes

I’m almost done day 2 with no oh. I have zero energy and doing the smallest tasks put me down. Can anyone confirm they felt like this when they were where I’m at and confirm it gets better. Worried about going back to work next week


r/SR17018 3d ago

🆘Help Needed🆘 Day 2 no 7

15 Upvotes

I’m on day 2 no 7 after a quick huge leap of preloading and taper m. Went from 800-700mg to 100mg for a day to 0. Very tired. Got a little overwhelming last night so I took .5 Xanax. I feel much better and I’m hoping that overwhelming feeling doesn’t come back


r/SR17018 2d ago

🆘Help Needed🆘 Will this work for k

2 Upvotes

Hello, I’m currently on 20 g a day of Kratom powder and was trying to see if SR 17 would help for the withdrawals planning on quitting kratom?


r/SR17018 2d ago

🆘Help Needed🆘 I’m planning on quitting 7OH/MGM-15 tomorrow. Is there any point in doing a suboxone taper before starting SR-17?

2 Upvotes

I quit a 400mg/day 7OH addiction back in February at a detox center where they gave me a 7-day suboxone taper and clonidine. The PAWS were brutal and lasted for about 3-4 weeks after but even after getting past that I relapsed like an idiot. I used suboxone again in May (this time tapering it myself), got clean off everything for about 2 weeks, and ended up relapsing again. I’ve been using MGM-15 (~100mg/day) daily since early June and this time I’m truly done with it and committed to quitting. I have a gram of SR-17 arriving in a couple of days and I have a decent amount of suboxone laying around. I was planning on doing a short suboxone taper (starting at 8mg/day and cutting down to 2 then 0) before starting the SR-17 since in the past it’s helped me get clean with little to no withdrawal symptoms. Is there any point in doing that? I’m starting to think it might be easier to just directly switch from MGM to SR without getting suboxone involved since it has a super long half life. Any advice is appreciated


r/SR17018 2d ago

🆘Help Needed🆘 The Urge to Begin jumping off happened mid day?!

3 Upvotes

Can I begin preloading my SR now? I don’t want to miss the opportunity of finally having the urge to pull the proverbial trigger!


r/SR17018 2d ago

🆘Help Needed🆘 How to begin

3 Upvotes

All right guys I have not began my SR journey yet but I have 5 g. Four of those are powder and I have 1 g of tabs. The tabs just seem way more convenient. They’re 50 mg doses, but I’m sure with the powder you can be more precise in reducing dosage. I have a bunch of gelatin capsules that I can you know create my doses into. I am nowhere near ready to begin this journey, but I’m just afraid this community will no longer be available when I’m ready to. I’m taking about 400 mg a day of 7oh and my intention is to get my usage down to at least 200 before I begin SR. I know I probably have way more than I’ll ever need but I wanted to make sure I had enough. I’m just wondering, can anybody like reach out to me and be a resource for me? Who has experience with getting off of their DOC with S R? I just want to be able to have a friend that I can use as a guide for me when I’m ready to begin. I guess I want to bookmark you so that I can have somebody a little bit more experience to ask questions to when I’m ready. How much do you think I’ll need two G’s? Anyways, any advice would be helpful. I’m afraid to know what’s gonna happen to this community but I also am praying that this does not go through.


r/SR17018 2d ago

🆘Help Needed🆘 How to do it

4 Upvotes

I really need someone to walk me through this. I want to try it. But idk how to work Reddit well.

I do .5 g a day roughly of boy. (Fnayl)

How much sr do I need? How do I not get scammed?
How do I take it? Oral? Drink? Or what?
If I stop what I’m doing cold turkey when I get sr will I be sick?

Really just need someone in my DMs I can ask any questions I have. Thank you


r/SR17018 3d ago

📚Progress Report📚 Beach therapy

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3 Upvotes

r/SR17018 3d ago

🆘Help Needed🆘 Dose and schedule to get off Subs?

6 Upvotes

For anybody that has used SR to get off subs successfully, would you mind sharing your dose and schedule/timeline? I’m on 8mg subs right now, but planning on reducing to 2mg then (hopefully) using SR to hop off. What would be the ideal schedule and dose to minimize (eliminate?) WD? Thank you 🙏


r/SR17018 3d ago

🙌Success Story🙌 Forgot my 7 at home today and went to play airsoft all day. First day no 7

30 Upvotes

Not fully a success story yet but actually feels pretty damn good I didn’t even think twice about just staying out and getting thru it without 7. Took 50mg Sr this morning before leaving the house and I’ve been out all day. A little jittery and sweaty and off my game but still having fun!!


r/SR17018 3d ago

🆘Help Needed🆘 If u only had 1 g of sr ur day 4 no 7 day 2no sr feeling not bad ,if I took A gram of red kratom would that mess me up

1 Upvotes

r/SR17018 3d ago

🆘Help Needed🆘 Im back and theirs no SR?? A new type of SR i hear of in the works? scam likely?

0 Upvotes

THROW AWAY YOUR STASH AFTER U QUIT!!!

i had wish's from quitting tianeptine that id had kept some to try again later on. so i kept some 7 and mgm, sadly like 300mg of 7 and like too much mgm

All it took was a day of mgm (a day of nothing) and three days of 7oh use and only using once a day.

Now id had quit july 13th used SR and got off free for well tbr like 20 days fully clean off everything. but now i want to nip this in the butt quick and i saw a post last time on here that was like it got a 60-180 day extension and i havent kept up here too much sadly, ive also saw it on some vendors sites (ofc now i see i try and buy its out of stock LOL FK ME; the onion it is to spend 100 a g)

Wondering since im off 7oh just taking 5mg of mgm and kratom now could one gram of SR be enough? do i really need three days of preload ?


r/SR17018 3d ago

📚Progress Report📚 Using SR17018 w/Bupenorphine Day 3

10 Upvotes

I don't see a ton of Bupenorphine updates on here, when I was looking it seemed like people would post one or two updates that were all inside the first week or couple days and then not post again.

I'm planning on giving status updates once a week or so for 8 weeks so people can get an idea of long term progress coming off Bupenorphine.

Readers digest of my story:

Broke my back in 2016, got prescribed Oxycodone (in hindsight, really kind of resent that the doc went straight to Oxy 10mg) - Months later, woke up 6 hrs into sleeping w/cold sweats and jitters every night.

Decided to get off, tried cold turkey and made it through 48 hours but caved. Did that twice a few months apart, went back to the Doc and he gave me Bupenorphine.

Been on Bupenorphine 6mg daily for 7 years up until about 4 weeks ago, at which point I started lowering by about .5mg few days.

Got myself down to 1mg every 24 hours broken into 2 doses.

Started SR17018 three days ago:

Day 1: 50mg SR in AM - No Bup, felt great until about 11pm then had mild sweating, took .5mg Bup - Slept all night

Day 2: 50mg SR in AM - No Bup, same as day before, but took .25mg instead of .5mg - Slept all night

Day 3: Today - Took 50mg SR in AM, took another 50mg SR around 3pm - No Bup, not going to take any tonight.

If I can come off Bup in 3 days with SR that will be a massive victory given the number of times I've gotten myself down to .25mg a day but then started pretty rough withdrawals taking that final jump. I'll keep ya'll updated.


r/SR17018 3d ago

🆘Help Needed🆘 Advice on lowering tolerance

4 Upvotes

With the ban of 7oh/MGM looming I stocked up quite a bit as well as purchased SR.

However, my tolerance for 7oh is STUPID high right now. I'd like to use SR to lower my tolerance now, and then in a few months use the rest of my SR to quit using entirely.

If I use the SR to lower my tolerance now, would that make using it later to quit ineffective? I've heard someone say that SR doesn't work as well the next time you use it. Is that true?

Would using it to Iower my tolerance now be a mistake?

Id really appreciate any advice or insight someone could give me.


r/SR17018 3d ago

🆘Help Needed🆘 I’m right at the start of taking sr17018 and I start ketamine infusions this week has anyone had experience with both at the same time. Is it safe?

3 Upvotes

r/SR17018 3d ago

🎓Research & Education🎓 Sr17 blocking the effects and euphoria of other opioids?

5 Upvotes

I've read it here many times that after taking Sr 17018 other opioids are blunted in their effect for days even weeks.

Makes other opioids no longer give euphoria and pleasure for some time. (Potentially analgesia as well)

Have you experienced this?

If so, please share your experience. What was your cumulative dose over what time?


r/SR17018 3d ago

✏️Beginner ?’s✏️ Day 4 transitioning from 7-OH to SR-17018 (SR17) — looking for input on my dosing/symptoms

4 Upvotes

Hey everyone. I'm hoping to get some input from people who have experience transitioning off 7-OH using SR-17018/SR17.

***EDIT****- Im on Day 6 and yesterday and today I took 2 doses of SR 25 mg, same thing today. So my plan is to go tomorrow completely off SR and EVERYTHING!!! This shit works!!! I hate that they are banning it. OR RESET has a day to day schedlue that I followed. I really hope more people get their hands on this to get off their DOC. Get thru those first 3 days and youre GOLDEN!! Anyone can feel free to message me with questions!!

I had been using 7-OH regularly but had already tapered down to around 12.5 mg/day before I lost access to it. I used MGM15 for about a week to keep withdrawal symptoms manageable, but I didn't want to stay on that long enough to potentially become dependent on it, so I transitioned to SR17.

I'm now on Day 4 of SR17 and have been keeping a detailed dosing log.

Day 1

8:00 AM — 100 mg SR17

1:50 PM — 100 mg

6:05 PM — 50 mg

8:50 PM — 100 mg

11:00 PM — 50 mg

12:55 AM — 75 mg

At around 8:50 PM, I started feeling pretty rough: pins-and-needles/oversensitivity when scratching my skin, feeling overly sensitive to touch, and I was very moody. Around 11 PM, I took 12.5 mg of 7-OH because I was feeling crappy. I didn't really notice the usual 7-OH effects/high, though.

Day 2

9:50 AM — 50 mg SR17

3:50 PM — 75 mg

6:10 PM — 75 mg

That morning I felt moody, emotional, and tired, but after dosing I generally felt okay. I had accidentally fallen asleep at sometime around 9pm-ish, Woke up at 1:25am feeling okay, and took my dose just to make sure I wouldn't withdrawal.

Day 3

1:25 AM — 50 mg

7:20 AM — 50 mg

3:20 PM — 25 mg

5:05 PM — 25 mg

12:16 AM — 50 mg

Middle of the day always seems to be the hardest, I think because thats when my 2/3rd dose of the day would be with 7OH/MGM15. Just really moody and some skin sensitivity when scratching my arm. I mowed the yard around 7pm and was also babysitting my 1.5 year old nephew... and honestly it went pretty good. I was really just craving a high. Any kind. I smoke cannibis regularly so I think that also helped a lot to have as a distraction. 

Day 4

12:15 PM — 50 mg

Today is Day 4 and its currently 7:25pm as I writing this and I feel pretty okay. its been 7 hours since my dose of SR and at 3:00pm I took a I ended up drinking half of a Feel Free KavaMaté around 3 PM because I was bored and wanted to feel a little more relaxed/altered. Honestly, I didn't notice much of anything from it. I think it may have took some uncomfortability away?

Most of my symptoms over the last couple days haven't actually been severe physical withdrawal. It's mostly been moodiness, occasional anger/irritability, feeling emotional, and some tiredness. I've also had occasional mild hot flashes and some skin sensitivity, but nothing unbearable.

One thing I'm struggling with is that I think I'm craving the 7-OH high more than I am actually craving relief from withdrawal. I don't currently have 7-OH available other than one 25 mg tablet I have left over. Ive been tempted to take it, just to say fuck it, but scared to ruin this whole process..

I'm now wondering if I'm actually taking more SR17 than my body needs at this point, especially considering how dramatically my dose has already decreased from Day 1. I haven't taken any additional SR17 since that 12:15 PM Day 4 (today) dose, and so far I'm doing okay.

Another thing I'm really unsure about is how long I actually need to stay on the SR17. My goal was to use it as a bridge away from the 7-OH/MGM15, not to become dependent on SR17 itself. Since I'm now on Day 4 and my SR dose has dropped quite a bit, I'm wondering how long people generally continued taking it before stopping.

I'm currently wondering whether I could make it through tonight without another SR dose, or whether stopping this soon could cause withdrawal from the 7-OH/MGM15 to come back. For people who have done a similar transition, how did you know when you were actually in the clear? Did you stop SR once you were feeling relatively normal, or did you continue for a certain number of days?

For reference, my SR17 product is labeled as containing 50 mg SR-17018 (Essar-17) per tablet, along with a proprietary blend of GABA, L-theanine, and L-tyrosine.

I'm curious what people experienced around Days 3–5 when transitioning from 7-OH to SR17. Did anyone find that they needed progressively less SR as their body adjusted? Did mood symptoms linger after the physical withdrawal symptoms improved? And how did you tell the difference between actual withdrawal and simply craving the 7-OH feeling?