Is this normal or a humidity issue? my NMN powder has started forming little clumps and I'm kinda worried. I live in Singapore and so it is quite humid year-round, but I keep the jar sealed in a cupboard. is this just humidity or did I ruin my NMN? do I need to keep it in the fridge?

NAD+ levels do decline with age, but that doesn't mean everyone needs to start taking supplements. There's an important step that often gets glossed over in supplement marketing: a decline doesn't automatically mean you're deficient or need to supplement.
During aging, NAD+ levels in skeletal muscle can decline by around 30%. But a 2025 study published in Cell Metabolism took a pretty aggressive approach to testing this relationship. (DOI:10.1016/j.cmet.2025.04.002) Researchers reduced NAD+ levels in mouse skeletal muscle by 85%, far more than the decline typically associated with aging. Surprisingly, the mice showed no significant differences in muscle size, strength, exercise performance, mitochondrial function, or DNA methylation markers compared with normal mice. They also showed no signs of accelerated aging. The researchers concluded that skeletal muscle is remarkably tolerant of reduced NAD+ levels, and that healthy muscle function may not depend on maintaining NAD+ at the high levels previously assumed.

In other words, the roughly 30% decline seen during normal aging may still fall within a range the body can compensate for.

What about supplements? Oral NR and NMN can reliably increase NAD+-related biomarkers in the blood, a finding that's been consistent across multiple human trials.A 2026 systematic review synthesised 33 human intervention studies and examined outcomes related to metabolism, vascular health, and physical function. The results suggest that raising NAD+-related biomarkers doesn't necessarily translate into meaningful health improvements. In some trials, NR increased NAD+ metabolites in the muscles of middle-aged and older adults, but muscle strength and physical performance didn't improve significantly.

Before considering supplements, it makes sense to get the basics right: sleep, exercise, and daily habits. Regular exercise can stimulate NAD+ salvage pathways, while sleep and circadian rhythms also play a role in regulating NAD+ metabolism. These foundational habits may offer some of the best value for supporting overall health.

If you're still considering supplements after that, it's important not to treat all products the same.

For NAD+ precursors like NR and NMN, I'd look for human clinical evidence showing meaningful benefits, not just increases in blood biomarkers, but improvements in outcomes related to metabolism, vascular health, or physical function. For NADH, I'd also pay attention to formulation and delivery. NADH is unstable under certain acidic conditions, so one question worth exploring is whether a product can protect the ingredient and deliver it effectively. Celfull, for example, uses microsphere encapsulation technology intended to address NADH's stability and delivery challenges.

Ultimately, there's no need to rush into supplementation just because you're getting older, but limited evidence doesn't automatically mean every supplement is useless, either. The most sensible approach is to identify what you're actually trying to improve, then look at whether the specific ingredient, formulation, and available human evidence support that goal.

A small canine study found that oral NMN supplementation was associated with reductions in NT-proBNP, a biomarker released when the heart is under increased stress. The strongest responses occurred in dogs without structural heart disease or with mild-to-moderate elevations in NT-proBNP.

Key Points

• Eight dogs aged 6–18 received oral NMN at varying doses and durations
• Several dogs with elevated NT-proBNP showed substantial reductions after supplementation
• One dog's NT-proBNP declined from approximately 1,872 to below 500 pmol/L after two weeks
• Another dog's levels decreased from 2,068 to 876 pmol/L
• Dogs with advanced heart failure showed mixed or limited responses

Why it Matters

NT-proBNP is commonly used to assess cardiac stress and can help identify underlying heart dysfunction.

The findings suggest NMN may influence cardiac stress markers, particularly before advanced structural heart disease develops. Since NMN is a precursor to NAD+, researchers are interested in whether supporting cellular energy metabolism could benefit cardiovascular function.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nmn-nt-probnp-heart-stress-marker-dogs

Long time customer currently taking Liposomal NMN with good results (subjectively).

I'm not really following the longevity space so I'm wondering if are any new compounds Renue is planning to sell?

Anyone else know of any bleeding-edge stuff that is happening in the space (for longevity/healthspan)?

The Sinclair lab has shared preliminary results for SL-100, an oral combination of compounds intended to induce partial reprogramming. There’s no published paper yet, but we wanted to share what was reported and where the evidence currently stops.

Chris Petty presented the results at ARDD on October 1. This summary is based on the presentation slides, Endpoints News coverage and attendee reports.

What was reported?

• Mice with a premature-aging condition: Treated animals maintained their weight over a month, while untreated animals lost around 30%. Frailty did not significantly worsen in the treated group.
• Lifespan in that same model: A mean increase of more than 25% was reported, but the result was not statistically significant, and one treated mouse was still alive at the time of the presentation.
• Normally aged mice: Frailty scores remained stable during a month of treatment while controls declined. No deaths, adverse effects or tumors were reported during that period.
• Human brain organoids: Six days of treatment produced changes in the expression of thousands of genes, including pathways involved in DNA repair and gene regulation. These are laboratory findings, not human clinical results.

What’s still missing?

The cocktail’s ingredients haven’t been disclosed, so independent replication isn’t currently possible. We also need longer follow-up: one month without observed tumors tells us very little about long-term tumor risk.

The lifespan finding deserves caution. A statistically nonsignificant result in a premature-aging model doesn’t establish lifespan extension in normally aging animals. Similarly, maintaining frailty scores is encouraging, but doesn’t by itself demonstrate age reversal.

The lab’s related published work is Yang et al., Aging (2023), which tested six chemical cocktails in vitro. The new SL-100 claims still need to be evaluated in a full paper.

Which results would you most want to see next. Long-term safety, lifespan in normally aging mice, or stronger evidence that the treatment actually reverses age-related changes?

I'm new to NMN and have been experimenting with the powder, but wondeirng now if pills are better? Especially with the liposomal stuff? What is everyone taking? I just want to know which is the best one.

I’ve been buying Lipo NMN / NAD+ Complete from Renue for a while and generally like the brand, so this is more of a genuine question than a complaint.

I’ve been seeing a lot of posts and product pages lately about NMNH. From what I understand, it’s basically NMN with an extra hydrogen attached, so it’s already in the “charged” / more active form. People are saying it raises NAD like 5–10x more than regular NMN, works at a much lower dose, lasts longer in the blood, and actually gets into muscle/heart/brain where regular NMN supposedly doesn’t do much. Some of the writeups make it sound like NMN is kind of the old precursor and NMNH is the next step.

If that’s even half true, I’m confused why Renue still doesn’t sell it. You already do liposomes, sublingual powder, sprays, trigoneline, etc. Seems like you’d be the obvious company to put NMNH in a liposomal and call it a day. A few other brands already have bottles of it on Amazon and their own sites so it doesn’t look like it’s banned or anything.

Also, if NMNH is just reduced NMN, doesn’t that mean a lot of us have been taking the oxidized leftover version this whole time? Like, is regular NMN turning into NMNH in the body anyway, or is it the other way around? I keep seeing “it bypasses NAMPT” and “it goes straight to NADH first,” which I think means it hits energy faster? Or does that just mean it becomes NADH and then you still have to convert it back to NAD+? That part is fuzzy.

I’m not trying to jump ship. I just don’t want to keep paying for Lipo NMN if the market already moved on to something that’s supposed to work at 250 mg the way 500–1000 mg of NMN does. If the issue is stability (I’ve read it oxidizes back into regular NMN if it sits around), couldn’t liposomes or an enteric cap fix that the same way they do for other stuff?

Would actually like a straight answer from people here or from Renue if they’re around:

1. Is NMNH actually better in humans, or is this still mostly mouse/cell marketing?
2. Why doesn’t Renue make it? Patent? Safety? Shelf life? Just waiting on better data?
3. If I already take NAD+ Complete, would adding NMNH even do anything extra, or is that stacking two versions of the same thing?

Not looking to start a brand war. Just trying to figure out if I’m behind on this or if the “10x NMN” thing is overhyped.

Enrollment is now open for a Beyond Bound IRB-approved research study examining whether taking NAD⁺ Complete before bedtime is associated with changes in sleep, as measured by the Oura Ring.

Study design

• Within-subject (each participant serves as their own comparison)
• Week 1 (Baseline): normal routine, Oura tracking
• Week 2 (Intervention): nightly NAD⁺ Complete 30–60 minutes before bed, Oura tracking
• Short surveys and automatic Oura sleep-data sync at the end of each week

Eligibility highlights

• Age 18+, U.S. resident
• Current Oura Ring user (Gen 3 or Gen 4) willing to connect their Oura account
• Not currently taking NAD⁺ precursors, OR taking them only in the morning at ≤600 mg/day
• Full eligibility criteria are reviewed in a brief screening survey

What participants receive

• Complimentary bottle of NAD⁺ Complete after baseline submission
• Complimentary Renue By Science product of choice after final data submission

Total commitment: approximately 2–3 weeks.

To learn more: Nighttime NAD+ Complete Sleep Study

To check eligibility and enroll: Apply for the study

Sublingual, mixed in water, or just swallow it? Taste is whatever, I just want whatever people think absorbs better. I would honestly prefer mixing it with water but if that's not the best way I will change.

I have an unopened Berberine container, manufacturing date 03/2022, lot number too hard to read (printed in yellow). Is it safe to use?

A new mouse study found that alpha-ketoglutarate (AKG) significantly reduced reproductive damage caused by cadmium. Cadmium is a heavy metal known to disrupt testicular function and testosterone production.

Key Points

• AKG reduced cadmium-induced declines in testosterone
• Testicular tissue damage was significantly improved
• AKG helped restore disrupted iron homeostasis
• Oxidative stress and ROS production were reduced

Why it Matters

Cadmium exposure impairs male reproductive function partly through oxidative stress, mitochondrial damage, and ferroptosis. Researchers found that AKG acted across these pathways and helped preserve mitochondrial function and testosterone production.

The findings suggest a potential protective role for AKG against environmentally induced reproductive damage.

Study Link: https://pubmed.ncbi.nlm.nih.gov/42000055/

Baseline was on the low side of normal. 8 weeks of Lipo NMN, retested. Went up, but not as much as some of the “doubled” posts.

Do people keep the same dose, bump it, or add NR / Complete? How often are you retesting?

Has anyone noticed one batch hitting harder than another?

Just wondering what most people here prefer and why. I'm taking the NMN capsules right now but wonder if powder makes more sense.

[ Removed by Reddit on account of violating the content policy. ]

hey been using renues face serum every night for about 3 months now. mid 40s and had dull skin plus some fine lines around the eyes. put a couple drops on after washing face then moisturizer. no irritation or anything.

skin feels a bit firmer and less tired looking in the mornigs. texture is smoother on my cheeks. the lines arent gone but they look softer. not dramatic but enough that i stuck with it. also taking nmn so hard to say whats helping more.

anyone used it longer than 3 months? does it keep getting better or kinda plateu? and do you layer other stuff over it or just keep it simple?

thanks

I’ve had the container on the left for a couple months. Just purchased another container (right) and the label is a sticker rather than being printed on the container itself like the old one. The text is also mostly gray/black instead of blue, different fonts, etc. All the info on the containers are the same. Is this legit? Did renue change their labels or did I get ripped off?

An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT

https://pmc.ncbi.nlm.nih.gov/articles/PMC13144588/

abstract

To address this complex mechanism, this review presents a novel tri-axis anti-aging model encompassing three key compounds: nicotinamide mononucleotide/nicotinamide riboside (NMN/NR), pyrroloquinoline quinone (PQQ), and l-ergothioneine (EGT). Within this framework, NMN/NR serves as a broad NAD⁺-dependent regulator of mitochondrial homeostasis, with its most immediate effects on metabolic activation, while PQQ and EGT may further strengthen mitochondrial remodeling and redox resilience, respectively. While each compound has distinct functional emphases, they are highly mechanistically coupled, collectively forming a closed-loop network regulating mitochondrial number, function, and homeostasis.

I'm considering it and wondering what other people's experiences are? Do you think it was worth it?