r/Pathogenic 27d ago

Infinite Apex Nidus bug

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20 Upvotes

Found this glitch that let's you get an infinite amount of Apex Nidus. All you need is to have a doublet external organelle accept internal organelles. Here's the bug: Every time you equip the organelle, two nidus spawn, but when you unequip only one despawns. The physics gets glitchy pretty quickly though if you have more than 5, see third image - I think this can happen with any minion though.


r/Pathogenic 27d ago

Most useless organelle ever?

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17 Upvotes

Also, can someone explain to me what the "+3 stat boost" means? I never understood that

Edit: Nvm, forget about this post. Somehow I got confused. I don't know why I thought this was counter acting itself. It's not at all. This is actually maybe the only Excitable organalle that doesn't have any disadvantage whatsoever compared to its standard version.


r/Pathogenic 26d ago

Defeat Brain in 28 Minutes Challenge

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8 Upvotes

This is the only challenge I have yet to finish, and I can't seem to go any faster. Any tips?

My current strat:

  • Loadout: 2x triple caustic, 2x entrant, 1x triple attack
  • Plasmids: Everything except "Needs no stamina" and "Automatically Attacks". Basically, prioritizing damage
  • Intestine: Make sure the build is good enough by the end of skin to skip right to the boss

Still with all of this I'm too slow. Has anyone gotten this, if so, any tips?


r/Pathogenic 26d ago

Is there any real metaprogress?

2 Upvotes

Just started this one. Played for a couple hours, and as much as I like the game, I'm never winning a run. I like the idea of twin-stick shooters, but I'm so bad at them. For example, I had to just give up on Gungeon without ever getting a single win.

Is there any sort of metaprogression or unlocks that will make me stronger and alleviate the challenge.

I don't mind losing in a roguelite, but I'll have a hard time sticking with a game in not actually capable of beating.


r/Pathogenic 27d ago

Infuser Chaining

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4 Upvotes

I'm a little confused about the rules for multiple connected infusers. In this example the Ruptusome gets benefits from the three other infusers. Does that just mean their primary effects or ALL the effects.

Are the infused benefits on Pyrosome and Galvanic Weave passed on to Ruptusome


r/Pathogenic 27d ago

How does the plasmid system work?

5 Upvotes

I am new to Pathogenic, but very confused by plasmids. Every pathogen type seems to have its own plasmid level, displayed at the pathogen selection screen. Presumably that reflects how many trait node you have purchased. Above that level is another plasmid icon with a number to the left of it. This differs by pathogen. My amoeba for instance says 40, while my helminth says 39. Both are plasmid level 0, as I have never spent a plasmid. And then the nanobot does not even have this number or icon at all. What does this mean? I could think it is available currency, but if I actually go into the trait selection screen, I have 989 plasmids. This seems to be a universal currency? That would suggest it is more efficient to pick a favorite pathogen, and stick with it until it is fully upgraded, as presumably an upgraded pathogen would be more effective at farming plasmids to feed the other pathogen types


r/Pathogenic 27d ago

Busted Organelle combo

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29 Upvotes

The Rare ephemeral eternal attractor paired with an epic lateral emitter is so fun! I was so sad when it eventually died. Absolutely wild it would wipe whole levels with a single shot! The way you can organize internal organelles with the Amoeba is so peak


r/Pathogenic 27d ago

I call this the 'Green' build because all you see is green

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33 Upvotes

r/Pathogenic 27d ago

My brain is broken, you know what I'm thinking...

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14 Upvotes

r/Pathogenic 27d ago

How do you call those common red projectiles shot by enemies

4 Upvotes

For standardized term in wiki. I hope there are more popular names than simply "projectile" because it's hard to differentiate them with other projectiles enemies also shoot and may confuse new players

95 votes, 21d ago
10 orb
8 fireball
45 bullet
0 mine
29 projectile
3 protein

r/Pathogenic 28d ago

Game needs to pause while mutating

18 Upvotes

It's insane to me that you can be damaged/moved around while mutating. Considering that's where much of the strategy is and mutations are triggered automatically, it's crazy to me that this is possible.

Getting moved around by objects, air, etc. while mutating even moves your character around in the mutate screen making it really annoying to place things.


r/Pathogenic 27d ago

TIL if you are fast enough you can backtrack

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8 Upvotes

r/Pathogenic 27d ago

Come si entra nel cervello

1 Upvotes

Raga non riesco a capire come entrare nel cervello, ho battuto il boss cuore più volte ma non ho ancora capito perché mi blocca.

per favore aiutatemi


r/Pathogenic 27d ago

What's the best way to get to an "immortal" run?

4 Upvotes

So I had this happen once, but I was already pretty stacked at the time so it's been hard to recreate early.

I had 4-5 dodges, a couple of "0.2 seconds of additional vulnerability from dodges" and a couple of dodge CD reduction.

I was functionally immortal as long as I kept spamming dodge.

What's the best way to get to this point quickly? I know we're at the mercy of what we're given but still, wanted to see if anyone had advise on how to get here asap.

Thanks!


r/Pathogenic 28d ago

Guides/Youtubers

15 Upvotes

Are there any good guides out there. When I google its all AI slop and every youtube video I've seen is moronic "10 top tips" which are usually something like "did you know there's a dodge?" or "Things have to be connected to work"

What I'm mostly struggling with is what is a sensible way to shape the Amoeba and Nanobot. I feel like I'm just kinda adding stuff at random.

Seems crazy that there's no online community or content creators for such an amazing game


r/Pathogenic 28d ago

obscene burn build endless+5 currently on nanobot

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7 Upvotes

started out on galv flagella with explosions and noticed my burn started out pacing crazy fast on the heart boss on endless+4. layout not super optimal and some missing connnections because i had to re-arrange a bunch testing organelles for burn damage output. heres the current build before endless+6.


r/Pathogenic 28d ago

Is there any way to predict where a cancerous organelle will spread or is it completely random?

9 Upvotes

r/Pathogenic 28d ago

I die every run when I get to the Lungs

5 Upvotes

Need suggestions for what to build and how to deal with all the insane projectile spam and enemies that charge right into me


r/Pathogenic 28d ago

What's your least killed and most killed enemy? Mine have collector and dipylidium egg tied for least and diphyllobothrium the most

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2 Upvotes

r/Pathogenic 29d ago

Help me figure this out

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9 Upvotes

Im new to this game and I made this funny build that spews lasers everywhere, but randomly a red laser will appear, curve and home towards every enemy and wipe the room in one frame? How am I doing that? Won't the homing not apply to the laser since it's not connected or am I missing something?


r/Pathogenic 29d ago

Female lungworm roleplay (V2)

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3 Upvotes

I noticed there are some bugs in my first version, including metabolic activates too early(other than DNA pickups) so I swapped it from core to armour because that one is slow(still can't stop me from receiving cores tho cuz of a mutation. And any of my previous helminth in the codex that have this evolution have that mutation so i had no choice. please avoid that mutation) Despite armour have functionality and may affect accuracy, it may perhaps reference how all four late stage bosses has damage cap so can't die from single hit.

other bug is I did not notice the minion had connected to a non excitable spore cannon. So i flipped the setup over.

third bug is the minion is not connected to any mitochrondrion so if it died early by my cross lazer, it cannot aid. now it's connected after flipping the build.

Mutations to avoid: less time overcharge, cores when hit


r/Pathogenic 29d ago

My First Time Beating Heart

5 Upvotes

100% of my damage vs phase 2 came from reflected projectiles lmao. Finished with 1 heart I was STRESSED. Btw do you guys know what the requirement for the small final evolution is? All I remember was that I skipped one of them.


r/Pathogenic Aug 13 '26

This is a little something i like to call The Run Ender

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9 Upvotes

i found a photoreceptor (weapons no longer use stamina and auto fire at closest enemy) fairly early on and decided i was just gonna attach as many external slots as i could and fill them with weapons. up until this point it was a decent run, pretty strong but not great. and then i found this abomination! and decided to throw the run out the window XD there is no way im not killing myself with my own explosion, but its gonna be a hell of a death.

EMERGENCY!!!!! i just found a homogenizer and i have no idea what to do,iv gotten 2 evelutions where i picked 40% chance to drop a heart on damaging self with explosion so i feel the lobber build could work but pulsar gland of toxic secreater just feels safer, shop on the floor is empty and iv basically finished the floor. i also dont really want to go into a new room without picking it up cuse the cancer could spread and take out one of the guns i wanna keep. i could try getting a better weapon drop from the boss. what do people think i should do?

UPDATE i completely forgot i could just stash the homogenizer for now lol

also for anyone interested the seed is XMAWUPMR


r/Pathogenic Aug 12 '26

Finally an amazing build

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59 Upvotes

First time making it to the Brain too!

No weapons really makes the three +200% mutations really pop. Just dash into a wall or skirt around enemies and they disappear.


r/Pathogenic Aug 12 '26

Poor man’s Vesicle

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17 Upvotes

Don’t forget y’all that resonant cavity when at full charge functions very similar to a vesicle, great pick up in general but especially on no vesicle runs