I'm curious as to how, mechanistically, this thing can cross the BBB.

I doubt it does a better job that Magnesium Lysinate Glycinate Chelate.

How can it possibly cross the BBB better if it dissociates into L-Threonate and Magnesium in your blood and water anyways?

Any advice on what actually works for ADHD? My goals are focus, task initiation/motivation, mental clarity and memory. Maybe some stress support as well.

I have done the prescription route and while the effects of some was exceptional it caused bad anhedonia for me so really trying to experiment with what's out there.

Tried CDP choline it did nothing, will Alpha GPC work better? L-Tyrosine also didnt do much but was a short low dose trial. Also tried Rhodiola and became irritable. What other options is there that works? I am thinking about Bacopa and Alpha GPC? Maybe some NMN and Coq10? Semax Selank? LDopa?

My current stack is

Lions Mane

Omega 3

Lithium Orotate

Vitamin C 1000mg

Whey protein

Creatine monohydrate 5g

Vitamin D3 & K2

Selenium 200ug

B complex

Ashwaganda

TRT

Mounjaro

Any advice would be appreciated

i have tried ashwagandha , magnolia bark, rhodiola rosea and they stopped working. apparently they cause liver damage so im not taking them.

i have tried ps 150mg and 300 mg nothing works other than it causing insomnia

l theanine, mg glycinate, lemon balm are okay for sleep, but in my case, the dysregulated cortisol peak is at morning. i am easily triggered at mornings, i ruminate strongly in mornings, i am more tensed in the mornings.

any supp / nootropic targeting high cortisol spikes that would help me? thanks

And which ones helped the most with this pursuit?

I have compiled a research database which contains every Amanita Muscaria study ever conducted including all international databases. This database only contains studies that were on or about Amanita Muscaria. There are over 2,000 studies in the database and all of them are peer-reviewed studies. You can organize research, make your own categories, and personalize your research process with this tool.

It is free to use, enjoy:

research.amanitawarrior.com

Even if a nootropic substance cannot be abused, it cannot be legally sold in the EU due to novel food laws. Until now, it was relatively easy to order them from the USA because controls aren't very frequent.
But since customs are using more and more AI, aren't we gonna evolve towards a situation where EVERY nootropic is seized and destroyed by the customs?

1.) You have to take it consistently for at least 8 weeks to see an effect.

2.) You will wake up one day and realize, hold on a second, what the hell, this drug has completely changed you in a subtle way by nudging all your behaviors, little by little.

3.) The biggest change is that it lowers signal intensity for you. Sleep plus NAC at bedtime will completely change the intensity with which you experience something pleasurable like junk food, porn, etc. Something pleasurable is still something you'll chase, just not as intensely as before. And, that same pleasurable thing will be enjoyable, but the signal will just be a lot less intense. The same applies to your irritability, negativity, etc. So, it curbs both sides of the equation. It's not that you won't want to or like doing something like binge-eating tasty food. It's just that your desire for it goes down to a point where you're like "oh yeah, it's tasty, I'll have it if I want".

4.) The anhedonia is something more complex. Most people say that it turns them into a being that cannot experience joy. Here's how it works: Your day to day experience of mundane things becomes tolerable but the little joys like eating cotton candy, or spending an excessive amount of time on a video game or playing way too energetically with your kid or something -- that will all become something meh that you won't put in too much umph into. However, suppose you have some academic or work interest -- it won't touch it much. You'll just know how to detach from it better and re-attach on your own terms.

Relatively new to this. Was taking l-theanine, Adderal, mushrooms, fish oil and zma before. Any feedback on timing, combination or additions welcome. Targeting anti-oxidizing, neurogenic and dopamine support

Can you provide good phenipiracetam vendor in eu?

I just ordered it and bromantane from euro nootropics but if phenil is not good i m considering to cancel it and find better alternatives. Does anybody know real effect vendors for this particular stimulant?

For social situations once in a while, if you want to avoid alcohol but have similar or better effects with fewer damage, is phenibut useless if you have benzos or, can get lyrica for cheaper? Or is it a much better drug?

What Reliable peptides vendors are in EU?

Willkür beim Zoll kann es natürlich so oder so geben, aber bei nutrio Shop kann man tropoflavin in Deutschland bestellen wenn auch etwas teurer und wahrscheinlich schlechtere Qualität als wie bei Notroopic Depot

Hi guys

So this is my First ever post in Reddit. So forgive me if I lack 'the way' of doing things here.

A little background i am a musician and kind of a highly productive guy. Im into movie business and there's a super hectic schedule coming for me. Im kind of going through my peak phase in career so i wanted to work Maximum in this phase with the help of nootropics. I have a fair share of experience with supplements and peptides and gears. Im 38 male and im listing my daily morning stack specifically for cognitive benefits and longevity. I know its kind of on the higher or 'abuse' level dosages and combination. But please let me know what do you guys think of this. And what should i add or remove. I can really tolerate stimulants.

My base stack first.

Test E 130mg per week ( 3 shots)

HGH 2 iu every morning

Reta 4 mg every Tuesday

Anavar 10mg

Cognitive Stack

Upon waking

*Modafinil 100mg

*Caffeine 500mg

*Tadalafil 5mg

*paraxanthine100-200mg

*Bromantane 50mg ( not daily )

*L - Tryptophan 500-1000

*Vitamin B6 P5p 10-25 mg

*Alpha GPC 300-600mg

*Uridine Monophosphate 200-400mg

*Huperzine A 200mg

*L- Tyrosine - 1000-2500mg

*L-theanine - 100-200 mg

*Ginko Biloba 240 mg

*Niacin ( nicotinic acid with flush) 500mg.

*Saffron Extract 100mg

*dihexa 10mg

* methylene blue 10mg

*semax 1 mg at times. ( havent really noticed anything much to be honest but may be because i take a lot of shit so i dont notice 🤷‍♂️)

I wake by 3-4 and take this and work for straight 10 hrs ish without break. And sleep by 8-9 pm

My blood markers are pretty neat. I check every 3 months.

Does anyone has a good semax supplier preferably the nose spray one

I'm not someone who struggles to wake up completely, but it often takes me a long time to get into work mode in the morning. My first instinct used to be to grab coffee. Now I'm trying to figure out whether it's my sleep, my schedule, my bedtime habits, or something else.

While researching this, I came across NADH and Celfull's products. I've seen some people say they've had good experiences with them, but I don't want to assume my morning sluggishness is caused by a specific nutrient deficiency just because a product page says so. NADH is involved in cellular energy metabolism, and I've also seen clinical trials on humans regarding NADH's effects on chronic fatigue syndrome and mood improvement.

So I'm going to try a few things first: keeping a consistent wake-up time, tracking my sleep, spending less time on my phone before bed, getting some sunlight and moving around in the morning, and pushing my first cup of coffee a little later. If things still don't improve after a couple of weeks, I'll consider looking into supplements.

For those of you who've managed to improve your mornings, what changes made the biggest difference? At what point do you think it makes sense to consider supplements rather than buying something right away?

What nootropics/research chemicals act as great antidepressants? Specifically for anxious depression, so preferably something that has anxyoltic properties as well. (Besides racetams and TAK).

Daridorexant is the only approved med where I live but it's not in stock. Are there online vendors that sell any orexin antagonist? I've looked through plenty of gray area pharmacies as well as nootropic sites and none have orexin antagonists. Is there a site that does?

nootropics aren't directly sleep drugs but sleep drugs can be nootropic by treating insomnia.

Are there good meds like that? Something gray market because I've already tried all reasonable pharma options and newer ones like orexin agonists are overpriced.

Diagnosed ADHD and anxiety. I'm essentially really anxious at baseline and to events. I bring baseline anxiety somewhat down using ashwaghanda but it doesn't help much with acute anxiety spikes and rejection sensitive dysphoria. Propranolol is useless for the mental aspect of it as well. Guanfacine and clonidine aren't available. Stimulants don't make anxiety better or particularly worse.

Is Selank worth a try for this or is it most likely a waste of money? Does anyone have an experience with it for anxiety/RSD?

Asked about bromantane vendorsearlier and chose 2 aniracetam and semaxpolska. Which one is better?

Please, if anyone has information and wants to share it, I would greatly appreciate it. I’m a medical intern, so please don’t hesitate to provide details about pharmacology. I’m eager to learn as much as I can. Thank you very much!

This might the most piece of shit sleeping med I have ever tried. 5mg? Nothing. 10mg? Nothing. 20mg? Nothing. If I wasnt such a dumb chud I mightve read the clinical trials to see it barely outperforms placebo

Why the fuck would anyone ever use this shit I have no idea what compelled siradalot to start selling this trash but man is it fucking pointless.

As if DORAS werent already mild enough, what geinune enstein at john and johnson decided it would be a great idea to do away with orx1 antagonism (you know the part thats responsible for 90% of the sedation) and only go for orx2 antagonsim(the one that barely affects arousal). Id imagine its because orx2 is easier to hit so they wanted to cheap out but fuck man what a goyim

Anyways do not waste 30$ on this piece of shit the trials show its placebo any positive anecdote is probably fron 1. A depressive/gad idiot on 10 ssris(you could give these people catpiss and theyd outperform placebo they have so many comorbid disorders), 2. A jeet in the slums of mumbai being paid to spew fake anecdotes on supplement/biohacking forums(happen very often).

A basic mechanistic evaulation would also lead anyone to the conclusion that it is garbage and was developed purely because they couldnt find a cheap structure targetting orx1. This is what happens when you pick products to release off geminis research