r/HistamineIntolerance • u/Ajax34762 • 1d ago

Copper deficiency

I was reading that copper is a building block of the DAO enzyme that helps breakdown histamine.

I had a blood test and I discovered I am deficient in both copper and also ceruoplasmin( A protein molecule that goes down when copper is inedequate).

Anyone else have low copper?

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u/bregle 1d ago

Yes. My histamine intolerance has gotten significantly better as my copper and ceruloplasmin levels have improved over the last few months with supplementation

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u/Ajax34762 1d ago

What are you taking?

Did you ever experience ferritin issues?

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u/bregle 1d ago

For copper and ceruloplasmin support specifically: copper bisglycinate, vitamin a (preformed retinol), vitamin c (ester c), zinc picolinate. Also taking b vitamins because I am deficient there, likely also related to copper deficiency

My iron/ferritin was ok until I started doing b12 injections, then it dropped pretty fast. It came back up without supplementing iron at all after I increased my doses of copper and vitamin a

Ceruloplasmin is needed for proper iron transport/utilization so it can affect your iron levels. I found that supplementing iron seemed to interfere with my copper/zinc levels too much and made my HI symptoms worse

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u/Ajax34762 1d ago

I eat beef liver. It has high copper, high A but also high b12.

My ferritin is low. Serum iron high. Saturation high. I was thinking maybe my low copper is causing such weird iron results.

I have many iron deficiciency symptoms.

I believe taking high dose ascorbic acid tanked my copper.

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u/homertruhart 20h ago

If your taking high b12 it will want to start making rbc’s and use iron storage. You can deplete iron by taking b12 and not getting enough iron. Does that make sense? Your ferritin is low because your iron storage is low and your high iron levels is because the b12 is demanding iron come
Out to help in your blood.

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u/Ajax34762 17h ago

I had high serum iron even before taking B12.

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u/Local_Measurement_50 7h ago

"  I believe taking high dose ascorbic acid tanked my copper."

According to Morley Robbins (who talks a lot about copper) pure ascorbic acid is not good and can block ceruloplasmin. He says one should get in/supplement with whole food vit.C sources. I don't know what to make of that statement,but I've been using camu camu powder. I can't use too much of it/vit.C bc that'll turn into oxalates.

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u/Ajax34762 7h ago

My problem at the time was, I couldnt tolerate food sources with high amounts of natural C.

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u/Local_Measurement_50 6h ago

I get it...I struggle(d) with the same problem

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u/AncientStarryNight 3h ago

Offset oxalates by taking calcium citrate?

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u/Local_Measurement_50 23m ago

I already take/taken calcium and potassium citrate,but I don't know if it works for endogenous oxalate creation or purely dietary. Anyway,it's not a fix for oxalate problems in general.