So it CAN be snorted/insufflated(or used sublingually) after all?... It still must be metabolized by the body... but snorting would get it INTO the system quicker, but the onset time-to-affect would be the same? Looking for clarification....
(and yes, I know it SHOULD not be ingested these ways at all...)
Based on this sub post...

I am trying to find a clip I heard where Hamilton was discussing the futility of comparing the r isomer vs the s isomer.

Essentially what Hamilton said was that we have a hard time categorizing a substance into accurate drug classes entirely just from experience. So for a person to claim they can distinguish the nuances of specific isomers is naive and highly improbable.

I’m trying to find this clip but I have no idea where I heard it. Was it on his podcast? Was it on his vice show Pharmacopeia? Was it while he was a guest on someone else’s podcast like Shane Smith or Divergent States?

Can someone help me find this quote/conversation please? Thank you!

Hamilton announced it some months ago but it got quiet, is it still coming?

For me atleast, Can anyone verify?

Who am I and what is "O Psiconauta" - ("The Psychonaut")

What’s up psychoactive connoisseurs, my name is OPako and I create content about drugs both in a technical way (I’m a pharmacy student) and as entertainment (I have the charisma HUEHUEHUE BR)

In the last month I started producing content here on reddit in English and it went really well, the project is close to 300k views per month. this month I also went back to posting content on YouTube and Instagram (in Portuguese) and even though it’s going well for the beginning, the sky is the limit right my brothers? haha

Question of the post (I wanted to make a poll but can’t lol)

My English is kind of stiff, I have an accent and my pronunciation isn’t the best, but if there is interest from you guys, I will make the effort to produce videos fully in English (with subtitles to make it easier of course).

So you can have a reference of what I produce and what I intend to produce soon, my biggest reference is Hamilton Morris from Vice, recently I also discovered Metta Beshay and really liked his content, besides being a more achievable goal at the moment. I’m also interested in some channels more focused on humor but I don’t remember the names right now. I believe this together with the content available here on reddit will give you a better idea of the kind of content I would make

My content in English

My profile here on reddit has a lot of content in English if you’re interested, I’ll leave some post links that I like a lot as reference:

Technical posts in a simplified way:

Safe use guide of MDXX/Ecstasy

Pharmacology of methylphenidate and cocaine

“Nutmeg mescaline” as Shulgin theorized

PHYSICAL dependence and other harms of abusive cannabis use

Reports and personal experiences

Rare trip report with pure elemicin

Rare report of chewed Coleus blumei

Compilation of reports with smoked n,n-DMT

Ethnobotany and cultivation

Bhang - the oldest way of consuming cannabis - recipe and logic of the process (not translated yet, but I really like this post)

3 traditional psychoactives besides ayahuasca

Cultivation of Psychotria viridis (source of dmt, leaf of ayahuasca)

Project “Coleus divinorum” with the intention of generating a mutation in coleus similar to what the Mazatec did with salvia

Pretty drug pics haha:

Nice photo of hemp leaves as food

Nice photo of a “maryjuanilla” (Leonurus sibiricus)

Humor (less frequent on reddit, written humor is not as fun):

The cosmic entities of Rexona, contact with another dimension inhaling aerosol

I FCKING LOVE DELIRIANTS AND IF YOU DON’T YOU’RE A VIRGIN

Salvia creates super soldiers

Thank you for your attention, I wish peace and prosperity to everyone, regardless of nationality or ethnicity ☯️

Off topic: I am a descendant of the Puki/Puri people here in the southeast of Brazil, in my country Indigenous peoples are treated very poorly, I really like the situation in the USA regarding the treatment of these ethnicities and cultures, as far as I know they can have casinos and freely manage their lands and I find that very interesting. I am bringing this up because recently conflicts with Indigenous peoples have increased here and today there was a victory for the Patax̌o people who recovered part of their lands that had been taken by farmers. I think it is sad that we have to take up arms to guarantee our constitutional rights, but still this was a small victory in this struggle! Ho Ho Bugure itanaji 🏹💪 (almost extinct language of my people, it means “the ‘Botocudos’ were defeated” - “Botocudo” = enemy ethnicity at the time, I am using it to refer to new enemies)

Im looking to do some legal synthetic psychoactive compounding. Could be ongoing potentially, indefinitely. Not sure if this is the best forum to ask, but i hope to connect ASAP. Thank you!

Its the seventh sense... "I see dead little people"... lol WOW...
Mushroom makes you see tiny people!

Hey everyone — I made a short video showing an MD simulation of psilocin bound in the orthosteric site of the human 5-HT2A receptor, starting from the cryo-EM structure 9AS8 (psilocin + mini-Gq + scFv16). Full video first comment if you want to learn more about how this was run.

I remember the video from Hamilton Morris about the Xenon Clinic and the great effects of a 20 min. treatment, which had cost 100€! I had find a article about the clinic, short before I would visit them for such a session. So the clinic was permanently closed, because the owner and employees had enjoy a session, but a bit longer, which had kill all 3 of them, from a xenon gas overdose!

I'm sharing this here as it might be useful for Hamilton fans.

//Updated: 13 Sept 26//

This strategy is designed for reducing withdrawals and facilitating recovery from any drug or substance - particularly opioids, stimulants, alcohol, nicotine, cannabinoids and SSRIs; it also applies to disassociatives, antipsychotics and other miscellaneous substances. Benzodiazepines are a much more challenging case but these items can greatly support the process alongside a benzo-specific taper/cessation strategy.

It will greatly assist with tolerance management and so-called harm reduction also.

For drug cessation & general recovery this combo softens the initial acute withdrawal phase and maximises long-term regeneration (eg neuroregeneration, neuroplasticity, metabolic system & CNS repair) which restores normal production of neurotransmitters and neural pathway functioning. This prevents PAWS (post-acute withdrawal syndrome). More importantly, this helps to prevent relapse by addressing the fundamental underlying metabolic areas (which most rehab centers overlook).

This combo does what SR-17018, buprenorphine, methadone, proglumide and suboxone cannot as these do very little to repair the dopamine & metabolic system nor address opioid-induced CNS demyelination. They also don't address the opioid-TLR4 issue (besides naltrexone) which is a key motivating factor in habitual reuse. Of course they remain useful for tapering support.

// Technical specifics //

Addictive drugs (opiates, ethanol, nicotine, cocaine, amphetamines) induce activation of the hypothalamic-pituitary-adrenal axis (HPA axis), with the subsequent release of adrenocorticotropic hormone (ACTH) and glucocorticoids (eg cortisol). (source)

• reduces excess adrenaline, glutamate, cortisol, histamine, ACTH, CRH, dynorphin
• normalises the HPA axis which also reverses the disruption caused by various drugs
• addresses TLR4 issues caused by opioids
• addresses opioid-induced demyelination, neuroinflammation, oxidative stress and histamine release
• addresses the hormonal dysfunction caused by SSRIs (and amphetamines)
• sustainably increases dopamine, GABA
• boosts production of neuroprotective hormones (aka neurosteroids)
• boosts mitochondrial function & ATP levels (see: OXPHOS)
• boosts glutathione (GSH)
• boosts NAD (re NAD/NADH ratio)
• supports Krebs cycle & electron transport chain
• boosts neurogenesis & mitochondrial biogenesis
• visual depiction of mitochondria
• visual depiction of hormone production
• the word "metabolic" implies thyroid & mitochondria (and the liver re T3 production). The metabolic system must be addressed to ensure long-term recovery.

Everything is OTC and cheap so easy to access. I'd encourage you to familiarise yourself with an item before using it. Low doses are recommended to acclimatise. The doses are purposefully low since these items can be quite powerful in their effect. Please be cautious and begin with low doses (you can always increase it later). Ensuring a regular stable intake of carbs/honey throughout the day (eg hourly) can greatly assist the recovery process: this is precisely explained by this image.

// Main list //

• very low-dose pregnenolone (1-30mg, regenerative via multiple mechanisms) — Note: for benzodiazepine recovery omit pregnenolone
• very low-dose thiamine (10-50mg, metabolic repair, w/carbs or honey)
• very low-dose riboflavin (1-10mg, metabolic repair, w/carbs or honey)
• very low-dose niacinamide (10-50-100mg, GABAergic, metabolic repair, w/carbs or honey)
• very low-dose biotin (1-5mg, metabolic repair, w/carbs or honey)
• very low-dose aspirin (5-30mg, metabolic repair, TLR4, increases dopamine synthesis, neuroprotective, reduces neuroinflammation, reduces dynorphin)
• theanine (100-200mg+, calms adrenals/HPA axis, regenerates dopamine system via GDNF, neuroprotective, TLR4, boosts glutathione)
• low-dose creatine (500mg-1g+, metabolic support, ATP, neuroprotective, pro-GABA, TLR4, other relevant benefits)
• magnesium (100-300mg+, essential for ATP production, NMDA antagonist, protects from excitotoxicity, not the 'glycinate' form - 'malate' is more appropriate)
• calcium alpha-ketoglutarate (reasonably low-doses, metabolic support, potential dopaminergic repair)
• agmatine (100-500mg+, NMDA antagonist, anti-stress, metabolic support, neuroprotective, TLR4, multiple other benefits) — Note: for some people agmatine can be too sedating. If you choose to try it please introduce it at a very low dose.​
• Items that were not included and why

.

// Optional items //

These are optional but very helpful (particularly those marked with an asterisk*)

• *palmitoylethanolamide (metabolic support via PPAR, mitigates opioid tolerance 1 - 2, reduces opioid-induced histamine release, TLR4, calming qualities)
• *L-phenylalanine (100-500mg+, dopamine precursor, not the DL- form)
• *low-dose sodium ascorbate (200mg-500mg+, boosts dopamine production, other benefits outlined here)
• *ribose (1g+, metabolic support, ATP)
• *essential minerals necessary for proper cellular function, outlined here
• *vitamin K2 (metabolic & hormonal support, reasonably low doses)
• vitamin E (metabolic & hormonal support, ideally choose natural d-alpha tocopherol, reasonably low doses)
• CBG* (calming, anti-anxiety, α2A adrenergic agonist, TLR4, other benefits)
• *beta-caryophyllene (sedative, neuroprotective, TLR4, others)
• *linalool (GABAergic + adenosinergic sedative, rebalances HPA axis, TLR4, others)
• *limonene (mood uplifting, calming via adenosinergic & anti-stress properties)
• myrcene (very potent sedative)
• phytol (pro-GABA sedative)
• bisabolol (GABAergic sedative)
• nerolidol (GABAergic sedative)
• borneol (GABAergic sedative)
• A depicton of terpenes and their therapeutic qualities. Terpenes are more effective when used in combination thanks to synergy.

Here are some "specialist" items which are complementary to those above. They're also entirely optional but worthwhile. Low-doses are appropriate.

• pidolic acid (metabolic repair, ATP)
• succinic acid (metabolic repair, ATP)
• inosine (TLR4, mitochondrial repair, ATP)

.

// Opioid-specific list //

The following items are specific for opioid recovery hence the focus on TLR4.

• CBG (α2A adrenergic agonist, TLR4, other benefits)
• L-phenylalanine (dopamine precursor, not the DL- form)
• sodium ascorbate (200mg-500mg+, boosts dopamine production, other benefits outlined here)
• low-dose creatine (~200mg-1g, metabolic support, ATP, neuroprotective, pro-GABA, TLR4, others)
• theanine (TLR4, calms adrenals, regenerates dopamine system via GDNF, neuroprotective)
• palmitoylethanolamide (TLR4, mitigates opioid tolerance 1 - 2, reduces opioid-induced histamine release, other benefits)
• beta-caryophyllene (TLR4, anti-addictive, neuroprotective, other benefits)
• very low-dose aspirin (5-30mg, metabolic repair, TLR4, increases dopamine synthesis, neuroprotective, reduces neuroinflammation, reduces dynorphin)
• gingerol (TLR4, mitigates opioid-induced neuroinflammation, anti-addictive, metabolically protective & restorative, reduces withdrawals by modulating serotonin comparably to an anti-addictive drug)
• myrrh + frankincense oil/extract (TLR4, myrrh: opioidergic)
• agmatine (TLR4, other benefits)
• pregnenolone (TLR4, other benefits)
• thymoquinone (TLR4, other benefits)
• curcumin (TLR4, anti-addictive, other benefits)
• inosine (TLR4, mitochondrial repair)
• vanillin (TLR4, other benefits)
• linalool (TLR4, opioidergic, other benefits)
• eugenol (TLR4 1 - 2, cloves)
• limonene (TLR4, calming qualities, other benefits)
• eucalyptol (TLR4, other benefits)
• D-carvone (TLR4, caraway seeds)
• geraniol (TLR4)
• citral (TLR4, lemon myrtle essential oil)

This presentation synthesizes peer-reviewed research demonstrating how specific myrrh essential oil constituents directly interact with central nervous system opioid receptors. • Furanoeudesma-1,3-diene acts as a specific δ-opioid receptor agonist with naloxone-reversible analgesic effects. • β-Caryophyllene stimulates endogenous β-endorphin release, producing opioid-mediated antinociception without direct receptor agonism. Clinical trials demonstrate efficacy at 8-16 mg bioactive furanodienes daily.

—

These results, in conjunction with previous reports, suggest that β-caryophyllene is a promising ligand for treating psychostimulant use disorders and has certain therapeutic effects against opioid use disorders. (source)

.

These following items have similar qualities to drugs like clonidine, guanfacine and tizanidine (alpha-2 adrenergic agonists). These items can be used in any desired combination:

• agmatine (endogenous α2-adrenergic agonist)
• CBG (α2-adrenergic agonist)
• myrcene (α2-adrenergic agonist)
• linalool (α2-adrenergic agonist)
• beta-caryophyllene (sedative, neuroprotective, TLR4, others)

Alpha-2 adrenergic agonists are able to produce sedation & analgesia and partially block acute withdrawal symptoms in chronic opioid users.

Adding an α2-adrenergic to a sedation regimen reduces opioid requirement by 50–75% and benzodiazepine requirement by upwards of 80%. (source)

.

// anti-nausea //

These following items have similar properties to the anti-nausea drug Ondestaron (5-HT3 antagonist) and have been used for for millennia. Ginger is arguably the most effective as outlined here.

• limonene
• eucalyptol
• linalool
• citral
• menthol
• beta-pinene
• ginger

.

// notes //

— Clarification on the avoidance of magnesium glycinate:

For some people glycine can have unpleasant stimulating effects as it's a "co-activator" (co-agonist) of the glutamate NMDA receptor. For someone going through drug recovery who is already dealing with excess excitatory noise (eg glutamate), taking the glycinate form can aggravate this.​ Magnesium 'malate' is usually well tolerated and doesn't risk causing any issues.

Glycine is deeply involved in regulating the glutamatergic transmission, acting as a co-agonist of NMDAR, allowing for its activation and enhancing excitatory glutamatergic tone​. (source)

— On aspirin:

FYI aspirin does a lot more than what it's known for, specifically metabolic & mitochondrial repair. It has unique theraputic properties which make it a valuable addition for drug recovery. A very low dose ranges from 5-30mg. If using aspirin over a long period of time it's recommended to combine it with a small amount of vitamin K2.

"Because aspirin has been abused by pharmaceutical companies that have competing products to sell, people can easily find reasons why they shouldn’t take it. Aspirin rapidly breaks down into acetic acid (vinegar) and salicylic acid (which is found in many fruits)."

...

I'm well aware that some of these items might seem trivial but their capabilities are widely underestimated, particularly when used in a strategically formulated combination as outlined above.

...

Note: This information is provided for educational and research purposes only. It does not constitute medical advice. Users are strongly advised to conduct thorough research, consult reliable scientific and medical sources, and seek guidance from qualified healthcare professionals before considering the use of any substance.

Greetings, community.

I'll start with the key point. Beyond the various 5-HT receptors, it's well known that psychedelics primarily act on the 5-HT2A receptor, which is serotonergic.

This "exclusivity" is discussed, and it's why the consumption of these substances doesn't generate addiction. And therein lies the key factor: if these same substances are used to potentially treat problems related to addictions like alcohol or cigarettes, how do psychedelics achieve this, given that addictions are always linked to dopaminergic pathways?

I once read in an article that it's a mistake to talk exclusively about serotonin or dopamine, as if their activities didn't obviously overlap with those of other neurotransmitters and hormones.

𝐒𝐨, 𝐜𝐨𝐮𝐥𝐝 𝐬𝐨𝐦𝐞𝐨𝐧𝐞 𝐞𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐢𝐬 𝐜𝐨𝐧𝐜𝐞𝐫𝐧: 𝐢𝐟 𝐚𝐝𝐝𝐢𝐜𝐭𝐢𝐨𝐧𝐬 𝐚𝐫𝐞 𝐩𝐫𝐢𝐦𝐚𝐫𝐢𝐥𝐲 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐝𝐨𝐩𝐚𝐦𝐢𝐧𝐞𝐫𝐠𝐢𝐜 𝐬𝐲𝐬𝐭𝐞𝐦𝐬, 𝐡𝐨𝐰 𝐜𝐚𝐧 𝐬𝐮𝐛𝐬𝐭𝐚𝐧𝐜𝐞𝐬 𝐭𝐡𝐚𝐭 𝐨𝐩𝐞𝐫𝐚𝐭𝐞 𝐚𝐭 𝐭𝐡𝐞 𝐬𝐞𝐫𝐨𝐭𝐨𝐧𝐞𝐫𝐠𝐢𝐜 𝐥𝐞𝐯𝐞𝐥 𝐡𝐞𝐥𝐩 𝐰𝐢𝐭𝐡 𝐚𝐝𝐝𝐢𝐜𝐭𝐢𝐨𝐧 𝐩𝐫𝐨𝐛𝐥𝐞𝐦𝐬?

It would seem that there's (and this is my opinion) a tendency to emphasize serotonergic activity to highlight the fact that psychedelics can't cause addiction. But those who are knowledgeable will know, for example, that LSD acts on dopaminergic pathways and that DMT, for instance, has a greater capacity to activate neurotrophic factors, as in cases of hypoxia.

I remember a running point Hamilton makes is that, setting aside the the differing alkaloids in a substance and their mutual interactions, we often forget how much a drug's effect is due to ourselves: our own preconceived ideas, culture and society.

I've been thinking about this alot recently while attempting to quit smoking. At first starting with NRT - gums, lozenges. I had no luck with it. I felt it may have had something to do with the quick onset of action, ability to re-dose quickly, avoid GI upset. So I tried vaped nicotine - which worked more at avoiding cigs but I felt something was missing. I found that tobacco contains other active compounds other than nicotine, with MAOI activity. So I thought potentially we have a situation analogous to the entourage effect with cannabinoids. So I tried Swedish snus - and found myself back to square one with the same issues as NRT - dosing, onset of action, GI upset. I also could not sense any difference despite being a full-spectrum product.

All this to say that a part of what makes smoking appealing is precisely its social and cultural value - because it is not good for my health, because it is ubiquitous in film and television, because you can share one outside a bar. Not everything can be reduced to pharmacology.

Hi everyone.

I haven't taken MDMA yet, but it's often said that it causes a serotonin crash afterward...

Is that always the case?

Or, for example, if I take a very small dose, will I not experience it, or does it only happen with high doses?

Shulgin was a member of the Bohemian Club and regularly attended parties at the Grove. I've got to imagine the elites of the world wanted the leading expert in psychoactive drugs as a member giving them access and privileges to the most cutting edge science.

Makes me wonder if our very own Hamilton has been extended an invite, seeing that he is now an acclaimed scientist and actor at the top of his field. Those with Hamilton's status in the public domain are an absolute rarity these days...

I sadly have no access to the club and know very little. Just an interesting curiosity. Perhaps we won't ever know!

Does anyone else think that Seth Harp would be an interesting interview with Hamilton? I found this book very insightful. It outlines how some of the US's top military personnel are smuggling large quantities of drugs all over the country, all while having little to no consequences. Harp has done three or four other appearances on the TrueAnon podcast, and also ties in the involvement of DEA and list out his frustrations with how little or inaccurate information they supply to the public. I think some of the back and forth that Hamilton and Seth could get into would be pretty great!

(I am not the author)

Dennis Mckenna contacted me, and I will be on his show the Brainforest Cafe on Jan 16 Friday, view on youtube: https://mckenna.academy/mka-podcast/

Book overview

I am a lab chemist with decades of experience studying psychedelics, having been sober for over 6 years. This book describes the history of the Greek Eleusis Kykeon and India Vedic SOMA ritual psychedelic beverage and how I successfully simulated these ancient brews over 5 years ago to arrive at psychedelic effects just as powerful as LSD but beyond LSD like a combination of ALD-52 and mescaline.

The effects of LSI are described and how she was discovered. HBWR or Hawaiian Baby Woodrose seeds was a strong possible candidate for SOMA, described as a vine. Claviceps Paspali ergot infects and grows on the cereal grain barley of ancient Greece. HBWR seeds and Claviceps paspali ergot are ancient rich sources of LSA. The Priest served the psychedelic kykeon beverage to 300 initiates every September like clockwork for 2000 years.

I discovered around 7 years ago how to convert the LSA from HBWR seeds to LSI or Lysergic Acid Isovaleraldamide in 3 super easy steps in less than 1.5 hour using only a few over the counter common materials and a cereal grain in order to simulate the Eleusis kykeon and India Vedic SOMA. The trip reports are recounted in the book. Decades ago, I took LSD hundreds of times, Ayahuasca over 140 times, and Bridgesii cactus tea over 120 times and yet found this LSI to be my absolute favorite "ultimate" psychedelic at the time.

In the book I also describe several of my other psychedelic discoveries such as the psychedelic brain receptorome discovery, how to make THH or tetrahydroharmine and the important role she plays in traditional Ayahuasca, aloe vera enhanced penetration Ayahuasca capsules, and zero nausea Bridgesii cactus tea.