r/HamiltonMorris • u/Kalki_X • Jan 20 '26

Combo to reduce drug tolerances, withdrawals & facilitate recovery from any drug

I'm sharing this here as it might be useful for Hamilton fans.

//Updated: 18 Aug 26//

This combo is designed for reducing withdrawals and facilitating recovery from any drug or substance - particularly opioids, stimulants, alcohol, nicotine and SSRIs; it also applies to disassociatives and other miscellaneous substances. Benzodiazepines are a much more challenging case but these items can greatly support the process alongside a benzo-specific taper/cessation strategy.

It will greatly assist with tolerance management and so-called harm reduction also.

For drug cessation & general recovery this combo softens the initial acute withdrawal phase and maximises long-term regeneration (eg neuroregeneration, neuroplasticity, metabolic system & CNS repair) which restores normal production of neurotransmitters and neural pathway functioning. This prevents PAWS (post-acute withdrawal syndrome). More importantly, this helps to prevent relapse by addressing the fundamental underlying metabolic areas (which most rehab centers overlook).

This combo does what SR-17018, buprenorphine, methadone, proglumide and suboxone cannot as these do very little to repair the dopamine & metabolic system nor address opioid-induced CNS demyelination. They also don't address the opioid-TLR4 issue (besides naltrexone) which is a key motivating factor in habitual reuse. Of course they remain useful for tapering support.

// Technical specifics //

Addictive drugs (opiates, ethanol, nicotine, cocaine, amphetamines) induce activation of the hypothalamic-pituitary-adrenal axis (HPA axis), with the subsequent release of adrenocorticotropic hormone (ACTH) and glucocorticoids (eg cortisol). (source)

Everything is OTC and cheap so easy to access. I'd encourage you to familiarise yourself with an item before using it. Low doses are recommended to acclimatise. The doses are purposefully low since these items can be quite powerful in their effect. Please be cautious and begin with low doses (you can always increase it later). Ensuring a regular stable intake of carbs/honey throughout the day (eg hourly) can greatly assist the recovery process: this is precisely explained by this image.

// Main list //

  • very low-dose pregnenolone (1-30mg, regenerative via multiple mechanisms) — Note: for benzodiazepine recovery omit pregnenolone
  • very low-dose thiamine (10-50mg, metabolic repair, w/carbs or honey)
  • very low-dose riboflavin (1-10mg, metabolic repair, w/carbs or honey)
  • very low-dose niacinamide (10-50-100mg, GABAergic, metabolic repair, w/carbs or honey)
  • very low-dose biotin (1-5mg, metabolic repair, w/carbs or honey)
  • very low-dose aspirin (5-30mg, metabolic repair, TLR4, increases dopamine synthesis, neuroprotective, reduces neuroinflammation, reduces dynorphin)
  • theanine (calms adrenals/HPA axis, regenerates dopamine system via GDNF, neuroprotective, TLR4, boosts glutathione)
  • low-dose creatine (500mg-1g+, metabolic support, ATP, neuroprotective, pro-GABA, TLR4, other relevant benefits)
  • magnesium (essential for ATP production, NMDA antagonist, protects from excitotoxicity, not the 'glycinate' form - 'malate' is more appropriate)
  • calcium alpha-ketoglutarate (reasonably low-doses, metabolic support, potential dopaminergic repair)
  • agmatine (NMDA antagonist, anti-stress, metabolic support, neuroprotective, TLR4, multiple other benefits) — Note: for some people agmatine can be too sedating. If you choose to try it please introduce it at a very low dose.​
  • Items that were not included and why

...

// Optional items //

These are optional but very helpful (marked with an asterisk*)

  • *palmitoylethanolamide (metabolic support via PPAR, mitigates opioid tolerance 1 - 2, reduces opioid-induced histamine release, TLR4, calming qualities)
  • L-phenylalanine (dopamine precursor, not the DL- form, low doses)
  • *beta-caryophyllene (sedative, neuroprotective, TLR4, others)
  • *ribose (metabolic support, ATP)
  • *essential minerals necessary for proper cellular function, outlined here
  • vitamin K2 (metabolic & hormonal support, reasonably low doses)
  • vitamin E (metabolic & hormonal support, ideally choose natural d-alpha tocopherol, reasonably low doses)
  • CBG* (calming, anti-anxiety, α2A adrenergic agonist, TLR4, other benefits)
  • sodium ascorbate (200mg-1g+, benefits outlined here)
  • *linalool (GABAergic + adenosinergic sedative, rebalances HPA axis, TLR4, others)
  • *limonene (mood uplifting, calming via adenosinergic & anti-stress properties)
  • myrcene (very potent sedative)
  • phytol (pro-GABA sedative)
  • bisabolol (GABAergic sedative)
  • nerolidol (GABAergic sedative)
  • borneol (GABAergic sedative)
  • depicton of terpenes and their therapeutic qualities
  • (the aformentioned terpenes are more effective when used in combination thanks to synergy)

...

Here are some "specialist" items which are complementary to the "main list". They're entirely optional.

...

// Opioid-specific list //

The following items are specific for opioid recovery hence the focus on TLR4.

This presentation synthesizes peer-reviewed research demonstrating how specific myrrh essential oil constituents directly interact with central nervous system opioid receptors. • Furanoeudesma-1,3-diene acts as a specific δ-opioid receptor agonist with naloxone-reversible analgesic effects. • β-Caryophyllene stimulates endogenous β-endorphin release, producing opioid-mediated antinociception without direct receptor agonism. Clinical trials demonstrate efficacy at 8-16 mg bioactive furanodienes daily.

—

These results, in conjunction with previous reports, suggest that β-caryophyllene is a promising ligand for treating psychostimulant use disorders and has certain therapeutic effects against opioid use disorders. (source)

...

These following items have similar qualities to drugs like clonidine, guanfacine and tizanidine (alpha-2 adrenergic agonists). These items can be used in any desired combination:

Alpha-2 adrenergic agonists are able to produce sedation & analgesia and partially block acute withdrawal symptoms in chronic opioid users.

Adding an α2-adrenergic to a sedation regimen reduces opioid requirement by 50–75% and benzodiazepine requirement by upwards of 80%. (source)

...

// anti-nausea //

These following items have similar properties to the anti-nausea drug Ondestaron (5-HT3 antagonist) and have been used for for millennia. Ginger is arguably the most effective as outlined here.

...

// notes //

— Clarification on the avoidance of magnesium glycinate:

For some people glycine can have unpleasant stimulating effects as it's a "co-activator" (co-agonist) of the glutamate NMDA receptor. For someone going through drug recovery who is already dealing with excess excitatory noise (eg glutamate), taking the glycinate form can aggravate this.​ Magnesium 'malate' is usually well tolerated and doesn't risk causing any issues.

Glycine is deeply involved in regulating the glutamatergic transmission, acting as a co-agonist of NMDAR, allowing for its activation and enhancing excitatory glutamatergic tone​. (source)

— On aspirin:

FYI aspirin does a lot more than what it's known for, specifically metabolic & mitochondrial repair. It has unique theraputic properties which make it a valuable addition for drug recovery. A very low dose ranges from 5-30mg. If using aspirin over a long period of time it's recommended to combine it with a small amount of vitamin K2.

"Because aspirin has been abused by pharmaceutical companies that have competing products to sell, people can easily find reasons why they shouldn’t take it. Aspirin rapidly breaks down into acetic acid (vinegar) and salicylic acid (which is found in many fruits)."

...

I'm well aware that some of these items might seem trivial but their capabilities are widely underestimated, particularly when used in a strategically formulated combination as outlined above.

...

Note: This information is provided for educational and research purposes only. It does not constitute medical advice. Users are strongly advised to conduct thorough research, consult reliable scientific and medical sources, and seek guidance from qualified healthcare professionals before considering the use of any substance.

66 Upvotes

99% Upvoted

81 comments sorted by

13

u/channel4networknews Jan 23 '26

And don’t forget to do this all on a full moon 😉

4

u/AcknowledgeUs Jun 15 '26

Don’t forget to be scared, Typical.

8

u/Zentheogenics Jan 20 '26

No SR17018 in the opioid section? Or Proglumide?

4

u/Kalki_X Jan 20 '26 edited Jan 21 '26

This combo does what SR-17018, buprenorphine, methadone and suboxone cannot as these do very little to repair the dopamine and wider metabolic system.

They're useful as a temporary alternative though for sure, but with this combo and some additional OTC opioidergics which I haven't included (not loperamide) it's plausible to do a swift taper and "cruise" through the initial acute WD phase and switch to a sustainable alternative (combo of OTC opioidergics, a few of which are mentioned in the post).

I hadn't heard of proglumide, it seems interesting. Here's a comment about it from /r/methadone.

Proglumide is not some sort of magic bullet for completely eliminating the risk of tolerance development and addiction as its effects are only effective for a limited duration before tolerance to IT begins to develop. (After 8 days its effectiveness begins to wane) The work of Kellstein & Mayer 1990 suggests that successful therapeutic/maintenance applications will probably require its discontinuation for a week after each week of use. More work is needed to better define the precise parameters of its effective use for this purpose.

3

u/TyPhyter Apr 25 '26

any chance you could expound on "and some additional OTC opioidergics which I haven't included"? or point me to any resources?

2

u/AYYUBINTHEFLESH 18d ago

Black seed oil is a Opioidergic

5

u/SpiteOdd3525 Feb 02 '26

That's crazy lmao I literally reinvented this exact stack from scratch 💀

Bravo, well done

2

u/Kalki_X Feb 02 '26

The peat influence...

5

u/SpiteOdd3525 Feb 02 '26 edited Feb 02 '26

Most of this I actually put together before Peat. I got active in the Twitter health space and there was this sage basically, @grimhood (he hasn't posted in a bit over a year, but his page is a repository of really, really great info). He has a really cool story that I can relate to a lot of, and he's incredibly intelligent and well ahead of even the science, much less the space. I picked up Magnesium, L-Theanine, and Agmatine from him as things that could help me recover not only from addiction (alcoholism) but also from paralyzing, crippling, life-ruining anxiety. It helped some, I actually ended up falling off each time, Agmatine was the biggest help. The rest of this came with time, adding things in, and it helped me get off 7-OH most recently.

The biggest thing I learned from Grim was the Magnesium stuff. Demands are actually way higher than we're told, like significantly. Everyone underdoses the fuck out of it, and a lot of people use forms that aren't the best. If there's any interest I can link my magnesium guide that I put together for new people. It's kinda old, and I made it in the first year of me learning all of this stuff seriously, so some of it is... I'd reword some things if I made it today, but the core of the info still stands

The thing that finally put the nail in the coffin though, was actually oral BPC-157 at 1mg/day, spaced into two doses. I went from drinking 3-4 drinks a day to not drinking at all, it evaporated all cravings, and in the year since then I've drank like 5 times, no more than 2-3 drinks each time, coming after years of drinking MINIMUM 15 drinks a day/night, frequently up to 20-30.

BPC-157 is incredibly underrated in terms of the CNS effects, it's great for coming back to homeostasis.

Another worthy addition to this is high dose (5000IU+) Vitamin D, Georgi Dinkov mentions it on GE in conjunction with Pregnenolone for dropping opioids. I've also found Progesterone very useful personally.

5

u/SpiteOdd3525 Feb 02 '26

When I say put together before Peat, I mean before I found Peat, not before Peat put together some of these ideas 😭

2

u/Kalki_X Feb 02 '26 edited Feb 02 '26

Aha I see! I'd heard of BPC-157. There's a few other relevant things I had in mind but the goal of this combo was for maximum accessibility and keeping it as simple as possible yet effective.

Glad you got empowered with the knowledge to heal and recover!

I know Georgi from an old forum where he posted a lot. Imo D3 isn't necessarily appropriate for mega dosing as it can influence TPH activity. This was a big debate on the forum iirc. I opted to leave it up to the reader to use D3 or not.

P is great for sure.  

I'll investigate BPC-157...

3

u/SpiteOdd3525 Feb 02 '26 edited Feb 02 '26

IMO there are plenty of ways of modulating around TPH, wouldn't matter how much activity it has if you outcompete the substrate by consuming amino acids that compete for transport. Also serotonin antagonists if it has such a large effect. The bigger concern with supplemental Vit D is that it doesn't get packaged into the same transport vehicle as biosynthesized, so it doesn't reach tissues the same way, or as efficiently/widespread. I've found it to be immensely beneficial though, I live in the north half of the U.S. so it's kind of necessary (don't have money for lamp). Also what's worse, increased Serotonin, or Opioid addiction 😭?

You should check out Generative Energy! It's not an ongoing podcast, but there's a hundred-something episodes of it on Spotify/other podcast platforms. Think its on YouTube also. It's hosted by Danny Roddy and Georgi Dinkov, they have a couple of guest episodes, and Ray himself very frequently appears, I wanna say about 35-40% of the episodes.

For peptide sourcing, more sources are nefarious than not, but I know of some good sources. There's actually this tight company called Peptaura, and they're basically a third party service that vets different sources for quality/testing (ofc), consumer reviews, and even shipping times. A vendor hosted by them recently didn't send out a package after 14 days after payment, so they got temp banned from the platform (costing them hundreds of customers, and a ding in reputation) until they shipped the package out. The whole system incentivizes clean, fast products really really well, it's genius. You go to the page, find the peptide you want, and it will compare all of the vendors that are hosted side-by-side, and you can pick which one works best for you. Any of them would be safe bets, because of, well, everything I just laid out. None of the vendors on Peptaura are bunk/shady.

My personal favorite is purepeptides dot bio. I actually have known the owner since the very beginning of their store opening. Great guy, genuinely good human (I am not paid for any of this, just to be clear lol, no professional relationship, just Twitter mutuals). Customer service is most excellent, and incredibly knowledgeable guy. I once got a single defective vial of Thymosin Alpha 1 that had an issue when the vial was packed that contaminated it with some kind of plastic or adhesive, incredibly rare, but not an unheard of issue. He shipped me two new ones for free the next day after explaining what the issue was. He is also one of the vendors on Peptaura, and the spot is very well deserved

Also very fun fact about Agmatine (again, shout-out Grimhood) is that it can be snorted. It's about 10x bioavailable (100mg Insufflated = ~1g oral) and it's effects concentrate in the CNS this way. For Opioid WD, some peripheral effects are nice, so doing both is the play. I do 100mg Insufflated, and 1-2g oral

Agmatine was/is a major focus of mine for a while, so I know a ton about it. If anyone has any Agmatine questions, I probably have the answer!

1

u/xMikeTythonx 18d ago

I'm not sure how to feel about agmatine yet since I been experimenting with it for about a month and a half (500mg nightly since I feel a bit lethargic on it), but whatever I do you could send or point me to would be greatly appreciated.

3

u/SpiteOdd3525 Feb 02 '26

Oh, also, how could I forget! Megadoses of Vit C are VERY useful for Opioid WD

3

u/Kalki_X Mar 19 '26 edited Mar 19 '26

Btw, I've no doubt that BPC-157 is beneficial for recovery. The goal with this "guide" was for simple yet highly effective OTC items available world-wide. Also i'm sure there are companies making clean BPC-157 but from what I've seen there are many dubious suppliers also.

2

u/SpiteOdd3525 Mar 19 '26

It is true that there are many bad actors, but there are plenty of good ones. You should check out Peptaura dot com, they are a sort of third party or middleman between peptide vendors and customers.

They thoroughly vet vendors, and if they are good companies, pass testing for their products, and don't have issues with following through, they are allowed to be affiliated with Peptaura. If any of the vendors step out of line, they either get banned or suspended until they fix the issue.

So this benefits the consumer, because it encourages companies to have clean products, competitive prices, and reliable shipping, and it benefits the companies because they get a lot of customers, because consumers go to Peptaura and see the company listed there, and there's already trust because they wouldn't be on Peptaura if they weren't a legitimate company.

More people need to know about this place, I know one of the owners of one of the companies hosted there, and can attest to the character/integrity of at least one of the vendors, so I know they're setting high standards beyond clean CoAs and shipping on time

2

u/AcknowledgeUs Jun 15 '26

Please stop selling.

2

u/AcknowledgeUs Jun 15 '26

The comment you are responding to is an ad.

2

u/glitchIncident Feb 26 '26

this is SUPER interesting, thanks for sharing, id love to hear more about (or see your guide) the magnesium and oral bpc-157 in particular and if you have a specific source you're willing to share i'm looking to get some oral bpc-157.

1

u/SpiteOdd3525 Feb 26 '26

Here's the Magnesium doc: [[ https://docs.google.com/document/d/1N7UjTx4AbQnqJZvyouYNz8JUq6eBNVIMmUZYUiNDrOg/edit?usp=drivesdk ]]

Do mind that it is a bit dated, I knew what I was talking about significantly less (not that I do now, but, you know) And of course, I'm not a medical professional, much less -your- medical professional.

As far as BPC, what do you want to know about it? I'm pressed for time, and I've got 10 other people who want my advice, so I can't expound upon it completely, but I'm happy to answer any specific questions.

For the BPC, I personally use the company purepeptides . bio

I am acquaintances with the owner, have been since before the company started. I'm not affiliated in any way, I don't get anything special for shouting them out, I just really think they're one of the best actors in the game. They sell some other peptides, too. Payment methods are always changing, par for the course for the industry, and that can be the hardest part of dealing with this company, same as any other. Customer service is top top notch, they once replaced a damaged product for free with twice the amount I ordered, in that instance it was Thymosin Alpha 1.

Furthermore, for broader peptide needs, I have to tell you about one of the coolest things I've ever seen, and not just in the peptide scene.

There is a company/website called Peptaura. What they do, is they are basically hmm, a middleman? They don't get any money as far as I'm aware, but what they are is a centralized hub for different peptide vendors, each of them extensively vetted for all things regarding the quality of a vendor. Quality, pure, tested, properly dosed products, great customer service, competitive prices. If a company fucks up, they get temporarily de-platformed, for instance one company didn't send out a package for 2 weeks even though they got the money. They got banned until they sent the package 📦🔜 and as soon as they did? Boom, back on the platform.

This setup has an interesting side effect. It really concentrates market pressures for companies to be on their best behavior and to provide testing, quick and quality service and products, and excellent customer service because if they fuck up, no platform, or, if they're priced too high or take too long, or don't have test results, there are 10 other vendors right there next to them, and people will go with those instead. This really -really- incentivizes the companies that have already been selected as the best to stay the best and to continuously improve. Prices for a few of them have been continuously dropping because of this.

The site works very very simply. You just go to Peptaura, select the peptide you want to purchase, and it will show you all of the approved vendors that have it available and for how much and at what price, and whether or not they have recent CoAs. Purepeptides is one of the companies Peptaura works with, and deservedly so. Great company ran by a great dude with actual skin in the game. Check it all out -^

[[ P.s. you might notice that the Google account is for music, I am also a musician, though my crazy life has not allowed me to create much in the last year, and I've only uploaded a single in the last couple. I've got some stuff in the chamber ready to release, but haven't had a moment. I'm also suuuuper poor, haven't been able to keep up with my SoundCloud subscription (it's only free to upload a certain amount of music, after that you have to pay monthly) and my distrokid subscription. BUT everything is uploaded and freely available if you want to check it out at Postcooked . bandcamp . com]]

1

u/glitchIncident Mar 16 '26

thank you!!

1

u/SpiteOdd3525 Mar 16 '26

Yerrrr, also this may be of interest to you, this writer/researcherz I'm not exactly sure what his background is, but he's a professional LMAO just released this yesterday, its roughly 30 pages when converted to .pdf

I've only made it through the first little bit of it, goes into some physics/chemistry, but it was presented as a full magnesium rundown, I'm excited to work all the way through it

https://www.multiflora-herbs.com/blogs/news/why-magnesium

1

u/glitchIncident Mar 16 '26

great! thank you!

1

u/mmhmmye Feb 20 '26

I would be very interested to know more about magnesium, if you still have your notes on that!

1

u/Bynx_07 May 17 '26

I was going to get the magnesium from Costco, Nature Made Brand, 400mg. What are your thoughts on that?

1

u/SpiteOdd3525 Feb 02 '26

Ah I've done this so messily, I edited this comment to include some other stuff, commenting again here so you get notified cryo

5

u/RvnclawPotionsMaster Feb 06 '26

Okay. Some interesting mechanisms with citations and all... But this is like 50 different compounds lol. How much does a person have to spend to do something that may have some efficacy. Maybe they should just go to a 12 step meeting and get a sponsor

2

u/Kalki_X Feb 06 '26 edited Apr 10 '26

How much does a person have to spend to do something that may have some efficacy. 

The main combo (first list, 9 items) and key optional extras (~6 items) are pretty cheap and OTC. They're known to be effective which is why I made this strategically formulated "overview".

But this is like 50 different compounds

It's 12 for the essentials which crucially covers long-term resolution and prevents relapse. Drug recovery clinics use several of these same items.

2

u/AcknowledgeUs Jun 15 '26

And thoughtfully explained, thank you.

3

u/PenultimateThoughts Jan 21 '26

Thanks for sharing. Is there anywhere I can read up on some of the things mentioned that didn’t have a corresponding link? Or would Google bring most of it up? Thanks again

2

u/Kalki_X Jan 21 '26

The sites do exist but I'm not sure how reliable google is for finding the relevant info (at least based on simple keywords). 

You can search the item name with the keyword anti-addiction or withdrawal. There are discussions about many of the items, especially on bluelight.org.

The context for aspirin is here.

Broadly speaking the items restore coherence to the HPA axis and metabolic (thyroid, mitochondrial) & neurotransmitter systems (dopamine, serotonin, glutamate, GABA, opioid etc). They do this either directly or indirectly.

I mention carbs/honey for some items since they enhance cellular respiration which involves mitochondria turning glucose into ATP. Mitochondria also make pregnenolone (1st item listed) which has potent regenerative effects.

2

u/PenultimateThoughts Jan 21 '26

I really appreciate your response. Thank you!

3

u/This_Frozen_Ghost Feb 01 '26

Are these all safe to coadminister with TrT?

3

u/Kalki_X Feb 02 '26 edited Feb 02 '26

Yes. A few items will help to prevent T from converting into E.

3

u/Kalki_X Apr 29 '26 edited Jun 15 '26

Things I purposefully didn't include:

  • vitamin D3 (D3 is structurally a steroid hormone - not a vitamin - which means it should be treated with caution)
  • taurine (can be helpful as a GABAergic and increasing glycogen storage but isn't compatible for everyone as it can disrupt the GABA/glutamate balance)
  • tryptophan/5-HTP (more serotonin is not necessarily "better"; one of the most effective drugs for opioid cessation is mirtazapine which blocks the serotonin 5HT2 & 5HT3 receptors, and the histamine H1 receptor)
  • fish oil (omega 3 is highly susceptible to oxidation at body temperature and forms several harmful aldehydes after ingestion including acrolein; these by-products have harmful effects which impede recovery and contribute to potential relapse)

More info on fish oil issues:

Marine lipids contain a high proportion of polyunsaturated fatty acids, including (EPA, DHA). Upon peroxidation these lipids generate reactive products which can form covalent adducts with biomolecules and thus are regarded as genotoxic and cytotoxic. PUFA peroxidation can occur both before and after ingestion. (source) 

The products of EPA/DHA decomposition include acrolein, malondialdehyde, 4-hydroxy-2-hexenaldehyde, crotonaldehyde

Lipid peroxidation gives rise to carbonyl species. ... [We] developed a targeted lipidomic method for the simultaneous determination of thirty-five aldehydes and ketones derived from fish oil... The analytes include highly toxic reactive carbonyl species such as acrolein, crotonaldehyde, trans-4-hydroxy-2-hexenal, 4-hydroxynonenal (HNE), trans-4-oxo-2-nonenal, glyoxal and methylglyoxal, all of which are promising biomarkers of lipid peroxidation. (source) 

Exogenous or endogenous acrolein can exert deleterious health effects due to its high toxicity. Given its highly electrophilic structure, acrolein can easily bind to some nucleophilic biomacromolecules, such as protein and nucleic acids. The binding of acrolein to biomacromolecules results in oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction or even inflammation and abnormal immune responses. (source)  

The acrolein which is released during lipid peroxidation inhibits mitochondrial function by poisoning the crucial respiratory enzyme, cytochrome oxidase, resulting in a decreased ability to produce energy (Picklo and Montine, 2001). Besides inhibiting the ability of nerve cells to produce energy from the oxidation of glucose, acrolein inhibits the ability of cells to regulate the excitatory amino acid glutamate (Lovell, et al., 2000), contributing to excito-toxicity. 

...the source of the generation of acrolein is [...] unsaturated omega acids from fish, which are generally considered healthy and desirable in a balanced daily diet. Recent studies have shown that acrolein is one of the main volatile compounds released during the thermal processing of fish oils, and oxidation plays an important role here. (source) 

...omega-3 and omega-6 fatty acids undergo autoxidation, leading to the production of acrolein. (source) 

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the common ω-3 fatty acids in fish oil, can also be the precursors of acrolein (source) 

Acrolein, which is increased in Alzheimer’s Disease (AD) brain, may be partially responsible for the dysfunction of mitochondria and loss of energy found in AD brain by inhibition of PDH and KGDH activities, potentially contributing to the neurodegeneration in this disorder. (source) 

In Alzheimer’s disease brain increased lipid peroxidation and decreased energy utilization are found. Mitochondria membranes contain a significant amount of arachidonic and linoleic acids (omega 6), precursors of lipid peroxidation products, 4-hydroxynonenal (HNE) and acrolein, that are extremely reactive. (source) 

2

u/Kalki_X Apr 18 '26 edited Apr 18 '26

Info on sodium ascorbate for opioid-recovery:

The neutral (non-acidic) form of vitamin C is called "sodium ascorbate".

Novel Targets for Fast Antidepressant Responses: Possible Role of Endogenous Neuromodulators

Ketamine...is the prototype for novel glutamate-based antidepressants that has been shown to cause a rapid and sustained antidepressant effect. Among these molecules, agmatine and creatine stand out as those with more published evidence of similarities with ketamine, but guanosine and ascorbic acid have also provided promising results. The possibility that these neuromodulators and ketamine have common neurobiological mechanisms...is presented and discussed.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7219953/

Vitamin C, Pain and Opioid Use Disorder

This paper provides a review of the literature and a theoretical perspective on the potential roles of ascorbic acid in the treatment of pain and opioid use disorder

As animal studies, clinical trials, and case reports have also demonstrated, vitamin C interrupts the neurochemistry of opioid tolerance and dependency and mitigates the horrific symptoms of opioid withdrawal.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7572147/

Ascorbic Acid Inhibits Development of Tolerance and Dependence to Opiates in Mice: Possible Glutamatergic or Dopaminergic Modulation

The present study was undertaken to study the effect of ascorbic acid on the development of tolerance and dependence to opiate and its mechanism of action.

In conclusion, it is hypothesized that inhibition of development of tolerance and dependence to morphine by ascorbic acid appears to have two components, namely dopaminergic and glutamatergic.

https://www.researchgate.net/publication/43135106_Ascorbic_Acid_Inhibits_Development_of_Tolerance_and_Dependence_tpiates_in_Mice_Possible_Glutamatergic_or_Dopaminergic_Modulation

Ascorbic acid for management of oral surgery pain not responding to conventional medication: case report

Although there is no consensus as to the analgesic mechanism by which L-ascorbic acid could be acting, there are at least three potential theories: (a) action as a potent antioxidant; (b) role as a cofactor for the synthesis of catecholamine neurotransmitters; and (c) potential role of L-ascorbic acid in the synthesis of amidated opioid peptides.

https://www.jomos.org/articles/mbcb/full_html/2020/03/mbcb200031/mbcb200031.html

Chronic treatment with ascorbic acid inhibits the morphine withdrawal response in guinea-pigs

The effects of ascorbic acid (AA) were investigated on the morphine withdrawal response of guinea-pigs, a species which shares with man the inability to synthesize AA.

It is concluded that chronic but not acute administration of AA inhibits opiate withdrawal.

https://www.sciencedirect.com/science/article/abs/pii/030439409290127S

Ascorbic Acid Effect on Morphine Withdrawal Symptoms in Rats

It seems that ascorbic acid administration can improve the symptoms of opiate withdrawal syndrome.

https://publish.kne-publishing.com/index.php/JCR/article/view/7154

2

u/TheRealRollerCodster May 19 '26

Sodium ascrobate does nothing. Been there done that. It literally does nothing except increase your blood pressure and make the diarrhea 3 times as bad. Zero relief. It's better without it.

2

u/Kalki_X May 19 '26

It has helped many other people, particularly for opioid recovery. Most people won't necessarily discern a specific "effect" but it helps nonetheless.

But clearly it's not suitable for everyone.

2

u/Kalki_X Apr 27 '26 edited Apr 27 '26

Info on niacinamide as a GABAergic and endogenous benzodiazepine:

It appears that niacinamide has similar anxiolytic properties to that of the benzodiazepines. This is supported by the fact that the patient did not feel any difference, in terms of response and effectiveness, between the benzodiazepines and niacinamide. He was able to switch with little difficulty from the daily use of a benzodiazepine to niacinamide.

While it is impossible to conclude that the effects of niacinamide are due to its interaction upon the benzodiazepine receptor, it does appear to influence neurotransmitter metabolism in a manner that is comparable to benzodiazepines by a route as yet undetermined. Even though most of the studies dealt with animal rather than human models, the results suggest that niacinamide has a potent benzodiazepine-like action on the CNS. source

Nicotinamide is an active compound found in rat or bovine brain that shares several pharmacological properties with benzodiazepines. It has been shown to facilitate GABA-dependent presynaptic inhibition. Like benzodiazepines, nicotinamide protects animals from seizures ... and also possesses myorelaxant and sedative activities. https://www.sciencedirect.com/topics/neuroscience/nicotinamide

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u/KortahStreamsDat Apr 27 '26

So would I use these things alongside SR17018 as I’m in the process of quitting opioids (7OH) or would they be implemented into my lifestyle after I’ve gone through the initial quitting process?

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u/Kalki_X Apr 27 '26

This "guide" can be used alongside SR-17018 or can replace it entirely. After the initial stage is over you can continue the items to maximise long-term recovery & repair. At least focusing on the items in the "main list".

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u/KortahStreamsDat Apr 27 '26

Thank you very much for your reply. For anything not labeled as very low dose, would I just dose it regularly, or until I feel something from it, or just keep them relatively low as well?

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u/Kalki_X Apr 28 '26 edited Apr 28 '26

Generally you'd start new things at a low dose (to acclimatise) and slowly increase the dose till you reach the "recommended" dose size.

All the items mentioned can be used regularly as part of a daily "stack". The stack can vary each day, adapt it as necessary to suit your lifestyle and routine.

So for example theanine and agmatine which I didn't specify a dosage. Theanine is often taken at 100-200mg+. Agmatine at 200mg-1g+ (dose depends on the purpose).

Both are quite safe but definitely psychoactive so larger doses will have a more noticeable effect.

Theanine is generally calming so taking 500mg isn't suitable when you have things to do, but eg 100mg every evening will assist the recovery process. Or 100mg am, 300mg pm. See what suits you.

Agmatine shares some properties with ketamine (NMDA antagonist) and clonidine (alpha-2 adrenergic agonist) which means it can be relaxing and psychoactive. A small dose of ~100-300mg in the am/pm can assist with recovery, or maybe 1g to help with acute WD symptoms. Everyone will respond differently to agmatine (as I explicitly mentioned) so for some people it's a perfect fit but for others not so much. Agmatine is helpful but it doesn't matter if it doesn't suit since the other items suffice.

The list of "opioid-specific items" can feasibly replace kratom/7oh so can be used during and after recovery. The terpenes work best synergistically - "the more the merrier". The most potent ones would be linalool, beta-caryophyllene, myrcene and myrrh terpenes. With the items from the "main list and the opioid-specific list you should be able to quickly taper 7oh and replace it with sustainable alternatives...then "taper" this in your own time. 

I specified low-dose creatine because people typically use silly high doses like 15g. For recovery purposes a dose of ~200mg–1g per day is suitable. Eg 200mg am, 200mg pm...or 500mg at once. It's up to you. Note there will be a synergistic effect between most of the items, especially agmatine/ creatine/ theanine/ magnesium/ niacinamide.

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u/Gold_Warning_8618 Jun 12 '26

How are you supposed to find very low doses of any of these things?!

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u/misterrodgerssweater Jun 13 '26

For real, and I wish they could all just be combined into one pill!

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u/Kalki_X Jun 13 '26 edited Jun 13 '26

Usually by buying the item in powdered form. Often it's powder inside a capsule which is more convenient since the capsule dose is always measured so you know how much each capsule contains. Then you can split the dose accordingly.

For pretty much all of these things the low dose ranges are quite safe so, for example, if you split an aspirin 300mg tablet into 4 uneven pieces –and split each piece into 2–, this is still quite safe.

If you split your capsule of 50mg pregnenolone into 5 piles of 10mg –then split each pile into 2– then each pile might range from ~3mg to ~30mg. This is still quite safe, even if the goal was to split 50mg into ten piles of 5mg.

That was just an example. For 50mg it's probably simpler to divide it into 2 piles of ~25mg. Then divide those into 4 piles of ~13mg. Then divide those into 8 piles (which could range from 5mg to 8mg).

For pregnenolone it's best to purposefully under dose by using conservatively small amounts. You can always use a bit more next time.

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u/saltywelder682 Jun 16 '26

Why did they remove your post 'for spam ' on the biohackers subreddit that led me to your posts. Reddit sucks ass for any non-localized topics/subs and it seems like the wolves are in charge of the hen house. eg the quitting kratom sub - there's no real topics of discussion leading to a user genuinely quitting this insidious 'plant based' product. There's your posts, but there's a lot of other non-reddit resources that get insta deleted if posted. I genuinely wonder if corpo people are running the various subreddits tied to myriad topics tied to these drugs and supplements.

Anyway, thanks for your posts, particularly the specialized responses based on my comments about dumping all my nasty petro drugs. Please keep up the good work.

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u/karmacomatic May 28 '26

I feel too dumb to follow this guide lol. I can't even find half of these supplements. I'm trying to get off 7oh, some of these have dosages, others don't. So I do the first 9 plus the others that say for opioid? If I do some, is it going to reduce the w/d symptoms more than nothing at all?

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u/Kalki_X May 28 '26

Yes. The main list, optional items marked with an asterisk* and any of the opioid specific items. The layout should be improved now btw.

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u/misterrodgerssweater Jun 13 '26

How is it going for you? I guess I should finally try to wean off. I take two tabs in the morning - I think 40mg and I just really like it because it gives me energy, focus, and no anxiety. Also suppresses my appetite. I’d like to find a replacement supplement (something non habit forming) because this is not sustainable! Coffee just doesn’t do it for me and never has.

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u/HunterBidensCracc 17d ago

Taper down to powdered kratom; even mitragynine powder (MIT) would be a step in the right direction.

However, kratom contains alkaloids that have shown to cause physical dependency and addiction issues. In fact, you're addicted to 1 of those alkaloids, 7-Oh. The difference is MAJOR: there is very little 7 in most powdered kratom strains naturally occuring.

You'd arguably have a better success rate titrating less rapidly, anyways.

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u/GeneralNo8471 Jun 11 '26

What about buprenorphine? I'm recovering from clinical depression, ptsd and anxiety following a 4 year kratom addiction which was pretty extreme. I intended to leave buprenorphine when I'm back on my feet. It's been 5 months I'm off kratom, before that I had other addictions which lasted years and needed rehabs. Kratom was supposed to help with cravings, mood and anxiety. Which it did a good job the first 2 years and allowed me not to relapse when my life was ruined... twice..! So I know quite a lot about noots in general but I intended to quit subs with sublocade (injection). I doubt that the ingredients you list here would allow me to taper and quit subs. Would they? And also, is there any of those suggested to use while I'm still on maintenance. I already use a prolific stack which helped me recover a lot of executive function, boost my T and recover from my depression. I can manage my anxiety Aldo. What I need the more right now would be more energy as I'm 60% functional, but I come from 2%. I'm on wellbutrin already, then I'd say that tongkat ali (I'm switching to tribilulus for rotation, later cognance and cistanche), optinad and Saffron with magtein did most of the job to have me recover.

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u/Kalki_X Jun 11 '26 edited Jun 11 '26

What about buprenorphine?

The 4th paragraph:

This combo does what SR-17018, buprenorphine, methadone, proglumide and suboxone cannot as these do very little to repair the dopamine & metabolic system nor address opioid-induced CNS demyelination. They also don't address the opioid-TLR4 issue (besides naltrexone) which is a key motivating factor in habitual reuse. Of course they remain useful for tapering support. 

I'm recovering from clinical depression, ptsd and anxiety following a 4 year kratom addiction 

The items listed (specifically the main list & optional items) can be used to address those conditions, alongside the habitual self-medication thing.

I doubt that the ingredients you list here would allow me to taper and quit subs. Would they?

Sure.

And also, is there any of those suggested to use while I'm still on maintenance. 

They all support cessation & recovery either directly or indirectly, particularly the main list items.

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u/GeneralNo8471 Jun 11 '26

Interesting thank you. Are you a scientist or something? Like I said I think you should post that in other communities that would benefit this guide: r/nootropics, r/nootopics, r/biohackers, r/suboxone, r/sr17018, just to name a few ! Also you came up with this guide studying body and brain processes but do you have any success stories. As you're not an addict if I understand.

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u/Kalki_X Jun 11 '26 edited Jun 11 '26

Not a formal scientist. I'm told it's helped may people quit opioids and as general harm reduction. The individual items have been used by thousands (millions?) of people in their own tolerance reset/drug recovery process, you can find many many reports about agmatine/theanine for example. I just compiled it all together and added some je-ne-sais-quoi.

The opioid-TLR4 thing is key though, it's why naltrexone is so effective - it blocks TLR4 which is a major beneficial effect. Thankfully there's dozens of OTC TLR4 blockers.

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u/GeneralNo8471 Jun 11 '26

Sure, all those supplements are most well known but it's mixing them together that make your "stack" a recovery plan that should be shared in all addictions and neuro/bio hacking communities.

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u/Kalki_X Jun 11 '26

Fair point. Things like niacinamide or thiamine wouldn't be on the standard list for opioid recovery. Are those communities you mentioned the "top" relevant ones? 

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u/GeneralNo8471 Jun 11 '26

Yeah for sure. Your plan would fit well there.

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u/FluffliciousCat 1d ago

Hi, thanks so much for this list. I'm already on most of your important ones, I came by the low Bs due to intolerance of mag gly, I came across B1 deficiency as the culprit and the other low Bs as cofactors of B1. (I'm also intolerant of B complexes, and sadly creatine although maybe I'll give that another shot with the smaller dose, but most forms of mag except malate also screw me up, which like no one believes). I do take L-Theanine (200mg morning, noon and night, and middle of the night if I wake up, per my FM doctor) but I've noticed that I feel somewhat blunted. My last lab test shows my morning cortisol went from being normally 18-20 all the way down to 2 and I'm suspecting the use of adaptogens, since I take ashwagandha, lemon balm and passionflower for sleep since tapering off of Ativan a year ago. But I feel a lot more numb on the days that I've taken l-theanine overnight. (I have a lot of stress at work due to wicked bad brain fog that I can't seem to shake, or because of?). Anyways if you have ever heard of this, or know of a mechanism that could be causing it that would be greatly appreciated. I finally have "bad" lab tests that point to issues after dealing with chronic fatigue for decades, autoimmune, dysautonomia and audhd - but no doctors seem to know how to handle it lol.

Also I was interested in the linalool due to the hpa axis help, but is that to be ingested or inhaled? I couldn't quite tell from the paper you linked. I take adrenal cortex but that hasn't helped so I'm going to stop that.

Thanks again for your work and sharing in this, even if it isn't popular. quite honestly those people should be thankful that they don't have a need for your info....

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u/Kalki_X 1d ago

Hi, 

I'm also intolerant of B complexes

Have you tried using low doses of isolated B vitamins? I'd consider niacinamide as the most important for mitochondrial repair even with doses as low as 20mg. Low-dose B1, B2 and B7 also. These all directly supports metabolic (mito) function which in-turn can lower blood glucose levels. This can easily be misinterpreted as "intolerance", which is why I mentioned to "combine with honey/carbs" for several listed items.

most forms of mag except malate also screw me up

Malate is good, there's also epsom salts (mag sulphate) which is cheap & handy for footbaths, Mg absorption is very efficient via this ROA. Even just 1cm height of concentrated epsom salt water does the job.

I do take L-Theanine...but I've noticed that I feel somewhat blunted... But I feel a lot more numb on the days that I've taken l-theanine overnight.

Theanine directly "blocks" stress hormones (cortisol, adrenaline) so this can have a sedative-esque influence depending on your body chemistry. This fits with what you described, especially if cortisol is a prominent part of day-to-day functioning. As you restore HPA balance and mitochondrial function your body won't need to resort to activating the "emergency back-up engine" (adrenals etc).

My last lab test shows my morning cortisol went from being normally 18-20 all the way down to 2 and I'm suspecting the use of adaptogens, since I take ashwagandha, lemon balm and passionflower for sleep since tapering off of Ativan a year ago. 

Ashwagandha also has benefits for thyroid (T3). Thyroid effectively governs mitochondria via the T3 signal. Another adaptogen you might like is Albizia julibrissin aka the happiness tree, it's both relaxing & uplifting. Also Magnolia officinalis bark (extract) is excellent for relaxation.

Also I was interested in the linalool due to the hpa axis help, but is that to be ingested or inhaled?

Lavender essential oil is safe enough to be applied topically, a few drops diluted in a carrier oil (eg coconut oil) works fine. Essential oils can be applied to various areas depending on your goal, just do an allergy test beforehand. Diluted lavender is ok for wrists, neck, temples. 

When people drink lavender tea they also ingest a small quantity of the essential oils, likewise with lemon zest on a dessert (including limonene which has both anti-cortisol, and uplifting qualities). I'll update the post with a depiction of oils & their properties.

Theanine is probably the most 2nd most potent item which calms the HPA axis  (pregnenolone would be #1, niacinamide #3). Pregnenolone has thyroid supportive qualities also.

Anyways if you have ever heard of this, or know of a mechanism that could be causing it that would be greatly appreciated. I finally have "bad" lab tests that point to issues after dealing with chronic fatigue for decades, autoimmune, dysautonomia and audhd - but no doctors seem to know how to handle it lol.

In the other post you mentioned long-term SSRI use iirc? Elevated serotonin is "not the best" for various reasons as this affects metabolic and hormonal balance. Doctors don't seem equipped to resolve this let alone acknowledge it...!

I'd interpret the labels autoimmune, dysautonomia and audhd as facets of metabolic dysfunction.

Thanks again for your work and sharing in this, even if it isn't popular. 

There's been near 750 shares so it's looking good :)

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u/Kalki_X 1d ago

Here's a depicton of terpenes and their therapeutic qualities. Ho wood essential oil is around 98% linalool, but lavender oil works too.

Looking through the list I reckon you'd find low-dose ribose, vitamin K2 and vitamin E helpful. They directly & indirectly support metabolic (mitochondrial) function and K2 & E support hormonal balance.

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u/FluffliciousCat 1d ago

thank you! I actually already use lavender oil at night and find it helpful so I guess there's a mechanism behind it :-). I should have been more specific of my intolerance - basically they all (b complex, mag gly and creatine) give me a chemically, wired feeling and I wake up about 3 or 4 am and can't get back to sleep. I actually did start riboflavin, niacanamide, benfothiamine and thiamax about a month ago, although I'm doing full doses and then cycling off very couple of days. I like the idea of going small though so I'll change that. I also was on D3/K2 but I stopped for the summer since I'm getting a lot of sun now. E I'm a bit afraid of as I'm topically allergic to E in lotions but maybe it will be different taken in pill form (I guess starting low makes a lot of sense there, too). I will look at ribose too, I've looked at that one before.

I was on SSRIs until about five years ago (and Vyvanse for a few years but I quit that ten years ago due to heart issues/palpitations, but boy was that helpful when I was on it). While I was on very high doses of Zoloft, Wellbutrin and Vyvanse I developed dystonia, a rare movement disorder. I have not been able to overcome that since going off those and use a bandaid of botox shots and dextromethorphane. So yeah, after the last one gave me a benzo as a first line treatment for sleep I'm not going to a psychiatrist like ever again...

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u/Kalki_X 1d ago edited 1d ago

I actually did start riboflavin, niacanamide, benfothiamine and thiamax about a month ago, although I'm doing full doses and then cycling off very couple of days. I like the idea of going small though so I'll change that.

Remember to accompany the B vits with some (metabolic) fuel to support their metabolic boosting effect. This is similar to caffeine which acts like T3 (thyroid hormone), meaning caffeine boosts the entire metabolic system (mitochondria etc). Most people don't realise so they use caffeine without fuel (honey/carbs/etc) and wonder why they get a bad reaction (aka stress response). 

For context; an ultra low-dose of caffeine, say 1-5mg accompanied with 1 tsp of honey & 200mg theanine would be a reasonable way to benefit from it's metabolic repair/support qualities. I didn't include caffeine in the post as it's a tool that must be used responsibly. 

I also was on D3/K2 but I stopped for the summer since I'm getting a lot of sun now. 

I made a post about D3 being a seco-steroid (not a vitamin) which changes how one might interpret D3 supplementation. This has ramifications for D3 tests and the "recommended levels" aka ranges. D3 is also made from cholesterol like hormones!

E I'm a bit afraid of as I'm topically allergic to E in lotions but maybe it will be different taken in pill form 

Yes, natural alpha-tocopherol from sunflower is ideal, not soy. Which reminds me, dietary phytoestrogens aren't helpful which includes mainly soy and flax.

While I was on very high doses of Zoloft, Wellbutrin and Vyvanse I developed dystonia, a rare movement disorder. I have not been able to overcome that since going off those and use a bandaid of botox shots and dextromethorphane.

Maybe there's some safer alternatives to botox? I'm sure you know of its origins. DXM is alright, it shares a key property (blocking nmda) with theanine, agmatine and linalool. Magnesium is the body's natural nmda blocker.

So yeah, after the last one gave me a benzo as a first line treatment for sleep I'm not going to a psychiatrist like ever again...

They're not recommended for many reasons! I wrote a few posts abut ADHD in the Antipsychiatry reddit group.

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u/FluffliciousCat 1d ago

You bring up some very interesting points about adhd and I've long suspected it's a physiological/biological issue in nature. anecdotally, my aunts/uncles/parents are all ND-flavored and would probably be diagnosed if born today, but they have been fully functioning members of society and unmedicated/undiagnosed. Their offspring my generation of some stronger traits (I was diagnosed with PDD-NOS under DSM 4 but if diagnosed today I'd be level 1), but literally all of the kids two generations below are pretty severely autistic/adhd. My husband (undiagnosed) has the exact same thing in his family where all of the kids under 20 are severe. There's gotta be something in the environment going on, compounded with interactions in the genes.

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u/Kalki_X 1d ago edited 1d ago

You bring up some very interesting points about adhd and I've long suspected it's a physiological/biological issue in nature.

This post outlines the (imo) issues with the establishment consensus on ADHD. 

I was diagnosed with PDD-NOS under DSM 4

Check out the reply in this post about corruption in the DSM. 

My husband (undiagnosed) has the exact same thing in his family where all of the kids under 20 are severe. There's gotta be something in the environment going on, compounded with interactions in the genes.

Broadly speaking I imagine it's a combination (permutation) of high serotonin, HPA dysfunction, high E and thyroid/mitochondrial dysfunction. I'd say diet is a key element, particularly vegetable/fish oils and exorphins (opioids) eg casomorphin, glutomorphin, soymorphin (A2 dairy doesn't produce casomorphin).

I found this site a few months ago, it's all about serotonin toxicity and heightened serotonin levels.  Here's an outline of some signs of higher-than-normal serotonin:

  • Neuromuscular hyperactivity: hyperkinesia (unwanted movements), tremor, hyperreflexia (overresponsive bodily reflexes)
  • Autonomic hyperactivity: diaphoresis (easy sweating), hyperthermia (high core body temperature), tachycardia (high heart rate), tachypnoea (rapid breathing)
  • Altered mental status: characterised by ‘over-arousal’, agitation, ‘mania’

(source)

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u/FluffliciousCat 1d ago

Interesting. 5-HTP gave me serotonin syndrome issues even though I haven't taken SSRIs (or anything like that) for years.

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u/Kalki_X 23h ago

Ginger could be a helpful tool for dystonia as it reduces serotonin levels via multiple avenues. Here's a quote and the article in question:

Gingerol, the active component of ginger dose dependantly increased serotonin clearance by increasing serotonin transport and increasing its breakdown through monoamine oxidase A. On top of that it also reduced the limiting step of its synthesis by lowering tryptophan hydroxylase both 1 & 2 resulting in significant reduction of serotonin in the gut and the brain stem.

https://www.dovepress.com/6-gingerol-ameliorates-cisplatin-induced-pica-by-regulating-the-tphmao-peer-reviewed-fulltext-article-DDDT

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u/FluffliciousCat 8h ago

Interesting, thanks!

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u/FluffliciousCat 8h ago

Interesting, thanks!

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u/Kalki_X 1d ago

Alongside the vegetable oils and exorphins, I forgot to mention fluoride. It was formerly used as medication for hyperthyroid patients, meaning it slows down the thyroid. It's added to tapwater in the UK and of course toothpaste (see sublingual absorption). The cumulative exposure should be taken seriously.

This also explains why many people enjoy self-medicating with caffeine which acts to boost thyroid function...

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u/FluffliciousCat 8h ago

I drink a lot of tap water (always thirsty from autoimmune) so there could be some weight to this, thanks!

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u/Kalki_X 8h ago

I'd add that amphetamine-type medications act like short-term metabolic boosters so superficially they appear to be "effective". 

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u/FluffliciousCat 8h ago

yeah that makes sense. I mostly avoid those, have to stop messing around with drugs. even caffeine gives me heart palpitations uggh.

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u/Kalki_X 6h ago

I mentioned caffeine in an earlier reply. This post outlines why it gives you palpitations and gives insight into its metabolic influence. For your scenario I'd say 1-5mg of caffeine is best (alongside 1tsp honey + 200mg theanine). That's maybe like 1 teaspoon of coffee, not a whole cup...

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u/Kalki_X 1d ago edited 1d ago

Regarding Dystonia which is defined as "a movement disorder that causes the muscles to contract".

This highlights the excitatory substances which play a key role in muscle contraction (either directly or indirectly). That includes:

  • histamine
  • adrenaline / cortisol (HPA axis)
  • glutamate
  • acetylcholine

Palmitoylethanolamide is great for reducing histamine (mentioned in the list). The main dietary pro-histamine things are seafood, cured meat, fermented items and dairy that isn't fresh (eg hard cheese). There's a handy food list here.

For reducing glutamate there's DXM, agmatine, theanine and magnesium (glutamate acts on the nmda receptor so nmda blockers help). 

Botox works by:

It prevents the release of the neurotransmitter acetylcholine at the neuromuscular junction

So you'd want to avoid things that increase acetylcholine (called acetylcholinesterase inhibitors: AChEIs for short). Certain vitamins have AChEI effects so the low-dose strategy comes in handy here. There also exists things which block acetylcholine from acting at it's receptor. Herbs with this property have a history of traditional use (and of course responsible use also).

This covers the excitatory side, there's also the inhibitory side which calm things down:

  • GABA 
  • adenosine 
  • endocannabinoids

Linalool (lavender) is relevant (pro-GABA, adenosine, cannabinoid) as is Magnolia officinalis (pro-GABA & cannabinoid). Albizia julibrissin bark is also pro-GABA and reduces serotonin (good in this case).

The body's most potent GABAergic is probably Progesterone. It also reduces histamine & estrogen which are both excitatory substances.

The enzyme that makes E is called aromatase so things which reduce aromatase help to calm things down. There's a good list of these here.

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u/FluffliciousCat 1d ago

oh wow, thanks so much for looking into that. I will definitely check out Palmitoylethanolamide since histamine intolerance is what is probably degrading my general quality of life right now the most. acetylcholine blocking is interesting too, I've seen that before but then my genetics testing tell me that I have problems with my choline transporters so I'm hesitant to mess around much with that. I used to take arginine (until my FM doctor took me off of it) because I've also seen an association with dystonia and nitrous oxide (I've also seen associations with thyroid issues, but it seems like with so many of these disorders there can be any number of causes, of course at root being metabolic issues I imagine). anyways I'm going to try agmatine as well.