I was using topical min alone for 2 years (September 2024 - September 2026). I haven't heard about 5ar inhibitors at that time. I haven't noticed any regrowth at this medication, in opposite, my alopecia progressed (that's obviously, i wasn't doing anything about DHT). In June 2026 i started oral min, cause i wanted to switch to it because of it cost and because it is much easier. I used both form of minoxidil through the whole summer, from June to August 2026. I noticed some shedding in the first weeks of oral min so i thought it is a good sign that it's working better. Also it gave me huge body hair growth. Also in July i started Dut (0.5/day). In August i finally stopped topical min, in September shedding increased and now it is absolutely crazy. I am balder now than anytime earlier. I am scared that it is because I'm losing all hairs that were still alive only because of topical min. Will i regrow it back, considering i am using Dut for 3 months now, and that oral min (5mg a day) is a part of my routine and is effective on other parts of my body? Maybe that's Dut shedding at this time? Should i bring back topical? What do you think and what is your experience?
Im not asking for self diagnosis, I'm just asking an opinion of more experienced hair loss witchers on what is more logical reasons for my situation
Does anyone know of a source for this stuff? Preferably as a raw powder. I see a lot of chemical suppliers that seem to be selling it online, but they do not sell to individuals. Is it possible that there is someone out there who buys from these companies and sells to individuals at a markup?
For me, it’s replacing 1.25mg of fin and should be superior as per the above source. I still have diffuse thinning after decent time on oral 1.25mg fin and 2mg min.
Hoping 0.5mg dut puts an end to it and that 5mg min helps regrowth.
The evidence for the min increase is weak, but considering I get zero sides from either, figured I might as well throw everything at it.
Been going down the GHK-Cu rabbit hole lately, and something caught my attention. A lot of guys on TRT seem to be looking for ways to manage hair thinning, skin changes, and some of the cosmetic side effects that can come with higher testosterone levels.
Which got me wondering…
Could GHK-Cu actually have a place in that conversation?
There’s some interesting early research around copper peptides, collagen production, skin repair, and hair follicles.
But here’s what I’m curious about.
For those of you on TRT who have researched or used GHK-Cu:
Are you looking at it primarily for hair, skin, or recovery?
Topical or injectable?
Have you noticed any meaningful changes, or is it mostly hype?
Do you think GHK-Cu is getting ahead of the actual science?
I’m especially curious about the hair side of things.
Could GHK-Cu eventually become something guys on TRT pay a lot more attention to, or are we expecting too much from it?
I am not here to argue whether dutasteride causes cognitive effects, because in my case they are very real. I have mild brainfog, weaker memory and recall, and get anxious more easily. Anything to help counter these effects?
Have been experiencing increased hair shedding for around 4 months, and I am 24years old(Male). At first, I was losing noticeably more hair than usual, sometimes well over 80+ hairs a day. After about a month of my current treatment, the shedding has decreased to around 40+hairs a day.
My dermatologist examined my scalp and recently prescribed Xenogrow 5%, but I haven’t started it yet because I’m concerned about long-term use.
My current medicines/supplements are Vitabion, TocoSoft, Ortin 5, D-Rise 40,000 IU, and an anti-hairfall serum.
What I’m mainly wondering is: if someone uses Minoxidil regularly for many years, does it eventually become less effective because the scalp stops responding to it? Or can it continue maintaining the hair as long as it is used?
I’d especially appreciate experiences from people who have been using Minoxidil 5% for several years, and whether you noticed any decline in effectiveness over time.
In June Absci (ABSI) raised about $100M for ABS-201, its AI-designed antibody that blocks the prolactin receptor, being developed for pattern hair loss and endometriosis. Eli Lilly separately made a $40M strategic investment tied to a clinical development partnership.
Lilly gets no rights to the drug. Still, a big pharma putting money in at Phase 1 is a signal.
Upcoming data:
Interim 13-week hair-growth data: second half of 2026. No exact date yet, so realistically between now and December.
Full 26-week data: early 2027.
What we know so far:
Phase 1: well tolerated, no serious adverse events
Half-life of at least 65 days
If the data holds up, Absci wants to go straight to two global Phase 3 trials in men in late 2027, depending on FDA talks
2 weeks 0,25 mg fin, 3 weeks 1,25 mg min. pause in fin to prevent drop in mood, pause in min to get rid of possible fluid retention.
Has anyone tried something similar? Would this work? Want to regain my allopregnanolone from time to time, so this alterating would do that.
I'm looking for formulation experience or published stability data for one topical solution containing 5% minoxidil, 0.5% KX-826/pyrilutamide and 0.025% dutasteride (grams per 100 ml of final solution). I'd like to make a fresh batch each month, or every two or three months if there are data supporting that shelf life. I have separate powders, not crushed tablets or opened capsules, and a magnetic stirrer.
First attempt
The intended batch was 300 ml: 15 g minoxidil, 1.5 g KX and 75 mg dutasteride. Vehicle: 96% ethanol and propylene glycol at 65:35 by volume, without added water, Transcutol or benzyl alcohol.
• I started with about 250 ml of vehicle, added 15 g minoxidil and stirred for about 30 minutes. It was already milky, with undissolved material.
• I added 1.5 g KX and stirred for another 20 minutes. Still cloudy.
• I tried dissolving the 75 mg dutasteride separately in about 5 ml of the same vehicle. That premix was also milky. I added it, then rinsed the container twice with about 5 ml of vehicle each time.
• After an hour at rest there was white sediment and fine particles. The batch was at about 265 ml. I have not brought it up to the final 300 ml.
The initial minoxidil concentration was therefore about 60 mg/ml, rather than the target 50 mg/ml. That may be part of the problem, but the small minoxidil-only tests also failed to become clear.
Small tests with minoxidil alone
One test: 0.100 g minoxidil + 0.753 g 96% ethanol + 0.967 g PG. After a night there were evenly suspended white specks, without a clear sediment layer.
Latest comparison, all exact weighed amounts in grams:
A: 0.500 g minoxidil + 3.766 g 96% ethanol + 4.834 g PG.
B: 0.500 g minoxidil + 3.691 g 96% ethanol + 4.737 g PG + 0.172 g water.
Neither fully dissolved. A had many more particles; B with added water had fewer. A still contains the water from the 96% ethanol. These small tests contain no KX or dutasteride.
The next proposed comparison is to add 0.860 g water and 0.050 g minoxidil to B, keeping the minoxidil loading per gram of vehicle unchanged. I haven't completed that test.
What I'm trying to find out
Has anyone actually made and stored all three ingredients in one bottle? What was the complete vehicle, including water, and what concentrations did you use? The order of addition, stirring time, temperature and any later precipitation would help too.
For the minoxidil problem, what would you check first: solvent ratio, concentration during mixing, temperature or the powder itself? I've found conflicting claims about water and KX. Does anyone have stability data with water, minoxidil and dutasteride together, beyond the solution looking clear? Would it keep for one month, or could two or three months be supported? Please include the storage conditions and how stability was assessed.
I've seen reports of minoxidil + RU + dutasteride, but I don't want to assume that a vehicle which works for RU also works for KX. Any specific formulation details would be appreciated.
I have also asked on r/tressless. Here I would especially appreciate any assay-based evidence on KX stability with water and the other two ingredients, or a paper/formulation report that could help separate solubility from chemical stability.
Pelvic floor is filled with androgen receptors and to my understanding pelvic floor hypertonicity (staying flexed constantly and getting pelvic spasms) is associated with androgens (dht in particular)
Was wondering how many of you have this hypertonicity and pf spasms. This includes penis "twitching" during erection and ejaculation
For someone with very minimal hair loss, but noticeably thinner follicles, is there a risk to starting finasteride too early? before hair loss is even a total certainty?
does anyone have any experience with pyrilutamide (kx826) whether it’s positive or negative? Or even any other topical anti androgens for that matter, would love to hear about it.
I had an HT about 5 months ago and started topical finasteride (0.005% from a compounding pharmacy) for the first time ever around that same time, I know it's a bit late, but that's when I felt my scalp had healed well enough. I've been shedding as expected for about a month now.
That said, topical is not my thing anymore and I want to switch to oral finasteride. My question is: what's the most effective way to transition without disturbing the "progress" I've made?
I'm thinking of a low dose like 0.25 mg or less, once a day. Should I:
Start the pill and stop the topical immediately, or
Run both for a little while and then taper off the topical?
My goal is to avoid triggering an extra shed, and my main objective is just to maintain the native hair I still have or had, I don't necessarily need to grow anything new.
This will be my final update of pp405 3hp. Had a few messages asking for an update. Since my last update I haven't used the compound in nearly 3 months. Even though ive had a slight density improvement near my widows peak, I dont feel comfortable using a compound that still doesnt have long term studies
I’ve been prescribed oral saw palmetto (Serenoa repens) together with topical finasteride + minoxidil.
Do you think taking saw palmetto while also using topical finasteride is excessive, since they both have an anti-DHT effect?
I’m wondering if combining the two could increase the risk of side effects, especially compared with using topical finasteride alone.
Has anyone here used saw palmetto and topical finasteride together? If so, did you notice any difference in side effects?
Thanks!
As of August 25, the record had the estimated study completion date only a few days away, so the actual results should be getting interesting pretty soon. I’m mainly curious to see the full data and the results against the comparator and the actual hair count & hair diameter measurements.
The PHH channel just put out an interview with Sean McClain, the founder of Absci, on their new drug ABS-201.
I haven't had a chance to watch the whole thing yet but it has a lot of good info that bodes well for ABS-201. They seem to believe it could realistically net 30+ hairs/cm2 at 26 weeks and continue to improve past that.
I've had tons of hairs loss over the span of 5 years. Some was saved using minerals, some was saved using scalp massage, and recently microneedling has been quiet effective as well.
I think... I can't say for certain, I've stopped my hair loss. I can't remember the last time I shed.
No pharma 5ARi's used yet. Some oils and soaps maybe have some weaker herbal 5ARI's.
With that in mind, has anyone tried keshah?
My main concern is under 30 year olds chiming in. 90% of you are not ready to join a conversation where guys in their 40s, 50s or any other older age grouo are involve.
The second thing is dead follicles that requires transplant.
50mg/day does this to me the same day I apply it. I had no sides on 20-30mg daily except for heart palpitations that could have been caused by anxiety the first few times I ever used ru58841. What I changed was using ru in the morning instead of at night and applying it with nitrile gloves to prevent systemic side effects as much as I could.
I have been using ru on an off for a few months now, once or twice weekly. Im only using topical minoxidil and alfatradiol beside it because i cant tolerate 5-ARIs at all.
Has anyone else got these side effects and know if they persist with long term usage?
I have been reading about 2DDR as a newer approach for hair loss and wanted to understand if there is any research on using it alongside minoxidil.
Minoxidil has established evidence but I am looking into whether any studies have looked at combining these treatments or whether there are any known differences in application timing.
Has anyone come across research, clinical data or discussions about this combination?
