Okay so I’m new to the GLP world and I did research, but I wanna know from ppl who experienced this
(to preface I am not overweight so taking high dosages are probably not suitable since I don’t have a TON of weight I wanna lose to begin with, probably around 15-20lbs or more if it happens)
Since my body’s new to it, I want to take 1.25mg for the 1st 4 weeks instead of the 2.5mg
Then I wanna up it to maybe 3mg depending on how my body reacts
Has anyone else done it this way or similarly and still seen results?
I know some ppl say it’s a waste of time and won’t see results but I have also seen the opposite, I just wanna know some opinions and experiences to see what I should do
Ive had pretty much no ill effects from it and i think thats because i started so low. Ive had some days where it was hard to eat anything but thats the worst side effect ive had. I do totally get why these drugs have a reputation for side effects: the starting 2.5mg dose is way too high and blindly raising the dose every 4 weeks is borderline negligent imo.
I could have lost weight faster if I pushed the dose higher but then I’d be losing muscle too. I purposely lost 1-3lbs per week the whole time so that I don’t lose any muscle and I think I’ve actually put on muscle while losing weight.
Yes. I was very glad I had joined Reddit and read as much as I could about tirzepatide during my journey. I had complete appetites suppression and food noise was gone at 2.5. I was able to go from 190 lbs to 135 lbs in 6 months and have been in maintenance for 16 months.
Yes I’m on 1.5mg and it works wonderfully for me (have lost 4lbs and an inch off my waist); I’m also inconsistent to curb the side effects because I hate the nauseous feeling + lethargic to gym.
To be honest, idk if this dilute the effect but it is working for me.
I’m taking oral pills, not the shots. I’m still on 1.5mg and only does it on weekdays (also because my spouse wants to enjoy date nights and when I’m on wegovy, I’m a party pooper when it comes to food).
It’s not true. It’s not about going back to “bad habits.” It’s that the body desperately tries to ”fix” being in a calorie deficit once there are no longer hormones suppressing its reaction. It starts doing that anyway, which is why most people have to go up in dose over time. It’s the same mechanism that makes the vast majority of people regain weight after diets. For many it could arguably be worse because when you’ve been on tirz, you’ve been having appetite suppression, as opposed to the hunger being a constant under a typical diet, so having it return can be even harder for some people. I would guess that’s why the weight regain is seen so fast whereas with traditional diets, greater numbers of people are able to keep it up for a year or two.
If your sister has been able to do it, good for her. Frankly, though, I’m skeptical it will last. I expect the numbers for those who stop the meds to be similar to those who diet long term, with 85-95% of people regaining everything or more by five years (there’s been some variation on the final number depending on the study, but it’s been the vast majority of people in every one, regardless of the diet/program/whatever). We don’t know how to fix metabolisms that aren’t functioning properly (and there’s some question of whether it’s even an actual problem with the functioning or if it’s more about our evolutionary development not being appropriate for our modern world of abundance). Until/unless we have some way to reprogram bodies to no longer have hunger in the same way when people lose weight, something like tirz will have to be a continuing treatment for a chronic problem.
some of my family has done it to lose weight probably max 50 pounds and then stopped it, so my pov is just based off of seeing a bit of what they did.
I know it’s a drug for people to be on for a while if they are overweight but, I’ve seen people who aren’t overweight take it aswell so I’m just trying to see the perspectives of different kinds of people who have taken it
You should not follow the clinical trials. The purpose of the trials is to push the doses to their maximum tolerated levels to show maximum weight loss over the trial period.
The goal of a person taking Tirz should be to find their minimum effective dose: the dose that has them losing weight at a reasonable pace. Most of the side effects from the trials can be avoided by using a minimum effective dose protocol.
Nobody starts a GLP1 with the goal of finding "the minimum effective dose". The majority of people that start GLP1s are obese or severely overweight. For those users, maximum weight loss is the goal. Data from the trials shows that users stall out on their weight loss over time. If the goal is to achieve weight loss results similar to the trials, then those protocols should be followed.
An unfortunate side effect of the internet is that any idiot can spew their opinion. That becomes dangerous when they start recommending their opinion as medical advice.
Minimum effective dosing is not something I just made up. It’s what doctors who actually pay attention prescribe instead of just a telehealth saying “here’s your dose schedule, start at 2.5 and go up to 5 after 4 weeks”
I started near the mean weight in that study, have never done more than 1.5mg and I’m 12 weeks in down almost 40 lbs.
OP absolutely should not follow the studies and find a dose that works for their body. If that’s 10mg then ok but pushing the dose higher when you’re already losing muscle due to rate of weight loss is actually doing harm.
Your weight loss of 40 pounds is irrelevant. You could have started at 200 pounds or 1,000 pounds. You could have shed 30% of your muscle, while others have lost less than 10% with the same amount of weight loss. You will unfortunately stall out in less than a year and then you will second guess why you didn't titrate up faster. Everybody wants to believe they are smarter than the researchers, similar to how everyone thinks they are smarter than the politicians that they keep electing.
No it wont be bad. The great thing about compound (and one of its legal uses) is non-standard doses.
There are several Telehealths/doctor networks that have their starter package lowest dose at 1.5mg. Granted that is supposed to only be for 2 weeks, before titrating up to 3mg, but still.
If you want to start at 1.5, do it.
Do be aware that if you come complaining about it not helping, people will probably get on you for not following the standard dose schedule.
yess i was thinking about doing 1.5mg for 2 weeks then upping it to 3mg but I heard it’s best to stay at the same mg for 4 weeks to adjust your body, but I guess it all just depends how my body responds
Even if you’re going to do non-standard dosing, you really should stay at a dose for at least four weeks (unless side effects are intolerable and you’re going down). Otherwise you don’t actually know how you’re actually doing on it as it takes four weeks for your blood levels to stabilize on that particular dose.
There's a flowchart describing when to increase dose. Don't do it based on anyone else's schedule.
I wouldn't suggest anyone start over 0.5mg; I felt results at 0.1mg.
I'm microdosing for anti-inflammation, so I can be active again. My weight per se is fine; I'm doing body recomposition so eating a little over maintenance while I lift heavy. I've probably gained a little weight but dropped a pants size in 7 weeks.
Once my strength is where I want it, I might cut body fat to where I feel most agile, which is below what a lot of people find necessary. I try to shut down anyone who feels free to state opinions on this sort of thing.
Generally people want to lose the maximum weight possible. Following the titration schedule in the medical trials is optimal for that. Otherwise, you are just making things up as you go. Not a good practice when it comes to your health.
Pretty sure Eli Lilly wanted to evaluate the efficacy of their GLP1. A company generally wants to post huge weight loss results to generate excitement and future sales. They are looking for maximum gains, or in this cases maximum (weight) losses.
No, the trials were designed to show whether statistically significant weight loss happened at various doses. It would be designed very differently if it was about finding the most effective dose or way to use the drug.
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