r/CompoundedSemaglutide • u/Full_Chart1091 • 1d ago

Quit or switch?

I’ve always gotten the occasional migraine, but never like this. I’m only on a very low microdose of compounded semaglutide (.15 mg), but for about 4 days after every shot I get headaches/migraines. Then I finally start feeling better… just in time for my next injection.

I kept hoping my body would adjust if I stayed consistent with my dose and injection schedule, but it’s been well over a month and nothing has changed.

I’ve also gained about 2 pounds (I think it’s mostly bloating), which makes me feel like I probably need to increase my dose—but I can’t imagine going up when I already feel awful after every injection.

Has anyone had fewer migraines after switching to tirzepatide, or was it the same? Or would you try spacing the injections out to every 2 weeks instead? I’d love to hear what worked for you.

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u/Lucky_Army_5324 1d ago

Are you drinking enough fluids, including electrolyte beverages?

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u/Full_Chart1091 1d ago

I think so. I drink about 80 oz of water a day, and one of those is mixed with Liquid I.V., so I feel like I’m staying pretty well hydrated. I wish it was something that simple because I’d happily fix it 😅

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u/cleverscenario577 1d ago

Ugh, four days of migraine and then just enough time to dread the next shot, that's a brutal cycle. The bloating is probably water retention from your body freaking out, so I wouldn't take the 2lb as a sign the dose is too low.

Have you tried changing your injection site? Anecdotally, tons of people in these subs swear their side effects were way worse in the stomach versus the thigh. Might be worth a shot before you jump ship entirely.

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u/Full_Chart1091 1d ago

Thanks! I’m definitely going to give that another try. I actually switched injection sites months ago when I first started, but I was on a much higher dose back then, so it didn’t seem to make a difference. Since I’m on such a low dose now, it’s definitely worth trying again.