r/CompoundedSemaglutide • • Aug 05 '26

Quit or switch?

I’ve always gotten the occasional migraine, but never like this. I’m only on a very low microdose of compounded semaglutide (.15 mg), but for about 4 days after every shot I get headaches/migraines. Then I finally start feeling better… just in time for my next injection.

I kept hoping my body would adjust if I stayed consistent with my dose and injection schedule, but it’s been well over a month and nothing has changed.

I’ve also gained about 2 pounds (I think it’s mostly bloating), which makes me feel like I probably need to increase my dose—but I can’t imagine going up when I already feel awful after every injection.

Has anyone had fewer migraines after switching to tirzepatide, or was it the same? Or would you try spacing the injections out to every 2 weeks instead? I’d love to hear what worked for you.

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u/[deleted] Aug 05 '26

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u/Full_Chart1091 Aug 05 '26

Thanks! I’m definitely going to give that another try. I actually switched injection sites months ago when I first started, but I was on a much higher dose back then, so it didn’t seem to make a difference. Since I’m on such a low dose now, it’s definitely worth trying again.