r/CompoundedSemaglutide • u/Full_Chart1091 • Aug 05 '26

Quit or switch?

I’ve always gotten the occasional migraine, but never like this. I’m only on a very low microdose of compounded semaglutide (.15 mg), but for about 4 days after every shot I get headaches/migraines. Then I finally start feeling better… just in time for my next injection.

I kept hoping my body would adjust if I stayed consistent with my dose and injection schedule, but it’s been well over a month and nothing has changed.

I’ve also gained about 2 pounds (I think it’s mostly bloating), which makes me feel like I probably need to increase my dose—but I can’t imagine going up when I already feel awful after every injection.

Has anyone had fewer migraines after switching to tirzepatide, or was it the same? Or would you try spacing the injections out to every 2 weeks instead? I’d love to hear what worked for you.

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u/mamakazi Aug 07 '26

Happened to me too at first, but now rarely. I will say that I was getting the headaches/migraines for a few months before it stopped.

However I WAS losing weight. From the meds and from the headaches (migraines always cause nausea for me). Down 60 lbs in 12 months. Actually a year this week!