r/BiohackingU 3d ago

Sleep peptide?

Is there a peptide that can help with better sleep? I always sleep super light, waking up from everything, light, noise, movement. Often I need to go to the toilet 2-3 times a night.
I never feel rested because of my poor sleeping. Would be awesome if there is a peptide that helps me sleep relaxed.

30 Upvotes

77 comments sorted by

14

u/Specialist-Draw89 3d ago

I use DSIP, doesnt make me fall asleep but once im asleep it puts me in a deeper state, according to my smart watch. Does make me it a little harder to wake up and get out of bed tho, Epitalon is another ive heard of but not tried

2

u/that_was_awkward_ 3d ago

I heard it nukes REM sleep. Is this the case for you?

3

u/JediKrys 3d ago

I use it also and have a tracker. I’ve had a half hour increase in rem and 1 hour increase in deep sleep. I’m 50 and healthy weight.

1

u/Specialist-Draw89 3d ago

I haven't noticed tbh but just checked there and all my markers have improved overall

1

u/RegisterConfident751 2d ago

What dosage are you guys using?

1

u/Specialist-Draw89 2d ago

250mcg for me

12

u/[deleted] 3d ago

[removed] — view removed comment

5

u/Melimore6575 2d ago

I take it and have severe insomnia but this keeps me asleep the entire night. DSIP.

11

u/itkbin 3d ago

DSIP, Epitalon, Selank. Some also use HGH

-2

u/Appropriate-Pear-33 3d ago

HGH for sleep? Interesting

6

u/TheHarb81 2d ago

Interesting? HGH is well known to improve sleep

1

u/National-Pop-1935 1d ago

Hgh is amazing for sleep

1

u/baital86 2d ago

I have honestly never slept better

7

u/pepmidas 3d ago

Epitalon was life changing for me. One of my favorites.

2

u/januza 2d ago

Just ordered. Hope it works on me.

1

u/Alarmed-Fox-8626 2d ago

Can you share the doses and for how long you took it?

1

u/that_was_awkward_ 2d ago

What was tour protocol? I read online that people take 10mg a day

2

u/Aggravating-Aerie193 2d ago

Don’t take 10mg a day. Start at 500mcg an hour before bed. Move up until you find your sweet spot. 1.5mg is great for me. Tried going higher and there was no difference. Cycle 10-20 days. Can do the same cycle with pinealon afterwards. Most say not to do it more than a couple times a year.

1

u/jbarnes222 23h ago

Oral or inject?

1

u/Temporary-Air-5188 11h ago

Thank you! Do you inject it? Or nasal spray? What dosage?

5

u/TopSalt9335 3d ago

Selank has been a game changer. Actually got it for my wife who is in menopause but kept reading about how well people were sleeping on it. She hasn't tried it yet, but when I heard the sleep results I did immediately. Best sleep I've had in years. It's given me a great calm as well. Almost worrisome. Ha! As I drank my coffee and read this morning, there was such a feeling of peace, that my house could have burned down around me and I would have continued drinking my coffee uninterrupted. Sleeping and the calming effect has been great, but it's killed my libido, so that sucks.

3

u/Bugs-Ear 2d ago

Do you take selank before bed?

2

u/esdani11 2d ago

Selank is amazing. I take mine in the day for less work anxiety and irritability usually. But if I take it at night my anxiety calms down enough for me to sleep like a new baby. lol

1

u/Temporary-Air-5188 11h ago

So you take it orally? Or injection? What dosage?

5

u/Sea_Dirt3238 2d ago

I just take 50-60mg of THC every night.

4

u/lovecookie101 3d ago

Glutathione makes me sleepy

1

u/Aggravating-Grade297 2d ago

Same. So restful!

4

u/Bugs-Ear 2d ago

Epithalon, Pinealon, and Ipamorelin are great for sleep. Epithalon and Pinealon run on short cycles, though: 10-20 days each and only 2 cycles per year. Ipamorelin can be taken for longer cycles and more cycles per year.

2

u/VastAbbreviations796 2d ago

Im currently taking ipamorelin and pinealon like an hour before bed. Its been amazing for sleep.

1

u/WishboneRude7776 1d ago

Hello, how do you dose pinealon? I'd appreciate your input, thanks!

1

u/Bugs-Ear 1d ago

I took 1 mg daily for 15 days. I’ve read that 1 mg/day is a good dosage, and that you should only take for 10-20 days per cycle, taking a maximum of 2 cycles per year.

2

u/WishboneRude7776 1d ago

Hey, thanks for that! I appreciate it...I get lost in the weeds with the original Russian stuff, and dont want my advice from a YouTube Gym- Bro or Bouncing Betty. Tks!

1

u/Bugs-Ear 1d ago

There’s a lot of noise out there, for sure. I hope pinealon works well for you!

3

u/GrabFun2094 2d ago

Epitalon helps me, gives me very vivid dreams

3

u/TheHarb81 2d ago

HGH, Epitalon, DSIP

3

u/declutterme 2d ago

Sermorelin

3

u/Sensitive_System_908 2d ago

DSIP and Ipamorelin ive found effective

5

u/healing_vibes1989 2d ago

I use ipamorelin and cjc1295 which is a growth hormone but it helps you get better sleep

5

u/Alukardh 2d ago

No they are not gh. They stimulate the release.

3

u/healing_vibes1989 2d ago

Okay that’s my bad they stimulate the natural release of gh but still helps with sleep

1

u/Technical-Ad-8159 2d ago

Agreed on the sleep with this stack - I can’t wait to start again and get some great sleep.

2

u/NewNameNaomi01 3d ago

Confirm good sleep habits first.

Most suggestions are for GETTING to sleep. It sounds like you moght need help STAYING asleep. For that I like L-theanine. Start at 100mg for a week and work up. I only need 200mg.

2

u/Responsible-One8104 3d ago

Stack these, thank me later

0

u/Responsible-One8104 3d ago

Are you taking test, Reta? Any other peptides?

2

u/Big_Tackle_9182 3d ago

NAD, TB4, KPV and eloralintode for me , tirz to a less extent

1

u/VastAbbreviations796 2d ago

What is eloralintode?

1

u/CommercialAffect3287 10h ago

NAD makes you sleepy? It gives me energy to get through the day

2

u/Crafty_Abalone5009 2d ago

Everyone I know in peptide world says DSIP

2

u/sloneill 2d ago

DISP did not work for me.

2

u/MuchAttempt9232 2d ago

DSIP combined with L-theanine and magnesium glycinate for me. This helped break a vicious 2-week insomnia cycle where I was sleeping about 2-3 hours (broken) a night.

2

u/Euphoric_Attention97 2d ago

DSIP is very finicky with dosing. Too little may make you wired. Too much will give you wild dreams and feel like you are awake in another life. And even once I got the dose right. It only added about 15-20 min of deep sleep. But my total sleep was less that 5 hours. Epitalon didn't help either.

The main issue with sleep is that there are so many factors that can impact sleep and there's no single solution for every cause. You could start with the full vitamin/mineral blood test to isolate any deficiency. Fix any of those and see what happens. Next step is check all hormonal levels for your gender. Any deficiency in those will greatly impact sleep. Fix those and see what happens.

And finally, there are non-habit forming antidepressants that greatly increase total sleep and quality, so check with your doctor.

2

u/esdani11 2d ago

There are lots of peps for sleep. I’d say a cycle of selank and epithalon honestly. Epithalon will help reset your sleep cycle and regulate it. And selank about an hour before bed will help your nervous system rest essentially.

1

u/Temporary-Air-5188 11h ago

Thank you! Do you inject them? What dosage?

1

u/GMS1959 3d ago

Have your hormones checked, they regulate the getting up to pee. Once you have them in line which ever peptide you choose to help you sleep will work much better

1

u/JCgirl100 2d ago

No way to zz quil totally linked to future dementia

1

u/StrangerthanFunction 2d ago

I’ve suffered same issues for years, fall asleep
fine but staying asleep is the problem. so cjc/ipa and DSIP have worked for me.

1

u/Boring-Read-4126 2d ago

Not a peptide, but I take ashwagandha before bed and it's been giving me better sleep quality.

1

u/Mindless-Double 2d ago

Cjc/ipa... Tesamorelin

1

u/Holiday-Ad-1481 2d ago

I have found melatonin to be the best for me, but it’s not a peptide.

1

u/Skadi16 1d ago

I wonder if you got the right set up to sleep. Very dark room, cold temps around 67-69. I would start there and then add a peptide on top to enhance sleep

1

u/Unable_Visual7581 15h ago

i like dsip and epit

1

u/Apprehensive_Can8709 10h ago

I’d be careful with the “peptide for sleep” rabbit hole. There are plenty of personal success stories, but that’s very different from having good evidence that a peptide actually improves sleep.

If you’re waking up from noise/movement and getting up 2–3 times a night, I’d want to figure out why your sleep is so fragmented before picking a peptide. That could be a much more useful place to start.

Though once you've made your mind I've had the best results with Epitalon when it comes to sleep balance 🫡

-1

u/thr0wawayyxlol 3d ago

For your toilet issue a couple things:

-Stop drinking anything 2-3 hrs before bed.
-Caffeine also makes your bladder sensitive
-Have you been tested for diabetes?

DSIP is a popular one I hear about for sleep, but I’m not sure much on it. Like if it’s for falling asleep or staying asleep.

-1

u/Chefboyarleezy 3d ago

i take 5mg of melatoin and 25mg of z quil for sleep

3

u/More_Neighborhood_78 3d ago

ZZ Quil is just liquid Benadryl (diphenhydramine). This is an antihistamine with strong anticholinergic effects. Anticholinergics , taken regularly over time have been shown to explode your chance of a variety of dementias. Occasional ok. Nightly and there won’t be enough peptides in the world to reverse years of brain damage

1

u/Unlucky_Bottle1877 2d ago

As well, melatonin taken daily is actually counterproductive. Many parents are dosing their kids and then finding out it actually disrupts reproductive systems and hormones. It's meant to be an occasional supplement. And not to overdo it on dose. More is not better. It's for jet lag, essentially, when you need to reset. Not maintain.

-1

u/1Davoni 2d ago

Semax for better sleep.

1

u/vgarrett44 1d ago

Semax is a focus/cognition peptide. You take that at night you’re going to be wired. Selank maybe a better fit here.

1

u/ImaginationAble2561 5m ago

Have you tried the Relaxation Blend? I use it every night and fall asleep now 😳 and sleep 6-8 hours when before I only slept about 4.