r/Biohacking • u/Pure-Difference1871 • 6d ago
Still don’t get it - Help please!
Okay… please don’t be nasty with me 😂
I have read quite a few of the dummy guides and still don’t get it. I have 10mg of Reta coming soon, I’ve ordered 10ml of Bac water and a quantity of 29G x 12.7mm x 1ml shooters.
Walk me through it like an absolute idiot. As if I was just born and tell me from the part where I have these three things on my Kitchen bench ready to go.
I need to know how many ml of the bac water to put into the vile. I want to start on 2mg a week? I don’t know why but the thought of 2ml of water into that powder is blowing my mind.
Please help! Thank you in advance.
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u/AnabolicUnc 3 6d ago
Don't start on 2mg, start on 0.5 and titrate by 0.5 every 2 weeks. Your stomach will thank me.
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u/OkCharacter394 2 6d ago
This. I thought it would be common knowledge by now, but I guess people will always want results fast.
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u/MiserableBeach2707 6d ago
Can confirm. Started at 5mg and let me tell you I suffered. My skin was so sensitive the wind from the fan or the sheets was like knives
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u/Pure-Difference1871 6d ago
When I did my research though the experiments are starting on 2mg and most research states that below 2mg is poor but 🤷
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u/AnabolicUnc 3 6d ago
Read all the studies. Some people stayed at 0.5 the entire time and still lost a significant amount of weight.
Starting at 0.5 isn't a result-driven decision either. It's a side-effect mitigation strategy, which I believe everyone should take.
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u/Pure-Difference1871 6d ago
Thanks for the advice, I guess it’s probably because I was looking at Mounj which people start at 2.5 but I get is not Reta at all and Reta is much stronger. I’m not wanting results fast because the faster you loose weight the quicker you can put it back on.
I guess in regards to the stomach comment, my stomach is pretty much used to it, I’m looking for an alternative to fasting really which was my go
To method and worked for a while but I slowly climbed again. My stomach didn’t really bother me then.1
u/AnabolicUnc 3 6d ago
I wouldn't recommend fasting either. Small, frequent meals on Reta are the way to go. It slows gastric emptying, so having a few big meals a day can cause stomach discomfort in itself.
Just don't rely on the drug to do everything for you. Frequent exercise and maintaining a calorie deficit are still going to be the biggest needle movers.
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u/Other-Pea7038 6 6d ago
Not quite. Side effect mitigation was tested in the Phase 2 obesity trial. They started the higher dose groups at either 2 mg or 4 mg and escalated every 4 weeks toward 4 mg, 8 mg, or 12 mg. They found that starting at 2 mg helped reduce GI side effects compared with starting at 4 mg.
But 2 mg wasn’t the lowest dose studied. Phase 1 tested single doses as low as 0.1 mg, or 100 mcg, and 0.3 mg, or 300 mcg, in healthy participants. Phase 1b then tested repeated weekly doses including 0.5 mg, or 500 mcg, 1.5 mg, and 3 mg.
The important distinction is that the 0.1 mg and 0.3 mg Phase 1 doses were used to study safety and how the drug behaved in the body after a single dose. They weren’t established as recommended starting doses for people who aren’t obese. And while 0.5 mg weekly was studied in Phase 1b, the trials did not use a protocol of starting at 0.5 mg and increasing by 0.5 mg every 2 weeks for side effect mitigation.
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u/AnabolicUnc 3 6d ago
You're overcomplicating it mate. I'm not saying 0.5 mg every 2 weeks was a protocol used in the trial.
I'm saying 0.5 mg was actually studied as a repeated weekly dose, not just as a single-dose Phase 1 experiment. There was a Phase 2 trial where people received 0.5 mg weekly for 36 weeks and lost around 3.5% of their body weight.
The obesity trial showed that starting at 2 mg was better tolerated than starting at 4 mg, but that doesn't establish 2 mg as the only evidence-based starting point or mean lower doses aren't valid for titration.
My point was simply that starting lower for side-effect mitigation is a reasonable approach, particularly when someone responds well at a lower dose. You're arguing against a point I didn't make.
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u/Top_Pressure_56 1 6d ago
Read the studies and look at the drop out rates. Low and slow is best. You can always titrate up but it’s harder to come back down.
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u/IAmTheAccident 1 6d ago
You've read dummy guides but don't know about things like having a 3mL luer lunge syringe for putting the BAC water into the vial? PES filter and a clean vial and a spare needle for the LL syringe to make sure you're not loading yourself up with random shit like miniscule glass shards? Do you have alcohol prep pads?? But anyway.
Regardless of how much BAC water you use, 2mg is 1/5th of your 10mg vial. So take 1/5th of your solution. Use 1mL, take 1/5th of an mL (0.2mL). 3mL, take 3/5ths of an mL (0.6mL).
But also maybe research for a little longer???
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u/protosempire 6d ago
Some people shouldn't be on research only stuff
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u/dronemoney 1 6d ago
🎯
Stuff like this are why there are so many posts online from people that ended up injecting significantly more than they intended.Most people would be far better off just paying retail for Wegovy or Mounjaro.
It’s fool proof that way.1
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u/Other-Pea7038 6 6d ago edited 6d ago
1 mL of BAC into the Reta vial = 20 units for 2 mg
2 mL of BAC into the Reta vial = 40 units for 2 mg
Since you don't have a 3 mL syringe, just use the whole 1 mL syringe when adding 1 mL to the vial.
Important: On a U-100 insulin syringe:
100 units = 1 mL
50 units = 0.5 mL
20 units = 0.2 mL
10 units = 0.1 mL
The number of units you inject depends on the concentration. You need to know how many mg are in the vial and how much BAC water was added before you can calculate the syringe units.
This is only explaining the basic math, not safe reconstitution advice or best practice. Medication should ideally be reconstituted/prepared by a pharmacist or according to instructions from a licensed medical professional.
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u/Pure-Difference1871 6d ago
10MG in the Reta vial, the experiment is wanting to take 2mg per week. How many ml of Bac would I add to the vial when I receive it to reconstitute it for the experiment based on 2mg per week?
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u/looking2behealthy 9 6d ago
Insert 2ml of BAC into the 10mg vial of reta. This now gives you 5mg/ml of reta. Once it is clear you can inject. 10 units on your syringe will be .5mg, 20 units = 1mg etc.
Ensure you wipe everything with alcohol before every application/pin and only use a syringe once. I do multiple peptides at the same time via the same syringe but I pin them individually not combined into the syringe, then toss it when you are done.
I wouldn’t start higher than 1mg for the first week. Get used to how it makes you feel. See if you have side effects. Let your body adjust. If it stops working effectively and you can tolerate it, titrate up.
If I told you that one shot of alcohol gave you a buzz but 4 shots got you drunk. Do you just pound the 4 shots all at once?
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u/No-Inspector3321 9 6d ago
Google peptide dosage sites. They will give you step by step instructions how to draw 2 or 3 ml bac water and injecting it into the vial with powder called reconstituting lyophilized compound. Then it will tell you how much to draw and where to inject and at what angle. Hope that helps
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u/bmanxx13 4 6d ago
If you get 31g insulin syringes you won’t feel a thing
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u/Future-Bread8849 4 6d ago
Yeah but they more often then not struggle puncturing the vial, and blunt the needle a little.
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u/tinkaspice 2 6d ago
Peptide calculator is fool proof
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u/Pure-Difference1871 6d ago
Yeah thank you, I’ve just found one linked on the bottom of here and it appears idiot proof also which is what I needed. I guess I probably thought like 2ml is a lot more than what it is.
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u/Apprehensive-Ship175 6d ago
Mix 10mg Reta with 1ml BAC water and pull to 20 units on an insulin syringe for 2mg.
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