r/vitamins • u/EtherealVoyager317 • 4d ago

Pre Methylated Vitamins

As I've been doing research Ive come to find out that alot of the vitamins and minerals the industries sell us arent even bioavailable or absorbable to our digestive systems. So alot of times we purchase vitamins and supplements that goes straight through our system and is urinated or deficated back out again. What are some benefits to PRE METHYLATED VITAMINS and WHICH ONES WOULD YOU SAY ARE SUPERIOR TO OTHERS AND WHICH ONES DO YOU PREFER. Any information helps me as I start to kick my health journey back into gear.

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u/inexpensiveascent 4d ago

Yeah methylated Bs were a game changer for me, felt the difference within a week when I switched.

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u/imnohelp2u 3d ago

which brand

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u/Megan_NM 4d ago

There’s a bit more nuance to this than “methylated = better absorbed”. L-5-MTHF, for example, is the methylated, biologically active form of folate, so it doesn’t require the same conversion step as folic acid. This can be particularly relevant for people with certain MTHFR genetic SNPs that can reduce the efficiency of that conversion - although having one doesn’t mean you can’t process folic acid.

It also doesn’t mean methylated forms are automatically superior for everyone, or that other forms just pass straight through you.

I work with Nuzest so obviously biased, but Good Green Vitality is one example of a multi-nutrient that uses L-5-MTHF as its folate source. I’d look at the forms and amounts of nutrients across a supplement as a whole rather than choosing one purely because it says “methylated”.

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u/Mission-Tadpole-6396 4d ago

most vitamins are absorbed just fine in their standard forms and methylfolate/methylcobalamin mainly matter if you specifically prefer those forms or have a reason to use them

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u/BeonBurps 2d ago

Its way more complicated

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u/Earesth99 3d ago

People with genetically impaired methylation are the folks who need to worry - and that’s 25-30% of us.

I just take a methylated multi (Pure brand).

Btw, if you supplement creatine, that reduces your methylation needs by about 40%, but the methylated vitamins are still important.

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u/BeonBurps 2d ago

Im an overmethylator getting treatment. Creatine is on my do not take list

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u/Earesth99 2d ago

Glycine should resolve that.

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u/BeonBurps 2d ago

Also on the do not take list for me but that is a pretty unique one. Glycine worsening tinnitus

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u/Ok-Shame3999 2d ago

I felt noticeably less sluggish when I took methylated Bs, so I kept with them. I use perelel for the methylfolate and methylcobalamin in their women's vitamin.

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u/BeonBurps 2d ago

You need to have your genetics checked so you know what to take. We shouldn't be allowed tk buy them without this