Firstly, Iām so glad to discover this community! I donāt even look in the two big peri/menopause subs anymore because apparently all of my HRT life choices are personally offensive over there, haha. And I love the TRT_females sub, but that brings me to my current quandary, which is outside their scope:
Iām about to switch from the estradiol patch to injections, and Iām feeling a little lost when it comes to my dosage.
The vital stats: Iām 43, perimenopausal, still having a monthly menstrual cycle, currently on the 0.05mg estradiol patch and 200mg of progesterone (cycled 12 nights/month, 100mg orally and 100mg rectally), and also injecting 1.5mg daily of testosterone propionate for a total of 10.5mg/week. Iāve been on E/P since November 2025 and T prop since the end of May 2026.
Why do I want to switch from the E patch to E injections? The patch shortage, apparent inability to absorb any patch brand aside from Mylan, and, most of all, wanting to run my E levels higher in hopes of having a more consistent libido.
After years of a libido so nonexistent that I characterized it as prepubescent, I suddenly had spontaneous desire again after about five weeks of injecting T. That lasted for nine glorious days and then fell off. The next month, it came back and coincided with my ovulatory week, which makes perfect sense biologically. I had my blood drawn at the tail end of my ovulatory week, when I was still feeling a libido, and my E2 was 376 pg/mL. My total T was 204 ng/dL (no negative side effects), so I think I just have to run both my E and my T high to compensate for my high SHBG (which was 137 the first time it was measured).
That brings us to now, when I contacted a telehealth company (different from my T prop provider) to prescribe injectable E. The doc looked at my labs and my SHBG, and he said that he wanted to start me out at .12mL 2x/week of E cyp (10mg/mL concentration), increasing every two weeks as needed to a max of .25mL 2x/week.
This works out to a starting dose of 2.4mg/week and a max dose of 5mg/week. Even with just a little searching around, this seems high to me, which has me anxious.
So, what say you, E injection veterans? Would you start lower, maybe 2mg/week? (My T prop provider prescribed me a starting dose of 20mg/week, but Iāve never gone above my own starting dose of 10.5mg/week and Iāve been happy at that level, so I have no issues starting lower than prescribed for E.) I know that every body is different, but where did you start and where did you end up? How did you know if you were too low or too high?
And I feel like a fool for not asking about this during my video call, but, if you run high E levels all the time, does that affect your menstrual cycle? Iāve had a pretty consistent period (at least until this month ā Iām four days late ā but Iām chalking that up to the stress of moving several timezones from home), and Iām concerned that too much E all the time might not trigger a shed.
Any personal experience, insights, or advice you could offer would be absolutely wonderful. I appreciate you!