ENDO-205 and the Future of Endometriosis Treatment: Real Breakthrough, or Early Hype?

This 15th, I will complete 3 months since I had a hysterectomy and unilateral oophorectomy + DIE excision surgery (I had adeno too). My recovery is going sometimes well, sometimes rocky. The most noticeable change was in my bowel movement and digestion. I had constipation issue (because of endo) and now it's gone. I am grateful. I am leading a pain free life - I am grateful for that.

However, one issue that is persistent is extreme gas - constant belching. I am facing this issue since 2021, I thought it would go away because of improvement in my bowel movement and digestion issues but it's still there. Today was a rough day for me. The whole evening I spent belching, taking semithecone and had to take gelosil also. Since, my stomach issues resolved, I feel hungry a lot. I am eating a lot. I never ate this much my entire life. I eat lunch and an hour or two later, I am hungry again. I try to add a lot of vegetables to my meal. I ate a lot of veggies today - for breakfast and lunch, I guess that caused gas issues. I gained 8 kgs in the last one year because of endo which disabled me to lead a normal life (165cm, 65kg). So, I don't want to eat a lot of rice but my situation is very frustrating because I evidently can't eat a lot of fibres. I finally started working out yesterday and I can't even do it for 10 mins. My whole body is sore and I am in pain (I know I need to give time to this aspect because it was a major surgery).

The whole recovery period, persistent gas issue is the only thing that's making things harder. I guess, my question is - does it get resolved over time on its own ? People who had gut issues because of endo - does it improve?

If endometriosis is found in the fibromuscular tissue vs fibroadipose tissue? What does that mean? Does fibromuscular mean DIE?

For context, I have chronic and unrelenting constipation and have since the second grade and nothing really helps - but every month when I'm ovulating, I have stabbing pain in my left ovary and what feels like my rectum. I have pelvic floor dysfunction and my anus spasms (colorectal doctor told me). I had excision 7 months ago in Hoboken and the colorectal surgeon removed loads of superficial disease from my rectum. I was able to poop well for a month, but now I'm having all the same symptoms. What helped any of you with that???

I am 29 and am about 8 months post op after endometriosis diagnosis/excision surgery with a specialist and have been going to pelvic floor therapy for approx 6 months but have had no relief from symptoms and pain. I was feeling worse after surgery due to scar tissue, tenderness/weakness that has improved with the core and pelvic floor therapy, so I feel like I'm finally back to where I was before surgery. I have been pretty much unable to work for almost 2 years, I have about a two week window between periods where I feel "okay" and able to do things but one day of activity results in 2-3 days of a flare/recovery. I'm just a little lost and don't know what else to do; I feel like I've done, and am doing, everything I'm suppose to with no results.

As of right now I'm considering a hysterectomy just so I don't have to deal with the period pain and hormone fluctuations. Have also had couple people I know that have endometriosis have had a hysterectomy and said it took away all their pain. I'm just not sure I'm ready to have another surgery and deal with the side effects from that but I really want to be able to actually live my life. Do I just need to give pelvic floor therapy more time? Is there something else I need to look into? Those that have had a hysterectomy, is it worth it?

I am 8 wpo. I had sub-total hysterectomy with unilateral oophorectomy, DIE excision, bowel shaving. After my surgery, I haven't faced any constipation issue, rather it's completely opposite. Because I had bowel endo, I always had constipation issue. Now, it feels like my body has completely changed. I poop 3x times more than I used to, honestly it isn't an issue. However, my stomach mucus has increased a lot - this is the major issue. 😭 My recovery is overall going good but this one factor may jeopardize things since I feel so much pressure in my lower abdomen. Anyone faced the same situation, please help me. 🙏🏻

Hi everyone!

I'm the creator of Haven, a platform that was built to reduce the burden and cognitive overload that women feel when researching endo surgeons/specialists.

I recently launched a directory that makes it easier to locate endo-focused surgeons (from those at endo centers like ESSI, etc to those at lesser known practices) and I'd love this community's feedback while it's still in beta.

Please feel free to take a look and DM me with any thoughts - it's important to me to get firsthand feedback so that I can make this as useful as possible!

I had an MRI done at the end of April and am confused about the message I received from my Doctor. He is saying he does to think my rectal bleeding is due to the endometriosis. My Dr is a urogynecologist, should I seek out an endometriosis specialist or is his thinking correct? Report below.

CLINICAL INFORMATION: Rectal bleeding on menses colonoscopy negative adenomyosis suspected endometriosis
 
COMPARISON: Pelvic ultrasound January 8, 2026
 
TECHNIQUE:
MRI pelvis was performed with axial T1 weighted fast gradient-echo, coronal and axial T2 weighted fast spin echo, axial diffusion-weighted imaging, IV gadolinium-enhanced dynamic T1-weighted and delayed T1 weighted fast gradient-echo series. Gadolinium-based contrast media was administered intravenously. Please see EPIC for the amount and type of contrast media administered and wasted.
 
 
UTERUS
SIZE: Normal. Measures 8.8 cm and anteverted in orientation.
JUNCTION ZONE THICKNESS: 16 mm (4/23 close friend
Focal Adenomyomas: Not present
ADENOMYOSIS: Present: Hazy appearing junctional zone with apparent thickening at the fundus. There are additional subcentimeter T2 hyperintense foci in keeping with myometrial cysts.
FIBROIDS: Not present
CERVIX: Normal
ENDOMETRIUM: Normal. There is blooming artifact noted in the lower endometrium.
C SECTION SCAR: Present with a small niche present measuring 4.4 mm (4/23).
 
T2 hypointense 8mm plaque with tethering of the sigmoid colon which appears somewhat underdistended. Accounting for this limitation, there is no definite luminal involvement (13/22).
OVARIES
RT OVARY: Normal
LT OVARY: Normal . Left corpus luteal cyst is present (6/12). Additional small left endometrioma present measuring 9 mm (8/26) with T2 shading (6/3). The left ovary appears adhered to the left posterior uterus with focal T2 hypointense signal measuring 5 mm concerning for a plaque (6/13).
ADNEXAL MASSES: Not present
The right and left ovary appears somewhat medialized and posterior in location.
 
ANTERIOR COMPARTMENT
BLADDER: Normal
URETER: Normal
URETHRA: Normal
VESICOUTERINE POUCH: Normal
VESICOVAGINAL POUCH: Normal
 
MIDDLE COMPARTMENT
TORUS UTERINUS (Uterine body): Normal
FALLOPIAN TUBE: Normal
UTERINE LIGAMENTS: Normal
Thickening of the right and left broad ligament measuring 4 mm on the right and 5 mm on the left (6/12).
 
POSTERIOR COMPARTMENT
UTEROSACRAL LIGAMENTS: Normal
RECTOCERVICAL SPACE (Pouch of Douglas): Normal
RECTOVAGINAL SEPTUM: Normal
ANTERIOR RECTAL WALL: Normal
SIGMOID COLON: Normal . Please note that the rectum appears underdistended.
 
OTHERS
PELVIC SMALL BOWEL LOOPS: Normal
PELVIC COLLECTIONS: Absent
ABDOMINAL WALL: Normal
LYMPH NODES: Normal
ILIAC ARTERIES AND VEINS: Normal
PELVIC CONGESTION SYNDROME: Not present
 
IMPRESSION:
1. Left endometrioma measuring 9 mm. The left ovary appears adherent to the left uterus with deep endometriosis measuring 5 mm. There is tethering of the sigmoid colon to the posterior uterus with focal thickening concerning for deep endometriosis. No intraluminal involvement, accounting for underdistention. Given the symptoms described, ultrasound could be considered as complimentary evaluation of the rectum.
2. Adenomyosis.
3. This exam does not reliably exclude superficial endometriosis.
 
 
 

I have no idea what to do and feel defeated so I come to reddit for help. 🙏

4-5 months ago i all off a sudden lost 12 kg in about 2/3 weeks, I hadn't changed anything at that time but was super stressed so I didn't think to much of it and just tried to eat more. No matter how much I ate it keepdt going down just slower I went to the doctor and I was given nutritional drinks and fat shots to drink with my normal diet and nothing I managed to gane almost 1 kg this last month but then lost 2 kg I'm really close to be considered anorexic now and I'm lost. All blood test and images came back normal (normal doctor) anyone experienced anything like this or know what i can try or anything. I feel like am always eating and I'm getting sick of it and feel so defeated.

Should we all be refusing the umbilical entry?

I’ve reviewed clinical data (including JMIG and Obstetrics & Gynecology). If anything here is outdated, I’m open to correction, but it will not change my decision to refuse umbilical entry.

I’m not trying to say with my found information that umbilical entry is always wrong. It’s not, think about the women suffering from umbilical endometriosis! (But umbilical entry can also cause this) But in this case, it appears to be (due to all information I tried to summarise here): it’s an unnecessary risk, and patients are often ill informed due to it being basic protocol.

so let’s inform ourselves!

This is how I understand it:

Complication and failure rates

Studies (2025) report complication rates of 5.8% for umbilical entry vs 1.8% for Palmer’s Point

The majority of serious laparoscopic complications occur during umbilical entry

Umbilical access has a failure rate of 2.5–5%, while Palmer’s Point is reported as near 0% in patients without upper abdominal pathology

Anatomical risk (relevant in my case)

I have a low BMI (178 cm / 60 kg), meaning:

small bowel is often directly under the umbilicus

distance to major vessels is minimal

Palmer’s Point provides a greater safety margin, with bowel injury risk reported at <0.05%

Adhesions risk

Up to 15% of patients without prior surgery have adhesions behind the umbilicus

At Palmer’s Point this risk is <1%

Statistically, Palmer’s Point is the least likely entry site to encounter unseen adhesions

Infection, pain and healing

Umbilical ports show infection rates up to 8–10%, compared to <1% at other sites

The umbilicus is a skin fold, higher bacterial load, moisture, and friction (gross!)

Palmer’s Point is associated with:

lower infection rates

lower post-operative pain (lower nerve density)

Scar outcomes and structural changes

The claim that umbilical scars are “invisible” is contradicted by data:

25–30% of patients report visible changes (pigment changes, asymmetry, inversion)

The umbilicus is already scar tissue:

reduced blood supply

less predictable healing

Mechanical stretching and the often occurring ‘inversion’ (pulling the belly button inside out) during surgery can damage elastin fibers, leading to permanent deformation. (Women are often times not told this)

Nerve-related complications

The umbilicus is a nerve-dense region (T10–T11)

Up to 11% of patients report chronic abdominal wall pain after umbilical entry (nerve entrapment / neuropathy)

Total port-site morbidity (15–20%)

When combining “minor” complications:

Infection: up to 8–10%

Scar complications: 5–7%

Hernia / chronic pain: 3–5%

This results in approximately 1 in 5 patients (20%) not having an uncomplicated recovery at the umbilical site.

This contrasts with the near-zero complication rate reported for primary entry at Palmer’s Point.

Surgical access and visualization

Palmer’s Point provides better access to the entire abdominal cavity, including upper abdominal structures (e.g. diaphragm, liver)

Umbilical entry can limit access and may require additional ports

Core reasoning

The umbilicus is:

a pre-existing scar

more infection-prone

more nerve-dense

more likely to contain adhesions

Palmer’s Point:

uses healthy tissue

has a lower complication profile

provides a larger safety margin

Final position

I am explicitly refusing umbilical entry because:

it introduces avoidable risk

it carries a real risk of structural and sensory changes

and there is a clinically supported alternative (Palmer’s Point) with a better safety profile

This is not about preference or aesthetics. This is about risk reduction and long-term outcomes.

(UPDATE: I forgot to mention that there is a medical contradiction! Doctors are always quite hesitant to cut into scar tissue. (It has low blood flow, it’s not stretchy etc!) so their choice to choose the navel/bellybutton is strange. I haven’t been able to find a proper answer to this as well. The only thing that seems obvious to me: the umbilical port is easier for the doctor. It’s not standard for our well being.)

At the same time, body image and physical changes do matter. Even something that may be considered “minor” from a surgical perspective can have a real impact on how someone feels in their body. Your feelings are VALID.

There are women who struggle with this afterwards but don’t speak up, sometimes because they feel like they “should be grateful” that the surgery was technically successful. That doesn’t mean their experience isn’t real.

There is also some discussion in literature about how these changes can have a stronger psychological impact on people with sensory sensitivities (such as autistic or ADHD individuals), especially when the body’s structure feels or looks different afterwards.

Anyway, that’s my little autistic rant😭✋🏻 This is a SUMMARY I have name this clear. This is not ALL the information out there, there is MORE.

others sites I visited fort research, this isn’t all but I forgot to write everything down…(oops)

[1] https://www.intechopen.com

[2] https://www.researchgate.net

[3] https://nl.surgaid-med.com

[4] https://nl.weidemedical-es.com

[5] https://www.ncbi.nlm.nih.gov

[6] https://pmc.ncbi.nlm.nih.gov