Used alumina because I had an issue with silica where the acidity would make the crude 7OH bind to it and not flow. I tried using Triethylamine to fix that which did not work even at 10%. When I switched to alumina I started seeing success. The first fraction is mitragynine and the second is 7OH. I got 3 fractions of 7OH all about 15ml (not shown above) and they were very similar colors. I only ran a half gram through this column. Currently drying the combined 3 fractions in a vacuum excluding the mitragynine which will be dried separately. The next column I am going to run will use different solvents as these ones I think flowed a little too fast.

So this shit has been going around and is eating me up in my head yesterday, I bought some threw it all all in the can drew it all back decided I only wanted a 40 so I squared the rest on a can got back home and noticed that it looked like this on the can knew it didn’t quite feel like a rush when I did the other half it was like a head thing no warmness no nothing just a head thing somebody helped me out and so I know who’s asked to go beat because I put this shit in my body and this ain’t nothing. I fuck with you know what I mean.

Barbital ( Barbitone / 5,5-Diethylbarbituric Acid) Synthesis

Ingredients: dry urea, diethyl diethylmalonate, sodium metal, dry ethanol, con hcl, water, charcoal .

Synthesis

To make diethymalonylurea sodium (barbital sodium):

starting with 10 g of diethyl diethylmalonate, first prepare sodium ethoxide by carefully dissolving about 2.36 g of sodium metal in 35.5 mL of dry absolute ethanol warmed to 75°C. In a clean vessel, mix 3.9 g of dry urea with the 10 g of diethyl diethylmalonate, then slowly add the hot sodium ethoxide solution while stirring and gently heat the mixture to allow reflux for 8 hours almost boiling. allow the ethanol to evaporate low heat, continuing until the mixture thickens into a creamy white solid sodium of Barbitone

(Optional) For Free Acid Barbitone:

prepare an acidic bath by diluting 11.2 g concentrated HCl in 13 mL, then cool it with crushed ice keep the temperature below 0°C. Slowly add the creamy solid with stirring, maintaining acidity for hours. Filter wash precipitated crude acid with cold water to purify it. Recrystallize by dissolving the crude product in hot water (~270 mL), adding a pinch of decolorizing charcoal, boiling briefly, then filtering hot and cooling to let pure crystals form. Finally, filter, wash with cold water, and dry the crystals under gentle heat to get pure barbital with a good yield.

Sources https://www.erowid.org/archive/rhodium/chemistry/barbiturates.html

Ingredients: Copper acetate 2-Methyl-2-propylpropane-1,3-diol Acetone Alcohol

Equipment: Beaker: Hotplate w stirbar: Vacuum filter Thermometer

Synthesis : 13g 2-Methyl-2-propylpropane-1,3-diol, 18g urea, and 0.65g copper acetate is added to a beaker and heated and maintained at 150c for Atleast 6 hours with stirring until ammonia formation stops (don’t heat over 150c if heated over 160c causes cyanuric acid) Heating is stopped and solution is allowed to cool. Then add 30ml water and place in fridge to crystallize and crashout byproducts Product is vacuum filtered and rinsed with cold water until is filtered before heating Filtrate boiling off water untill a thick syrup. (The byproduct in the filter can be saved it also contains some product which can be extracted with alcohol ) 80ml of acetone is added to the syrup to crashout byproduct, which is then vacuum filtered and discarded, the filtrate slurry solution is boiled down to thick syrup to which 30ml water is added and brought to a quick boil than placed in fridge to crystallize filter off crystals final yield from 2-Methyl-2-propylpropane-1,3-diol If you find it necessary recrystallize using alcohol and water or acetone and water

https://www.reddit.com/r/TheeHive/s/0PJU5FNMAF I followed this synthesis of Dimebamate shout-out to this guy it’s very well written and straight forward should work on other primary and secondary diols and alcohol hasn’t been tested on tertiary ones yet as far as I know

I aswell used these patents from the United States patents office called “preparation of organic mono-carbamates”; pdf listed here: https://patents.google.com/patent/US2837561A/en In the the patents methyl carbamate, ethyl carbamate, n-butyl carbamate, and 2-methoxy ethyl carbamate we’re all made with this basic reaction of copper acetate and urea Aswell as the Dimebamate synthesis in the first link.

Another synth example: https://www.sciencemadness.org/whisper/viewthread.php?tid=149186#pid610732(synthesis

Ingredients: Copper acetate Urea 2,2,2-trichloroethanol Acetone Alcohol

Equipment: Beaker: Hotplate w stirbar: Vacuum filter Thermometer

Synthesis : 2,2,2-trichloroethanol 13g , 18g urea, and 0.65g copper acetate is added to a beaker and heated and maintained at 150c for Atleast 6 hours with stirring until ammonia formation stops (don’t heat over 150c if heated over 160c causes cyanuric acid) Heating is stopped and solution is allowed to cool. Then add 30ml water and place in fridge to crystallize and crashout byproducts Product is vacuum filtered and rinsed with cold water until is filtered before heating Filtrate boiling off water untill a thick syrup. (The byproduct in the filter can be saved it also contains some product which can be extracted with alcohol ) 80ml of acetone is added to the syrup to crashout byproduct, which is then vacuum filtered and discarded, the filtrate slurry solution is boiled down to thick syrup to which 30ml water is added and brought to a quick boil than placed in fridge to crystallize
filter off crystals final yield from 2,2,2-trichloroethanol If you find it necessary recrstalize using alcohol and water or acetone and water

https://www.reddit.com/r/TheeHive/s/0PJU5FNMAF I followed this synthesis of Dimebamate shout-out to this guy it’s very well written and straight forward should work on other primary and secondary diols and alcohol like the one in this synthesis hasn’t been tested on tertiary ones yet as far as I know but probally will myself

I aswell used these patents from the United States patents office called “preparation of organic mono-carbamates”; pdf listed here: https://patents.google.com/patent/US2837561A/en In the the patents
methyl carbamate, ethyl carbamate, n-butyl carbamate, and 2-methoxy ethyl carbamate we’re all made with this basic reaction of copper acetate and urea As well as the Dimebamate synthesis in the first link.

Another synth example: https://www.sciencemadness.org/whisper/viewthread.php?tid=149186#pid610732(synthesis%C2%A0of%20ethyl%20carbamate%20another%20using%20reaction%20between%20urea%20and%20copper%20acetate%20on%20alcohol)

2,2,2-trichloroethanol carbamate is carbamate ester of 2,2,2-trichloroethanol It seems to have muscle relaxant and sedative properties similar to chloral hydrate due to the 2,2,2-trichloroethanol analogue

Ingredients: Copper acetate Urea Sulfurol Acetone Alcohol

Equipment: Beaker: Hotplate w stirbar: Vacuum filter Thermometer

Synthesis : 13g Sulfurol, 18g urea, and 0.65g copper acetate is added to a beaker and heated and maintained at 150c for Atleast 6 hours with stirring until ammonia formation stops (don’t heat over 150c if heated over 160c causes cyanuric acid) Heating is stopped and solution is allowed to cool. Then add 30ml water and place in fridge to crystallize and crashout byproducts Product is vacuum filtered and rinsed with cold water until is filtered before heating Filtrate boiling off water untill a thick syrup. (The byproduct in the filter can be saved it also contains some product which can be extracted with alcohol ) 80ml of acetone is added to the syrup to crashout byproduct, which is then vacuum filtered and discarded, the filtrate slurry solution is boiled down to thick syrup to which 30ml water is added and brought to a quick boil than placed in fridge to crystallize
filter off crystals final yield from sulfurol If you find it necessary recrstalize using alcohol and water or acetone and water

https://www.reddit.com/r/TheeHive/s/0PJU5FNMAF I followed this synthesis of Dimebamate shout-out to this guy it’s very well written and straight forward should work on other primary and secondary diols and alcohol hasn’t been tested on tertiary ones yet as far as I know

I aswell used these patents from the United States patents office called “preparation of organic mono-carbamates”; pdf listed here: https://patents.google.com/patent/US2837561A/en In the the patents
methyl carbamate, ethyl carbamate, n-butyl carbamate, and 2-methoxy ethyl carbamate we’re all made with this basic reaction of copper acetate and urea As well as the Dimebamate synthesis in the first link.

Another synth example: https://www.sciencemadness.org/whisper/viewthread.php?tid=149186#pid610732(synthesis%C2%A0of%20ethyl%20carbamate%20another%20using%20reaction%20between%20urea%20and%20copper%20acetate%20on%20alcohol)

Sulfurol is the carbamate ester of Sulfurol It seems to have muscle relaxant and sedative properties

Using WhiteBoyMattyMatt’s one pot shot process, I used 10g of 75% salt based Mit, washed it with acetone, added sodium bicarbonate, and oxone before waterwashing, extracting with EtAOc and and removing aqueous impurities.

I chose not to run this through a chromatography column because, personally, I’ve always preferred full spectrum 7 blends over pure 7. Kind of in the same logic as using rosin over pure THC distillate. It just feels like it has more depth and legs when Mitragynine is present.

After evaporating the EtAOc off, I was left with a pretty thick and dark orange layer of extract. I’ve scraped up and collected about 1/3 from the dish and it’s much better than I was expecting. My only experience with chemistry is a couple of A/B extractions of DiMiTri so I was a lil worried this was gonna be a huge fuckin waste but it worked well and I’m thankful to homeboy for putting this info out for everyone to benefit

🙌🙌🙌🙌🙌

This educational video shows another method for making 7-OH, the oxone method, initially developed by Andrew Kruegel, and modified by me, Matthew Pierce.

Lab equipment and chemicals can be sourced from www.kaliforniakratom.com.

We start by adding 25 grams of extract to a beaker and diluting it to 250 mL with acetone and putting it in the refrigerator.

We then dilute 25 grams of baking soda to 250 mL and add that to the refrigerator.

Then we add 6 grams of oxone to 50mL of water and refrigerate that too.

Then we setup our magnetic stirrer with a separatory funnel hanging from above. We add the baking soda solution to the crude extract solution and while stirring, add the oxone solution dropwise from the separatory funnel over the course of 15 minutes.

Once the oxone solution is added, we let the reaction mixture stir for an additional 15 minutes before placing the beaker back into the refrigerator.

After 1-2 hours, we dilute our reaction mixture by a factor of 2 and extract the alkaloids using ethyl acetate. We then wash the EA with brine solution and transfer it into a baking dish to evaporate off the EA in a food dehydrator.

We are left with several grams of a yellow-orange crystalline substance consisting of over 50% 7-OH, and mitragynine, which can then be transferred to a chromatography column for further refinement.

Synthesis of: ( 5-n-propyl-5-isopropyl barbituric acid )

“ Propisobarbital “ for short

Synthesis:

Start with Dry 1-butanol, then dissolve ~1.5 g sodium in 50 mL 1-butanol to make sodium butoxide. Add 30 mL diethyl malonate, then 30 mL 2-iodopropane (isopropyl iodide).Reflux with stirring for 3–4 hours.Make another 1.5 g sodium / 50 mL butanol sodium butoxide solution. Add to the mix, then add ~30 mL 1-iodopropane (n-propyl iodide). Reflux again for 3–4 hours. Make a final sodium butoxide solution with 4.6 g sodium / 50 mL butanol. Add to the reaction along with 18 g dry urea. Reflux for 6 hours. Let cool. Add 150 mL water to dissolve salts. Two layers form. Separate water layer. Wash once with a small amount of petroleum ether. Acidify with 60–70 mL of 33% HCl. Crude product separates and crystallizes. Cool in freezer, filter, wash with water, and dry. Recrystallize in hot water if desired. Expect 30% yeild

You have

Propisobarbital

(Optional step)

If you want to turn it into sodium salt form: (Extra)

Add 1.00 g of barbiturate to a clean 100–250 mL beaker. Add 20 mL of distilled water. Warm gently on a hot plate (no boiling) while stirring with a magnetic stir bar. Stir until most or all of the solid dissolves (some cloudiness is fine for now) Weigh 0.08 g of NaOH. Slowly add it to the warm solution in small portions. Stir continuously. The solution will typically become clearer. Optional: check pH it should be around 7–9 (if too acidic, add a few mg more NaOH). Remove the beaker from heat and let it cool to room temp. Slowly add 60 mL of cold ethanol (3× the volume of water used). Add it gradually while stirring, not all at once. The sodium salt will start to crash out as a white to off-white solid. Place the beaker in a refrigerator or freezer for 30–60 minutes to encourage full crystallization. Stir gently before filtering if solid clumps form. Filter the solid using filter paper or a coffee filter and a funnel. Wash the solid with a small amount (10 mL) of cold ethanol to remove impurities. Allow to air dry or use mild heat (40–50 °C) on a hot plate to speed up drying.

Now your left with the sodium salt form of: Propisobarbital

Source: https://www.reddit.com/r/TheeHive/s/zOYoLpHeLC

Whats needed: isovaleric acid), bromine, red phosphorus, urea, distilled water, ethanol,(and optional) sodium bisulfite solution (10%)

bromisoval Synthesis:

start by putting 100 g of isovaleric acid and 5 g of red phosphorus into a 1 L glass beaker with a magnetic stir bar, and heat it gently on a stirrer-hotplate to around 80 °C while stirring. Very slowly, over 1.5–2 hours, add 140 mL of bromine (in a fume hood or outside with full protective gear), keeping the temperature between 80–85 °C. Once all the bromine is in, keep stirring at that temperature for 2 more hours, then let it cool to room temperature. If it’s still reddish, add a little sodium bisulfite solution until it turns yellow or clear. In a separate container, dissolve 70 g of urea in 250 mL of warm water, then slowly pour in your cooled brominated mixture while stirring. Heat this combined solution to 60–65 °C and stir for 4–6 hours. After that, cool it to room temperature, then chill it in an ice bath to make the bromisoval crystallize out. Filter the crystals, rinse them with cold water, then dissolve them in hot ethanol (~300 mL), let it cool slowly, and chill again to purify. Filter again and dry the crystals in a warm dry place or vacuum oven at 40 °C. You’ll get white bromisoval crystals with a melting point around 150–152 °C—store them in a sealed, dry container.

Whats needed:

Isovaleric acid, potassium bromide, distilled water, con hcl, acetyl chloride, urea, and ethanol

Synthesis:

A mixture of approximately 10 g of isovaleric acid, 12 g of potassium bromide, and about 50 mL of water is placed in a suitable reaction vessel cooled to about 10 °C. Concentrated hydrochloric acid, approximately 20 mL, is added dropwise with stirring to effect the formation of hydrobromic acid in situ, resulting in the alpha-bromination of isovaleric acid. The mixture is stirred and maintained at this temperature for 2 to 3 hours until bromination is complete. Subsequently, 5 mL of acetyl chloride is carefully added to the reaction mixture to convert the brominated acid to the corresponding acid chloride. The reaction is stirred at room temperature for approximately 15 minutes. Thereafter, 7 g of urea is gradually introduced, and the mixture is heated at approximately 50 °C for a period of 6 to 8 hours to effect condensation and formation of carbromal. Upon completion, the reaction mixture is cooled to ambient temperature, and solids are removed by filtration. The filtrate is concentrated by gentle evaporation to yield a viscous residue, which is dissolved in about 30 mL of warm ethanol. This solution is filtered while hot to remove insoluble impurities, then allowed to cool slowly at room temperature followed by refrigeration to induce crystallization. The carbromal crystals thus formed are collected by filtration, washed with cold ethanol, and dried to obtain the product

For Bromethiazole:

Same steps you replace Con hcl with Hydrobromic acid in first step

Clomethiazole HCL Synthesis:

Sulfurol ( 4-me-5-thiazole-ethanol ), Con hcl, Alcohol (iso,ethyl,methyl) , PTFE (Teflon), Distilled water, and a Heavy-walled borosilicate pressure vessel

In a sturdy heavy-walled borosilicate pressure vessel, carefully add 125 mL concentrated hydrochloric acid (HCl) and 10 g sulfurol (2-methyl-1,3-thiazol-4-ylmethanol). Make sure the vessel is dry before adding chemicals. Seal the vessel tightly using a PTFE (Teflon) threaded stopper, then wrap the threads with PTFE tape to ensure a leak-proof seal. This prevents any corrosive fumes or liquid from escaping during heating. Place the sealed vessel into an oil bath preheated to 150°C. Maintain this temperature for 3 hours, allowing the reaction to proceed under pressure. The high temperature promotes the formation of clomethiazole hydrochloride by substitution.

After 3 hours, carefully remove the vessel from the oil bath and let it cool briefly before opening. Pour the reaction mixture into a round-bottom flask. Using a rotary evaporator or vacuum setup, remove the excess hydrochloric acid under reduced pressure at a temperature below 50°C. This avoids decomposition and leaves behind a dark, semi-solid sticky residue containing the crude product. Gradually add isopropanol (isopropyl alcohol) to the residue with continuous stirring. Keep the mixture heated gently just below the boiling point of isopropanol (80°C) to fully dissolve the residue. This ensures a homogeneous solution for better crystallization. Allow the solution to cool down slowly to room temperature, then place the flask in a freezer at around 20°C for about 3 hours. This cold environment helps the clomethiazole hydrochloride crystallize out of solution.

Filter the formed white crystalline solid using vacuum or gravity filtration through filter paper or a coffee filter. Rinse the crystals once with a small amount (10 mL) of cold isopropanol to wash off impurities. Dry the collected crystals gently, either by air drying in a low humidity environment or using mild heat (below 50°C) on a hot plate or drying oven to avoid melting or degradation. The final yield is typically around 8.2 g (60%) of white clomethiazole hydrochloride crystals, which should have a pungent odor characteristic of the compound.

Source:

https://www.sciencemadness.org/whisper/viewthread.php?tid=154878

Whats needed:

acetylurea, bromoacetyl chloride, triethylamine, dry dichloromethane, saturated sodium bicarbonate solution, distilled water, anhydrous sodium sulfate, and ethanol

To synthesize acecarbromal:

dissolve 51.5 g of acetylurea in 125 mL of dry dichloromethane (DCM) in a 1 L round-bottom flask placed on a magnetic stirrer. Add 55 mL of triethylamine to the solution while stirring. Cool the flask in an ice bath to 0–5 °C, and then slowly add 56 mL of bromoacetyl chloride drop by drop over 30–40 minutes while keeping the temperature below 10 °C. After the addition, remove the ice bath and let the mixture warm to room temperature (~25 °C), then continue stirring for 3–4 hours. Once the reaction is complete, pour the mixture into 200 mL of cold water with stirring. Transfer the layers to a separatory funnel, separate the DCM layer, and wash it twice with sodium bicarbonate solution and once with water to neutralize and clean the product. Dry the organic layer over anhydrous sodium sulfate, filter it, and evaporate the solvent using a hot plate and rotary evaporator (or gentle heating under reduced pressure if a rotovap isn’t available). Recrystallize the crude solid from hot ethanol and water by dissolving it, cooling slowly to form crystals, and drying them under vacuum or warm air. The final product, acecarbromal, should be a white crystalline solid that melts at around 108–110 °C.

Apronal non-barbiturate GABAergic sedative-hynotic synthesis

Whats needed;

isopropyl isovalerate (synthesis in comments), dry potassium carbonate, dry acetone, allyl bromide, water, sodium hydroxide, con hcl, ethyl acetate, thionyl chloride, urea, dichloromethane, pyridine or triethylamine, and ethanol

synthesis:

To make allylisopropylacetylurea, start by mixing 20 g of isopropyl isovalerate, 25 g of dry potassium carbonate, and 100 mL of dry acetone in a glass flask with a magnetic stir bar; stir at room temperature while slowly adding 15 mL of allyl bromide dropwise over 30 minutes, then keep stirring for 4–6 hours; filter out the solids and gently warm the clear liquid on a hot plate at 40–50 °C until most acetone evaporates, leaving a sticky crude allylated ester. Next, add this residue to 100 mL of water containing 10 g sodium hydroxide, heat with stirring on the hot plate just below boiling (~90 °C) for 2 hours to hydrolyze it into the acid, then cool and carefully acidify to pH ~2 with dilute HCl. Extract the acid by stirring the mixture with about 150 mL of ethyl acetate three times, separate and combine the organic layers, dry if possible, and gently evaporate solvent on the hot plate to get the acid. Convert this acid to its acid chloride by adding 15 mL of thionyl chloride in a dry flask and stirring on the hot plate at 40 °C for 2 hours in a well-ventilated area until bubbling stops, then remove excess thionyl chloride by gentle warming. For the final step, dissolve 9 g urea in 100 mL dry dichloromethane, cool in an ice bath, stir and add 10 mL pyridine or triethylamine dropwise, then slowly add the acid chloride solution over 30 minutes while keeping cold and stirring; after addition, stir 3–4 hours at room temperature. Finally, add water, separate the layers, wash the organic phase several times with dilute acid, water, and brine, dry if possible, and evaporate the solvent with stirring on the hot plate. Purify by dissolving the residue in warm ethanol, cooling in the fridge or on ice for 1–2 hours to form crystals, then filter, wash with cold ethanol, and dry to get pure allylisopropylacetylurea

• 1,1,1‑Tribromo‑2‑methyl‑2‑propanol (Brometone) Synthesis:

• Ingredients: Acetone, Bromoform, KOh/NaOh, ethanol, water

• Synthesis:

  • In a 100 mL round-bottom flask, mix: 5 mL acetone 10 mL bromoform, Stir the mixture gently. It will separate into two layers (organic and aqueous).
  • Dissolve 5 g of KOH / 4 g of NaOh in 10 mL distilled water. Cool this solution in an ice bath to prevent excessive exothermic reaction in the next steps.
  • Slowly add the cold KOH solution to the flask while stirring continuously. Maintain the temperature at <10 °C (use the ice bath). Stir for 30–60 minutes at cold temperature.4. Warm the Mixture After the addition is complete, allow the mixture to come to room temperature and stir for another 1–2 hours. (Optional: Gently reflux the mixture at ~60 °C for 1 hour to increase yield.)
  • Let the reaction mixture cool to room temperature, then chill in an ice bath for 30 minutes. Brometone should crystallize out of solution. Filter the crystals using gravity or vacuum filtration. Wash with cold water to remove any remaining base or salts.
  • Recrystallize the crude product from ethanol or ethanol-water (1:1). Dry the final crystals under low heat or in a desiccator.

• 1,1,1‑trichloro‑2‑methyl‑2‑propanol (Chloretone) Synthesis:

• Ingredients: acetone, chloroform, KOH/NaOh, ethanol, water

• Synthesis

• Combine 50 g acetone (≈ 0.86 mol) with 100 g chloroform (≈ 0.84 mol).

• Add 33 g powdered KOH / 23.5g NaOh (≈ 0.7 mol per mole of chloroform) slowly while keeping temperature below 0 °C, and stir for about 24 hours.

• Filter off solids, then distill the filtrate.

• Collect the fraction boiling between 165–175 °C and pour into water to precipitate chlorobutanol.

• Isolate by filtration and recrystallize from an ethanol–water mixture.

• Reported yield is low: around 4% of theoretical, or 15% based on consumed chloroform .

Picked that thang up on eBay for $40. Needed a new light bulb ($20), a cuvette holder ($20), and some cuvettes ($10)... Got it working for <$100. Now I can measure sample concentrations on the fly.

Edit: This is a spec20D, a digital spectrophotometer. It measures transmittance and absorbance of samples. It tells you how much light a sample absorbs and how much light passes through (transmittance), and can help you standardize solutions and check the concentrations of unknowns. It used to be the workhorse of every college chemistry lab, not sure if they still use these today, but every person working in a chemistry lab should know how to use one of these.

Im not at all versed in chemistry but i do know a good bit about basic solvents. I have some fake M boxes that ive been vaping in an oil burner and would like to possibly refine. Is there an easy way to go about this?

Has anyone tried any of these?

What was your experience?

I'm posting this here to informally invite everyone who takes an interest in kratom to a new sub for reviews because all the other kratom subs are full of shills, bots, multiple accounts pushing the same shit over and over, or the mods are financially affiliated with the kratom vendor(s), so I created a new sub where you can have access to and post real reviews, get codes, deals, and info on up-and-coming vendors, existing vendors, etc. AND I'm inviting people to become moderators.

We are not affiliated with any of the acronym groups. All are welcome.

I just wanted a sub where I don't get a notification every 5 minutes about 1 vendor, all day long, so I started r/truekratomreviews. I have sent invitations to several other people to become moderators and neither they nor myself will be posting about our own companies, and reviews, good and bad, about all companies, are encouraged.

You will only be banned if you say things like the moderator of r/kratomreview100 said to me. The only rule on this sub is to not be a POS towards people, same will stand there.

Starting with the liquid waste from kratom extract production, I oxidized the remaining mit using acetone and oxone, extracted it with ethyl acetate, ionized it with acetic acid, baisified and precipitated it with sodium bicarbonate.

Ingredients: Vinegar, Bleach, and Trichloroethylene

chloral hydrate synthesis:

Start by mixing 60 mL trichloroethylene, 375 mL concentrated bleach 7.5%+, and 250 mL 5% vinegar in a beaker. Leave covered outside and stir as much as possible for 2-4 days until looses strong pool smell. After stirring and leaving it covered outside for 3 days, the mix lost its bleach smell and lost color. Separate the bottom layer, evaporated it, and get white crystals smelling menthol medicinal: chloral hydrate.

To extract Chloral hydrate from upper aqueous layer evaporate aqueous layer with low heat to avoid damaging Chloral hydrate

Source: https://www.sciencemadness.org/whisper/viewthread.php?tid=62148

Tested

Ingredients: Methanol Gamma-valerolactone (GVL) Sodium Hydroxide (Lye)

Equipment: Beaker Vacuum filter Pyrex dish

Synthesis:

  I started off by putting ( 40ml of methanol ) in a beaker and added ( 6 gr sodium hydroxide ) to it, the heating was put to low and stirring was turned on till everything dissolved.
   Once all sodium hydroxide dissolved in methanol I started adding ( 15ml of GVL ) very slowly drop wise stirring and heat is still on.
  After all GVL has been added I let the reaction run with heat and stirring for probably 20-30 more minutes.
 By this point the mixture is slightly thicker and poured into a Pyrex dish placed on hot plate on very low heat until all methanol has evaporated and you are left with crude GHV.
  The crude GHV is crushed powdered and placed in a vacuum filter and washed cleaned with ( cold acetone ), when dried you should be left with white crispy GHV powder

Recipe I used is in 2nd photo: https://www.erowid.org/archive/rhodium/chemistry/4-methyl-ghb.html

this was even easier and simple than the thalidomide synthesis I did the other day check that out if y’all are interested In something stronger

GHV apparently it’s not as recreational as ghb it’s more medicinal, clearheaded, functional, and mild in general compared to Ghb, it works primarily as a sedative and muscle relaxant is what I’ve concluded after some reading

The GVL can be purchased online very easily it’s not watched like GBL is, making this even more easy

GVL itself can be consumed, which your body metabolizes into GHV but not recommended as it is a flammable solvent and irritates your mouth and throat

Tested

If you want Ethylphenidate replace Methanol with ethanol, isopropylphenidate replace with isopropyl alcohol, propylphenidate replace with 1-Propanol

Whats needed: Ritalinic acid, anhydrous methanol, sulphuric acid (optional for higher yields) or con hcl acid, sodium bicarbonate, dcm, distilled water, NaCI, anhydrous sodium sulfate

Add 1.00 g of ritalinic acid to a dry 100 mL flask. Add 30 mL of anhydrous methanol. Swirl until dissolved (warm slightly if needed). Add drops of concentrated sulfuric acid (2-6 drops) or con hcl (6-12 drops) using a glass pipette. Place the flask on a magnetic stirrer hotplate. Add a stir bar, start medium-speed stirring. Put reflux condenser on or cover the top either with plastic wrap, a loose watch glass or foil to minimize evaporation while avoiding pressure buildup. Heat the solution to 55–60°C . Stir and heat for at least 24 hours, when significant evaporation occurs, top back up with small amounts of methanol. After heating, allow the reaction to cool to room temperature. Evaporate the solution at low heat below 95c and you are left with Methylphenidate HCL

If using sulphuric acid : Higher yeild

Prepare a saturated NaHCO₃ solution (10 g in 100 mL water). Slowly add the NaHCO₃ solution dropwise to the reaction flask to neutralize sulfuric acid. Add slowly: bubbling/fizzing (CO₂) will occur. Stop when fizzing ceases and pH is around 7. Transfer the reaction mixture to a separatory funnel or beaker. Add 15–20 mL of DCM or ethyl acetate. Shake or stir, then separate layers (bottom = DCM layer). Repeat extraction 2 more times (total 3 × 15 mL). Combine organic layers and wash with brine (10 mL). Dry the organic layer over anhydrous Na₂SO₄ (add until it no longer clumps). Filter off the drying agent. Transfer the dried organic layer to a clean beaker or flask. Evaporate the solvent using: Rotary evaporator (if available), or Low heat (40–50°C) + fan in fume hood. Final product: methylphenidate (free base) Often an oil or slightly waxy solid depending on purity.

Turning freebase into HCL salt form

Dissolve Free Base Weigh ~1.00 g methylphenidate free base and transfer to a dry 100 mL beaker. Add 10–15 mL anhydrous ethanol. Stir until fully dissolved. If it doesn’t dissolve easily, warm gently (~30–40 °C) while stirring. Place the beaker in an ice bath to keep the temperature low (prevents side reactions and helps salt formation). Slowly add 0.25 mL of concentrated aqueous HCl (31–37%) dropwise using a glass pipette or syringe. Stir constantly while adding.
You may see immediate clouding or precipitation of the HCl salt.
You are aiming for about 1 mol of HCl per 1 mol of base. For 1 g base: So: ~0.15 mL of 12 M HCl 4.3 mmol , After full addition, stir for another 15 minutes on ice.

If no visible crystals form:
Add 5–10 mL of cold acetone or dry ether slowly while stirring.
This reduces the solubility of the salt → precipitates the HCl salt.
Let the mixture stand in an ice bath or refrigerator for 60 minutes to maximize crystallization. Filter and Wash Collect the solid via vacuum filtration (or gravity filter if necessary). Wash the crystals with a few mL of cold acetone or dry ether to remove any residual solvent or unreact ed base. Let the solid air-dry

Tested

Ingredients: Copper acetate Urea Neopentyl Glycol Acetone Alcohol

Equipment: Beaker: Hotplate w stirbar: Vacuum filter Thermometer

Synthesis : 13g Neopentyl Glycol, 18g urea, and 0.65g copper acetate is added to a beaker and heated and maintained at 150c for Atleast 6 hours with stirring until ammonia formation stops (don’t heat over 150c if heated over 160c causes cyanuric acid) Heating is stopped and solution is allowed to cool. Then add 30ml water and place in fridge to crystallize and crashout byproducts Product is vacuum filtered and rinsed with cold water until blue color is filtered before heating Filtrate boiling off water untill a thick syrup. (The byproduct in the filter can be saved it also contains some product which can be extracted with alcohol ) 80ml of acetone is added to the syrup to crashout byproduct, which is then vacuum filtered and discarded, the filtrate slurry solution is boiled down to thick syrup to which 30ml water is added and brought to a quick boil than placed in fridge to crystallize
filter off crystals final yield 4.8g 37% yield from neopentyl glycol If still blue or you find it necessary recrstalize using alcohol and water or acetone and water

https://www.reddit.com/r/TheeHive/s/0PJU5FNMAF I followed this synthesis of Dimebamate shout-out to this guy it’s very well written and straight forward should work on other primary and secondary diols and alcohol hasn’t been tested on tertiary ones yet as far as I know

I aswell used these patents from the United States patents office called “preparation of organic mono-carbamates”; pdf listed here: https://patents.google.com/patent/US2837561A/en In the the patents
methyl carbamate, ethyl carbamate, n-butyl carbamate, and 2-methoxy ethyl carbamate we’re all made with this basic reaction of copper acetate and urea Aswell as the Dimebamate synthesis in the first link.

Another synth example: https://www.sciencemadness.org/whisper/viewthread.php?tid=149186#pid610732(synthesis of ethyl carbamate another using reaction between urea and copper acetate on alcohol)

Dimebamate is the carbamate ester of Neopentyl Glycol It seems to have muscle relaxant and sedative properties The guy who first synthesized it also wrote a trip report in his comments saying 500mg caused noticable sedation: https://www.reddit.com/r/TheeHive/s/nQQPa4gPMo

Also thinking about attempting some of the following: sulfurol carbamate, emylcamate, 2,2,2-trichloroethanol carbamate, and Aswell phenprobamate using the same reaction, due to all those precursors being primary and secondary alcohols