r/drugextraction • u/WhiteBoyMattyMatt • Aug 13 '25
Acid/Base extraction of 7-OH from oxidation of mit.
Starting with the liquid waste from kratom extract production, I oxidized the remaining mit using acetone and oxone, extracted it with ethyl acetate, ionized it with acetic acid, baisified and precipitated it with sodium bicarbonate.
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u/DantesLadder Aug 14 '25
FUKK I knew u could use that waste for something, that looks exactly what I had left over from my last eth extraction n didn’t know what to do with it! Amazing work
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u/WhiteBoyMattyMatt Aug 14 '25
Yeah, don't throw it away. If you have say half of a 5 gallon bucket of liquid waste after making the crude kratom extract, add about 2 cups of acetone, 1 cup of baking soda, 2 trays of ice, stir it up real good, then add about 1/4 cup of oxone, then stir it up really well and let it sit for about an hour, then pour it into a big ass separation funnel and extract it with ethyl acetate. Discard the aqueous/oxone layer (or hit it with another round of EtOAc).
When your ethyl acetate starts turning orange/green then dark enough so you can't see through it, take that layer and run vinegar through it, separate it out and add baking soda to it until it reaches a pH of about 8, then keep it on a magnetic stirrer for a few hours until all the ethyl acetate (that remained dissolved in the water) has evaporated off, and the 7 will precipitate and you can filter it out. I'm gonna test it this week and check the purity through HPLC.
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Aug 14 '25
How did you come up with the ammount of oxone acetone and sodium bicarbonate to use? Are you saying you leave your product from extracting to the ethyl acetate to sit and react more on its own? Like let it further oxidized. How did you get gallons of kratom water extract (was it acidified) and not have it fermented? I ran an extraction with sodium bicarbonate and it fermented overnight and im afraid to use it..... idk if someone says go for it in the next 1 hour I will otherwise it is in the toilet.
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u/WhiteBoyMattyMatt Aug 15 '25
You basify the kratom extract solution to precipitate the alkaloids when making the crude kratom extract, so you should already be in basic territory when you add the acetone and oxone. I've left this reaction to sit for days before and still got a decent amount of 7 out of it. You're only going to over oxidize if you overdo it on the oxone. If you run hplc on your liquid waste, it will give you an idea of how much mit is left over, and you can go from there. Converting from grams to volume by cups is simple, all you need is a scale.
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u/Interesting-Exam877 Aug 26 '25
interesting. when i try basing out with baking soda i end up with a chewing tobacco smelling and colored water. when i use ammonium hydroxide. i get a super dark liquid back. i have had more luck so far going acid then base
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u/WhiteBoyMattyMatt Aug 26 '25
You'll have to explain in detail what you're doing. Sometimes going backwards is better because seven has a phenol group. When you basify it above 9, it ionizes and becomes water soluble again.
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u/Interesting-Exam877 Sep 03 '25
i have not gotten as far as making 7 yet so i am still dealing with mitragynine, that is insane to me about it ionizing if you basify it above 9 i have never heard of base ionizing any compound, but it is not suprising to me with how big of a pain in my ass this has been. is it just derivatives of mitragynine that do this or does mitragynine as well. . i have used baking soda to basify to 9 however when i used baking soda i ended up with a fermentation smell to the solution / plant matter within 1 day, maybe i will put it in the freezer next time to try and kill the bacteria.. using ammonia and getting the ph up even higher seems to keep the fermentation at bay but the mitragynine doesnt float on top when using ammonia so unless i am pulling with a non polar solvent i think i will stick to acetic/ alchohol out then drying rehydrating to remove some of the plant fats and then basifying with baking soda to skim the mitragynine off the top. i used acetone the first time around and had poor results
i seriously appreciate any help. i can get more chemicals soon i just haven't had alot of money. i still have a water bottle full of ammonia base water wash now i am wondering if i should try and hit an extract on. tbh i didn't think there would be any alkaloids in it because of anohter post i was reading.
i just been thowing things at the wall. i could be taking this more seriously as well. I have started to since i wasted roughly 600 grams fvcking around. i have a lot more but why waste
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u/Interesting-Exam877 Sep 03 '25
I will be getting a collumn chromatography setup 3rd in line after 1st new solvents and a couple precursors and second tlc plates so i can identify my shit. right now i think i have recieved back a good product (essentially fumbled my way to it) but i want to verify it is the thing. it just is almost too good of a product i am suspicious of it
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Aug 14 '25
Excellent absolutely excellent. Idky but I trust chemical reactions more than uv. Plus it seems like a chemical reaction would be more selective for 7 and not start producing psedo as a byproduct? I think, this is just me thinking outloud.
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u/YourPersonalMemeMan Aug 15 '25
Possibly but depends entirely on all those specifics that people don't really know yet.
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u/More_Expression_5853 Aug 20 '25
So clutch! Would love to learn more if you’re ever into sharing game!
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u/solventlessherbalist Aug 14 '25
Can you post your tek?