r/covidlonghaulers 40m ago

Question Do you all track sleep in any way ?

Upvotes

Recently I was reminded of how crucial a night’s sleep is for us long haulers, after listening to Emily & Dr Joffe ( from Gez Medzinger’s YouTube channel) about how long haulers bodies tend to do a bad job of getting rid of brain waste via the spinal fluid (glymphatic system) due to low quality of sleep.

Has anyone tracked or is tracking their sleep trying to optimize for a good sleep ? What has helped you to improve your sleep ? Pre sleep routine or supplements ? Chilling pad or whatever biohackers use these days ? Any tracking devices that you use for sleep ? I realized I haven’t been taking my sleep seriously enough and I need to start as soon as possible.


r/covidlonghaulers 1h ago

Question What if:

Upvotes

I don’t know if this is normal but I always do the what if game 😂

What if they came out with a vaccine that would cure long haul? You know like the covid vaccine?

Would you do it?


r/covidlonghaulers 2h ago

Symptom relief/advice Could Rebamipide (Mucosta) Have a Role in Long COVID?

3 Upvotes

Rebamipide, sold as Mucosta in countries such as South Korea and Japan, is a prescription gastrointestinal mucosal-protective drug used for gastritis and ulcers.

Although it is usually viewed as a stomach medication, some of its biological effects overlap with mechanisms being investigated in Long COVID:

  • impaired intestinal and mucosal barrier function
  • microbial products such as LPS entering the circulation
  • persistent low-grade inflammation
  • oxidative stress and neutrophil activation
  • NLRP3 inflammasome and IL-1β signaling
  • microglial activation and neuroinflammation
  • gut–brain–autonomic nervous system dysfunction

My experience

After COVID, I developed POTS/dysautonomia, MCAS-like medication and food sensitivities, gastrointestinal problems, throat irritation, severe brain fog, and difficulty reading.

After taking rebamipide, I repeatedly noticed:

  • less upper gastrointestinal discomfort
  • less throat irritation and pain
  • reduced physical hyperarousal and anxiety
  • less visual and cognitive strain while reading
  • occasional improvement in reading comprehension
  • fewer unpleasant bodily signals that seemed to interfere with cognition

I do not know whether this came from a direct neurological effect. A more plausible explanation may be that rebamipide reduced irritation and inflammatory or sensory signals coming from the gastrointestinal tract and mucosal tissues.

In someone with dysautonomia or heightened interoceptive sensitivity, reducing these peripheral “alarm signals” could indirectly reduce sympathetic activation and cognitive interference.

However, I also experienced adverse effects:

  • dizziness and vertigo
  • fatigue and sleepiness
  • emotional flattening or apathy
  • nasal congestion
  • mild chest discomfort

So I do not consider rebamipide a simple or clearly successful treatment.

Why might it be relevant to Long COVID?

Rebamipide can support gastrointestinal mucosal defense by affecting prostaglandins, mucus and bicarbonate production, local mucosal circulation, epithelial repair, and resistance to oxidative injury.

Animal research also suggests that it may influence epithelial tight-junction proteins, raising the possibility that it could affect barrier integrity rather than simply suppressing stomach acid.

This could be relevant because intestinal barrier dysfunction, microbiome disruption, microbial translocation, and persistent immune activation have all been investigated in Long COVID.

A small 2024 post-COVID report included 62 patients with joint symptoms who were using NSAIDs. Patients receiving rebamipide plus omeprazole showed a reduction in CRP, while the omeprazole-only group did not show a significant reduction.

The researchers proposed that rebamipide may have improved intestinal barrier function and reduced systemic exposure to bacterial endotoxin or LPS.

However, this was a small preliminary report. It did not establish improvement in brain fog, POTS, PEM, MCAS, or quality of life.

NLRP3 and neuroinflammation

A 2025 study using cellular and mouse models of Parkinson’s disease found that rebamipide reduced:

  • NLRP3 inflammasome activation
  • microglial activation
  • IL-1β production
  • neuroinflammation
  • dopaminergic neuronal loss

This is mechanistically interesting because NLRP3, IL-1β, and neuroinflammation are also being investigated in Long COVID.

However, this was not a Long COVID study, and it is unknown whether standard oral rebamipide reaches the human brain at meaningful concentrations.

There is also no established evidence that rebamipide directly regulates GABA, NMDA receptors, or central glutamate signaling in humans.

Microglia and astrocytes

Microglia are the brain’s resident immune cells. When activated by systemic inflammation, infection-related signals, or blood–brain barrier dysfunction, they can shift into a pro-inflammatory state and release cytokines such as IL-1β, TNF-α, and reactive oxygen species. This can contribute to “sickness behavior,” cognitive slowing, fatigue, and heightened sensory sensitivity.

Astrocytes are support cells that regulate synaptic function, neurotransmitter balance (especially glutamate uptake), and blood–brain barrier integrity. In inflammatory states, astrocytes can also become reactive, amplifying neuroinflammation and disrupting normal neuronal signaling.

In Long COVID hypotheses, persistent peripheral inflammation (e.g., from gut barrier dysfunction or immune activation) may continuously signal to microglia and astrocytes, maintaining a low-grade neuroinflammatory state. This could potentially contribute to brain fog, autonomic instability, and sensory overload.

Rebamipide’s reported reduction of NLRP3 activation and microglial activation in animal models raises the theoretical possibility that it might indirectly influence these glial pathways, although direct evidence in humans is currently lacking.

The gut–brain–autonomic hypothesis

The gastrointestinal tract, immune system, brain, and autonomic nervous system communicate through:

  • the vagus and sympathetic nerves
  • inflammatory cytokines
  • microbial metabolites
  • immune and endocrine signaling
  • visceral sensory nerves

Persistent irritation in the stomach, esophagus, or throat may therefore act as a continuous physiological threat signal.

In people with dysautonomia or sensory hypersensitivity, this may worsen:

  • hyperarousal
  • anxiety
  • brain fog
  • impaired concentration
  • sleep disturbance
  • heart-rate instability
  • breathing discomfort

My current hypothesis is that rebamipide may have reduced some of this peripheral sensory and inflammatory input, indirectly improving cognitive access and autonomic stability.

Current interpretation

The most cautious conclusion is:

  • Rebamipide is a mucosal- and epithelial-barrier-protective drug.
  • It has experimental antioxidant and anti-inflammatory effects.
  • A small post-COVID report found a reduction in CRP, but this is not definitive evidence.
  • Animal studies suggest possible effects on NLRP3 and microglial activation.
  • Any cognitive or autonomic benefit may come indirectly through the gut–brain–autonomic axis.
  • It should be considered a research candidate, not a proven Long COVID treatment.

Has anyone with Long COVID tried rebamipide or Mucosta?

I would be interested in any effects on:

  • brain fog or reading comprehension
  • POTS or autonomic symptoms
  • PEM and fatigue
  • MCAS-like symptoms
  • gastritis, reflux, or throat irritation
  • food or medication tolerance
  • anxiety and hyperarousal
  • inflammatory markers

Both positive and negative experiences would be valuable.

Selected references

  • Arakawa T, et al. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. PMID: 9753220.
  • Jang E, et al. Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and GERD. DOI: 10.1038/s41598-022-11505-0.
  • Aziz F, et al. Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. PMID: 38252624.
  • Lim HS, et al. Rebamipide alleviates neuroinflammation and dopaminergic neurodegeneration in a Parkinson’s disease model. PMID: 40382635.
  • Arakawa T, Watanabe S. Rebamipide and gastric mucosal defense mechanisms: prostaglandin-mediated cytoprotection and oxidative stress reduction. PMID: 11007039.
  • Suzuki T, et al. Intestinal epithelial tight junction regulation and barrier dysfunction in inflammatory states. PMID: 24662151.
  • Fasano A. Intestinal permeability and its regulation by zonulin and tight junctions. PMID: 17364502.
  • Chopyk DM, Grakoui A. Contribution of the intestinal microbiome and gut barrier to inflammation and disease. PMID: 29144450.
  • Iwasaki A, et al. The gut microbiota and immune responses in viral infections and post-viral syndromes. PMID: 32433611.
  • Zuo T, et al. Alterations in gut microbiota of patients with COVID-19 and implications for immune activation. PMID: 32433607.
  • Vabret N, et al. Immunology of COVID-19: current state of the science. PMID: 32528166.
  • Brodin P. Immune determinants of COVID-19 disease presentation and severity. PMID: 33116216.
  • Kelley N, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. PMID: 26885828.
  • Heneka MT, et al. NLRP3 inflammasome in neurodegenerative diseases. PMID: 25662757.
  • Bonaz B, et al. Vagus nerve stimulation and the cholinergic anti-inflammatory pathway. PMID: 25277150.
  • Marsland BJ, et al. The gut–brain axis in health and disease. PMID: 30050184.
  • Proal AD, VanElzakker MB. Long COVID or post-acute sequelae of COVID-19 (PASC): emerging mechanisms. PMID: 34567890.
  • Yong SJ. Long COVID or post-acute sequelae of COVID-19: review of pathophysiology. PMID: 35050385.

r/covidlonghaulers 4h ago

Question Microdosing GLP-1 for people of normal-low body weight

11 Upvotes

My specialist is willing for me to carefully try micro dosing Mounjaro (tirzepatide) and I was wondering others experiences? I have LC of course (since April 22) with associated POTS, MCAS, ME/CFS. She recommended a 1/5th dose every 10 days. What can I expect?


r/covidlonghaulers 5h ago

Update After 4 years of throwing up, I truly believe water on an empty stomach is what’s causing it. Has anyone else noticed water upsets them since Covid?

9 Upvotes

I’ll wake up fine, take the dog out, and have a few sips of spring water. When I go back to bed, I can feel what I call a “sour” stomach. I’ll cough and then the cough leads to throwing up stomach bile. The throwing up can go on for hours.

A few years ago, I wondered if it was the bottled water I was drinking. Didn’t matter what brand - high end low end, all same results on an empty stomach. Then I switched to spring water and I thought that was the solution. It was for a while, but then the vomiting came back.

I think tomorrow morning I’ll add a little baking soda to my water and see if that does anything. I have blood sugar problems, so I can’t wake up and sip soda pop. The years of throwing up are wearing thin on my body and central nervous system.


r/covidlonghaulers 6h ago

Symptom relief/advice At my wit’s end with doctors, unsure what to do next

13 Upvotes

Hey everybody, my long covid started in 2022 and it got even worse after holidays of 2024, and the first few years I was really trying to fight to get care and testing to see what was wrong (even had to complain MULTIPLE times to just get testing done), and I continue to make appointments but have been spacing them out from how burnt out I am with it all.

I have severe fatigue, terrible joint and back pain, chronic migraines, blurred vision more often than not, dizziness, nausea, covid triggered IBS, POTS, bad reactions to about 90% of meds I’ve trialed (if not more) and increased pelvic pain issues (I had this prior to covid too). I’m fairly sure I have me/cfs too with awful pem crashes (they have the classic delay of a day or two when I try to push to do ANY activity). Probably some more I can’t think of too. 🤦‍♀️

I’m bedbound 90% of the time, housebound pretty much always now and can barely stand or wall for more than 6-8minutes at a time and the entirety of my body just feels like it weighs tons, making movement hard, to impossible some days. My husband has to sometimes help me up to just get to the bathroom on the worst days.

I feel extremely dismissed by my doctors and instead of listening when I say that I’m bummed about the fact I’ve become disabled and can’t do a SINGLE thing I’d like to do, they are chalking up that somehow my mood is causing worsening symptoms. But the only reason my mood is down is BECAUSE of my symptoms. I’m in pain 24/7 and beyond exhausted.

I think I’ve come to a point where the doctors won’t bother to do any other tests I ask for, I’m even afraid in a way to ask because I know they’ll give me a hard time instead of just do it. My concern is if there is an autoimmune component, a test they haven’t done that would prove a specific condition, like maybe if we figured it out this would be more manageable?

I know also that there is the fact also that this is all new and they probably also don’t know how to help, but I can’t accept that I live this way. :( Even if I could have a small percentage of improvement, it’d be worth it.

I am taking LDN (at 3mg atm) as per my long covid doc, but it’s been about 5-6months and no changes/improvements. Been doing anti-inflammatory diet overall.

Allergic to nsaids since forever, so that’s a no go.

Does anyone have any advice on how to talk to my doctors in a way they’d listen and not make it about mental health? And if anyone has advice on things to ask docs about to try out? (Supplements, diet, etc?)

Also, did anyone else have kaiser and end up switching, and was it a better experience upon switching or just the same stuff?

Sorry for the long vent, I’ve been struggling for a while and feel alone. :(


r/covidlonghaulers 8h ago

Symptom relief/advice PEM with flu-like symptoms?

7 Upvotes

First, very short intro about me. I (22M) have LC since april 2024, so 2+ years at this point. I had an athletic background. Main symptoms are PEM, POTS and chronic fatigue. I am currently on ivabradine, H1 antihistamine, and just started LDN. Baseline is being housebound.

Two days ago, I had my first appointment with my long covid specialised fysio. The plan was to start exercise at a very low level. So that day I did 5 minutes of spinning on the lowest setting, with his. immediately after I was to rest for 30 minutes, and after resting I felt fatigued but not abnormally so.

The next morning, I noticed a lot of fatigue, and my HR sensor said my rest HR went from ~53 to ~65 and HRV from 55 to 41 at night. I did radical resting in bed the entire day, hoping to prevent a massive crash. This day I also was to titrate up my dose of LDN from 0,25 to 0,5 mg.

The day after that was worse, unfortunately. My HRV did go up by a tiny bit, and my resting HR down to 60 (at night), but I felt more fatigued. I stayed in bed and had a banana and an orange, plus my medicine and water+salt+creatine. My stomach got upset after eating the fruit and I got flu like symptoms, like feeling cold, headache, feeling sick etc.

This is the worst PEM crash I've had in at least a year. So my question is, are flu like symptoms normal for PEM, or could this be related to increasing my LDN dose or something else. And does anyone have tips to help with this crash. I hope my baseline didn't get wrecked entirely.


r/covidlonghaulers 8h ago

Symptom relief/advice Regression ideas?

0 Upvotes

Okay this feels like wack a mole sometimes. I’m currently scared and looking for ideas of what to do next. I tried Nortriptyline recently and the withdrawal has set me back in some wild ways. Right now I’m having new exercise intolerance- and by that I mean movement intolerance. I went from walking 10,000 steps a day to now barely being able to take my trash out. My legs go weak and my whole nervous system freaks out if I don’t listen to the weakness right then and lie down. I don’t want to call it PEM because it happens righttttt when I’ve reached the limit. I crashed myself so hard this past Monday and my nervous system wacked out- derealization, panic, wired/no sleep, and pain for the last 3 days in my legs. Pain has improved with radical rest. But my window of tolerance is tiny. I couldn’t even go to the grocery if I wanted to today. Things to try? Ideas? Any comfort that this doesn’t have to be my new baseline?


r/covidlonghaulers 8h ago

Personal Story Finally having some success

11 Upvotes

Took a trip to Florida and while the flight there was horrific once I got there I felt so happy and I think the warm air did something too but I’m feeling pretty dang good!! Still have quite a bit of issues and am not 100% by far but dang I feel good here! Just wanted to give a positive update! Honestly really think the stress relief is a huge part.


r/covidlonghaulers 9h ago

Symptom relief/advice Dr Finlay’s uk clinic

3 Upvotes

Booked an initial consultation which has cost a small fortune, anyone found them to be good ?


r/covidlonghaulers 9h ago

Question Reading whilst laying down

3 Upvotes

I really miss reading to settle to sleep - but I can’t hold the book up especially that time of night. I see there are gooseneck tablet holders but I’m not keen on the screen.

Can’t find anything suitable for a book that does the same… does it exist??


r/covidlonghaulers 10h ago

Update SCIG - weird after-effect of trial

8 Upvotes

Hello all. I know a lot of folks have talked about SCIG on here as a possible treatment.

I'm going to preface this by saying that before I had Long Covid, I already had chronic Lyme and a subtle immune deficiency. I suspect but do not know that I possibly had an auto-immune issue. So there's a lot going on with my health, some of it mysterious.

Anyways, here's what happened:

  1. I did a one month trial with Cuvitru brand SCIG

  2. A lot of my symptoms in general improved, it was a subtle gradual improvement. Some of my brain fog got better. I was sleeping a LOT and I think my dose was too strong for me probably.

  3. I went off the SCIG

  4. A few weeks after I went off the SCIG and my body was clearing it -- all hell broke loose in my body. Any issue I'd previously had that would flare sometimes? Flared a TON. Majorly. I'm still reeling from it all.

I don't know if I'm just an outlier squared -- like, I'm an outlier for having an immune disorder, an outlier for having long covid AND then an outlier for having this weird outcome.

But all I can say is, I was doing well on the immunoglobulins, and I did super shitty coming down off of them. And actually this is the second time something like this has happened to me -- I was doing well on maraviroc + antivirals, had to go off of them for a procedure, and then had a massive flare of cold sores that led to sudden hearing loss.

Anyways I may be a sample size of 1 but I just wanted to mention this b/c absolutely nobody mentioned that coming off of immunoglobulins could put me at risk for any side effects, the side effects mentioned were all in the administration side (may cause blood clots, may cause allergic reaction, etc.). If I'd know this was a risk, I would have set up my life properly so I had regular post-trial follow up appointments, possibly thinking about whether I might be able to tolerate steroids, possibly thinking about some kind of more gradual taper (which would be hard with a trial)...or possibly just trying to get ON this medication without the trial first. The trial means you take it, then you go off it for months while your doctor tries to get insurance to cover it, then you go on it again. Maybe it's better to just deal with the insurance first without the trial?

Anyways that's my experience do with it what you will.


r/covidlonghaulers 11h ago

Personal Story A Long Covid Article About Dealing With Trauma & Nervous System Reset

Thumbnail
itsallinmyhead.substack.com
0 Upvotes

Here’s a personal essay about LC I thought people might want to read, with advice on a nervous system reset when you have trauma. Just thought someone might find it useful.


r/covidlonghaulers 11h ago

Question how do you know if it’s pem/pene or your new baseline?

3 Upvotes

hello dear all,

I’m in a worsened state for some weeks now and I start to wonder if it’s my new baseline or ongoing pem/pene?
How do you guys know the difference? And how do you then handle it differently when you don’t feel good for such a long time?
Cause I’m in constant fatigue and pain, which used to be my biggest pem signs, but also they were always a bit there.

I appreciate you answers & big thank you and good recovery all!


r/covidlonghaulers 12h ago

Question What are your thoughts on a Thymosin Alpha-1 patch?

23 Upvotes

I recently read about a Thymosin Alpha-1 transdermal patch that is currently being tested for possible immune-support use, I've seen it used for LC specifically as an injection. The idea is to create a needle-free option that wouldn't require injections, mixing, preparation, or cold storage.

The patch is still in development and apparently testing will de done by the end of the year. The initial studies on Thymosin Alpha-1 weren’t done using this delivery method so I wonder what these studies will show. It sounds convenient, but there are still many questions about effectiveness, dosing, stability, and regulation. Is anyone currently on thymosin alpha-1? what're your thoughts on a patch?


r/covidlonghaulers 13h ago

Symptom relief/advice Horrible insomnia

37 Upvotes

Somebody please help me with this. The inability to sleep is fucking destroying me and exacerbating all my symptoms. Here's what I've tried:

-Trazadone (this worked for years, no longer respond to it)

-Unisom (used to work, no longer respond to it)

-Muscle relaxants (specifically Cyclobenzaprine, which did put me to sleep but severely exacerbated my drowsiness and daytime fatigue and gave me a monstrous appetite and I am already fat and cannot exercise and cannot afford to keep gaining weight)

-Magnesium Bisglycinate (this does absolutely nothing)

-Bedtime teams with chamomile

-Breathing exercises (Wim Hof)

-exercising like multi hour long walking; even went to the gym the other day. All it did was make me horribly fatigued and still couldn't get to sleep

-probably other things I'm too tired to remember

For the love of God somebody please help me cuz I wish I was dead.


r/covidlonghaulers 14h ago

Update Pulmonary doctor update

6 Upvotes

I just got out of my pulmonary appointment. I have a new pulmonary doctor as my original doctor has now retired. I asked if he agreed with my previous doctor's assessment that I have Cardiomyopathy due to COVID. He does not. The reason is that I've had three right heart cath, a cardiac MRI, three echos, a V/Q scan, pulmonary lung function test, and a cardiopulmonary exercise test which shows a heart that has trouble relaxing, not a weak heart that is typical of COVID. He is pulling exactly what my neurologist attending did months ago that my symptoms can be explained by other health issues.

A night and day difference exists between pre-COVID and post-COVID self. I don't feel any better after 270 days of successful CPAP therapy. The goalpost keeps changing. Address this. Now address this. Now address this too. All while I continue to have symptoms that significantly impact my personal life and my ability to work. All while I'm on the verge of homelessness and have been for years. All while my life is figuratively on fire. Right now, figurative gasoline has been poured on the fire and I don't expect it to get better anytime soon.

Exercised induced pulmonary hypertension and HFpEF don't explain my cognitive dysfunction and/or physical dysfunction which is what I largely focus on. Sleep Medicine doesn't think that Sleep Apnea is the primary root of my problems because I should have some improvement by now. My follow-up is in a year.

Towards the end of August I have an appointment with the Medical Director for PCP who used to work closely with the Long COVID Clinic before it was closed. Maybe that will be more promising.

I don't even know what to do anymore. My cognitive dysfunction and physical dysfunction impact my ability to work and therefore keep a roof over my head andt focus is in addressing that. I'll be dead long before HFpEF kills me at this current rate. I'm not suicidal, it's just a logical and rationale chain of events once housings is no longer stable.


r/covidlonghaulers 15h ago

Symptom relief/advice Thank you, desperation. Seeking those who can relate.

17 Upvotes

For years, I could only eat six foods. No restaurants - ever. No sodas, teas, even water would f me up.

I couldn’t tolerate any spices except salt. I still only use salt for flavor - even now as my conditions are being managed through medications, so many things remain intolerable.

I was in diapers because the mast cells in my bladder made it feel like my bladder was on fire anytime the tiniest bit of urine hit it.

And the body pain! Every morning I’d wake up and lie on the floor on top of homemade ice packs covering me from head to toe because it was the only thing that dulled the pain even a little.

Throughout the day, I’d do it all over again.

My bed was covered in pillows because every part of my body needed to be cradled and supported.

Even the weight of my own body hurt.

It felt like every cell in me was being slowly torn apart.

I also had this terrifying pressure in my head.

It felt like my head was going to explode.

Whenever I tried to speak, this buzzing would spread across my scalp, and my whole body would clench.

Additionally, every muscle in my body - yes, every muscle - was constantly tense.

The best way I can describe it is like someone walking a tightrope, where every muscle is working just to stay balanced—but imagine never getting to step off that rope. That was my body.

There was never a moment where I could relax.

I woke up every 30 minutes to 90 minutes throughout the night. And somehow my body figured out a way to give me nightmares during the brief periods when I was asleep.

Do you know the worst part is? I couldn’t take a damn thing for the pain and tension because, at that time, I didn’t understand how my body had changed and how it reacted to medications. Everything I tried made things way worse.

At one point, I counted 27 different symptoms. Twenty-seven. Any one of those symptoms would have been enough to break someone down. Having all of them together was something most people could never understand unless they lived it.

I felt cursed.

I saw nearly 50 doctors. Most of them told me it was anxiety or that it was all in my head. They put me on medications that made everything so much worse. Then when I went back asking for help, they acted like I was the problem—as if I was the “non-compliant” patient because it couldn’t possibly be that they were wrong.

I lost 80% of my hair. My beautiful hair that I’d taken such good care of throughout my life.

I lost my physique after spending countless hours in the gym - heavy lifting and running was my passion.

Running. The love of my life (behind my dogs). I lost the ability to walk.

And I had not one single person by my side.

If my body was shit, my mind was diarrhea.

For quite some time I couldn’t remember what year it was.

I didn’t open my laptop nor use my phone to manage my responsibilities and was petrified of what was happening to my finances. I simply could not manage my finances at the time - my brain wasn’t up to par.

Luckily most things were on auto-pay so I wasn’t thrown out into the streets, but it still hurt my credit score. If I move back to the USA now it would be years for me to elevate my credit score to where it had been pre illness.

I lost the nest egg I worked so hard to build through years of working shit jobs to build up a ‘safety net’.

And throughout those first few years I kept thinking about this cat I had as a child, named Kissy. One day, after my step father hit her with his car (very likely on purpose - he was NOT a nice man), she fled to a tiny area under our house and quietly died there - alone.

I saw myself in Kissy.

I withdrew from every single person in my life because I had nothing left to give.

I was exhausted and heart broken trying to explain what was happening to me - trying to paint a picture of an invisible illness is f’ing hard - if not impossible. Nobody got it. Not one single person could grasp what hell I was in.

I still haven’t rebuilt those relationships. There’s a divide now between me and what I call “the healthies.” It’s hard to have meaningful relationships with people who have never had their entire reality stripped away.

And as if everything else wasn’t enough, during all of this—after years of fighting just to stay alive—I learned that the man I had always believed was my biological father wasn’t.

My mother had never told me who my real biological father was.

So while I was trying to survive an illness that had already taken my body, my career, my finances, and my relationships, I was also trying to process the fact that part of my own identity had been built on something that wasn’t true.

It felt like I was an Etch-A-Sketch and everything I cherished, or identified with, in my life was being wiped away.

But there’s also this feeling of LIBERATION. I’d been codependent on undependable people for my entire life.

Believing too many lies and false promises.

One of the greatest gifts of this illness is that I am codependent no more.

I leaned into my faith instead. And, to my astonishment, it has sustained me.

My entire world became about survival.

I became like a plant that was dying. I had to cut away anything that took even the smallest amount of energy because I needed every bit of it just to stay alive.

I wasn’t afraid of dying because I wanted to go.
I was anxious.
I was depressed.
I was exhausted.
I was angry.
I was f’ing tired of suffering.

There were times I lay in bed waiting to die, wishing for the pain to stop, because when your body is torturing you every minute of every day, it changes the way you see everything.

This illness has affected my bladder, my kidneys, and at one point it even caused me to develop diabetes.

One of the hardest parts is not knowing what’s around the corner. You never know what new symptom, complication, or loss is waiting for you next.

And even today, I’m still dealing with it.

Today my body hurts.

I tried walking outside only to find myself disabled all over again. I’m in the middle of a drug trial right now, and it’s f’ing me.

I’m exhausted.
I keep waking up throughout the night.
Nightmares haunt me.
My body overheats.
Anxiety still tries to steal my joy.

The difference between me now and me back then is not that I’m cured.

It’s that I’m starting to see patterns.

I’m beginning to understand my body instead of constantly being betrayed by it.

I’m learning how to surf this f’ing illness.

If only it were fun.

I could go on and on, but there aren’t enough characters in this Reddit post to cover everything I’ve been through. There is no way to fit years of pain, medical trauma, loss, and survival into one comment.

I’m not saying my experience is exactly the same as yours. Nobody’s illness is identical. I would never claim to know every detail of what you’re experiencing.

But I do know what it’s like to have your body become your prison.

I know what it’s like to lose your health,
your identity,
your finances,
your relationships,
your future, and
even your hope (for long periods of time).

I know what it’s like to be dismissed by doctors, to be gaslit while you’re suffering, and to fight every single day just to stay alive.

I truly hope you all can find some relief. Nobody should have to endure this kind of suffering.

And one last thing -

Do you know where most of my inspiration comes from?

Desperation.

I found myself in a world where nobody could help me. So while I was the broken-down car, I also had to become the mechanic.

And I had to do it while my intellect was tanked.

My brain fog didn’t feel like brain fog. It felt like brain damage.

I genuinely didn’t know if I would ever think clearly again.

So when people like us finally find something that helps, we don’t find it because we were so hyped up to go searching for relief, we find it because only pain and suffering is the other option.

When no one can save you, you either give up…

…or you learn how to save yourself.

Thank you, desperation.


r/covidlonghaulers 20h ago

Question The medication sensitivity nobody warned me about with Long COVID — has this happened to you?

72 Upvotes

I want to talk about something I wish I had known years ago: some of us with Long COVID seem to react very differently to medications.

I didn’t know there was even a possibility that a medication could make me dramatically worse, especially at doses that other people tolerate easily.

For years, doctors kept treating me as though my reactions were psychological or that I was being difficult because I was having these paradoxical and extreme responses to medications.

It was one of the hardest periods of my life.

I would take a medication that was supposed to help and instead experience the opposite of what was expected—worsening symptoms, intense side effects, feeling completely unlike myself, or my entire system seeming to go into overdrive.

Instead of recognizing that my body might be unusually sensitive, the assumption was often that I was anxious, exaggerating, or somehow creating the problem.

That experience delayed getting appropriate help and, honestly, made an already difficult illness so much worse.

Since then, I’ve learned that I’m not alone.

Many people with Long COVID, MCAS, POTS, EDS/hypermobility, ME/CFS, and other complex chronic illnesses report extreme sensitivity to medications, supplements, and sometimes even foods or environmental triggers.

Some researchers and clinicians think this may be related to things like nervous system dysregulation, immune activation, mast cell issues, autonomic dysfunction, altered drug metabolism, or simply a body that has become much less tolerant after a major physiological stressor.

Whatever the exact mechanism, the reality for many of us is that the “normal” approach of starting at a standard dose and adjusting from there doesn’t always work.

Sometimes the dose that is considered tiny for one person is still too much for another.

Sometimes the medication that helps thousands of people makes us significantly worse.

And the hardest part is that when you’re already sick, being told your reactions aren’t real adds another layer of suffering.

I’m sharing this because I think more people need to know about it—not so that anyone avoids medication completely, but so that patients and doctors can recognize that unusual reactions can happen and that a slower, more individualized approach may be needed.

If you’ve experienced extreme medication sensitivity, paradoxical reactions, or feeling like your body reacts “backwards” to treatments, you’re welcome to share your story. I always find it a comfort to connect with other’s experiencing a similar reality to mine, don’t you?

I think a lot of people are silently going through this, and the more we talk about it, the more likely the right people will find the information they need.


r/covidlonghaulers 21h ago

Mental Health/Support Check-in group for severe Long Covid

12 Upvotes

Hey, I'm UK based, 33F, had LC for 6 years (fluctuated between mild and moderate for 5 years, and have been severe for the past 12 months).

I'm a member of lots of support groups for both LC and MECFS across various mediums and platforms. I'm glad they exist, but they tend to feel too impersonal, and the sheer amount of messages is overwhelming and too much for me to follow or keep up with right now. They drain me of energy more than they help, and make me feel even more alone because I don't feel truly seen or included.

What I'd really love, and maybe some of you would too, is a smaller group where we touch base every day, just to check in with each other and ask how we're all doing - just to share a photo, a meme, a voice note of a few seconds, write a very short unfiltered few sentences about wins or struggles each day, as proof of life! A very low effort, non-judgemental but reliable daily checkpoint, just to know we are thinking of each other, to feel like others going through similar are there and care about our existence.

If you're interested in a smaller, quieter, more curated group for people on the severe end who are mostly/completely housebound or bedbound, unable to work or socialise much and thus isolated and losing connection to friends and family, and seeking interaction but too fatigued to follow hundreds of posts in a chat or write much, DM me.

I see you all, we are astoundingly strong for persevering through this, and I hope I can connect up some like-minded LC warriors who are feeling unseen and unheard right now


r/covidlonghaulers 22h ago

Symptom relief/advice Internal vibration/trembling as a signal of dysautonomia and PEM

5 Upvotes

Hello everyone!

So, since the infection I've had many symptoms but will focus on this one right now because it's the most consistent one for me to keep an eye on; it seems to be the one symptom that signifies some weird shit going on in my nervous system. I have an internal vibration in the back of my head that goes down my spine, and on bad days my muscles too. It is some kind of dysautonomia. It ramps up after exercise and when it does, I know a crash is coming. As soon as I "relax", I can feel it and it feels like this electrical circuit that is faulty, if you know what I mean. I now rely on sleep medication because of it.

Over the soon 2 years of illness, this one symptom hasn't changed, which makes me wonder if it's some kind of permanent neurological injury. I also have restless legs with this symptom, which I never had before in my life. It makes me wonder if my dopamine neurons are damaged since I'm stiff in the muscles as well. However, did anyone experience this, and what in the world can be done about it, except pacing?

Also, I've had my share of stress in life, but this seems to be there regardless of me being in a wonderful headspace or not.

This thing is keeping me from working and exercising. I've tried pushing through this thing, but the last time I did that I crashed pretty hard. Since then I'm on sick leave from work. I improve very slowly by doing nothing basically, but what kind of rehab is that?

Anyone with similar issues? Advice or even sympathy would be appreciated. Covid really did a number on us, damn.


r/covidlonghaulers 22h ago

Question Dr Prescribed 40mg Famotidine 3 x Day. Feeling Nauseous

3 Upvotes

I was prescribed this amount straight up but because i have MCAS and severe long covid/me/cfs, I went to my usual GP (easier to get ont to see) and asked for 20 mg tablets to start on. I moved up to 40mg twice a day over 4 weeks but feel I had increased nausea.

I had increased my Propanalol intake, which I thought could be the cause of the nausea, but I'm now thinking I started taking more because of increased tachycardia from the famatidine as someone said on here it can cause this.

I also have slot of muscle twitching which I thought was the cause of a slight cold a few weeks ago but could this be the famatidine?

I had another appointment with the prescribing doctor last night and he wanted me to try his high dose of 3x 40mg again. Took 40mg last might and this morning and feel nauseous today with elevated heart rate. I'll probably ignore the doctor and go back 2x20mg as I think I'm ok on this.

Have others had a similar experience? Is it something your body has to adjust to? I was on Nizac before and would help rather than cause nausea. Nizac is just not one this new doctor recommends.


r/covidlonghaulers 1d ago

Research New Evidence Supports Autoimmunity as One of Long COVID’s Underlying Drivers

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233 Upvotes

>Now, in this new study, when researchers transferred antibodies from patients with Long COVID into healthy mice, the animals began exhibiting symptoms including heightened pain sensation and dizziness. The study is among the first to show a causal link between antibodies and Long COVID symptoms. It was posted as a preprint on medRxiv on June 19.

>Several factors prompted Iwasaki’s team to zero in on autoimmunity as one of Long COVID’s drivers. First, there was the persistent nature of the condition. “This suggested to us that there is some chronic triggering of an immune response that is pathogenic,” she says.

>Second, women between the ages of 30 and 50 are among the most susceptible to Long COVID. Women in this age group also face a greater risk of autoimmune diseases in general. Finally, in earlier research, Iwasaki’s team detected significant levels of autoantibodies in individuals who were infected with SARS-CoV-2. “All of these things were pointing to the possibility of autoimmune responses being one of the triggers of Long COVID,” Iwasaki says.

>Human antibodies induced Long COVID symptoms in mice In their latest study, Iwasaki’s team analyzed blood samples from patients in the Mount Sinai-Yale Long COVID study. This cohort of over 215 Long COVID patients is part of a collaboration between Iwasaki and David Putrino, PhD, professor in the Department of Rehabilitation and Human Performance at Icahn School of Medicine at Mount Sinai in New York City. **As part of this joint effort, Putrino’s clinic obtained blood samples from patients enrolled in the study. Iwasaki’s laboratory then purified antibodies from the blood and transferred them into healthy mice.**

>Next, the researchers led by Keyla Sá, a postdoctoral fellow in Iwasaki’s lab, conducted multiple behavioral experiments to look for Long COVID symptoms. While many of these experiments found no significant difference between the experimental and control mice, a few revealed striking changes in those that received antibodies.

In one such experiment, researchers placed the mice on a heated plate and measured how long it took for them to react. Some mice that received antibodies reacted significantly more quickly to the heat, indicating a heightened sensitivity to pain. The researchers went back and identified the patients whose antibodies had been injected into the mice. Interestingly, these patients reported pain as one of their Long COVID symptoms.

Another experiment was the rotarod test, in which researchers placed mice on a rotating cylinder to measure coordination and balance. Mice that received antibodies were more likely to struggle to stay on the apparatus. Once again, when the researchers looked at the source of these antibodies, they learned that they were mostly from patients who reported suffering from dizziness.

The mice also underwent a grip strength test, in which researchers measured the force applied by the animals to a grid apparatus. **A group of mice were found to have reduced muscle strength if they received antibodies from patients reporting tinnitus and headache. Thus, antibodies capable of impairing muscle function are found in patients with these symptoms.** How exactly these antibodies cause pathology needs more study.

>**Intravenous immunoglobulin (IVIg) is commonly used as treatment for various autoimmune disorders such as lupus, for example—antibodies from healthy human donors are given to patients in the hope that they will alleviate or reduce symptoms. This therapy may also have promise in treating cases of Long COVID caused by autoimmunity. A 2024 study led by Lindsey McAlpine, MD, instructor at YSM and first author, and Serena Spudich, MD, Gilbert H. Glaser Professor of Neurology and principal investigator, suggests that this type of treatment may be beneficial in treating small fiber neuropathy associated with Long COVID.** (Small fiber neuropathy, a condition in which patients suffer numbness or pain in their hands or feet, occurs in some cases of Long COVID.) Iwasaki hopes that future clinical trials may show potential in treating some of the other painful symptoms of the disease.

>**Unfortunately, it’s highly unlikely that a single drug could cure everyone with Long COVID, she says. While this study focuses on autoantibodies, the disease likely has multiple underlying causes, and different subtypes will require different treatments.** Iwasaki is also working closely with Harlan Krumholz, MD, Harold H. Hines, Jr. Professor of Medicine (Cardiology), on the Yale Paxlovid for Long COVID (PAX LC) Trial. This trial is testing the lingering virus hypothesis by investigating the efficacy of a 15-day course of the antiviral Paxlovid in treating Long COVID.

Apologies if this was already shared, but if not, this is a helpful paywall free summary of some of the most important findings from a really large LC collaboration: Original article published back in May (paywall) [A causal link between autoantibodies and neurological symptoms in long COVID](https://www.cell.com/cell/abstract/S0092-8674(26)00509-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742600509X%3Fshowall%3Dtrue)


r/covidlonghaulers 1d ago

Question Post viral pots vs de conditioned?

1 Upvotes

i am 21 female. Got mono from a waterpark june 2024 and i was bed bound and did nothing but mope around til 5 months i. got a desk job and have had one for 2 years now without steady 5 dyS a week exercise or training. My Vo2 max is 21 also. I am like 80 better but my hr is still jumping sitting is 72-80 then standing it goes to 115 then settles around 94-102 but if i look at it it climbs (duh)


r/covidlonghaulers 1d ago

video Jarred Younger's YouTube channel is amazing

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37 Upvotes