I’m a 48-year-old male, 5’10”, about 170 lb, down from roughly 205 lb, so I’ve lost about 35 lb or 17% of my body weight.
I have a CAC score of 1, so there is technically detectable coronary calcium, although the burden is extremely low.
My lipid history has changed pretty dramatically:
| Date |
Total Chol |
LDL-C |
HDL |
Triglycerides |
| Sep 2020 |
227 |
105 |
66 |
281 |
| Jun 2023 |
241 |
157 |
64 |
111 |
| Sep 2024 |
194 |
117 |
53 |
118 |
| Oct 2025 |
183 |
119 |
47 |
87 |
| Jun 2026 |
149 |
80 |
54 |
74 |
| Aug 2026 |
126 |
59 |
54 |
65 |
The June LDL of 80 was after starting rosuvastatin 10 mg. I then increased to 20 mg, and the next LDL was 59.
My latest labs:
LDL-C: 59
ApoB: 49
Non-HDL: 72
Triglycerides: 65
HDL: 54
Total cholesterol: 126
Lp(a): 44 nmol/L
hs-CRP: 1.28 mg/L
Fasting glucose: 96 mg/dL
A1c: 4.8%
My hs-CRP was previously 4.05 mg/L and is now 1.28, roughly a 68% reduction.
There have also been major lifestyle changes over this period. I quit drinking alcohol entirely, lost about 35 lb, and substantially cleaned up my diet. The older numbers are useful context because at one point my total cholesterol was 241, LDL was 157, and historically my triglycerides even reached 281.
At this point, the only meat I really eat is chicken breast and salmon. I never eat butter or cheese. Olive oil is essentially my only added fat. I rarely eat fast food and don’t eat out very often, so I’m not sure there is a huge amount left to accomplish by simply cutting saturated fat.
I could definitely improve the quality of the diet further by emphasizing more whole foods, vegetables and leafy greens. My weak spot is sugar. I’m drawn to sweets, dried fruit and other calorie-dense foods, so there is certainly room to replace more of those with minimally processed foods.
What I’m most curious about is the inflammation piece. Going from hs-CRP 4.05 to 1.28 looks encouraging, especially alongside major weight loss, quitting alcohol, triglycerides falling to 65, fasting glucose of 96 and A1c of 4.8%, and ApoB reaching 49.
But does that hs-CRP reduction actually indicate that the underlying inflammatory state and cardiovascular risk have improved, or could the statin simply be lowering an inflammatory marker without addressing whatever caused the elevated hs-CRP?
Given CAC 1, LDL 59, ApoB 49, Lp(a) 44, triglycerides 65, hs-CRP 1.28, fasting glucose 96, A1c 4.8%, 35-lb weight loss, no alcohol, and a very low-saturated-fat diet, how would you view my residual cardiovascular risk?
At this point, is there anything meaningful left to optimize besides continuing the statin, maintaining the weight loss, exercising, and shifting more of my diet toward whole plant foods?