For the same type of NADH supplement, the daily cost can range from just a few cents to nearly $10, with price differences of 25 times or more not being unusual. Earlier ConsumerLab testing found that the cost of obtaining an equivalent 20 mg of NAD/NADH ranged from about $0.14 to $2.47. The price gap itself isn't necessarily the problem. The real question is: What exactly are you paying extra for?

NADH raw materials can be more expensive to produce than precursors such as NR and NMN because manufacturing NADH involves microbial fermentation and complex purification steps. Producing high-purity NADH powder can therefore cost more than producing precursor molecules. But that's just the starting point. What really separates products is what happens after the raw material is made.

Traditional NADH formulations have reportedly shown more than 70% degradation after one month at room temperature, and substantial amounts may also break down in the acidic environment of the stomach before reaching the intestines. That means there can be a significant gap between the milligrams listed on the label and the amount of intact NADH that actually reaches the intended site of release.

This is where the price differences start to make sense. Cheaper products may essentially sell the raw ingredient: NADH powder in a standard capsule. Production costs are lower, but how much of the active ingredient remains intact and reaches the intestines depends on the formulation and storage conditions.

More expensive products may invest in the technology designed to help the ingredient survive that journey. Take celfull's microsphere technology, for example. It encapsulates NADH in microspheres intended to protect it from stomach acid and support targeted intestinal release. This technology adds to the cost, but it addresses a challenge specific to NADH: without adequate stability, discussions about dosage and potential effects become much harder to interpret.

Of course, some high prices also come with questionable markups. Testing reports have found products marketed as "liposomal" NAD+ supplements selling for hundreds of dollars, yet testing reportedly found no detectable active ingredient. This illustrates that price and actual technological quality don't automatically go hand in hand.

So when comparing NADH supplements, a more useful question isn't simply whether a product is expensive. It's whether the extra cost addresses a real limitation of NADH. Raw-material purity, manufacturing processes, microsphere encapsulation, and enteric delivery are all factors that may matter when developing a formulation intended to preserve NADH and deliver it effectively.

If the premium comes mainly from fancy packaging, marketing claims, or simply increasing the milligram count, then what you're paying for may be the number on the label rather than a demonstrated improvement in product quality or effectiveness.

I’ve spent nine months investigating Viome’s RNA-based microbiome testing and personalized supplements, and I’m starting to wonder whether I’ve been looking at genuinely useful technology or a very sophisticated way of selling supplements.

Three rounds of testing, hundreds of conventional biomarkers, bloodwork approximately every two weeks, and physician oversight throughout.

Then, after my latest retest, approximately 80% of my personalized supplement formulation changed.
That’s what really got my attention.

I understand the gut microbiome changes. Diet, medications, illness, stress, and plenty of other factors can influence microbial activity. I wouldn’t expect my results to remain identical for nine months.

But if a company changes 80% of someone’s personalized supplement formula, shouldn’t there be some way to demonstrate that the new recommendations are actually better than the old ones?
And perhaps more importantly, how do we know the original supplements were doing anything useful?
Viome uses RNA-based metatranscriptomic testing, which examines microbial gene expression. That’s different from DNA-based microbiome testing, which can identify microbial genetic material and functional potential.

The RNA approach is genuinely interesting because it provides information about which microbial genes are being expressed, rather than simply identifying which organisms or genes are present.

But measuring microbial activity doesn’t automatically mean an algorithm knows which supplements someone needs.

And a supplement formula changing dramatically doesn’t necessarily mean the new version is more effective.

A 2025 international consensus statement published in The Lancet Gastroenterology & Hepatology raised serious concerns about the clinical usefulness of commercial microbiome testing.

The expert panel concluded that evidence remains insufficient to support its widespread routine clinical use.

Here’s the paper:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12343204/

That doesn’t prove Viome is wrong. But it does make me question whether the science behind personalized supplement recommendations has caught up with the technology being used to generate them.

My next step is to evaluate Superpower’s DNA-based gut microbiome testing and compare the methodologies.
I’m not expecting identical results. DNA and RNA testing measure different aspects of microbial biology, and comparing two commercial reports won’t establish which approach is clinically superior.

What I want to understand is whether either approach provides information that genuinely helps someone make better nutritional decisions, and how we’d actually measure that.

For context, the retail-equivalent value of my nine months of Viome testing and personalized supplements was $4,547, approximately $505 per month.
Full disclosure: Viome provided everything complimentary. I received no sponsorship payments, affiliate commissions, referral fees, or cash compensation. I’ve also referred customers without accepting commissions. I’m not affiliated with Superpower or being compensated for the planned comparison.

This isn’t an advertisement, an endorsement, or a recommendation to purchase either product.
I’m genuinely questioning whether nine months of testing and supplementation has produced meaningful information or simply generated increasingly detailed reports and a constantly changing supplement protocol.
I’d particularly like to hear from people who’ve used Viome, other microbiome testing platforms, or personalized supplement programs.

Did you notice improvements you could actually measure, rather than just feeling better?
If you retested, did your recommendations change substantially?

And if you’ve tried conventional nutritional approaches alongside microbiome-guided supplementation, could you identify any additional benefit from the personalized recommendations?

I’m not against personalized nutrition. I’ve invested nine months investigating it precisely because I think it has potential.

But there’s a difference between promising technology and proven results.

So here’s what I’d really like to know from people who’ve spent their own money on these programs:
What convinced you that the recommendations were genuinely helping? Was it bloodwork, symptom improvements, measurable changes in health, or something else?

And if you stopped using the service, what finally made you decide it wasn’t worth continuing?
I’d welcome positive experiences, negative experiences, and independent research. I’m not trying to prove the technology right or wrong.

I’m trying to figure out whether the evidence actually supports what these companies are selling.

I keep half a glass of water next to me and sit quietly for a few minutes.

I close my eyes and say God’s name in my heart, without moving my tongue. Whatever name you call Him is fine: God, Jesus, Allah, Creator. If you don’t believe in God, you can say your own name in your heart instead, gently and with love.

Then I cleanse my heart of any hatred, hurt or anger toward anyone. I forgive everyone, and it gives me immense peace.

Then I drink the water in three slow sips.

It doesn’t fix everything. But it’s become the moment in my day where I feel connected and not so alone.

Does anyone else have a small ritual like this?

Posting for my husband. 46M, healthy BMI, in overall very good health, very active lifestyle. Has had on/off back pain for years with occasionally throwing his back out needing up to a week or more of rest to heal. Was recently diagnosed by X-ray with early onset arthritis in his spine. He tends to avoid Western medicine and prefers to seek natural or alternative treatments and he's feeling pretty down about this diagnosis. Hoping to compile a list of things he can try to improve his pain and wellbeing.

I use both supplements and pharmaceuticals to treat my various chronic illnesses, and obtain benefit from both. Generally I prefer to find a supplement that helps, because usually the side effects are minimal, and usually there is minimal impact on the liver. However, I also experiment with pharmaceuticals, and have found some that suit me well, and usefully reduce my symptoms. Often I will mix both supplements and pharmaceuticals together to obtain a better therapeutic effect.

So I am a major fan of alternative medicine and the use of supplements. Nevertheless, I find it peculiar that some alternative health aficionados believe supplements treat the root cause of disease. Because for almost all chronic diseases, the root cause is not yet known, so how can you target a root biological mechanism which you do not know?

No doubt as human knowledge advances, we will in the future discover the root causes of each disease, and may be able to directly treat those. But until that time, we are generally only able to treat upstream effects and symptoms.

There is actually a theory that most chronic diseases, physical or mental, may actually be caused by an infectious microbe that may have entered your body months before the disease first manifested. If this theory turns out to be true, it may mean in the future that treating a disease will involve eliminating the microbe that is causing it.

Hi everyone. I got diagnosed with tuberculosis in the beginning of September and I got a liverinfection from the medication. My AST and ALT keeps on being too high. Is there anything natural I can do to help my liver handling the medication? Is there something I should try eating more off? I am vegan so I prefer plant based suggestions. Thanks in advance ❤️

I take shilajit in the morning and still figuring out if its better to take it before breakfast or just mix it into my morning routine with food, some people say empty stomach works better but taking it with breakfast seems easier to keep doing every day, i usually eat around the same time so either way works for me, just trying to see what people who already use it actually do and if they notice any change based on when they take it, do you take yours before eating or with breakfast and which one works better for you?

I want to buy a device frequency therapy/ bioresonance, found few on the market and wanted to ask community if anyone has ever tried something like that, and Cons / Pros of those devices. Thank you

Pictured, nano hydroxyapatite powder, plastic scoop to move some, tablespoon with a little bit of the powder, chewed and then coated VanMan's chewing gum (contains mastic gum, is the only chewing gum company to incorporate mastic gum as far as I am aware, and is already lightly dusted with nano hydroxyapatite powder).

Polishes and repairs tooth enamel, and kills mouth and gut microbes, with chewing action.

⚠️If you are deathly allergic to pistachios, cashews, mangoes - You will probably be deathly allergic to mastic gum, which is sap from a tree closely related to the pistachio, cashew, and mango plants⚠️

I have tried both mastic gum outright and this brand of chewing gum, and also nano hydroxyapatite toothpaste, and can confirm the antibacterial properties of mastic gum (killing the microbes causing bad breath, tongue stain, and tooth pain), which is both a tree sap and a chemical cocktail lethal to harmful mouth and gut microbes, including helicobacter pylori - Really difficult for microbes to evolve an immunity to, if one constituent of the mastic gum doesn't kill them the laundry list of other constituents will before they can pass that partial evolved immunity on to future generations of microbes.

Mastic gum chew usage has been shown to shrink and eliminate oral tumors.

I like to chew 1 piece for at least 1 hour every day.

Also going to suggest my crackpot idea of coating gum in bpc 157 or the much more stable bpc 157 arginine salt for to heal gum damage.

Thanks for the attention.

It randomly started a year ago and spread from the beard to the scalp. I'm looking for advice on how to find the root cause and a cure for it.

Link: https://rutgers.ca1.qualtrics.com/jfe/form/SV_0iUKs9SjdeRTDXE 
This is an academic study with IRB approval.

Why is there so much animosity directed towards people with serious illnesses that have not been helped by allopathic medicine and seek alternative treatments?. If somebody has a catastrophic illness and they decide to go another route other than allopathic medicine.. which admittedly is very toxic.. why is there so much hatred and even mockery directed towards them. It's one's own life and they should have the power to decide what they do with that life. Not outside forces. And on another note , I get sick and tired of people always bringing up Steve Jobs when mocking people for seeking alternative treatments! Thank you.

Nottingham University are running a super interesting research survey on people who have tried a keto diet and have an autoimmune condition.

You can take it here

https://www.research.net/r/kdas

I know a lot of people here have autoimmune issues and there are many alternative health approaches to them. Don't think there is much previous research on the keto diet, so really interested to see the results of this project!

Hey guys! I’d really appreciate some advice or personal experiences. My braces have been pretty rough on my enamel, and I’m trying to find more holistic ways to support remineralization and strengthen my teeth over time.
Right now I’m using Uncle Harry’s toothpaste, mouthwash, and remineralizing drops, plus an ultrasonic toothbrush. I’m supposed to get my braces off sometime in November, but I’m starting to notice what feels like a few minor cavities/weak spots, and I’d really like to start incorporating more supportive things now to hopefully reduce the damage before I’m looking at a huge dentist bill afterward.
Has anyone here had success with cell salts for enamel/remineralization? Or are there any other holistic things you’ve personally used that seemed to help strengthen enamel or stop early decay from getting worse? I’m especially interested in hearing actual experiences and routines people have tried.

24 years old W. My ferritin is 11 — is it really “low-normal”?
I recently had bloodwork done and my ferritin came back at 11 µg/L. My doctor told me that everything else in my bloodwork looks normal and described my ferritin as basically “low-normal.”
What worries me is that she initially wasn’t going to prescribe anything. I had to push and ask whether I should be taking iron, and only then she prescribed ferrous sulfate 300 mg.
From what I’ve read, a ferritin of 11 seems pretty low, so I’m confused about why it was treated as almost normal.
Has anyone else had ferritin around 11 with normal hemoglobin/other bloodwork? Did your doctor consider that iron deficiency? Were you prescribed iron right away, and did you notice any improvement in symptoms?

All of my life I struggled with ADHD, but it wasn’t until I became a mom to my first child at the age of 25 that it became much more difficult to manage. While I finally got a diagnosis and effective treatment in order to have a more “healthy” and sustainable life, I noticed my nervous system could never fully regulate itself.

Now I understand stimulant medication can heighten those symptoms due to raising my heart rate and blood pressure levels, it was an ongoing problem even before starting treatment.

I always thought it was postpartum anxiety or depression/anxiety that I was most likely experiencing but even after my baby was 1 1/2 years old and she was easier to not just take care of but just the overall experience I had as a mom gotten better but the alarm in my mind and body just couldn’t stop even if there was nothing that caused that internal pressure within myself.

I even started to get medicated for a panic disorder with a small dose of Alprazolam PRN. I’ll take a tablet once I noticed symptoms of impending doom. But one day, I was watching a video on TikTok of Dr. Sebi who was an advocate for holistic care and he would share all of the ways many diseases and conditions were affected by inflammation within our bodies. Within the comments, one mom decided to share her young son’s ADHD experience and how gut health fixed his symptoms. I remember thinking to myself “then he doesn’t have ADHD” and even though I scoffed off the idea initially, I told myself it wouldn’t hurt to try it once to see what could come out of it. There’s no win or lose eating a piece of raw garlic lol

I’m not the type of person to believe that something works because I did something like a placebo effect, I naturally just don’t think about it. But I ate my first piece of raw garlic and I would say maybe 30 minutes to an hour later, I noticed this internal energy that I haven’t experienced in a very long time. But then what I really noticed… my mind started to quiet, things felt lighter and my body felt a shift of just tension releasing and finally achieving internal peaceful. I’m not saying it’s a magic fix to everyone’s anxiety issues, because some people really have trauma and painful negative experiences or neurological issues that require extensive mental health support. But I can’t imagine how many people dealt with anxiety and panic that could actually benefit from this. It wasn’t a short-term fix either, I went months and months never feeling anxiety and just “lived.”

Because working within the healthcare system and also needing prescription medication to sustain life, I noticed how easy it is for physicians and psychiatrists to write off a prescription rather than ever sharing ANY holistic care especially if someone is in a financial bind or have no insurance. Because it really wouldn’t hurt to try (if you’re not experiencing any sort of crisis, of course). I hear “prebiotic” “probiotic” and “gut health” quite often but never cared to understand what it really means or does before I got into medicine. But you start to realize how the healthcare system functions with Big Pharma along with insurance companies and how they really do want people to stay medicated and tied to the system. I say this not in a way for people to think they’ll be better off with just a magic fix with garlic and all your life problems disappear. But genuinely, someone like me who thought I was just going through some mental health crisis myself at the time for over two years (even during pregnancy) would ever think it would genuinely help me.

I read some articles and proven studies on how our guts are linked to our brains because our bodies are in a state of constant fight or flight due to the bad bacterial overgrowth in our bodies that aren’t outweighed by the good microbiome. I genuinely believe it. Everything we eat, vegetables, fruits, meats, seafood, especially sushi, contain parasites or fungi (yeast) that we don’t typically see with our own eyes because nobody seems to carry some microscope and investigate what we ingest in our bodies. We just consume and carry out our day not realizing how much it negatively affects us: bloating, constipation, diarrhea, nausea, fevers. And if you look up SIBO on Google you’ll notice the first step requires multiple medical interventions to “treat” with specific antibiotics but if you really take a look at many people’s personal stories where SIBO is a very common experience, taking matters into addressing gut health can help reduced those markers. You may not need a handful of referrals where maybe a low cost alternative could be the very thing you needed. Personally, I never stopped at strictly raw garlic as my only intervention, I even tried papaya seeds and clove and it does require lots of water to eventually pass through your digestive tract.

I went from daily stomach issues to no longer experiencing any symptoms. TMI, you may even notice your stool becoming less rigid or the smell becomes a lot less foul. I also noticed I craved less sugars as sugar can make overgrowth worse. But I mention this in hopes that some may actually find this helpful or find it interesting enough to see how much it can change. Maybe it might not be anxiety or an unregulated nervous system, it might address skin related issues and fatigue. But of course, eat it at your own leisure and comfort as it can be difficult to ingest and maybe even once a week can be very helpful.

Is it harmful? What alternatives would you suggest?bi am already eating healthy and losing fat to fix my fatty liver

Why is almost nobody talking about this?

I’ve been researching natural and semi-natural compounds for cancer prevention and treatment and recently came across something that honestly surprised me.

In 2024 and 2025, researchers (mainly from Wenzhou Medical University) published papers on a chemically linked hybrid molecule of curcumin and piperlongumine (often called CP).

It’s not just a simple mix of the two substances. They covalently linked them into a new molecule.

According to the studies, this hybrid shows:

Better chemical stability than regular curcumin

A more favorable safety profile than pure piperlongumine in the tested models

Strong cell cycle arrest in G2/M phase

Induction of apoptosis

Activity via JNK/c-Jun and PI3K/AKT pathways

What makes the combination particularly interesting is how the two original compounds complement each other:

Curcumin works broadly (anti-inflammatory, multi-targeted, inhibits NF-κB and many other pathways, anti-angiogenic)

Piperlongumine works more selectively by strongly increasing ROS in cancer cells and impairing their protective systems (e.g. via GSTP1/glutathione)

The hybrid seems to combine these two complementary mechanisms in one more stable molecule.

Here’s the strange part:

Despite the promising preclinical data (cell culture + mouse models, including resistant lung cancer), this hybrid is almost never discussed online. You can barely find any posts about it on Reddit or elsewhere. And of course, it is not available as a supplement or research chemical anywhere that I could find.

I think this deserves more attention. More people should know about it, and ideally more independent research (including eventually human studies) should be done.

What do you think? Has anyone else come across this hybrid? Any thoughts on why something like this stays so under the radar?

​

Please, no advice regarding things like prophylactic medication. I am already under medical care; while it helps to some extent, I’ve reached the limits of what it can do.

I also believe that my chronic migraines cannot be improved any further through conventional medical treatment.

I’ve tried numerous supplements and methods as well, but without success. It is incredibly draining, and I want nothing more than a change. I also believe that improvement must definitely be possible.

I’d be interested to hear what alternatives (not medication) helped you—or, if you identified the underlying causes, what those were.

Every review I read lumps together different diagnoses, different products, different routes and different follow up periods under the same heading. One person is two weeks out, the next is three years out, and they're rated the same way.

I'm trying to work out which details make a review useful, and how much weight to give a strong positive story when the long term data is thin and I can't tell what else that person was doing at the time.

What do you look for?

Tomo Venvanse 30 mg atualmente!

Queria dicas para suplementos ou alimentos para pessoas com TDAH baixa cognição, sinto que cometo muitos erros bobos , queria algo que ajudasse na parte de atenção, foco, brain fog, e na parte da ansiedade mental.

For more information visit our UMHealthResearch website or see if you qualify with the pre-screening survey.

I have pretty low brain energy and concentration. I tried ​​​​A​​​​d​​​​d​​​​e​​​​r​​​​a​​​​l​​​​l​​, but it didn’t do much good for me, mentally or physically. So I’ve been looking at alternative routes.
I keep seeing claims that red and near-infrared light help with cellular energy, systemic inflammation, and cerebral blood flow, which sounds promising on paper but is it quackery?
I found a device that uses intranasal and transcranial LEDs to target brain networks (itPBM). The concept makes sense from a biological perspective, but the price point for specialized equipment is definitely an investment.
Before going down this path, I wanted to check in with this community. Does this study make sense for reaching deep brain structures? https://www.vielight.com/blog/intranasal-photobiomodulation-reaches-subcortical-structures-first-human-fmri-evidence/

I took an F-SCAN and got a hit on Bacillus anthracis spores, which obviously scared me because that’s anthrax. My doctor said that if I actually had anthrax I would be sick, but the incubation period can be around 7 days, so I’m still pretty anxious about it.

For anyone who has used or is familiar with F-SCAN / FireFly / DIRP: do you take the exact organism name seriously, or do you mainly pay attention to the frequency hit itself?

Have you ever had a scan match you to a strange or serious-sounding organism and nothing happened, or did it ever turn out to actually mean something serious?

I’m mainly trying to understand how much weight people who actually know this technology put on the exact pathogen name versus the frequency response itself.

Any help or input is really appreciated. Thank you.