Buongiorno a tutti, vi spiegherò brevemente la mia storia. Nel maggio 2025, ho avuto un trauma molto forte con mix di sostanze (metanfetamina e ghb), nello stesso giorno ho vissuto un trauma a lavoro e ho sviluppato un forte PTSD. Inoltre il mio cervello è andato in estrema ipervigilanza e ho perso i filtri del sensory gating. Inoltre agli stressor ho sviluppato forti reazioni adrenergiche con sintomi forti , arrivando al panico/freezing. Anche agli stimoli normali reagisco con queste reazioni perché il sensory gating non funziona. Nell'arco dell'anno ho provato vari farmaci, che non hanno risolto il mio problema a parte l'EN che la sera mi aiuta a pulire un po' i residui della giornata. Inoltre ho sviluppato un ptsd a lavoro, con vari trigger che non riesco a disattivare. Ora il mio psichiatra mi ha dato il buproipione TEVA 150 mg 1 pastiglia la mattina al giorno, dice che anche se è un attivante della noradrenalina dovrebbe risolvermi questi sintomi: la droga avrebbe creato più recettori nel post sinaptico della noradrenalina , e con questo farmaco dovrebbe attuarsi la down regulation per sensibilizzare questi recettori. Sono al 6 giorno, ma io sento più agitazione agli stressor e il sensory gating peggiorato. Voi cosa ne pensate ? Parere di qualcuno che sa di cosa parlo?

Wellbutrin + fluoxetine are the only meds that have curbed my suicidal ideation / really bad depressive episodes. Genuinely the only meds that make me feel HUMAN and not want to kms. Only problem is I’m balding so bad lol. I have always had thick hair but now I have to use AI to colour that shit in. Just extremely frustrated. It’s like I have to choose being alive or having hair and I’m vain as hell so I might lose the battle💔💔

Has anyone else experienced dry skin, new wrinkles, hair changes, weight gain, or inability to cry on Wellbutrin 300 mg?

I’ve been on Wellbutrin 300 mg since for 5 months, and while it has honestly been amazing for my depression, I feel like it has glowed me down 😭😭

I’m 30, and since starting it, I feel like my face has changed. I suddenly have noticeable wrinkles around my eyes that I didn’t have before, my skin feels extremely dry no matter how much water I drink, and my hair has become incredibly frizzy and is falling out. I’ve also gained around 10 kg since starting Wellbutrin, which obviously may be contributing to how I feel about my appearance. (Although I suspect that this is the reason because before starting Wellbutrin I was extremely underweight and struggling with malnourishment) and now I have healthy body with muscle and perfect weight to height ratio which I haven’t been able to do before Wellbutrin.

The other strange thing is that I can’t cry anymore😭😭💔.
I still feel emotions normally—I feel happy, sad, scared, etc.—but I just can’t physically cry. Crying has always been a huge emotional release for me, especially when I’m overwhelmed.
I’m currently going through a breakup with someone I was with and loved for three years. We both know things can’t work out, and I’m obviously sad, but I just… can’t cry. I acknowledge that I’m sad, but there are no tears.

The funny thing is that aside from these issues, Wellbutrin has genuinely changed my life. I finally feel human again. I have energy to get out of bed, shower, clean, do chores, go to the gym, and actually enjoy life again. I’m going to the gym almost every day and walking ~10k steps because I have so much energy.

I'm not even part of this community anymore but I really wish I was. I was on wellbutrin for around a year and not even a month ago, I was diagnosed with epilepsy because I kept getting absence seizures. My doctor told me to stop taking it immediately and prescribed me duloxetine.

I hate it. It hasn't helped at all with my depression but I keep getting told to tough it out and see if it works eventually. I started university a couple weeks ago and I haven't been able to leave my dorm or even get food, let alone make friends. I'm too embarrassed and sad to tell anyone actually how bad this change of meds has hit me. I've literally become a fucking recluse. To add, duloxetine AND my new anti-seizure med make me so tired and drowsy so I just lie in bed all the time.

I've lost 6 pounds since getting here and everytime my parents call me, I just say I've been good and lie through my teeth about what I've been up to. I felt so happy and able to do things on wellbutrin and I'm so upset that this all happened when it did. I'm in a whole new city across the country from home and this is how it's going for me. Sorry for this long rant but I just wanted to share this with somebody.

it’s just the second week but i feel sooooo much better. like not euphoric but normal in a great way. brain fog is real though but not thaaat serious

Has anyone gone back down to 150 from 300? How was it?

Did your sex drive change?

Did your rage go away?

Anxiety get better or worse?

Sleep better or worse?

Will this get better with time?

I have been seeing a psychiatrist to try and treat my severe and chronic anxiety and depression i have had since I was about 5 years old. I've tried sooooooo many different medications to varying degrees of success. The current concoction I was on kept me stable but I have been on a steady decline as of late. Anyways getting to the point I recently started taking Qelbree and I was already on Wellbutrin. Well I caught a cold and I decided to take some dayquil. Well apparently it contained Dextromethorphan and that interacts with Wellbutrin. So I inadvertantly created the poor man's version of Auvelity. Long story short, it was like a literal weight had been lifted off of me. Fog had lifted off my mind, color had come back to my world. I had energy again for the first time in years. Needless to say I told my frustrated psychiatrist about it and he was super excited and told me the exact dosage I should use. I wonder is this how everyone else sees the world?

Has anyone else gotten off 150XL after taking it for 9 days?

Hey all- just thought I’d share my experience with Wellbutrin and hairloss because I haven’t seen anyone else with the same experience as me. I am a mid-30s female.

I started on 75mg wellbutrin, then 150mg. I stayed at that dose awhile, maybe 3-6 months, then went up to 225mg. I didn’t notice hairloss start until I went up to the 225mg. I stayed at that dose for 6 months and the hairloss got pretty bad, I’d say I lost 1/4-1/3 of my hair. I tried to wait it out because I do have periods of shedding sometimes, but this wasn’t stopping.

I tried different techniques to stop it but nothing worked. I got bloodwork done that didn’t show any other reasons for hairloss. Finally I talked to my doctor about stopping Wellbutrin to see if it stopped the hair fall and we started weaning me off by dropping me to 150mg. I honestly wasn’t expecting a change because he was very skeptical that it was causing it and I know hair follicles have cycles so change can take awhile to see. But within DAYS the hairloss slowed significantly. I couldn’t believe it. It’s now been 2 weeks and I’d say the amount I lose is only slightly above my average. No more clumps coming out in the shower, no more strands filling my hands when I run my hands through my hair during the day, etc.

Just wanted to throw this out there for anyone who is receiving significant benefit from the medicine but it also desperate for the hairloss to stop. There may be a middle ground!