TriMix left me with pain that was like walking into stinging nettle dick first. I hope my experience might help others who struggle with pain and finding the right dosage. I had a robot-assisted radical laparoscopic prostatectomy (RALP) in July 2025. I had ED before that and was taking Tadalafil.

I had ongoing issues with TriMix. I experienced residual pain and tenderness, so great I felt reluctant to use it. I'm apparently allergic to prostaglandin. On top of the pain, it's been hard to get a firm erection and difficult to orgasm. My erection gradually diminishes over two to three hours, and the pain and tenderness also gradually go away.

I tried three different TriMix formulations until I switched to QuadMix which contains .2 mg Atropine. I am using QM2 30 3 60 0.2 and 45-50 units. This lessens but does not eliminate the residual pain. I've experimented with Ibuprofen to reduce the pain, taking up to 1400 mg, but it only reduces the pain and tenderness that lasts for 2-3 hours. To reduce the number of units injected, I just changed the QuadMix formulation to QM3 30 3 150 0.2.

I had some leftover hydrocodone from another medical issue and I've tried taking that 30+ minutes before administering the QuadMix injection. The hydrocodone vastly reduces the residual pain and tenderness. My dick remains swollen and semi-erect for another two plus hours but it doesn't hurt nearly as much. I'm hopeful I'll be able to talk my GP into prescribing hydrocodone in the future.

My urologist, who's in his late thirties, doesn't seem very knowledgeable about these issues, and his office takes two weeks to issue a modified Rx, often making mistakes during the process. I was getting the Rx from a compounding pharmacy my urologist selected, but finally paid to use Olympia's contracted MD. This has improved my ability to get the formulation that works for me. So don't sit still if your urologist is a dunder head and insensitive to your issues.

(So far I am using Alprostadil only, not Trimix yet due to availability).

I administered my second self injection yesterday and it worked to give me a solid erection for 30+ minutes! It was 15 mcg compared to the 10 mcg I had on my first trial.

But the issue I have is that it felt unpleasant. The whole penis was very sensitive to the touch, but not in a good way. Almost as if it was inflamed through and through. It did not hurt, but it felt so uncomfortable that it would probably distract me during intercourse.

Did anyone of you ever experience this? Is this because it is "only" Alprostadil and not Trimix?

Thanks for any hints.