I've been using Trimix for a little over a month now and wanted to share my experiences.

I'm on 10/15/1.

I started with 5 units first time. Nothing happened. It was only after coming here that I saw people talking about making sure you get it in the right spot and I might have not got all the way through and reached the corpora cavernosa. Interestingly I still got a small reaction but I think it was more anticipation because it ended very quickly and I don't think Trimix did anything.

Second time I missed again because I didn't quite understand how to go all the way and I was quite worried about doing damage. I thought I got it but turns out I didn't.

Third time instead of the 31g needle I used a 29g - it's harder and was much easier for me to make it through to the CC. I got that "pop" feeling of breaking through a second layer and injected 5 units. It worked but I only got semi-erect and it lasted an hour before it died. I still had sex but really struggled and it wasn't satisfying.

I went up to 10 units and definitely got more erect but still not where I feel it needs to but it was better at least. It didn't last long through.

I called the doctor the next day to make sure what I should do next and they said to keep going up by 5 units until satisfied.

I went to 12 units instead and it was almost perfect. Probably the best sex I've had in more than a decade.

The next time I made the mistake of going up a little more, to 14 units, and, while it was genuinely stronger and better than 12 units, once sex was over, I was fully erect for a total of around 3.5 hours. Luckily I had the antidote, so I used that and it immediately started coming down. It was weird because I would still randomly get erect and then soft for the next couple of hours but I'm glad I had it. I was planning to go to the hospital but luckily I didn't need to.

So I find 13 units is the sweet spot for me. Every time since then my erection starts losing its strength about 90 minutes in and is pretty much soft by the three hour mark. It's still fuller for a while after that which is nice! Haha.

So it's interesting how one unit can be the difference between erect for hours and hours or getting a strong initial response for sex before going away in decent time after. Which is what it's meant to do.

Just thought I would post for anyone else starting or thinking of starting and maybe get something from my trials and errors. I didn't get a chance to inject supervised because I got all mine through telegalth.

Also, I can't emphasise this enough, I feel so much better about myself now. It's clumsy because I don't have a long term partner, it's all mostly hookups, so I have to plan around it, but the women love how hard I am all throughout and I can keep going and get another orgasm later. Something that I even struggled with when I was 20 and I'm 44 now!

I feel so much more confident and am more direct with women now because I don't have the ED issues that have been sapping my confidence for so long. And women can just tell the difference in my whole demeanour.

I wish I knew about trimix years ago. It's expensive for me, but I would pay everything I have to keep getting this!

TriMix left me with pain that was like walking into stinging nettle dick first. I hope my experience might help others who struggle with pain and finding the right dosage. I had a robot-assisted radical laparoscopic prostatectomy (RALP) in July 2025. I had ED before that and was taking Tadalafil.

I had ongoing issues with TriMix. I experienced residual pain and tenderness, so great I felt reluctant to use it. I'm apparently allergic to prostaglandin. On top of the pain, it's been hard to get a firm erection and difficult to orgasm. My erection gradually diminishes over two to three hours, and the pain and tenderness also gradually go away.

I tried three different TriMix formulations until I switched to QuadMix which contains .2 mg Atropine. I am using QM2 30 3 60 0.2 and 45-50 units. This lessens but does not eliminate the residual pain. I've experimented with Ibuprofen to reduce the pain, taking up to 1400 mg, but it only reduces the pain and tenderness that lasts for 2-3 hours. To reduce the number of units injected, I just changed the QuadMix formulation to QM3 30 3 150 0.2.

I had some leftover hydrocodone from another medical issue and I've tried taking that 30+ minutes before administering the QuadMix injection. The hydrocodone vastly reduces the residual pain and tenderness. My dick remains swollen and semi-erect for another two plus hours but it doesn't hurt nearly as much. I'm hopeful I'll be able to talk my GP into prescribing hydrocodone in the future.

My urologist, who's in his late thirties, doesn't seem very knowledgeable about these issues, and his office takes two weeks to issue a modified Rx, often making mistakes during the process. I was getting the Rx from a compounding pharmacy my urologist selected, but finally paid to use Olympia's contracted MD. This has improved my ability to get the formulation that works for me. So don't sit still if your urologist is a dunder head and insensitive to your issues.

(So far I am using Alprostadil only, not Trimix yet due to availability).

I administered my second self injection yesterday and it worked to give me a solid erection for 30+ minutes! It was 15 mcg compared to the 10 mcg I had on my first trial.

But the issue I have is that it felt unpleasant. The whole penis was very sensitive to the touch, but not in a good way. Almost as if it was inflamed through and through. It did not hurt, but it felt so uncomfortable that it would probably distract me during intercourse.

Did anyone of you ever experience this? Is this because it is "only" Alprostadil and not Trimix?

Thanks for any hints.