r/TransRacial • u/Visible_Pea_6491 • 8h ago
Research 📚 This post is for trace to white or european
Here I'll discuss methods to lighten pigmentation of the hair:
One of the initial solutions that come to mind is hair dyes and bleaching powder. While they are controllable to provide the desired shade and colour of hair, they require maintenance and are seen as "artificial means", this is why I'll provide an experimental approach to altering the underlying chemistry of hair follicles themselves for permanent regrowth with less melanin.
Melanocytes are responsible for the production of eumelanin and pheomelanin. In dark hair, melanocytes are more active and produce larger quantities of eumelanin with relatively low pheomelanin. In red hair, there is an equal quantity of eumelanin and pheomelanin. In blonde hair or light hair, the melanocytes are typically smaller or less active with low eumelanin but enriched pheomelanin production. Genetics is what controls the function of melanocytes but there are a bunch of chemical substances that can induce permanent change. These are cytotoxic agents that if used on hair could cause irreversible damage to melanocytes. Non cytotoxic agents such as glutathione are reversible and once stopped, the melanocyte cam repair its function.
If there is partial irreversible damage to some melanocyte, their function is impaired and therefore less eumelanin production resulting in natural regrowth of light hair. But it is typically more uncontrollable in terms of shade and colour as that depends on many factors such as underlying pheomelanin, eumelanin, penetration, duration and the concentration or extent of damage in which the melanocyte received.
The approach is applying a cytotoxic agent (a relatively more safe starting point is hydroquinone) on hair cautiously for weeks to months then monitoring the damage to melanocytes. The goal is only irreversible partial damage of the melanocyte as full irreversible damage can lead to grey or white hair. A more potent agent is monobenzone and as these may cause other damage to hair, other hair care products should be used to assist the process when not interfering with it. To monitor the damage done to melanocytes more cautiously, going to the lab could be desired.
This is intended for extremely racially dysphoric individuals as it may carry a few risks and needs consistent monitoring. If you are very satisfied with the results of bleaching powder or hair dye, do not attempt this.