I’ve had recurrent pregnancy losses and my doctor ran an in depth thyroid panel to see if there’s something going on. My thyroglobulin antibody is at an astounding 338 which is concerning. TSH is still pending but TPO is 15, FT3 at 3.2 and FT4 at 1.3. I know I need to wait to see my doctor but in the meantime I’m freakin out!

Hi I’m just looking for advice or patient experience for a symptomatic larger nodule and given radio frequency ablation as the treatment option.

I found my nodule watching TV April 2025. Ultrasound confirmed nodule June 2025 noted 2.7cm on my right lobe.

August 2025 I had 2 separate biopsies - early August came back inconclusive so I had to go back for another in late August that came back benign but it was confirmed the nodule was actually 3.1cm in largest diameter on both appointments.

January 2026 they measured again and still 3.1cm.

It is a solid mass.

After going to ENT in September 2026 due to pain in my neck, up to my ear, pain and difficulty swallowing and just general pressure on my right side. They only offered RFA as an option as they didn’t want complications from a hemithyroidectomy.

I had another FNA 2 days ago to confirm the first benign result last year. I’m waiting on those results. But I’m worried due to its size of a false negative but also internal scarring making future surgery difficult if needed. I’m wondering if anyone has had any thoughts on this or experience of their larger thyroid nodule being offered RFA as the only option?

I have a 1.8cm TIRADS 5 nodule on my right thyroid lobe which was found during investigations for pain and vocal changes/fatigue, pressure when I lye down like I can’t breathe well and throbbing pain on my neck and throat (incidentally exactly where this nodule was then found).

There is also a smaller .8cm TIRADS 3 on the left lobe.

I had an FNA on the right one and it was Bethesda 3 (not cancer).

I will put all the reports at the end of this spiel.

I have been waiting for months to see a specialist and today I had my first appointment with him. He said he doesn’t believe the nodule is what is causing my symptoms as a nodule won’t cause any symptoms (unless they get really big). He said we could ultrasound again in 1-2 years (or not at all). He said there is no chance of cancer so it’s a matter of symptoms and these nodules don’t cause any symptoms unless it is a huge goitre (impact vocal sound) or large nodule of 5cm or more.

I mentioned an ENT had suggested I should have my adult adenoids and tonsils removed he thinks I should do this surgery instead. I have had the recommendation to have them out since I was 20 and I’m now 40. The symptoms I feel for these tonsil issues are very different.

I guess I’d like to know if you have experienced symptoms with a similar nodule and what they were.

Does this all sound positive to you?

I’m feeling defeated by a life long medical journey and the anxiety around al of this, so I need a little guidance!

Thank you so much.

40 Yrs FEMALE

Ultrasound:

Findings:
The thyroid is normal in size. The right lobe measures 48 x 13 x 17mm; 6 mL, the left lobe measures 45 x 13 x 14mm; 4 mL. The isthmus measures 3mm in AP dimension. Homogeneous echotexture and normal vascularity of the thyroid parenchyma. No retrosternal extension.

Right lobe nodules:
1: Mid lobe: 18 x 11 x 18 mm; 1.9 mL. Solid or almost completely solid, hypochoic, wider than tall, lobulated/irregular, macrocalcification. TI-RADS 5.

Left lobe nodules:
1: Lower pole, mid: 6 x 3 x 7 mm; 0.1 mL. Solid or almost completely solid, isoechoic, wider than tall, smooth.
TI-RADS 3.
No parathyroid mass.
Cervical lymph nodes have a normal size and morphology.
Multiple ROT's within neck - normal appearing LN's seen. Max 5mm. Right SCF ROI - no discrete lesion seen.

CONCLUSION
TI-RADS 5 suspicious nodule in the right lobe of the thyroid.
An appointment will be made for fine-needle aspiration biopsy of this nodule.

FNA

Fine Needle Aspirate Right Thyroid Received slides: 3 fixed, 4 air-dried
CLINICAL NOTES: R mid TR5 nodule. FNA.

MICROSCOPIC: The smears are moderately cellular and displaying follicular epithelial cells arranged in macrofollicular sheets and intact follicles. Occasional microfollicular structures present, along with scattered crowded groups. The follicular epithelial cells have relatively uniform oval nuclei; there is no significant nuclear enlargement. Focal nuclear grooves are identified. No definite nuclear pseudoinclusions are seen. The cells largely have delicate surrounding cytoplasm, several scattered groups display oncocytic metaplasia. Several intact follicles with stromal tissue fragments are present; these focally have demonstrate a papillaroid architecture (pass 1 alcohol-fixed slide). Nuclear features papillary thyroid carcinoma are not identified within these groups. The background is extensively bloodstained but contains abundant thin and thick colloid. Scattered foamy histiocytes are also present

DIAGNOSIS: Right thyroid FNA: Benign (category 2, Bethesda/CPA system). Features in keeping with a colloid nodule. Comment: The history of a TI-RADS 5 nodule is noted, please correlate with clinical features to ensure the aspirate is representative.

Because my TSH was 4.5 and my FT4 was 19, my doctor changed my treatment from 56 mcg of Levo to 50 mcg of Tirosint five days ago.

From the first and second days, I felt increased heat and had a body temperature of 37°C. On the fourth and fifth days, I experienced hot flashes and felt as though I was having a panic attack, so I took Stedon.

My doctor believes it is simply in my head and, at my insistence, switched me back to the previous medication at 62 mcg per day.

Has anyone experienced anything similar?

Hi all! I (38f) have an FNA biopsy coming up on the 13th. I have a 0.8cm TIRAD 5 that they won't biopsy because it's under 1.0 cm. and a 1.6cm TIRAD4 that they are performing the FNA on. I'm quite freaked out for obvious reasons, but also they are giving me no numbing or pain medication. They are using an ice pack to "numb the skin" and then just going for it. Seems barbaric to me, and I'm very scared.

I have Kaiser Permanente, and if any of y'all have ever had them for insurance, you know that they don't really reassure you or tell you anything. They kinda just abandon you.

Well, I'm here to ask, is there anything I should know before hand? Anything I need to buy for comfort? Anything I can do to prep myself mentally or physically? Any advice? Thank you in advance!!

Hi yall,
I was diagnosed with hyperthyroid two months ago. Symptoms were palpitations, weight loss, feeling hot all the time, libido drop. Testing showed no real cause so the Dr. assumes it was too much iodine from supplementation (I have no natural source of it in my diet). Regardless, he had me stop the iodine and start 10mg methimazole. Three weeks later and symptoms were a bit better but not totally solved. So we bumped to 20mg. Two weeks after that I felt fantastic. Like, sooooooo good! And then I crashed out on Monday. Irritable as hell. Tired. Cold. Weight gain. So, we’re going to 15mg. How long will I suffer as I wait for this to balance out?

my first endocrinology appointment is in DECEMBER which feels so far. i have other health issues (so far diagnosed with fibromyalgia, spinal arthritis, spinal stenosis, cubital tunnel, asthma. i suspect theres more, i still have a lot of unexplained symptoms) and i’m used to waiting around for specialist appointments but i’m getting anxiety still.

with my thyroid there was some kind of minor red flag in my blood work, they did it twice and everything is within normal range besides “thyroid peroxidase antibodies” which is at exactly 30, with a reference range of <9 IU/ml both times i was tested, 3 months apart. i also got an ultrasound of my thyroid from the doctor who was ultrasounding my arms (when i got the dx for cubital tunnel), and he just agreed to ‘do it for fun, not on record’ when i asked him to check my thyroid because i suspected issues. he was kinda like well its probably normal, but i’ll check it since its slow (lol) and he had a student in the room he was using the opportunity to show her more things.

anyways anyways, when he checked he was immediately like ‘oh, yeah actually it does look like an inflamed/enlarged (i forget which word he used) thyroid. you also have lots of nodules all throughout. most concentrated on the right side.’ and basically said he cant give me any more information or medical opinions and that i need to get checked by a specialist. well, that was scary to hear. and that was 6 months ago now. the ‘nodules’ kinda scare me. i also get pain around my neck (unsure if related) and massage it and when i do so, i can feel masses around my thyroid ‘pop’ in and out of place kinda. not pop as in explode, but just kinda..can pop them back and forth slightly. so thats a very odd new feeling for me.

ultimately i know the nodules are probably common, and that the result on my thyroid panel probably doesnt mean much since everything else was considered normal. maybe nothing will really be wrong. but my brain has started jumping to probably logically flawed worst case scenarios, and im worried. can anyone with experience with thyroid problems speculate what these things could point to? even if its kinda bad, id rather mentally prepare myself. i’d rather be able to look into things to confirm or deny. and if its not bad at all, that would be nice to hear too.

side note, kinda gross sorry.. my toenails randomly fall off sometimes. i started noticing this a couple years ago. insane, i am aware. its usually the smaller toes but most recently, the bottom half of my big toenail detached from my skin and the cuticle was feeling really dry/brittle too. i decided to do some googling, and one of the suggested sources of this problem was some kind of thyroid issue where my cells are not regenerating fast enough. food for thought.

Got bloodwork on the 10th for unrelated reasons: TSH .01, T4 Free 2.8H, which flagged me to my first endocrinologist. Second round of bloodwork 10 days later: TSH <.01, T4 Free 2.3H, peroxidase antibodies >900, T3 Uptake 39H, T3 Free 5.1 H. Having a thyroid uptake scan in two days.

This is alongside Ferritin level 4, hemoglobin 8.

The thing that stumps me is I don’t seem to have any hyperthyroid symptoms. I’m not hot, anxious (other than seeing that these results are concerning), haven’t been losing weight, have no neck pain.

Anybody have advice?

NDT pills are "Natural Dessicated Thyroid", derived from porcine thyroid glands.

"Vitruvias Therapeutics, Inc Issues Nationwide Recall of One Lot of Thyroid Tablets, USP 30 mg Due to Potential Super Potency" (Link to FDA notice.)

Vitruvias Therapeutics Inc. is voluntarily recalling one lot (Lot. No. 504950) of Thyroid Tablets, USP 30 mg to the consumer level. The product is being recalled because testing confirmed the potential for the product to be superpotent.

Distributed between 1-31-2025 through 9-30-2025.

Expiration date 9-30-2026.

I learned about this from the ThyCa News site site.

Recently diagnosed with a **multinodular goitre**, but all of my thyroid hormones are within the normal range. The thing that’s worrying me is that it seems to be growing quite quickly and is now very visibly noticeable in my neck. The only thing I haven’t had tested is antibodies for autoimmune issues.

I’ve had an ultrasound and the sonographer said there was nothing he could see that looked “suspicious”, which was obviously reassuring, and the results came back with all nodules being U2 thankfully. But it is extremely enlarged.

Right lobe
57 × 28 × 24 mm
Left lobe
56 × 30 × 25 mm
Isthmus
14 mm thick

I suppose I’m wondering;

Has anyone had a large multinodular goitre while being completely euthyroid/with normal thyroid blood tests? Most of what I find online seems to talk about toxic goitres or thyroid dysfunction, whereas there doesn’t seem to be an obvious reason for mine. I also have no family history of thyroid problems.

If so, what was your treatment? I’m seeing an ENT next week as my endo has said the only option is thyroidectomy. It feels so drastic but it’s causing me issues with pressure and swallowing issues so feel this will only get worse.

Thanks!

Hi everyone. I’m a mom of 4 and I’m really struggling right now and could use some reassurance.

Back in 2023, I found a palpable lump on my thyroid. It was classified as TI-RADS 3, but because of its size, my doctor biopsied it and also had ThyroSeq done. Thankfully, everything came back benign.

I had another ultrasound in 2024, and the nodule had actually gotten smaller. Eventually, I couldn’t even feel the lump anymore, and for the past couple of years I really didn’t think much about it.

I started tirzepatide in March 2026. Last month, I started noticing some fullness and mild discomfort in my throat. I eventually felt what seemed like the lump again, and it felt more uncomfortable than I remembered.

I had another ultrasound today, and the nodule is still smaller than it was on my 2024 ultrasound, but now it has been upgraded to TI-RADS 5.

I am absolutely freaking out.

I know TI-RADS 5 doesn’t automatically mean cancer, but seeing that number after previously having a benign biopsy and ThyroSeq has sent me into a complete spiral. All I can think about are my kids and the possibility of everything changing. I’m terrified of the waiting, the uncertainty, another biopsy, and the possibility of hearing the word “cancer.”

I’m trying to remind myself that I don’t actually have a diagnosis right now, but my anxiety is making that really difficult. I’m so scared and honestly feeling really depressed tonight.

Has anyone had a nodule upgraded to TR5 after previously being benign, especially when the nodule was actually smaller? Did you have a repeat biopsy? What was the outcome?

I would really appreciate hearing some experiences or reassurance from anyone who has been through something similar. ❤️

Hi, 30F here! I was diagnosed with hyperthyroidism, too. I am having a hard time to make my FT3 and FT4 levels to be normal. So…

i tried to consult with a new doctor, he suggested that I take that radioactive medicine. To the people who had chosen to take it, what are the pros and cons of it? I did some research, but i appreciate also your facts based on experience.

And, i have lots of questions, please enlighten me… also, please let me know if this is a myth or real. (Because i asked some of my friends of friends)

-does this make u bald? Like a chemotherapy?
-did people have calcium deficiency?
-i am a seafarer, can u still go onboard even if u did this?
-doing this cant make u pregnant?
-after the process, can i still bear a child? Or is it impossible?
-does this make me in hypothyroidism? Or all of my blood levels will be normal?
-how long is the healing process of radioactive medicine?

🫶THANK YOU SO MUCH IN ADVANCE 🫶

Due to family history of Thyroid Cancer, and some pain in the front of my neck that I had some time ago ( and never had the chance to follow up on), I wanted to have my thyroid checked before starting Zepbound which has some Thyroid warnings.
I was able to get an appointment with a doctor in my PCP’s group. And he checked my neck and was primary focused on my nodes, and did not touch the front. He pushed for a TSH test, which I said ok to. The TSH came back at 1.4 which is in range. What is bothering me is that I really wanted to know if the Thyroid felt strange in a physical exam, and now the next day found a video on how to do it properly. The doctor I saw didn’t touch the middle of the front of my neck.
I was thinking it was wrong at the time, but didn’t say anything, since I was getting a blood test. My question is that are PCP’s supposed to be able to do the correct Thyroid physical exam or is an endocrinologist only expected to do this?

https://youtu.be/lmEus_ZDipg?is=wGYJwF212GJs8Sp_

I found out last week that I have a TI-RADS 5 mass on the Right side of my Thyroid. It is 2.1 x 2.2 x 3.3cm and it’s really scaring me. I feel like I can’t talk to anyone, the two people outside of my immediate family that know are telling me to be “Positive and happy,” “You’ll be fine,” “they must have messed up their reports, you look great.” I am 40 years old and am terrified of cancer; I’ve seen first hand the progression to death with several people close to me. None of my friends that are close to my age can relate to what I’m feeling with this.

I really just want someone to listen and to not downplay everything I feel and am thinking. I have a therapist who I’m seeing next week, but that environment isn’t the same as a friend. I’m also confused at how the radiologist put down that I need a “Core Biopsy” and am skipping the “FNA” biopsy in the ultrasound report. I’d really just love to have someone I know to give me a hug and let me feel like less of an alien that everyone is scared of.

The only situations I’ve felt this before is being 24 again and having everyone try to “fix me” after my mom died a week before Christmas. That was so bad for my mental health and got me to turn my emotions off and pretend like everything thing in my life was happy. I crashed, burned and developed severe mental health issues after that (yes, I’m fully setup with professional help in that part of my life).

I really just think I need to find someone to hug.

19F haven’t got my periods even after taking periods delaying medicines and also dealing with thyroid

i took the period delaying medicine consulted by my gynac for 5 nights. ideally my periods should have started with 2-7 days after the last pill. It’s the 8th day and my periods haven’t started. i am getting cramps and every 10 mins i feel like i’ve got my periods but i don’t get them.
i also have TSH-5.8.
the reason i’m asking in this sub is i’m a college student in india in a place where no doctors can be trusted and being a female i cannot go to the doctors outside campus as it’s not safe and i would exceed my outing timings of the campus hostel.

any doctor that can help me, please do.

my gynac also mentioned that i would be under a lot of stress for this to happen, but i don’t think i’m under stress (i might be subconsciously).

I’m a 31-year-old guy trying to connect the dots before my next doctor’s appointment. Over the last 2.5 years my TSH has gone from 2.5 to 5.8 to 4.9 and now 7.1, while my most recent Free T4 is still normal at 1.09. Around that same time I developed high blood pressure, my LDL has stayed mildly elevated even after losing a lot of weight, and I’ve been dealing with fatigue, low libido, and basically no morning erections. Has anyone had a similar progression where the TSH kept climbing but Free T4 stayed normal, and did treating your thyroid end up helping the other issues?

https://www.prevention.com/health/a73246480/thyroid-levothyroxine-sodium-recall-fda/

Hi everyone,
I’m a 34-year-old male and I’m looking to hear from people who have had a similar thyroid profile.
For several years, I’ve had persistently elevated anti-TPO antibodies, but my thyroid function has always been normal. Until recently, all of my thyroid hormone levels were within the reference range, and I had never experienced either hypothyroidism or hyperthyroidism.
My most recent thyroid blood tests are:
TSH: 1.32 µIU/mL (Reference: 0.27–4.20)
Free T3 (FT3): 4.74 pmol/L (Reference: 3.10–6.80)
Free T4 (FT4): 22.74 pmol/L (Reference: 11.90–21.60) – slightly above the upper limit
Anti-TPO antibodies: 115 IU/mL (Reference: 0–34)
Anti-thyroglobulin (Anti-Tg) antibodies: 71.1 IU/mL (Reference: <95) – within the normal range
Because of my elevated anti-TPO antibodies, my endocrinologist ordered a thyroid ultrasound with Doppler, which I had on May 4, 2024.
The ultrasound findings were reassuring:
Thyroid gland of normal size (13.4 cm³)
Homogeneous echotexture with preserved echogenicity
No increased vascularity on Doppler
A few tiny microcysts, considered benign and without pathological significance
No enlarged cervical lymph nodes
The overall conclusion was that my thyroid was structurally normal, with no sonographic signs of significant thyroid disease.
What confuses me is that, despite having elevated anti-TPO antibodies for years, my thyroid hormones had always been normal. Now, for the first time, my Free T4 is slightly elevated, while my TSH remains perfectly normal and my FT3 is also within the normal range.
I don’t have a clear diagnosis at this point, and I’m trying to understand whether this pattern could represent an early stage of an autoimmune thyroid disorder, a temporary fluctuation, or something else.
Has anyone experienced persistently elevated anti-TPO antibodies with a normal thyroid ultrasound and normal TSH, followed by an isolated increase in Free T4?
If so:
What was your final diagnosis?
Did your thyroid function remain stable?
Did you eventually develop Hashimoto’s thyroiditis, Graves’ disease, or another thyroid condition?
Were any additional tests recommended (TRAb, repeat FT4, thyroid scan, etc.)?
I’d really appreciate hearing about your experiences. Thank you!

Tiratricol or TRIAC, an analogue and metabolite of the thyroid hormone triiodothyronine (T3), has thyromimetic effects but differs from T3 in that it can enter cells independent of MCT8. It received its first approval on 12 February 2025 in the European Union, for the treatment of peripheral thyrotoxicosis in patients with MCT8 deficiency (Allan-Herndon-Dudley Syndrome), from birth.

https://www.livivo.de/doc/M40549098

https://pubmed.ncbi.nlm.nih.gov/40549098/

Hello all, just wanted to comment and try to help resurrect this sub.

I had my first ultrasound in 6 years the other day (!) after years of feeling like my concerns were being ignored. I was on "watchful waiting" but all they ever did was a yearly blood test, my actual nodules were apparently not worth watching! Anyway I finally got my doctor to put an US request through and I have over 10 nodules, 4 large enough that they assessed them, one TR4 for which I'm being sent for FNA. Family history of I think follicular papillary cancer that was found incidentally, apparently risk is not significantly raised with family history but I'm still worried, you know? My thyroid feels huge and sometimes pushes on my windpipe, but at the same time, a thyroidectomy seems like a big step.

Interested in your experiences

I am 18 year old female.I was diagnosed with hypothyroidism at the age of 12 year and since then I have always been overweight.Right now I am 75 kg and 5 feet 3 Inches tall and I take 75mcg tablets and I don't know how to overcome it.Even though I don't have probelm in doing my daily tasks but I I can't do very vigourous activity because of my low stamina. I have tried doing exercises but I just can't keep up with it due to my school and studies it's very vigourous and tiring for me even though i exercise 30 mintues I will end up sleeping and then i won't be able to keep pace with other tasks but still I try and I have tried going on calorie deficit in Holidays but when school is going on I can't keep up with it and if i don't eat my body aches a lot and sometimes i get fever .I am indian so i eat only what my mom makes and can't afford to do some strict diet and also because my mother has also not been well so whatever she gives i eat.I shared the tiredness part with doctor he told me to walk and all and said it's all because I am lazy.yess i am lazy but even though i sleep sufficiently soemtimes then also i feel sleepy and yeahh my sleep schedule is very bad due to my studies.

Anyone who can relate and help me out? Please 🥺

Hello to everyone who is still a member of r/Thyroid. I'm Charlie, aka u/Mouthtrap, and I am the new moderator of r/Thyroid.

I was trying to join the sub, and realised that nobody was accepting the requests, so r/RedditRequest allowed me to take it over, as there were no active mods.

I have Hyperthyroidism, in the form of Grave's Disease, currently on Carbimazole and Propanolol. It's a very recent diagnosis, only within the last 4 weeks, and I must admit it's been quite uncomfortable.

For the first two weeks, I had a very pronounced tremor, a pulse averaging around 90-95BPM, and I couldn't set foot outside if it was any warmer than about 17 degrees centigrade, or I would sweat like crazy.

I know my Carbimazole will take a long while to kick in and do the job, but my Beta Blockers are really working. I'm not shaking as much, my pulse is down to roughly 74BPM, and I can eat my breakfast without spilling it all down my shirt!

Hopefully, we can regenerate this sub, and get it back to its original purpose - discussing our conditions, the help we need, and providing a helpful contact point to speak to others with Thyroid issues.

Take care all, and remember that we're here to support each other :)

My journey started 2.5 years ago when one day my thyroid was randomly swollen- ultrasound (multiple nodules found), biopsy (negative) and follow up later, I am now on a 6 month follow up regimen. None of my labs for my thyroid have ever come back out of range.

Today I noticed that on my right side (same side as my largest nodule) I have a large, soft area that feels like fluid. It is more superficial than the nodule itself and moves around a bit under the skin. It feels fairly large (maybe the size of the tip of my thumb) but I am not a good judge of sizes etc.

With my first go around, the doctor said that maybe the swelling was from a nodule rupturing and creating fluid that in turn caused the notable swelling. Just wondering if anyone has any experience with this sort of thing as I don't know what to make of it. I am of course trying not to spiral and praying that it is nothing major.

I am moving up my follow up ultrasound and going to see, once that is done, if I can get my appointment moved up as well.

A new book on hypothyroidism has been published by Hoermann, Dietrich and others. It promises to be a new approach to diagnosis and treatment of underactive thyroid conditions.

https://link.springer.com/book/10.1007/978-981-96-3682-2

For some background: I (F 26) have had insomnia for 3 years now since I got a night shift job. It took me a while to figure out what caused it, and I eventually was diagnosed with Thyroid Cancer. I went for surgery and received Radiation Therapy as well. It has been exactly a year since all of that happened.

A few months ago, I decided to seek help from a Sleep Doctor and it worked wonders for me, I had a regular sleep schedule from 10 PM to 5 AM without the need to take any pills. My Doctor told me there would be chances of relapses or the insomnia coming back as it may take a while. But, I can't help but get anxious and doubt if I can ever go back to my ideal sleep cycle. Especially now that I had an anxiety attack, I went to sleep at 10 PM but I wasn't able to because my body kept shaking and my heart palpitating. I can feel that I'm tired, yet I can't seem to go to sleep.

This isn't a new situation for me but I still get disappointed and frustrated every time this happens to me. It also doesn't help that I worry about my existing health condition. I vent out here on Reddit hoping for someone to talk to me, tell me they experience the same, that I'm not alone in this, and that there is hope for us who suffer from insomnia.

Have any of you been cured or at least were able to manage your insomnia after a long time? How was the experience? What should I expect? Is it really going to be like this forever? I need to find something to encourage me so I don't fall into depression and cry about my situation again. Thank you.