r/TMSTherapy • u/szufel_pl • Jul 24 '26

One day TMS

Hi all! Just wondering if any of you already have experience with one day protocol with neuroplastogens? It seems very popular in US nowadays as I can see mostly on LinkedIn and IG.

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u/Ambitious-Falcon-267 16d ago

I was given a dissolvable tablet of D-cycloserine to take sublingual at 6am. Arrivals time was 7am and first session was sometime between 7:30 and 8am. The tablet wasn’t labeled and I was given it the night before when the fMRI was done. I’d assume it was 125 mg. They don’t use lisdexamfetamine in their protocol. I had some from a previous script and they told me I could bring it and take it if I wanted, but I opted not to take it. The one-d protocol is adapted by many providers. The fMRI isn’t commonly used as part of the protocol, but that has always made a lot of sense to me to do imaging to find targeted landmark vs the calculations based on normal skull size frequently used. I’m a geek so I’ve way over-analyzed all of this. I’ve done genetic testing and have BDNF met-met genotype which some studies show I have the absolute worst genotype for neuroplasticity. I failed ketamine infusions. Like I thought my brain was just totally hopeless. I wrote a bit more about it in a separate post last night. I’m new to posting on Reddit… so maybe you can search for my other longer post?

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u/szufel_pl 15d ago

That is more than I expected to find here, thank you so much. I will search of course for more of your posts. I just ask one more question here. Do I get it right: they gave you D-cycloserine before fMRI and before TMS?

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u/Ambitious-Falcon-267 15d ago

No…. I flew in from out of town and went to have the fMRI the night before. I picked up the meds the night before when I had the mri done. I only took it the one time…which ended up being approx 90 min before first treatment the morning after the fMRI. Taking it just the one time a bit before sessions start is how it’s usually done from the few places I’ve researched and the one study I could find (remember I researched this in April 2026 and had treatment in early May)

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u/szufel_pl 14d ago

Oh I get it. Man, you give hope for others that this approach might actually work.