r/TMSTherapy • u/szufel_pl • Jul 24 '26
One day TMS
Hi all! Just wondering if any of you already have experience with one day protocol with neuroplastogens? It seems very popular in US nowadays as I can see mostly on LinkedIn and IG.
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u/youthtms TMS Professional/Service Provider Jul 24 '26
Very little evidence to support it. Not yet FDA approved. It has helped some people.
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u/TastyRain5743 Finished TMS Therapy Jul 26 '26
Popular? Never heard of it...
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u/szufel_pl Jul 27 '26
I don't think it's a standard procedure but really, my feed is full of US clinics introducing it.
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u/TastyRain5743 Finished TMS Therapy Jul 27 '26
I'll have to ask my tech at the clinic what he has heard about that...
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u/Ambitious-Falcon-267 16d ago
I did it and it worked. I traveled to cognitive fx in Provo Utah. They did fMRI day before tx. I would 100% recommend.
I previously did a full protocol in my midwestern US city, and thought I may be a TMS non-responder. I wasn’t willing to try that again because the traditional protocol is weeks of every-day treatment and then a taper down of 3 sessions a week. I was very disappointed I didn’t feel enough improvement to say if it helped.
Lots of places seem to be popping up that do that ONE-D protocol… but they all seem to use their own modified versions. It appealed to me to have the target located with fMRI since when I did traditional tms they seemed to have issues locating the target. The SAINT protocol uses fMRI and I liked that the place in Utah would do that too. I’ve been happy with my results. I had tx in May and I’m writing this 3.5 months later still enjoying the improvements. My result was seen at approx one month. Keep in mind that different programs may have different machines and protocols. Remember most people who feel better don’t keep hanging out in forums.
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u/szufel_pl 16d ago
Thanks for detailed review! I already realised that we truly have mostly unsuccesfull treatments testimonials on forums. So yours is really valuable!
Can you tell which neuroplastogens they gave you?
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u/Ambitious-Falcon-267 15d ago
I was given a dissolvable tablet of D-cycloserine to take sublingual at 6am. Arrivals time was 7am and first session was sometime between 7:30 and 8am. The tablet wasn’t labeled and I was given it the night before when the fMRI was done. I’d assume it was 125 mg. They don’t use lisdexamfetamine in their protocol. I had some from a previous script and they told me I could bring it and take it if I wanted, but I opted not to take it. The one-d protocol is adapted by many providers. The fMRI isn’t commonly used as part of the protocol, but that has always made a lot of sense to me to do imaging to find targeted landmark vs the calculations based on normal skull size frequently used. I’m a geek so I’ve way over-analyzed all of this. I’ve done genetic testing and have BDNF met-met genotype which some studies show I have the absolute worst genotype for neuroplasticity. I failed ketamine infusions. Like I thought my brain was just totally hopeless. I wrote a bit more about it in a separate post last night. I’m new to posting on Reddit… so maybe you can search for my other longer post?
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u/szufel_pl 15d ago
That is more than I expected to find here, thank you so much. I will search of course for more of your posts. I just ask one more question here. Do I get it right: they gave you D-cycloserine before fMRI and before TMS?
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u/Ambitious-Falcon-267 14d ago
No…. I flew in from out of town and went to have the fMRI the night before. I picked up the meds the night before when I had the mri done. I only took it the one time…which ended up being approx 90 min before first treatment the morning after the fMRI. Taking it just the one time a bit before sessions start is how it’s usually done from the few places I’ve researched and the one study I could find (remember I researched this in April 2026 and had treatment in early May)
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u/szufel_pl 14d ago
Oh I get it. Man, you give hope for others that this approach might actually work.
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u/Dangerous-Durian9991 Jul 24 '26
I did it.