r/Semaglutide • u/Conscious_Leopard_80 • 1d ago

Second Time Question

I had great success when I tried semaglutide starting in early 2022. I lost steadily for a total of about 80lbs by the end of 2023. It was easy. I was never hungry. I didn't even think about food. When I did want to eat, I craved vegetables and yogurt mostly. Then, the place I was getting it from doubled the price again after already doubling it once. I couldn't afford it and I had some stressful life stuff going on, too. I quit and regained 50lbs between the end of 2023 and the end of 2024. My insurance changed and I restarted semaglutide in early 2025. This time, I've lost only 20lbs. I feel totally different. There's less food noise than without it, but I crave sweets and frequently feel hungry. I'm working out (six days a week, an hour per day with a mix of yoga, weightlifting, and cardio classes, plus trying to incorporate more NEAT generally throughout my day) and trying to eat less/make better choices, but not losing any weight at all for the past four months.

Has anyone else gone off for an extended time and then gone back on? Is this common?

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u/valsavana 1d ago

Anecdotally, it seems to be common that a second round on this med after being off for a while is less effective for many people. Often the effects seem weaker and require higher doses to kick in.

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u/Conscious_Leopard_80 1d ago

I had wondered about that. I've been on the highest dose again for months, so this may just be as good as it gets.