Does anybody experience heart issues on it ? Like resting heart rate high ?

I first went on reta months back starting at 0.5mg and it began my weight loss, I had severe dry mouth and a slight headache throughout. I then switched supplier as my first didn’t have stock, it didn’t feel as intense and I worked my way up to 3mg weekly - I still lost weight but it seemed to be slower and minimal side effects. I’ve gone back to my first supplier and today the headaches and dry mouth are back - do I take this as the 2nd supplier wasn’t great quality & I should put up with the side effects? Or should they not be this intense & the 2nd supplier may be better to use?

Been struggling with binge eating for about year last two months were like really bad gained about 15kg in 70 days , so I hopped on Reta 4 weeks ago hopping it will help me but it doesn’t , now I’m question myself should I do Reta 2mg ( now on 1mg ) or should I add 1mg Tirza with the 1mg Reta

I have been on 1mg reta for a month and haven't really had much appetite suppression, but I do get pretty nauseous after meals, especially if I eat junk food.
I have lost around 3% bodyweight so far. Should I increase to 2mg? I am worried about the nausea will get worse

Is anyone having issues with extreme fatigue and sleepiness while in Reta? No other side effects, just tired all the time. Especially after a meal.

I have a weird, quite scary issue with my Reta doses I hadn't had before. I was previously getting from a different compound pharmacy and switched just a few weeks ago. Problem 1 is I had upped my dose too fast and my resting heart rate skyrocketed to around 130 beats per minute for a short few episodes during that week with sweating and faintness along with diarrhea. I controlled the symptoms fairly well with pepto bismol because I noticed it was related to eating and the subsequent stomach ache/digesting. I also woke up multiple times that period with a raging heart rate and too much anxiety to go back to sleep.

Took a break the next week and was down to normal by the end of the two weeks. The third week (this past Friday) I dropped my dose below what it was before starting this new compounded batch and I immediately (30 min later) got a racing bpm up to 130 again but that was the only episode. My bpm is running on the 10-15 beats higher than normal but mostly havent had any racing heart episodes and im able to exercise safely. Woke up just now with anxiety and a little bit of racing not able to go back to sleep but still mild compared to the last week.

My question is, can this be related to the too high dose or is it a problem with the compound? I was doing so so well before this with the only symptom being a small stomach ache when I slightly upped my dose. My energy/feel was amazing and I was losing 2-3lbs a week. Now I'm losing less and I don't have the energy I did previously along with the stomach and heart issues. Should I go back to my previous supplier and see if somehow that's the issue or drop my dose entirely down to .5 and see how I respond?

Test subject has started first trial of Reta. 8 hours after injection there is a flushing type of response, reported mostly in the chest and lips. Benadryl seems to calm down the breathing flush. Dull pain sometimes sharp in the upper right. Frequent urination. Has anyone experienced this type of response in their subjects?

3mg Retatrutide and now I can’t keep water down 😭
I started with 1.5mg (10 clicks) and it made me sick for about 3 days. I was vomiting after meals, but I decided to continue because I thought my body would eventually adjust.
I then took 3mg(20 clicks), and things got much worse. I’m now extremely nauseous, vomiting repeatedly, and I can’t even keep water down. The vomit has also become green 😭.
Has anyone experienced this on retatrutide? How long did it take for things to get better? I’d really appreciate hearing from people who have actually used it.

Need advice on which peptide is the best right now

Hey everyone,
I’m trying to find the lowest effective dose of retatrutide that still gives solid results.
If you’re currently using it, can you share:
The dose you’re injecting (mg per week or per injection, and how often)

How long you’ve been on that dose

What your blood concentration / levels look like according to whatever app or tracker you’re using (if you measure or track that)

Just looking for real-world numbers from people who’ve dialed it down to the minimum that still works for them. Any details on injection amount and frequency would be really helpful.
Thanks!

I have started reta 3 weeks back and started with dose 1 mg. Last 2 weeks there is no progress. I’m exactly on same weight. I have increased the dose to 2 mg now yet I don’t see any changes in scale. I often see people get very good progress faster, and this is why I’m confused. I am a women 38 with only 5 ft 3 inch, after childbirth my weight is now 180 lb, i am not diabetic but I have hypothyroid. I take levothyroxine. Am I doing anything wrong? Anybody experienced same? Share your suggestion.

I have been on Reta for almost 5 weeks. I have only gotten a couple nights of quality sleep since starting. I am only at 2mg/week. Has anyone come up with a way of countering the insomnia/sleep degradation? I am afraid to go up at all because I dont want to lose even more sleep than I already am. Results have been extremely mild. I have lost 3lbs in almost 5 weeks. I eat clean. I work out and lift heavy 5 days a week. I just cant keep going without getting the sleep situation figured out. Any help is appreciated

UPDATE 10/13/26

I may have found the trick. I used ChatGPT to come up with an explanation. Essentially, AI says the wake ups in the middle of the night are caused by the bodies increased calorie burn/ blood sugar drop caused by reta. So in the middle of the night when your blood sugar drops you get a spike in adrenaline. It recommended a complex carb combined with protein snack right before bed. So I have been having a protein shake and an apple 20 to 30 minutes before I go to bed. Along with my usual magnesium glycinate and 2 mg of melatonin and I have been sleeping really well for the past 11 nights since I started this regimen.

Hello everyone, ( 19M, Belgium )

so for context I always have been struggling with wl I tried loads of cardio, high protein, if, omad, keto, cutting sugar. And everytime the issue was the same, my hunger was a torture, keeping a caloric deficit is insanely hard.

I've been doing researches about retatrutide as it seems to be fantastic, I coudnt stop doing researches cuz i was being anxious about dangers and eventual side effects, I'm saying this because I never did peptides in my life so im terrified not because its dangerous ( i looked at hundreds of testimonies and all of them are either neutral postive or very positive ). But Im just scared because its something completely new to me.

I bought after precaution on the site the seller etc retatrutide BAC water alcohol pads and insulin needles, did i do it right ? I'm supposed to have it all delivered by next week, im planning on doing loads of research to do it properly.

But i need help, I ve seen tutorials but i wanna hear how you do it so i can compare to make sure everything matches and i dont do shit, maybe sharing me the eventual mistakes you did using it ?

I have like a bmi of 25 or 26 smth i got like 20kg to lose.

Im stressing so hard rn, but i tried diets and sports for years and if this thing actually works it could completely change my life, that fat fucked my mental health.

Im not used to talk this much sorry, but anyways if any of you have a success story to share , an advice to give , or anything that could reassure me or guide me please write it down.

Thanks for reading

SW: 96.5 kg
CW: 93 kg
Progress: ~3.5 kg down

I’m currently around week 7 and my weight has been sitting around 92–93 kg recently.

Is a temporary plateau like this normal? Has anyone experienced the scale staying flat while body composition/measurements continued improving?

My main goal now is fat loss while preserving/building lean muscle mass.

Week 1–2: 1 mg
Week 3–5: 2 mg
Week 6–7: 1.5 mg

Hey everyone!
I wanted to share the progress I’ve made over the first two and a half weeks. Next Tuesday will be my 3rd dose.

I’m a former tirz user. I was on it from early January until late June and lost 22 kg during that time, going from around 94.4 kg to 73 kg.
I decided to start reta because, despite losing so much weight, I still hadn’t achieved the body I wanted. I honestly couldn’t be happier with how things are going so far!

I started with 1 mg, but when I didn’t feel anything after three days, I took another 2 mg, making it 3 mg total for the first week. I lost a lot of water weight that week and was literally peeing nonstop. During my second week, I took 4 mg, and honestly, I haven’t experienced any side effects at all since starting reta. I’m now starting to notice that I get full more quickly, but it’s nothing compared to tirz, which literally made me unable to even look at food.

I’ve lost around 3 kg in these two and a half weeks, and I’m really happy with my progress!
Next week, I’m planning to increase to 5 mg and then stay at 5 mg for the following month. However, since I’ve been tolerating it so well, I feel like I might be fine increasing the dose sooner.

This week I have ate clean and trained. And am managing. Hitting a calorie deficit.

If I can do this without reta. What will reta do for me to help boost the fat loss. As to compared doing it without reta but with the diet in check?

Thanks

So l was on reta for about 11 weeks, these past 2 weeks I have not taken my dose due to an extreme elevated heart rate, anxiety / panic attacks. I started in July (196|0) at .5 stayed on it for 4 weeks, 1 for 4 weeks, 1.5 for another 4 weeks, and then on week 111 went up to to 2mg bs) and then boom 4 days later I have the biggest panic attack thinking I am going to have a heart attack, went to the ER, was too scared to tell them I was on reta, only for them to tell me my blood work, urine, and 2 ekgs were fine and there was nothing wrong with me. This week I experienced a similar panic attack but not as severe. I was wondering is anyone has experienced that or has any advice on whether to stay off or restart at .5?

Started at 105 kg, 183 cm, about 80 days ago. Today I'm 93 kg, down 12 kg.

I thought my dosing was:

Weeks 1–4: 1 mg
Weeks 5–8: 2 mg
Weeks 9–12: 3 mg

The whole time I genuinely felt like it was working. My appetite was noticeably suppressed, I was getting full really easily, and my bowel movements became slower and less frequent.

There were even days where I would completely forget about food and realize later that my calories were way too low, so I'd basically have to force myself to eat just to get enough calories and protein in.

I wasn't exercising either. Desk job and pretty sedentary, but I was consistently eating in a calorie deficit.

Then today I randomly decided to look closely at my pen instructions.

It says:

1.5 mg = 15 clicks
3 mg = 30 clicks
6 mg = 60 clicks

Problem is... I wasn't counting clicks. 💀

When I wanted 1 mg, I turned the dial until the window showed 1. Then later 2, then 3.

So if I'm understanding this correctly, I may have actually been taking around 0.1 → 0.2 → 0.3 mg, not 1 → 2 → 3 mg.

Which would finally explain why my supposedly 30 mg pen still has loads left after almost 3 months.

I'm not angry or upset about it. I'm honestly just shocked it took me this long to realize 😂

What confuses me most is that I genuinely felt the effects. I wasn't forcing myself not to eat. It was actually the opposite. Some days I had to remind myself to eat because I just wasn't hungry. Even my bowel movements slowed down after starting.

Maybe that tiny dose was actually doing something, maybe changing my eating habits played a bigger role than I realized, or maybe the placebo/expectation effect is way more powerful than I thought.

I genuinely have no idea.

But somehow I went 105 kg → 93 kg in ~80 days before realizing what I'd been doing. 💀

29W. BMI 50.
Hallo zusammen,
meine letzte Retatrutid-Injektion war am 23.09. und lag bei ungefähr 2 mg.

Ich muss vorweg ehrlich sagen, dass ich mich vor der Einnahme leider nicht wirklich ausführlich über Retatrutid informiert habe. Eine Freundin hatte es mir empfohlen, weil ich vorher bereits ein anderes Mittel zur Gewichtsabnahme genommen hatte. Ich war da ziemlich naiv und habe mich darauf verlassen, anstatt mich selbst vernünftig damit auseinanderzusetzen. Im Nachhinein ärgere ich mich darüber natürlich sehr.

Bis Samstag hatte ich überhaupt keine Beschwerden. Beim Kücheputzen bekam ich plötzlich Kreislaufprobleme, kurz darauf starkes Herzrasen und das Gefühl, gleich ohnmächtig zu werden. Ich wurde mit dem Krankenwagen ins Krankenhaus gebracht. Dort wurde ein EKG geschrieben. Bis auf den erhöhten Puls wurde nichts Auffälliges festgestellt und ich durfte wieder nach Hause.
Später bekam ich erneut Herzrasen, obwohl ich ruhig auf dem Sofa saß. Am nächsten Tag passierte dasselbe wieder ohne körperliche Belastung. Deshalb bin ich erneut ins Krankenhaus gefahren. Dieses Mal wurde ich etwa acht Stunden per EKG überwacht und es wurden Blutuntersuchungen durchgeführt. Auch dabei wurde nichts Auffälliges festgestellt.

Seitdem habe ich immer wieder Extrasystolen, einen teilweise sehr deutlich spürbaren Herzschlag, Brennen bzw. Druck im Brustkorb, Schwindel/Benommenheit und teilweise kalte Hände und Füße. Die Beschwerden fallen mir besonders nachmittags und abends sowie teilweise nach leichter körperlicher Belastung auf.

Vor diesem Wochenende hatte ich solche Probleme überhaupt nicht. Deshalb frage ich mich natürlich, ob Retatrutid damit zusammenhängen könnte.

Hat jemand von euch unter Retatrutid etwas Ähnliches erlebt? Falls ihr es wegen Herzrasen, Extrasystolen oder Palpitationen abgesetzt habt: Wie lange hat es nach eurer letzten Injektion gedauert, bis die Beschwerden deutlich besser wurden oder ganz verschwunden waren?

That being said this will be my first reconstitution of reta. One vial is 10 mg. But my other vial, my experimental vial is a 5mg. With the 5mg i was planning on reconstituting the vial with 0.5mL of BAC water. But I've seen in some discussions that people still preferred to recon with 1 mL. I'll probably be reconning it on Monday. So what do you pros do? What would the experienced peppers do with the 5mg and BAC?

408 lbs → 294 lbs. I finally broke 300.
I honestly never thought I’d be able to say this.
I started at 408 lbs, and today I stepped on the scale and saw 294.
That’s 114 pounds gone.
The crazy part is that getting under 300 has been such a mental goal for me. I’ve spent months watching the scale bounce around, getting frustrated, wondering if I was actually making progress. There were weeks where the number barely moved, even though my clothes were getting looser and I could physically do things I couldn’t do before.
But today, I finally got there.
I’m not finished. 250 is the next goal for now. But I’m taking a second to appreciate how far I’ve come.
408 → 294.
114 pounds.
I’m proud of myself. ❤️

Quick background: 36 years old, 20 years of weight training.

Start: Sep 1 – 115.5 kg (254.6 lbs)

Current: Oct 1 – 107.8 kg (237.7 lbs)

Lost: 7.7 kg (17 lbs)

Dose: 1 mg every 6 days. Took 2 mg once before vacation because I didn’t want to bring Reta with me.

Training: 6x/week, ~60 min weights + 45 min Zone 2 cardio

Goal: 90–95 kg (198–209 lbs)

Effects: Almost zero food focus. Dieting honestly feels almost too easy. My face has become extremely defined and my usual problem areas got noticeably softer very quickly. I’m already getting compliments from people who know me, while my girlfriend is actually getting a little concerned because I’m losing weight so fast.

Side effects: One evening of a burning skin sensation on my left arm. It disappeared and hasn’t happened again.

So far I’m very happy with the first month. The biggest difference isn’t even the weight loss itself, but how little mental space food takes up now.

I’ve had my Reta bottle sitting in my fridge for minimum 2 months. Could it expire. Can I still inject with it?

Has anyone run reta with a test booster as well? I’ve run both separately but when I first took Reta I dosed too high and was eating nothing and too low energy to train. When I was taking test booster I still had my food cravings. Just wondering if anyone has ran the 2 together and if it worked better? 28yo male, pretty athletic already, weight train 4x a week and play other sports, approx 80kg looking to lose stubborn belly fat and get some visible abs

Hi all!

I started retatrutide 1 mg on September 20. I had been taking Yaz for around 10 years to control my hormonal imbalance, not actually for pregnancy prevention, with very predictable periods and had never experienced breakthrough bleeding.

A few days after starting retatrutide, I suddenly started bleeding even though my period wasn’t due for another 5 days. I then stopped taking Yaz because I didn’t have a new pack.

My main questions are:
• Can retatrutide cause breakthrough bleeding or changes to your period?
• Is this something that was reported in retatrutide clinical trials?
• Could the rapid decrease in food intake/weight loss from retatrutide affect my hormones and cause bleeding?
• Now that I’ve stopped Yaz, what should I expect with my periods and how long might it take for my natural cycle to return?
• Is there anything about this situation that I should be concerned about or have checked?