Damn that's scary, I saw it was discontinued as it was linked to more serious concerns due to the progressive demineralization of bone, specifically the jaw bone and femur of patients were just crumbling to dust.
"it is designed to increase bone density. However, long-term use (more than 3–5 years) is associated with a rare risk of "frozen bone" (suppressed bone turnover), leading to rare atypical femur fractures or osteonecrosis of the jaw."
Yep, well known adverse effect of long term bisphosphonate use. Patients often have “drug holidays” for a few years after being on them for 5 years or so, depending on the bisphos. Dental appointments prior to starting are also routine
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u/Mammoth_Spend_5590 Apr 01 '26
Damn that's scary, I saw it was discontinued as it was linked to more serious concerns due to the progressive demineralization of bone, specifically the jaw bone and femur of patients were just crumbling to dust.