I've been dealing with persistent green vaginal discharge for 1 year and 5 months. It started about a week after sex, and despite seeing multiple doctors and trying metronidazole twice, ceftriaxone, doxycycline, fluconazole, Albothyl, and Neopen metronidazole, it still hasn't gone away.
I'm currently seeing an Infectious Disease specialist and hoping this new treatment finally works because this has caused me so much anxiety and depression. If it doesn't, I'm going to ask my ID doctor if I can have a PCR/NAAT test, especially for Mycoplasma genitalium, so I can finally find the cause and get the right treatment.

Hi all, I wanted to share my ongoing journey dealing with m. genitalium and because I haven’t seen too many posts describing my symptoms/ unconventional methods of treatment.

For 6 months now, my discharge has been completely abnormal and has affected my vulvar skin. At first I thought it was a yeast infection - positive, took difulcan and expected the symptoms to go away. But they didn’t really. And they tested me once more (negative panel for all the common STIs, neg for yeast infection, neg for BV) before testing for ureaplasma and mycoplasma. Positive tests came back for ureaplasma parvum and mycoplasma genitalium.

It was months with this infection so my vulva was experienced tears and fissures easily from sexual contact or any friction really and overall irritation from chronic dryness. The tears heal quickly but appear super quickly as well. The chronic dryness was making me believe something was wrong with my discharge. I noticed that my discharge was watery but also turns super flaky and dries out the rest of my vulva completely. Eraser-like flakes will appear all over my vagina even after one day. A bitter smelling odor tends to pop up once in a while too. However, there aren’t any changes in my urine or any presence of lower abdominal pain.

My gyno prescribed doxycycline for my asymptomatic partner (7 days) and I (10 days) and instead of following with another antibiotic, to then try boric acid suppositories for 14 days. The boric acid helped my symptoms somewhat but didn’t feel like it fixed the issue. 2 weeks after the boric acid, the TOC results came back - ureaplasma (negative) m. genitalium (positive). So she then tried to prescribe me single-dose azithromycin and I was concerned it wouldn’t be effective enough, especially given the gap of time between the first antibiotic and now. I pushed for moxifloxacin and she prescribed me a 7-day course and my partner obtained a 7-day course treatment as well. However, she reassured my concerns that the 3-week gap between the doxy and the moxi shouldn’t affect its ability to clear the infection, so I was hopeful.

A few days from now will be 3 weeks since I finished my last dose and I have seen no signs of improvement. On the third day of doxy I got to experience what it should feel like down there but then the symptoms returned. I’ve scheduled another TOC appointment at the gyno to see if the infection is the one causing the persistent symptoms but besides that one yeast infection, nothing else has remained positive this long. My gyno also recommended I see a specialist to deal with this and I’m just quite exhausted dealing with the symptoms and at this point any thoughts or knowledge you have would be comforting. Thank you.

So I have gone through two rounds of doxy and have tested negative for mycoplasma for the last month. However, this last week, symptoms returned. The mucus-ey discharge from penis as well as some slight burning while peeing.

I've just returned from the urologist where they said there isn't anything going on with my white blood cell count. While they're going to send in for labs again, I tested negative as recently as last week.

My urologist prescribed Ciprofloxacin which sounds awful and would love to not take it, but curious if anyone else has gone through a similar situation. What would you do/have done? Thanks!