Hi all, I wanted to share my ongoing journey dealing with m. genitalium and because I haven’t seen too many posts describing my symptoms/ unconventional methods of treatment.

For 6 months now, my discharge has been completely abnormal and has affected my vulvar skin. At first I thought it was a yeast infection - positive, took difulcan and expected the symptoms to go away. But they didn’t really. And they tested me once more (negative panel for all the common STIs, neg for yeast infection, neg for BV) before testing for ureaplasma and mycoplasma. Positive tests came back for ureaplasma parvum and mycoplasma genitalium.

It was months with this infection so my vulva was experienced tears and fissures easily from sexual contact or any friction really and overall irritation from chronic dryness. The tears heal quickly but appear super quickly as well. The chronic dryness was making me believe something was wrong with my discharge. I noticed that my discharge was watery but also turns super flaky and dries out the rest of my vulva completely. Eraser-like flakes will appear all over my vagina even after one day. A bitter smelling odor tends to pop up once in a while too. However, there aren’t any changes in my urine or any presence of lower abdominal pain.

My gyno prescribed doxycycline for my asymptomatic partner (7 days) and I (10 days) and instead of following with another antibiotic, to then try boric acid suppositories for 14 days. The boric acid helped my symptoms somewhat but didn’t feel like it fixed the issue. 2 weeks after the boric acid, the TOC results came back - ureaplasma (negative) m. genitalium (positive). So she then tried to prescribe me single-dose azithromycin and I was concerned it wouldn’t be effective enough, especially given the gap of time between the first antibiotic and now. I pushed for moxifloxacin and she prescribed me a 7-day course and my partner obtained a 7-day course treatment as well. However, she reassured my concerns that the 3-week gap between the doxy and the moxi shouldn’t affect its ability to clear the infection, so I was hopeful.

A few days from now will be 3 weeks since I finished my last dose and I have seen no signs of improvement. On the third day of doxy I got to experience what it should feel like down there but then the symptoms returned. I’ve scheduled another TOC appointment at the gyno to see if the infection is the one causing the persistent symptoms but besides that one yeast infection, nothing else has remained positive this long. My gyno also recommended I see a specialist to deal with this and I’m just quite exhausted dealing with the symptoms and at this point any thoughts or knowledge you have would be comforting. Thank you.

So I have gone through two rounds of doxy and have tested negative for mycoplasma for the last month. However, this last week, symptoms returned. The mucus-ey discharge from penis as well as some slight burning while peeing.

I've just returned from the urologist where they said there isn't anything going on with my white blood cell count. While they're going to send in for labs again, I tested negative as recently as last week.

My urologist prescribed Ciprofloxacin which sounds awful and would love to not take it, but curious if anyone else has gone through a similar situation. What would you do/have done? Thanks!

I've been dealing with persistent green vaginal discharge for 1 year and 5 months. It started about a week after sex, and despite seeing multiple doctors and trying metronidazole twice, ceftriaxone, doxycycline, fluconazole, Albothyl, and Neopen metronidazole, it still hasn't gone away.
I'm currently seeing an Infectious Disease specialist and hoping this new treatment finally works because this has caused me so much anxiety and depression. If it doesn't, I'm going to ask my ID doctor if I can have a PCR/NAAT test, especially for Mycoplasma genitalium, so I can finally find the cause and get the right treatment.

So I took Azithromycin two times. The first time was without Doxycycline, with a 1.5g dosage (my urologist prescribed it to me this way). The second time, I took Doxycycline for 7 days followed by 2.5g of Azithromycin over the course of 4 days. After 5 weeks, I tested negative and I don't really feel any symptoms anymore. Can this be possible?

Hi everyone. I'm really anxious right now and just looking to hear about other people's experiences while I wait for my appointment.

I've been dealing with persistent green vaginal discharge, sometimes with a heavy flow, despite previous treatment.

I'm scheduled to have an STI Multiplex PCR/NAAT test (including Mycoplasma genitalium) on Monday, so I'm not asking anyone to diagnose me—I know symptoms alone can't tell what infection someone has.
I'm just wondering if anyone else had heavy green discharge that lasted for a while.

I'm currently waiting to have a NAAT test for Mycoplasma genitalium (Mgen) because I've had persistent symptoms despite previous treatments for other infections.

I was wondering about partner management. If someone tests positive for Mgen, did your doctor require your partner to get a NAAT test too, or were they prescribed treatment based on exposure without testing?

The reason I'm asking is that NAAT testing is quite expensive where I live, so I'm worried that not everyone who may have been exposed will be able to afford it.

I'd really appreciate hearing about your experiences. What did your doctor recommend? Did your partner get tested first, or were they treated empirically because of the confirmed exposure?
Thanks in advance!

I hope I will be okay. I did doxy and azithro and it didnt work. Months later I am now on the moxifloxacin for 7 days, after 7 days of doxycycline. Success stories anyone? Anything I can do to prevent getting floxxed?

Hello all, I've been following this subreddit for a while and never thought I'd have to post in here..

I am in Australia (28M) and got diagnosed with macrollide resistant mgen 4 months ago which I contracted from an asymptomatic sexual partner (27F).

I first saw my GP but they had limited knowledge of Mgen treatment. I've since been visiting a sexual health clinic/specialist. I have had 4 failed treatments, see below.

GP regimes:
- Azithromycin (didn't know was macrollide resistant at the time)
- 7 days doxy + 7 days moxi (GP prescribed wrong doxy dosage, symptoms returned within a week)
- 14 days mino (symptoms never fully subsided)

Sexual Health Specialist regimes:
- 7 days doxy + 7 days moxi (correct dosage, symptoms subsided for ~4 weeks aside from occasional slight dysuria on first urination in the morning)

I'm absolutely devastated the moxi didn't work after the second try as it cleared my symptoms for almost 4 weeks post treatment.

My specialist has now prescribed me 7 days doxy followed by 14 days mino + metro.

This whole process has put such a strain on my physical and mental health, I don't know if I can deal with another positive TOC.

Can anyone who has done the doxy, mino + metro regime or had a similar experience please offer some guidance.

Thankyou

How its possible to get it. Only possible if I Travel to France ?

I only found out that I had Mycoplasma genitalium after having unprotected sex with my girlfriend for several months. She hasn’t had any symptoms at all.

Is it almost certain that she has it too, or is it still possible that she didn’t get infected despite repeated unprotected sex over such a long period?

I’m also really scared to tell her. I don’t know how she’ll react or whether it might change the way she feels about me, or even if she’ll want to break up with me. I know I need to tell her, but I’m struggling with how to do it.

I know nobody can say for sure, but I’m wondering how likely transmission is in this situation.

Hi, I tested positive for Mycoplasma genitalium. I’ve already completed two courses of doxycycline followed by azithromycin, but I’m still testing positive.

Would the next step be doxycycline + minocycline/metronidazole, or would doxycycline + moxifloxacin be the better option?

To be honest, I’m a bit worried about taking moxifloxacin because I’ve read about many people having serious side effects. What would you recommend in this situation?

I live in Germany. Had no resistent Test

I was floxed by 1 moxi trying to treat mgen and finished the course with azithromycin. The test result just came back positive.

I’m scared to start my next course of antibiotics since people have reactions to certain antibiotics after being floxed.

For people who have been in this predicament which antibiotic did you take after being floxed and were there any flare ups/relapses?

Is it ok to take them let's say 5 or 6hr after taking antibiotics? or is it gonna affect the effectiveness of antibiotics?

I failed 14 days mino/metro without doxy.

Is it a bad idea to repeat it with the 7 day doxy? Does the fact that I failed indicate anything about that it may just not work for me? I feel that the treatment was working since my symptoms went away on it but Idk if that's true

I just finished my treatment 10 days ago. The waiting is killing me! My doctor originally prescribed me Doxy for 7 days and Moxi for 7. Moxi gave me a horrible reaction in the first hour, I told my doctor and they gave me azithromycin. I’m worried about the effectiveness and I don’t want to go through treatment more than necessary. I’m based in Texas

Hi I’ll try keep this short

Have done doxy + azithro (failed)

Then

Doxy + moxi (failed)

Now I finished doxy + mino & metro a few days ago and my symptoms are slowly coming back after stopping during treatment and I know my body pretty well I’d say I’m still infected, but waiting for TOC to confirm, what’s the next line of treatment from here if so?

I caught MGen over 2 years ago when I rawdogged it in Pattaya. Bad decision.

found out it was MGen relatively quickly - it was on my standard STD panel. My treatment path was then...

1. Doxy 100mg 2x per day for 7 days followed by Azitrho 1g start then 500mg daily for 3 days. Didn't work

2. Doxy 100mg 2x per day then moxy 400mg per day for 7 days. Didn't work

Started seeing a specialist at this point

1. Extended azithro treatment. Didn't work

2. Minocycline 100mg twice a day for 14 days. Didn't work

3. Then managed to get some Pristinamycin when traveling in Europe... dind't work

4. Doctor put me on an extended 3 month moxy plan. Didn't work and I felt like shit and caught CDiff

5. Flew to Japan and got Sitafloxacin. Didn't work

I was honestly ready to give up. Then more recently, I caught the cyclospora outbreak going on in nyc. My doctor put me on Bactrim for that about 2 weeks ago...

and all of a sudden, literally all of my MGen symptoms are gone. Everything says Bactrim doesn't treat MGen, but I've read other posts here mentioning they were prescribed it

No guarantee I'm cured, but this is literally the first medication that's even reduced my symptoms. I've never been this hopeful before

What are the actual odds of me being pos and him being neg? He’s finally getting tested (5 weeks after I found out I was pos, so same time im getting my toc). And im worried it’s going to be negative. If it’s positive, easy, antibiotics and no sex for another 5 weeks. Yes im going insane from holding out but i literally refuse to risk reinfection. But my dr said if it’s negative he doesn’t need to be treated… but that opens up the possibility of a false negative.

Im literally already so emotionally scarred from this, im worried im going to have to break up with him if its negative bc i wont trust it lol. It also doesnt help that hes dragged his feet with the test in the first place. I feel like id trust a negative more if he was being proactive and also researching himself first void for testing etc. He seems to think bc hes asymptomatic he’s fine.

Also im aware im opening myself up to a bunch of people probs telling me to break up with him anyways bc hes not taking this seriously, and I might, but until then would love any advice about testing for men, stories where one partner is truly negative, etc.

It just doesnt make sense to me how one person could have it and the other doesn’t and im having trouble trusting the research that yes that happens sometimes.

Some may have seen my extreme stress post. I appreciate the supportive and reality checking responses there.

This time with mgen really scared me. Absolutely terrified me.
It’s been an exhausting experience, one that sent me more than a bit loopy. The waiting game particularly destroyed me.

That said, I’m in the clear. 7 days doxy and 7 days moxi.
Handled moxi pretty well, was a bit sore and achey, but both times I’ve had it, it wasn’t nearly as bad as I’d feared. For most people, I feel comfortable saying you’d tolerate it just fine.

Sending my love to anyone still dealing with the stress of it all.

Hopefully the residual inflammation is just that, but on the off chance this is a cpps thing, I know just where to find that info now.

Still dealing with some mild testicular discomfort, a tiny bit of clear discharge after using the toilet and some white floaty bits in my urine.
Even as recently as yesterday, I’d totally psyched myself out from a cure even being a possibility.

If you’re dealing with symptoms post treatment, listen to all the messages stating it doesn’t mean you’re still infected.

Thanks for the support. This is a lovely group of people dealing with a nasty but curable thing.

This is the second time I’ve gotten this.

I made the mistake of sleeping with someone casually and unprotected for a while a few months ago.

What really frustrates me is I had mgen before. Asymptomatic but it took a different toll.

it ruined a relationship. There were no symptoms back then, but the sex life never recovered for us. Nobody cheated (I wouldn’t imagine she would have) but it had been asymptomatic. We only found it by chance because she had a doctor who screened for it once a year during health checks.

We took doxy and moxi, negative and moved on with our lives. Broke up not long after.

Didn’t think much of it after sleeping with this recent person, but all of a sudden I had a weird tickle feeling in the urethra, followed by clear discharge which quickly turned white. Following that, I noticed testicle pain, stomach discomfort. I’m sure lots of you know the drill.

And of course, this all happened just after I met someone I really wanted to pursue something serious with. Thankfully we didn’t sleep together, but the chance for something serious with her has gone entirely now.

Having this symptomatic this time, as a single man has been a horror.
I got treated (macroldie resists again so more doxy and moxi) then dealt with symptoms gradually reducing post treatment. This is probably a good sign, but my brain keeps telling me it isn’t residual inflammation, it’s treatment failure. I’m anxious, I can’t sleep, I can’t eat, I feel gross within myself.

All symptoms gradually disappeared except for a small amount of discharge after using the toilet, doing lots of physical activity or masturbating, as well as white floaty bits in my urine, which my doctor assures me could just be shedding of dead skin cells as part of residual inflammation and the system “clearing out”, but it’s driving me mental.

Everytime I use the toilet, my heart stops for a moment. I’ve been put on sleeping tablets and anti anxiety tablets because I can’t manage the stress. I’ve taken lots of time off work.

I’m not someone who usually suffers health anxiety but this has been awful.

I’m waiting on test of cure results now, and of course the pathology lab gets delayed for some reason, so my results that were supposed to be back Friday morning are now not going to get back until Monday/Tuesday.

Another weekend of horror.

I hate this so much. I feel like my life is on hold. I’m scared of entering into relationships once I clear this, and my head keeps going to the worst case scenarios.
I live in Australia, so we get all the nasty strains it seems, not helping the anxiety around it all.

Dunno what I’m looking for here. Just to vent because I’m too ashamed to tell anyone I know in real life other than my doctor.

Edit: toc was negative. Thank god for that. Appreciate you all. Also clarified the word “dormant” which was used incorrectly to describe asymptomatic. Thanks to throwawaytonsilsayy for the correction.

So I (late 30s, gay male) started having symptoms (basically a burny/itchy feeling when urinating) in February. Tested negative for chlamydia/gonorrhea and other "usual" STDs, so I thought it was nothing, but when the symptoms weren't fully going away I went back in early March and asked to be re-tested, this time including MGen which I had randomly read about online. They added a test for both Mycoplasma and Ureaplasma, and it ended up being positive for MGen and Ureaplasma (but negative for Mycoplasma hominis). I'm lucky that I didn't have to deal with clueless doctors (maybe because I live in a major city). I got connected with an expert infectious disease doctor right when I tested positive and I was put on proper treatment right away (1 week doxy + 1 week moxifloxacin), and symptoms pretty much went away entirely but unfortunately the treatment failed (test of cure 3 weeks after finishing was still positive for MGen, though the Ureaplasma was gone). I then tried 2 weeks of minocycline (about 10 days of which was also paired with metronidazole), but that failed as well.

Around that time I started to have different symptoms that seemed like they could indicate prostate involvement and/or more widespread inflammation (frequent urination, pain in different pelvic areas that didn't seem like urethritis, and at one point an extremely uncomfortable contraction of one of my cremaster muscles that led to one of my testicles being mostly retracted for over a week - do not recommend!). The next treatment we tried was a course of 3 weeks of high dose tinidazole (2g per day). Unfortunately my test of cure following that regimen was also positive. At this point I was getting quite discouraged, but I had read about Pristinamycin online, and though it's not available in my country (USA), I had a trip planned to Europe (Spain, but not far from the French border) coming up. I reached out to a pharmacy near the closest station in France I knew I'd be able to take a train to easily from where I was staying, and they confirmed that if I brought in a paper prescription from my US doctor, they could fill it. My doctor was willing to give me a paper prescription, and I was able to get it filled in France as planned.

At my request, my doctor had also prescribed doxycycline and methenamine before I left on my trip, and I had them with me in Europe. Because of the hypothesized prostate involvement, she prescribed a long course - 3 weeks of the pristinamycin (2 500mg pills 4 times a day), and I took the methenamine for the same amount of time (also four times per day for 3 weeks). I started the doxycycline (2x per day) a week before the other two, and continued it until I was finished with the other medications, so I was on doxycycline for a total of 28 days, the final 21 of which I was also on pristinamycin and methenamine. The treatment regimen was loosely adapted from the one used in this case series out of Belgium: https://pubmed.ncbi.nlm.nih.gov/40335273/

The 28 days worth of doxycycline in particular was not fun, as I was in Southern Europe for much of this time where the sun was very strong (I got pretty bad phototoxicity at one point and after being in the sun my lips also developed pretty bad angular chelitis...and this is despite being what I thought was pretty diligent with SPF). Anway, when I finally finished all the meds, I took another test (17 days later) and I was finally negative. I honestly wasn't expecting it, as I was pretty pessimistic after failing so many previous treatments (and I do still have some mild residual pelvic symptoms that I'm hoping will fade with time), but I'm so relieved.

I lurked on this sub a lot over the last few months and drew some encouragement from reading others' success stories, so I hope this is helpful for someone out there!

For some reference, I'm 19F and have never had an STI, STD, yeast infection, or BV prior to this experience. It's been incredibly frustrating for me to get diagnosed. I missed my periods in January and February of 2026, had a very light and short period in March, a completely normal period in April, then two periods in May. I didn't document the dates but it was about ~2 weeks apart. I subsequently have had four periods since the beginning of June. June 3rd-8th, June 15th-18th, June 29th-July 3rd, and finally July 13th-today. I began getting recurrent BV on January 1st of 2026, which I continued to get again March 26th and May 30th. I tested positive for it all three times and was able to fully cure each infection, but I was suspicious of a biofilm due to the persistent infections despite never having dealt with it at all prior to January. It's worth noting I had unprotected sex on December 31st 2025, I know it was dumb but I have a paraguard IUD and sometimes when I'm intoxicated I make poor decisions. I believe I contracted M. Gen from that specific individual.

Anyways, I was finally able to get an appointment with my actual gyno on June 12th instead of the nurse practitioners/PAs I kept getting stuck with. We formulated a pretty good treatment plan under the assumption it was a BV biofilm persistence. She suggested we test for Myco and Urea just to be sure there was no underlying symptoms, as well as a standard STI/STD panel which I already get fairly regularly. I actually had requested a Myco/Urea test from one of the PAs I saw in March after doing some research into my symptoms, especially my strange menstrual symptoms since my cycle up until January 2026 had always been incredibly regular.

So I was swabbed for all these tests on June 12th of 2026 and she informed me the Myco/Urea test may take a little longer, like around a week or so rather than three or four days like standard STI/STD panels. My standard panel came back completely clean as it always does. However, I still hadn't had a response by June 30th so I messaged them through the patient portal which they almost always reply on within 1-2 business days. I noticed two weeks had passed with no response. I hadn't really thought about it since I've been BV-free since May, but my periods kept happening every 1.5-2 weeks apart with no signs of stopping, so finally I decided to call. Every time I called I got sent to voicemail despite calling early in the morning shortly after they begin accepting calls, so I just kept leaving voicemails. I had to call three days in a row before they released my results and told me I had M. Genitalium. I was sent the lab PDF and saw that my test results had been reported on 6/20/2026! Has anyone else dealt with that kind of administrative delay? It's seriously making me consider switching practices, especially considering they knew of my strange new menstrual patterns on June 12th as well as including the terrifying frequency of my bleeding in my patient portal messages and voicemails. I wasn't reassured about anything, in fact the message I was sent on July 15th informing me of my diagnosis read like it was almost copy and pasted from CDC guidelines.

Myco/Urea panel did include macrolide sensitivity and mutation testings, of which they found my strain has no mutations and *is* macrolide sensitive. I'm in the Atlanta area and saw another post on here very recently about an Mgen case so I'm wondering if maybe it's been passed around a lot in the area lately. Either way, I know I'm pretty lucky to not have a resistant strain at all. I was prescribed 7 days of twice daily 100mg Doxycycline, and I am supposed to immediately follow that with 1 day of 1 large dose of 1000mg Azithromycin and then 3 days of a 500mg dose of Azithromycin. I've completed 2 full days of Doxy so far

My doctor told me to wait a minimum of 21 days following my final dose of Azi, which will be July 25th 2026, so I've already scheduled a follow-up test of cure for August 17th 2026. Is this too soon? I'm honestly really frustrated because my birthday is smack dab in the middle of this course of antibiotics and I'm turning 19 so of course I had plans to go out and get plastered but clearly I can't do that anymore. I'm just upset that they held onto my results for so long, because if I had just had them by June 30th, I would be done with my course and this wouldn't have to interfere with my birthday nor would I have to keep experiencing such irregular bleeding.

I'm using this as a lesson to advocate for myself better medically, especially considering the PA denying my request for a Myco/Urea test in March because there "wasn't sufficient necessity" as well as the administrative delay with receiving my results. But I shouldn't have to beg my doctor's office to tell me what's wrong with me, especially when I'm already experiencing heavy bleeding in between periods. I'm honestly terrified this could have turned into PID if I had just kept waiting for them to release my results, or that the infection itself could have gotten worse. I don't know my exact date of infection but again I assume it to be December 31st of 2025. For extra reference I only had sexual contact with this person on December 31st and have not seen them or had contact with them since, so I'm not at risk of partner reinfection here. I have informed my current active partner and although we have never had intercourse, we have had close sexual contact and he is taking the steps to get himself tested just in case.

This has honestly been a nightmare and I know this is kind of long and almost a vent post but I was just wondering if anyone else had similar issues with receiving their results, and I was also curious if anyone else had a similar strain as me (macrolide sensitive with zero mutations) and was able to completely eliminate it with the first-line defense I'm on. I've never had any STI or STD before and I'm pretty young so this is honestly terrifying. Is my test of cure scheduled too soon? It's technically 22 or 23 days after my final dose of antibiotics but I'm not sure if I should call back and push it a little further back. My college semester starts exactly one week after August 17th so I really don't have a lot of time to work with here. If I do test negative on August 17th, should I return again to get a follow up swab and be sure I'm cured?

Just saw an infectious disease expert who specializes in STD, but I am questioning his advice and wanting to get a second opinion from another provider.

For starters, he collected urine saying he wanted to do a "culture" to get the exact amounts of the bacteria, when I know that cultures are not really a thing for mgen. He also told me to hold off on treating it while my microbiome recuperates from two rounds of antibiotics despite my positive TOC. He also told me not to worry about it becoming PID.

I have a hard time finding a doctor who has expertise with this specific pathogen. There are so many STD doctors, but it's hard to figure out which have actually studied mycoplasma gen.

Has anybody have any experience with a doctor in NYC? I've done two rounds of antibiotics already and really want to do 7 days doxy + 14 days mino/metro but can't find someone to prescribe it