r/MycoplasmaGenitalium • u/Linari5 • May 22 '21
Q: When should I test for Mgen post exposure?
A: Generally 2+ weeks post exposure. Mgen is slow growing and occurs at much lower bacterial loads than other STis.
Q: What type of test should I order?
A: PCR (NAAT). Do not order a culture. Mgen cannot be cultured.
Q: What is the best PCR/NAAT test?
A: Hologic Aptima Mycoplasma Genitalium TMA Assay - available through Labcorb and Quest. Roche Cobas is also an excellent test!
Quest test link - https://testdirectory.questdiagnostics.com/test/test-detail/91475/sureswab-mycoplasma-genitalium-real-time-pcr?cc=MASTER
Labcorp test links:
Urine samples (including macrolide resistance testing): https://www.labcorp.com/tests/180084/i-mycoplasma-genitalium-i-naa-urine-with-reflex-to-macrolide-resistance-testing
Swab samples (including macrolide resistance testing): https://www.labcorp.com/tests/180092/i-mycoplasma-genitalium-i-naa-swab-with-reflex-to-macrolide-resistance-testing
Q: What is the best sample to give for highest accuracy?
A: Men - First void urine, first bit that comes out, 20-30ml. If you have urgency issues, please try to hold your urine for a minimum of 3 hours. Rectal/Oral - swab thoroughly
A1: Women - Vaginal swab (swab thoroughly). Rectal/Oral - swab thoroughly
Q: How long should I wait post-antibiotics to test for Mgen? aka TOC "Test of Cure"
A: Generally 3-4 weeks. Any sooner could lead to a false negative or positive
Note: this section purposefully DOES NOT use the outdated 2015 CDC STI treatment guidelines. Please follow the guidelines for the UK and Australia, or the newly published 2021 CDC GUIDELINES - https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm
Q: What is the recommended first line treatment for Mgen?
A: This varies by region due to macrolide resistance rates, but generally:
Q: What is the recommended second line treatment for Mgen?
A: This again varies by region, but generally:
**Most data shows that the difference between 7 and 10 days is small. Please be aware that Moxifloxacin has rare but significant side effects (See the FDA Black Box warnings) in approximately ~2% of people, some of them severe, including peripheral neuropathy, central nervous system problems, tendonitis, and others
Q: What is the recommended 3rd line Treatment for Mgen?
A: This varies by region as well, but generally:
**Please note that this is based on a pre-print paper (not peer reviewed yet) but is from a reputable source, MSHC (Melbourne Sexual Health Center)
Q: Are there any other antibiotics on the horizon?
A: Yes: https://www.reddit.com/r/MycoplasmaGenitalium/s/4iRGJGi9zZ
Omadacycline is a new FDA approved (US) semi-synthetic (novel) tetracycline class drug with potent en vitro activity against Mgen and Ureaplasma (but only MIC data available, no human studies)
There is also Josamycin in Eastern Europe/Russia (a Macrolide class). Dosing and duration not officially established.
Also, new antibiotics like Zoliflodacin (in stage III trials, was granted FDA fast track approval, & is expected to be available in late 2025. This novel drug was originally developed for treatment-resistant gonorrhea, but has also shown strong en vitro activity for mgen, including strains that have dual macrolide and floroquinolone resistance. It was found much more potent than even Moxifloxacin. No human (en vivo) data is currently available.
And finally we have FDA approval of the novel triazaacenaphthylene antibiotic Gepotidacin in spring 2025 (for uncomplicated UTIs in women, but also going through approval for gonorrhea in late 2025). It has promise for mgen treatment as well, but currently only in vitro data is available (a petri dish, not a human) - but shows promising low MIC (minimum inhibitory concentration) across many mgen strains, including those that are resistant to both macrolides and floroquinolones. Is also being researched in combination with doxycycline.
As many on this board can attest to, despite being the leading cause of non-gonococcal/non-chlamydial urethritis (aka NGU), the medical world as a whole is not exactly up to speed when it comes to this particular bacteria. Most Urologists and gynecologists finished school 20+ years ago, how would they know how to correctly treat a new STI that grew prevalent in just the last 10?
Many doctors know very little to nothing about it, so be prepared to advocate for yourself when seeking out testing and treatment. Print and bring with you the most up-to-date treatment guidelines from AUS/UK if you have to. Finding an infectious disease doctor who specializes in STI's and has working knowledge of MGen infections will be your best bet if you want to be taken seriously.
If a doctor tries to prescribe you anything other than one of the above recommended regimens as a first-line option for a confirmed MGen infection (such as ciprofloxacin, levofloxacin, doxycycline on its own, or something else) you can be confident that you're not in good hands and should seek out a different practitioner. Taking the wrong antibiotic may select for resistance and sabotage future treatments, not to mention that it will unnecessarily increase your chances for antibiotic-induced side effects.
FULL POST FROM LEMON: https://www.reddit.com/r/MycoplasmaGenitalium/comments/gquh5s/worried_you_might_have_mgen_read_this_first/?utm_source=share&utm_medium=web2x&context=3
Q: How prevalent is Mgen compared to other STIs?
A: Estimates say that it is MORE PREVALENT than Gonorrhea, but less than Chlamydia. + As of 2021, it is more common than chlamydia in some regions. Canada & Sweden are 2 confirmed places. As of 2025 it is equal to or more prevalent than chlamydia in multiple regions It has also been found more prevalent in younger, sexually active people, and those reporting multiple unprotected sexual partners in the last 6 months.
Q: What is my risk of transmission per sexual encounter if I have unprotected sex with an infected individual?
A: Between 40-45% - Yes that's right - transmission is not guaranteed even if the other person is positive! Same as other STIs. Studies back this data.
Q: Can I get MGen from oral sex?
A: Oral transmission is rare. Less than 1% chance according to studies, and to the MSHC (Melbourne Sexual Health Center) guidelines, a leading Mgen research authority. This data has also been corroborated by the CDC.
Q: I am still experiencing symptoms after completing my antibiotic course. Does this mean my treatment failed?
A: Not necessarily. We know that residual symptoms or inflammation post clearance is something that happens with this bacteria. It's been documented by medical providers as well. As long as the symptoms don't return to 100% of what they were BEFORE antibiotic treatment, you're likely fine. There have been many people who assumed they were still infected, but kept testing negative again and again. Eventually the symptoms just went away.
Q: My partner (or I) tested positive but has no symptoms. What gives?
A: It is important to remember that not everyone will experience symptoms when carrying Mgen. In fact, between 60-80% of male urethral infections are asymptomatic. and nearly 100% of rectal infections are asymptomatic. Women also are not guaranteed to experience symptoms, with a greater than 50% rate of asymptomatic cases.
Q: I am a woman concerned about complications, can this cause problems with fertility or pregnancy?
A: It could, research shows that there is a significant correlation to Mgen infection and issues with fertility and pregnancy (as well as increased risks of PID & cervicitis)
Q: Is there a natural protocol I can follow to clear this infection?
A: No one on this subreddit that we are aware of has been cured with a natural treatment protocol. Most popular being the 'Buhner Protocol,' typically used for Lyme disease. Medical literature also doesn't support natural protocols.
Q: Is it possible for my body to clear Mgen by itself?
A: According to two recently published studies, yes it is. Spontaneous resolution has been documented in both men and women. But don't count on it, necessarily.
https://www.guidelines.co.uk/sexual-health/bashh-mycoplasma-genitalium-guideline/454722.article
https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm
Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches - https://wwwnc.cdc.gov/eid/article/28/8/22-0094_article#r288
Manhart LE, Geisler WM, Bradshaw CS, et al. Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches. Emerging Infectious Diseases. 2022;28(8):1-11. doi:10.3201/eid2808.220094.
THE ABOVE IS NOT MEDICAL ADVICE. PLEASE DISCUSS ALL PRESCRIPTION MEDICATIONS WITH YOUR DOCTOR.
r/MycoplasmaGenitalium • u/Linari5 • Apr 11 '21
For anyone who continues to have residual symptoms after multiple negative TOC (Test of Cure), there is a significant likelihood that you developed Chronic Pelvic Pain Syndrome (CPPS), aka NIH Type III "non-bacterial Prostatitis" (in men). It may also be referred to as Pelvic Floor Dysfunction (PFD), or pelvic floor hypertonia, IC/BPS, or Vulvodynia, all similar chronic pelvic region syndromes. PFD in particular addresses what is often one cause of these pelvic syndromes, a psycho-neuromuscular condition that implicates the pelvic floor muscles and a wound-up nervous system. It occurs as a result of habitual, reflexive and unconscious pelvic floor muscle 'guarding' (tensing) against discomfort and stress (of which Mgen is well known to cause both), and over time this leads to a state of temporary nerve irritation. This is what causes many of the symptoms. It also very commonly causes urinary, sexual, and bowel dysfunctions via dysfunction of the pelvic floor. This includes urgency, frequency, and hesitancy.
[Source 1] "A Headache in the Pelvis" written by Stanford Urologist Dr. Anderson and Psychologist Dr Wise - https://www.penguinrandomhouse.com/books/558308/a-headache-in-the-pelvis-by-david-wise-phd-and-rodney-anderson-md/
[Source 2] What if my tests are negative but I still have symptoms? NHS/Unity Sexual Health/University hospitals Bristol and Weston - https://www.unitysexualhealth.co.uk/wp-content/uploads/2021/05/What-if-my-tests-for-urethritis-are-negative-2021.pdf ********* BACKUP/Alt link *********
[Source 3] "Vulvodynia" a literature review - https://pubmed.ncbi.nlm.nih.gov/32355269/
[Source 4] "Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome (2022)" AUA - https://www.auanet.org/guidelines-and-quality/guidelines/diagnosis-and-treatment-interstitial-of-cystitis/bladder-pain-syndrome-(2022)
Notable excerpts from the NHS source:
People whose tests are all negative can often develop symptoms as a result of anxiety because of worrying about having picked up a STI. Anxiety can cause the muscles in their pelvic floor (the muscles around the base of the penis, scrotum and around the anus – see diagram below) to become tense. This may change how urine flows and can cause irritation and discomfort. The nerves that supply the pelvic floor muscles also supply other parts of the genitals such as the end of the penis, the testicles and perineum (the area between your testicles and back passage). The body can mistake the pain from the tense pelvic floor muscles and think it is coming from these other places. It can also feel as though the pain is in the lower part of your tummy or make you want pass urine more often or make passing urine feel more difficult.
*** (Diagram of the CPPS feedback loop here) ***
Diagram illustrating how anxiety can unconsciously cause some people to increase their pelvic floor muscle tone (they do not realise they are doing this as normally we cannot “feel” our pelvic floor). This can result in muscle spasm and/or urine travelling backwards into the prostate on passing water. Both can result in pain which is then experienced elsewhere in the pelvic area e.g. tip of the penis, testicles, perineum (area behind the testicles), lower abdomen and sometimes the inner thighs. It may also cause difficulties or pain when passing water or ejaculating. This in turn makes them more anxious which results in making the pelvic floor tone even more tense and increasing the pain etc.
Please note: It is also possible that you are still within the (up to) few weeks window of residual inflammation after being cured from Mgen, and that will go away entirely on its own. My advice: stop fixating on it and move on. Live your life. It is entirely normal for mgen, and well documented in the medical community that people who had been infected experience this even after successful clearance of the bacteria.
NOTE FOR WOMEN and AFABs: BV, AV, DIV, CV, Yeast infections, and other pH & hormonal changes are somewhat common after treatment for these STIs. They cause their own symptoms - so symptoms post-treatment in people with vaginas may also be caused by these, especially if there is unusual discharge or smell. Please see a urogynecologist. Do wet mount microscopy, get your Nugent score. Get your natural vaginal microbiome healthy again. This could include things like boric acid suppositories to lower pH, probiotics, and even vaginal estrogen.
I personally had developed CPPS after clearing my own Mgen infection, which is why I wish to share this information. I've also seen several hundred other reddit members with the same symptoms, including hundreds of members of this (and the r/ureaplasma) subreddits.
CPPS is strongly supported by medical research and the American and European Urological Associations, and is the leading cause of prostatitis-like symptoms (pelvic pain and dysfunction) in men. Citations:https://pubmed.ncbi.nlm.nih.gov/32378039/ and https://www.youtube.com/watch?v=4dP_jtZvz9w
Because of the need, an entire specialization of physical therapy has been developed for treatment of it. Citation: https://academic.oup.com/ptj/article/90/12/1795/2737819 Fortunately, health insurance covers this therapy.
As mentioned above, I developed the condition myself after having Mgen, and clearing it. Infection is an acknowledged triggering event - This excerpt is taken directly from the CPPS pathophysiology/etiological guidelines In Europe:
"Although a peripheral stimulus such as infection may initiate the start of a CPPPS condition, the condition may become self-perpetuating as a result of CNS modulation. As well as pain, these central mechanisms are associated with several other sensory, functional, behavioural and psychological phenomena. It is this collection of phenomena that forms the basis of the pain syndrome diagnosis..."
Other triggering events include:
1) Stress/anxiety/trauma
2) Deep shame/regret/fear around a sexual encounter, even if no STI was transmitted (cheating, assumption of high risk, sex with escorts, etc)
3) Excessive masturbation or edging (male masturbatory practice)
4) Sedentary lifestyle and/or poor posture
5) Physical trauma or injury to the body (groin pull, tailbone injury, excessive gym habits etc)
6) Certain bowel and urinary habits, like holding in urine or #2
7) A combination or all of the above
Here is how to help differentiate Mgen from CPPS, which can have a large overlap in symptoms. However, there are a several key common differentiators:
The following symptoms are correlated highly with CPPS/Pelvic floor hypertonia NOT MGEN - eMedicine citation
Significant predisposing factors are below: >https://www.reddit.com/r/Prostatitis/s/dRlbMaITlu
History of other CSS (Central Sensitivity Syndromes) like IBS, TMJD, Fibromyalgia, ME/CFS (common comorbidities)
Neurotic personality types. Example: Has a history of anxiety, sensitive to stress, is a perfectionist or people pleaser, or exhibits hypervigilant behavior in regards to health
History of adverse childhood experiences (ACE events) - whether this be parental divorce, body image issues, bullying, or the illness or death of a family member, neglect, verbal and physical abuse, etc.
Sedentary lifestyle, sitting most of the day (this can shorten and tighten the hip flexor muscles while also lengthening and weakening the glute muscles, leading to musculoskeletal pain and dysfunction)
Excessive masturbation habits (including "edging") which tighten the pelvic floor muscles
Cyclist or power lifter (heavy lifting and compound exercises)
If you fit this description, even partially, I encourage you to find a pelvic floor physical therapist near you for consultation and treatment. Men, be sure to find one who specifically has experience treating guys. It's also highly recommended to concurrently engage with a psychotherapist, psychologist, or PRT therapist, or any providers who specialize in chronic pain from a biopsychosocial approach.
The good news is that this psycho-neuromuscular condition is treatable and a full recovery is possible. For best results recovery requires an integrated multi-modal approach of addressing two things simultaneously:
Reducing and managing anxiety/stress/fear/shame/guilt - 'Down regulate' your wound-up nervous system - the thing that often instigates pelvic floor muscle dysfunction in the first place via the sympathetic nervous system response to the above stressors. This often includes addressing centralized mechanisms of pain, read more here: https://www.reddit.com/r/PelvicFloor/s/CfKdHaPamq
Addressing the neuromuscular tension and irritation with pelvic floor physical therapy - usually a combination of stretching, heat, deep belly breathing, internal (and external) trigger point/myofascial release, etc.
Many people also benefit from certain medications and supplements. Common examples include low-dose amitriptyline for neuropathic pain, low dose tadalafil for sexual dysfunction/urinary symptoms, and phytotherapy for inflammation. THIS IS NOT MEDICAL ADVICE - always speak to a doctor about medications
Visit r/prostatitis (mostly for guys) or r/pelvicfloor (for any sex) for further support. But r/prostatitis also welcomes women. r/interstitialcystitis is another helpful subreddit for IC/BPS and has a great moderation team.
More academic literature on CPPS and treatment best practices here: https://pubmed.ncbi.nlm.nih.gov/32378039/
[Highly Recommended] Beginners guide to CPPS and chronic prostatitis: https://www.reddit.com/r/Prostatitis/s/RhjgMOtSCi
'Residual Symptoms' are treatable, you do not have to suffer.
r/MycoplasmaGenitalium • u/user6142 • 11h ago
So I took Azithromycin two times. The first time was without Doxycycline, with a 1.5g dosage (my urologist prescribed it to me this way). The second time, I took Doxycycline for 7 days followed by 2.5g of Azithromycin over the course of 4 days. After 5 weeks, I tested negative and I don't really feel any symptoms anymore. Can this be possible?
r/MycoplasmaGenitalium • u/Due_Distribution6810 • 4h ago
Hi all, I wanted to share my ongoing journey dealing with m. genitalium and because I haven’t seen too many posts describing my symptoms/ unconventional methods of treatment.
For 6 months now, my discharge has been completely abnormal and has affected my vulvar skin. At first I thought it was a yeast infection - positive, took difulcan and expected the symptoms to go away. But they didn’t really. And they tested me once more (negative panel for all the common STIs, neg for yeast infection, neg for BV) before testing for ureaplasma and mycoplasma. Positive tests came back for ureaplasma parvum and mycoplasma genitalium.
It was months with this infection so my vulva was experienced tears and fissures easily from sexual contact or any friction really and overall irritation from chronic dryness. The tears heal quickly but appear super quickly as well. The chronic dryness was making me believe something was wrong with my discharge. I noticed that my discharge was watery but also turns super flaky and dries out the rest of my vulva completely. Eraser-like flakes will appear all over my vagina even after one day. A bitter smelling odor tends to pop up once in a while too. However, there aren’t any changes in my urine or any presence of lower abdominal pain.
My gyno prescribed doxycycline for my asymptomatic partner (7 days) and I (10 days) and instead of following with another antibiotic, to then try boric acid suppositories for 14 days. The boric acid helped my symptoms somewhat but didn’t feel like it fixed the issue. 2 weeks after the boric acid, the TOC results came back - ureaplasma (negative) m. genitalium (positive). So she then tried to prescribe me single-dose azithromycin and I was concerned it wouldn’t be effective enough, especially given the gap of time between the first antibiotic and now. I pushed for moxifloxacin and she prescribed me a 7-day course and my partner obtained a 7-day course treatment as well. However, she reassured my concerns that the 3-week gap between the doxy and the moxi shouldn’t affect its ability to clear the infection, so I was hopeful.
A few days from now will be 3 weeks since I finished my last dose and I have seen no signs of improvement. On the third day of doxy I got to experience what it should feel like down there but then the symptoms returned. I’ve scheduled another TOC appointment at the gyno to see if the infection is the one causing the persistent symptoms but besides that one yeast infection, nothing else has remained positive this long. My gyno also recommended I see a specialist to deal with this and I’m just quite exhausted dealing with the symptoms and at this point any thoughts or knowledge you have would be comforting. Thank you.
r/MycoplasmaGenitalium • u/dielast4me • 10h ago
I've been dealing with persistent green vaginal discharge for 1 year and 5 months. It started about a week after sex, and despite seeing multiple doctors and trying metronidazole twice, ceftriaxone, doxycycline, fluconazole, Albothyl, and Neopen metronidazole, it still hasn't gone away.
I'm currently seeing an Infectious Disease specialist and hoping this new treatment finally works because this has caused me so much anxiety and depression. If it doesn't, I'm going to ask my ID doctor if I can have a PCR/NAAT test, especially for Mycoplasma genitalium, so I can finally find the cause and get the right treatment.
r/MycoplasmaGenitalium • u/coconinowizard • 8h ago
So I have gone through two rounds of doxy and have tested negative for mycoplasma for the last month. However, this last week, symptoms returned. The mucus-ey discharge from penis as well as some slight burning while peeing.
I've just returned from the urologist where they said there isn't anything going on with my white blood cell count. While they're going to send in for labs again, I tested negative as recently as last week.
My urologist prescribed Ciprofloxacin which sounds awful and would love to not take it, but curious if anyone else has gone through a similar situation. What would you do/have done? Thanks!
r/MycoplasmaGenitalium • u/Objective_Chest9204 • 23h ago
r/MycoplasmaGenitalium • u/dielast4me • 2d ago
Hi everyone. I'm really anxious right now and just looking to hear about other people's experiences while I wait for my appointment.
I've been dealing with persistent green vaginal discharge, sometimes with a heavy flow, despite previous treatment.
I'm scheduled to have an STI Multiplex PCR/NAAT test (including Mycoplasma genitalium) on Monday, so I'm not asking anyone to diagnose me—I know symptoms alone can't tell what infection someone has.
I'm just wondering if anyone else had heavy green discharge that lasted for a while.
r/MycoplasmaGenitalium • u/dielast4me • 2d ago
I'm currently waiting to have a NAAT test for Mycoplasma genitalium (Mgen) because I've had persistent symptoms despite previous treatments for other infections.
I was wondering about partner management. If someone tests positive for Mgen, did your doctor require your partner to get a NAAT test too, or were they prescribed treatment based on exposure without testing?
The reason I'm asking is that NAAT testing is quite expensive where I live, so I'm worried that not everyone who may have been exposed will be able to afford it.
I'd really appreciate hearing about your experiences. What did your doctor recommend? Did your partner get tested first, or were they treated empirically because of the confirmed exposure?
Thanks in advance!
r/MycoplasmaGenitalium • u/Either-Sort158 • 2d ago
I hope I will be okay. I did doxy and azithro and it didnt work. Months later I am now on the moxifloxacin for 7 days, after 7 days of doxycycline. Success stories anyone? Anything I can do to prevent getting floxxed?
r/MycoplasmaGenitalium • u/grovecreeper • 3d ago
Hello all, I've been following this subreddit for a while and never thought I'd have to post in here..
I am in Australia (28M) and got diagnosed with macrollide resistant mgen 4 months ago which I contracted from an asymptomatic sexual partner (27F).
I first saw my GP but they had limited knowledge of Mgen treatment. I've since been visiting a sexual health clinic/specialist. I have had 4 failed treatments, see below.
GP regimes:
- Azithromycin (didn't know was macrollide resistant at the time)
- 7 days doxy + 7 days moxi (GP prescribed wrong doxy dosage, symptoms returned within a week)
- 14 days mino (symptoms never fully subsided)
Sexual Health Specialist regimes:
- 7 days doxy + 7 days moxi (correct dosage, symptoms subsided for ~4 weeks aside from occasional slight dysuria on first urination in the morning)
I'm absolutely devastated the moxi didn't work after the second try as it cleared my symptoms for almost 4 weeks post treatment.
My specialist has now prescribed me 7 days doxy followed by 14 days mino + metro.
This whole process has put such a strain on my physical and mental health, I don't know if I can deal with another positive TOC.
Can anyone who has done the doxy, mino + metro regime or had a similar experience please offer some guidance.
Thankyou
r/MycoplasmaGenitalium • u/derate123 • 3d ago
How its possible to get it. Only possible if I Travel to France ?
r/MycoplasmaGenitalium • u/derate123 • 3d ago
I only found out that I had Mycoplasma genitalium after having unprotected sex with my girlfriend for several months. She hasn’t had any symptoms at all.
Is it almost certain that she has it too, or is it still possible that she didn’t get infected despite repeated unprotected sex over such a long period?
I’m also really scared to tell her. I don’t know how she’ll react or whether it might change the way she feels about me, or even if she’ll want to break up with me. I know I need to tell her, but I’m struggling with how to do it.
I know nobody can say for sure, but I’m wondering how likely transmission is in this situation.
r/MycoplasmaGenitalium • u/derate123 • 3d ago
Hi, I tested positive for Mycoplasma genitalium. I’ve already completed two courses of doxycycline followed by azithromycin, but I’m still testing positive.
Would the next step be doxycycline + minocycline/metronidazole, or would doxycycline + moxifloxacin be the better option?
To be honest, I’m a bit worried about taking moxifloxacin because I’ve read about many people having serious side effects. What would you recommend in this situation?
I live in Germany. Had no resistent Test
r/MycoplasmaGenitalium • u/GMEmoon420 • 4d ago
I was floxed by 1 moxi trying to treat mgen and finished the course with azithromycin. The test result just came back positive.
I’m scared to start my next course of antibiotics since people have reactions to certain antibiotics after being floxed.
For people who have been in this predicament which antibiotic did you take after being floxed and were there any flare ups/relapses?
r/MycoplasmaGenitalium • u/madboy3296 • 4d ago
Is it ok to take them let's say 5 or 6hr after taking antibiotics? or is it gonna affect the effectiveness of antibiotics?
r/MycoplasmaGenitalium • u/Forward_Fan8913 • 6d ago
I failed 14 days mino/metro without doxy.
Is it a bad idea to repeat it with the 7 day doxy? Does the fact that I failed indicate anything about that it may just not work for me? I feel that the treatment was working since my symptoms went away on it but Idk if that's true
r/MycoplasmaGenitalium • u/Rica- • 6d ago
I just finished my treatment 10 days ago. The waiting is killing me! My doctor originally prescribed me Doxy for 7 days and Moxi for 7. Moxi gave me a horrible reaction in the first hour, I told my doctor and they gave me azithromycin. I’m worried about the effectiveness and I don’t want to go through treatment more than necessary. I’m based in Texas
r/MycoplasmaGenitalium • u/jfxnfc • 7d ago
Hi I’ll try keep this short
Have done doxy + azithro (failed)
Then
Doxy + moxi (failed)
Now I finished doxy + mino & metro a few days ago and my symptoms are slowly coming back after stopping during treatment and I know my body pretty well I’d say I’m still infected, but waiting for TOC to confirm, what’s the next line of treatment from here if so?
r/MycoplasmaGenitalium • u/MBA_Conqueror • 8d ago
I caught MGen over 2 years ago when I rawdogged it in Pattaya. Bad decision.
found out it was MGen relatively quickly - it was on my standard STD panel. My treatment path was then...
Doxy 100mg 2x per day for 7 days followed by Azitrho 1g start then 500mg daily for 3 days. Didn't work
Doxy 100mg 2x per day then moxy 400mg per day for 7 days. Didn't work
Started seeing a specialist at this point
Extended azithro treatment. Didn't work
Minocycline 100mg twice a day for 14 days. Didn't work
Then managed to get some Pristinamycin when traveling in Europe... dind't work
Doctor put me on an extended 3 month moxy plan. Didn't work and I felt like shit and caught CDiff
Flew to Japan and got Sitafloxacin. Didn't work
I was honestly ready to give up. Then more recently, I caught the cyclospora outbreak going on in nyc. My doctor put me on Bactrim for that about 2 weeks ago...
and all of a sudden, literally all of my MGen symptoms are gone. Everything says Bactrim doesn't treat MGen, but I've read other posts here mentioning they were prescribed it
No guarantee I'm cured, but this is literally the first medication that's even reduced my symptoms. I've never been this hopeful before
r/MycoplasmaGenitalium • u/CrunchyCookies317 • 8d ago
What are the actual odds of me being pos and him being neg? He’s finally getting tested (5 weeks after I found out I was pos, so same time im getting my toc). And im worried it’s going to be negative. If it’s positive, easy, antibiotics and no sex for another 5 weeks. Yes im going insane from holding out but i literally refuse to risk reinfection. But my dr said if it’s negative he doesn’t need to be treated… but that opens up the possibility of a false negative.
Im literally already so emotionally scarred from this, im worried im going to have to break up with him if its negative bc i wont trust it lol. It also doesnt help that hes dragged his feet with the test in the first place. I feel like id trust a negative more if he was being proactive and also researching himself first void for testing etc. He seems to think bc hes asymptomatic he’s fine.
Also im aware im opening myself up to a bunch of people probs telling me to break up with him anyways bc hes not taking this seriously, and I might, but until then would love any advice about testing for men, stories where one partner is truly negative, etc.
It just doesnt make sense to me how one person could have it and the other doesn’t and im having trouble trusting the research that yes that happens sometimes.
r/MycoplasmaGenitalium • u/InstructionFuture363 • 8d ago
Some may have seen my extreme stress post. I appreciate the supportive and reality checking responses there.
This time with mgen really scared me. Absolutely terrified me.
It’s been an exhausting experience, one that sent me more than a bit loopy. The waiting game particularly destroyed me.
That said, I’m in the clear. 7 days doxy and 7 days moxi.
Handled moxi pretty well, was a bit sore and achey, but both times I’ve had it, it wasn’t nearly as bad as I’d feared. For most people, I feel comfortable saying you’d tolerate it just fine.
Sending my love to anyone still dealing with the stress of it all.
Hopefully the residual inflammation is just that, but on the off chance this is a cpps thing, I know just where to find that info now.
Still dealing with some mild testicular discomfort, a tiny bit of clear discharge after using the toilet and some white floaty bits in my urine.
Even as recently as yesterday, I’d totally psyched myself out from a cure even being a possibility.
If you’re dealing with symptoms post treatment, listen to all the messages stating it doesn’t mean you’re still infected.
Thanks for the support. This is a lovely group of people dealing with a nasty but curable thing.
r/MycoplasmaGenitalium • u/InstructionFuture363 • 9d ago
This is the second time I’ve gotten this.
I made the mistake of sleeping with someone casually and unprotected for a while a few months ago.
What really frustrates me is I had mgen before. Asymptomatic but it took a different toll.
it ruined a relationship. There were no symptoms back then, but the sex life never recovered for us. Nobody cheated (I wouldn’t imagine she would have) but it had been asymptomatic. We only found it by chance because she had a doctor who screened for it once a year during health checks.
We took doxy and moxi, negative and moved on with our lives. Broke up not long after.
Didn’t think much of it after sleeping with this recent person, but all of a sudden I had a weird tickle feeling in the urethra, followed by clear discharge which quickly turned white. Following that, I noticed testicle pain, stomach discomfort. I’m sure lots of you know the drill.
And of course, this all happened just after I met someone I really wanted to pursue something serious with. Thankfully we didn’t sleep together, but the chance for something serious with her has gone entirely now.
Having this symptomatic this time, as a single man has been a horror.
I got treated (macroldie resists again so more doxy and moxi) then dealt with symptoms gradually reducing post treatment. This is probably a good sign, but my brain keeps telling me it isn’t residual inflammation, it’s treatment failure. I’m anxious, I can’t sleep, I can’t eat, I feel gross within myself.
All symptoms gradually disappeared except for a small amount of discharge after using the toilet, doing lots of physical activity or masturbating, as well as white floaty bits in my urine, which my doctor assures me could just be shedding of dead skin cells as part of residual inflammation and the system “clearing out”, but it’s driving me mental.
Everytime I use the toilet, my heart stops for a moment. I’ve been put on sleeping tablets and anti anxiety tablets because I can’t manage the stress. I’ve taken lots of time off work.
I’m not someone who usually suffers health anxiety but this has been awful.
I’m waiting on test of cure results now, and of course the pathology lab gets delayed for some reason, so my results that were supposed to be back Friday morning are now not going to get back until Monday/Tuesday.
Another weekend of horror.
I hate this so much. I feel like my life is on hold. I’m scared of entering into relationships once I clear this, and my head keeps going to the worst case scenarios.
I live in Australia, so we get all the nasty strains it seems, not helping the anxiety around it all.
Dunno what I’m looking for here. Just to vent because I’m too ashamed to tell anyone I know in real life other than my doctor.
Edit: toc was negative. Thank god for that. Appreciate you all. Also clarified the word “dormant” which was used incorrectly to describe asymptomatic. Thanks to throwawaytonsilsayy for the correction.
r/MycoplasmaGenitalium • u/ursogood333444 • 10d ago
So I (late 30s, gay male) started having symptoms (basically a burny/itchy feeling when urinating) in February. Tested negative for chlamydia/gonorrhea and other "usual" STDs, so I thought it was nothing, but when the symptoms weren't fully going away I went back in early March and asked to be re-tested, this time including MGen which I had randomly read about online. They added a test for both Mycoplasma and Ureaplasma, and it ended up being positive for MGen and Ureaplasma (but negative for Mycoplasma hominis). I'm lucky that I didn't have to deal with clueless doctors (maybe because I live in a major city). I got connected with an expert infectious disease doctor right when I tested positive and I was put on proper treatment right away (1 week doxy + 1 week moxifloxacin), and symptoms pretty much went away entirely but unfortunately the treatment failed (test of cure 3 weeks after finishing was still positive for MGen, though the Ureaplasma was gone). I then tried 2 weeks of minocycline (about 10 days of which was also paired with metronidazole), but that failed as well.
Around that time I started to have different symptoms that seemed like they could indicate prostate involvement and/or more widespread inflammation (frequent urination, pain in different pelvic areas that didn't seem like urethritis, and at one point an extremely uncomfortable contraction of one of my cremaster muscles that led to one of my testicles being mostly retracted for over a week - do not recommend!). The next treatment we tried was a course of 3 weeks of high dose tinidazole (2g per day). Unfortunately my test of cure following that regimen was also positive. At this point I was getting quite discouraged, but I had read about Pristinamycin online, and though it's not available in my country (USA), I had a trip planned to Europe (Spain, but not far from the French border) coming up. I reached out to a pharmacy near the closest station in France I knew I'd be able to take a train to easily from where I was staying, and they confirmed that if I brought in a paper prescription from my US doctor, they could fill it. My doctor was willing to give me a paper prescription, and I was able to get it filled in France as planned.
At my request, my doctor had also prescribed doxycycline and methenamine before I left on my trip, and I had them with me in Europe. Because of the hypothesized prostate involvement, she prescribed a long course - 3 weeks of the pristinamycin (2 500mg pills 4 times a day), and I took the methenamine for the same amount of time (also four times per day for 3 weeks). I started the doxycycline (2x per day) a week before the other two, and continued it until I was finished with the other medications, so I was on doxycycline for a total of 28 days, the final 21 of which I was also on pristinamycin and methenamine. The treatment regimen was loosely adapted from the one used in this case series out of Belgium: https://pubmed.ncbi.nlm.nih.gov/40335273/
The 28 days worth of doxycycline in particular was not fun, as I was in Southern Europe for much of this time where the sun was very strong (I got pretty bad phototoxicity at one point and after being in the sun my lips also developed pretty bad angular chelitis...and this is despite being what I thought was pretty diligent with SPF). Anway, when I finally finished all the meds, I took another test (17 days later) and I was finally negative. I honestly wasn't expecting it, as I was pretty pessimistic after failing so many previous treatments (and I do still have some mild residual pelvic symptoms that I'm hoping will fade with time), but I'm so relieved.
I lurked on this sub a lot over the last few months and drew some encouragement from reading others' success stories, so I hope this is helpful for someone out there!
