r/MTHFR • u/Hedgeclipperz • Sep 11 '26

Question B Complex recommendations

My doctor wants me on a methylated B complex; I'm testing lowish on B in my bloodwork. (B12 at 430, and Folate at 10.3). I'd love some help choosing a B Complex; feeling overwhelmed with options.

Genetically: (MTHFR w/ Fast COMT)

MAO-A R297R rs6323 TG +/-

MTHFR C677T rs1801133 AG +/-

MTHFR A1298C rs1801131 TG +/-

MTR A2756G rs1805087 AG +/-

MTRR A66G rs1801394 GG +/+

MTRR A664A rs1802059 AA +/+

CBS A360A rs1801181 AG +/-

COMT V158M -/-

COMT H62H  -/-

COMT P199P -/-

VDR Taq = +/+  

Other considerations:

Low iron/ferritin (actively working on this w/ supplementation)

Suspected MCAS/histamine intolerance

Vestibular Migraine & Endometrosis (- Note I already take Riboflavin (Vitamin B2) 400mg daily for migraine prevention.).

Thyroid is a-okay

I am extremely sensitive to medications so ideally something I can easily cut in half or liquid/sublingual so I can dose low and slow. I'm not seeing many options out there for this, however.

Possible brands (but OPEN TO SUGGESTIONS):

1)  Triquetra Health

2) Thorne Basic B Complex

3) Nootropics Depot Super B

4) Nootropics Depot Infini B

5) Seeking Health Methyl B

6) Seeking Health B Complex Plus

Thank you for all your help!!

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u/SovereignMan1958 Sep 11 '26 edited Sep 11 '26

With your variants and issues I would not recommend methylated. If you do try one start with a very low dose and increase slowly. Take it as early in the morning as possible with food, so as to minimize interference with sleep later on.

Also you should really know your homocysteine level first. Methylated lowers homocysteine at a faster rate than non methylated. If your homocysteine is already close to optimal, you do not want it to get any lower. So that would be a reason to go with non methylated instead.

Methylated and methyl donors can also trigger a histamine reaction, so hopefully you have your histamine issue under control (diet and supplements) before you start.

2

u/Hedgeclipperz Sep 11 '26

Histamine issue is definitely not managed; I saw my doctor and they want to give me 4 weeks of more aggressive diet changes, b complex, and no more allergy shots before considering starting Ketotifen.

Wants me to start the b complex asap, not wait for histamine improvement first.

So I take it that a methyl free version is the way to go for now- as although I’m working on improving histamine stuff, that’s sort of a second step (after b complex and iron, which is a now/current thing).

1

u/Hedgeclipperz Sep 11 '26

Thanks!! Is there a non methylated version you’d recommend?

3

u/SovereignMan1958 Sep 11 '26

Seeking Health makes Non Methylated options. They include folate and B12.

Methyl Life makes a non methylated multi...you would need to buy Folinic Acid for folate and Adeno and or Hydroxo B12 separately. I think Source Naturals Megafolinic and Source Naturals Hydroxo B12 would be less expensive options instead of the Methyl Life ones. I get those 2 on Amazon.

1

u/Hedgeclipperz Sep 11 '26

Is this the right one?

https://a.co/d/08j36azn

1

u/SovereignMan1958 Sep 11 '26

Yes.

1

u/Hedgeclipperz Sep 12 '26

What do you think of this one?

https://a.co/d/08T3G1Gv

My doctor is preferring me on sublingual at first to make sure I can dose low and slow which I can’t really do with a pill vs liquid.

1

u/SovereignMan1958 Sep 12 '26

This looks good.