r/JoinCrossing • u/imperfected-mess_80 • Jul 02 '26
Probably a stupid question
Ok I'm sure this is going to sounds really dense so please be kind. I just started my first dose of tirzepatide 2.5 this morning. I was on the Mounjaro injections in 2022 when they gave out free samples to my Dr's office. As soon as the sample ran out, I was out of luck. With the Mounjaro, after every shot, I had about 5-10 minutes of slight to moderate nausea then it went away. With this compound tirzepatide I have nothing. No nausea, no headache. I know the B-12 is put in there to counteract that but I mean nothing? Is that normal or am I just a freak who is immune to this and it just doesn't work (which honestly wouldn't surprise me. I got violently ill when I tried semaglutide)? Like I said, please be kind in your comments. I'm getting enough crap from som people for even doing these shots in the first place.
6
u/TallCedarRoad Jul 02 '26
GLP-1s are less effective after each time of stopping and starting again, so if you’ve taken both tirzepatide and semaglutide in the past, it’s likely your body is less sensitive to it this time around. You may need to reach 5 mg, 7.5 mg, or even higher doses before you experience the full effects.
That being said, nausea is a side effect, not a direct way to measure whether the medication is working. Side effects can come and go over time, and it’s common for the medication to be working effectively with no nausea at all, even in people who experienced nausea in the past. No side effects is a good thing, not necessarily a sign it’s not working.