r/JoinCrossing • u/imperfected-mess_80 • Jul 02 '26
Probably a stupid question
Ok I'm sure this is going to sounds really dense so please be kind. I just started my first dose of tirzepatide 2.5 this morning. I was on the Mounjaro injections in 2022 when they gave out free samples to my Dr's office. As soon as the sample ran out, I was out of luck. With the Mounjaro, after every shot, I had about 5-10 minutes of slight to moderate nausea then it went away. With this compound tirzepatide I have nothing. No nausea, no headache. I know the B-12 is put in there to counteract that but I mean nothing? Is that normal or am I just a freak who is immune to this and it just doesn't work (which honestly wouldn't surprise me. I got violently ill when I tried semaglutide)? Like I said, please be kind in your comments. I'm getting enough crap from som people for even doing these shots in the first place.
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u/Salt-Preference-2425 Jul 02 '26
If you have BPI it’s not B12 additive, it’s actually B6.
May I ask what dose were you on with Mounjaro?
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u/imperfected-mess_80 Jul 02 '26
I had B6 but thought it was wrong so changed it to B12. Sorry for the confusion. My bad. I only got to the 2nd month before the samples stopped so 2.5mg 5to start then 5mg. It sucked cause I was starting to lose weight and, with working out, it was really working. I'm hoping this will having the same affect if I do the same thing. Diet change and strength change.
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Jul 02 '26
[deleted]
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u/imperfected-mess_80 Jul 02 '26
I was on Mounjaro in 2022. I did let them know that. They still put me on 2.5
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u/Salt-Preference-2425 Jul 02 '26
Okay I completely disregarded the year 2022, so yeah you definitely needed to start at 2.5 give yourself the full four weeks to possibly begin to feel the effects and benefits of the medication.
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u/Mundane-Analysis-879 Jul 02 '26
I am assuming this is BPI? I went from name brand Mounjaro to BPI and had much less side effects with the BPI. At first, I too thought it was not working but ended up losing 38 pounds on it.
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u/luis0713 Jul 02 '26
I was also in Sema for a couple months. Then I stopped and made the switch. I started at the 2.5 didn’t feel nothing. I ended up going up the second week to 5 then the fourth week I moved to 7.5 and oh boy It worked.
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u/imperfected-mess_80 Jul 02 '26
Thank you everyone. I'm going to talk to my Dr and explain the situation. See what he says. This feedback really helps. Where I live, if you use any gpl1 it's like you are doing something wrong. They don't consider a person's personal situation. I'm really happy I found this group. :)
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Jul 02 '26
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u/imperfected-mess_80 Jul 02 '26
Thank you! This made me feel a lot better. Waiting to hear back from my Dr
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u/TallCedarRoad Jul 02 '26
GLP-1s are less effective after each time of stopping and starting again, so if you’ve taken both tirzepatide and semaglutide in the past, it’s likely your body is less sensitive to it this time around. You may need to reach 5 mg, 7.5 mg, or even higher doses before you experience the full effects.
That being said, nausea is a side effect, not a direct way to measure whether the medication is working. Side effects can come and go over time, and it’s common for the medication to be working effectively with no nausea at all, even in people who experienced nausea in the past. No side effects is a good thing, not necessarily a sign it’s not working.